(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 13gs | SAS | Sulfasalazine (DB00795) | Sulfasalazine is an anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis. | GLUTATHIONE S-TRANSFERASE (Homo sapiens) | GST_C_3GST_N | ||
| 1a95 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | XANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (Escherichia coli) | Pribosyltran | ||
| 1acj | THA | Tacrine (DB00382) | Tacrine is an anticholinesterase drug used for the management of Alzheimer's disease symptoms. | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 1afs | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Rattus norvegicus) | Aldo_ket_red | ||
| 1aod | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C (Listeria monocytogenes) | PI-PLC-X | ||
| 1apw | HSY | Xylose (DB09419) | Xylose is a monosaccharide of the aldopentose type consisted of five carbon atoms and an aldehyde functional group. Xylose is a sugar isolated from wood. D-Xylose is a sugar widely... | PENICILLOPEPSIN (Penicillium janthinellum) | Asp | ||
| 1aqu | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | ESTROGEN SULFOTRANSFERASE (Mus musculus) | Sulfotransfer_1 | ||
| 1b2i | AMH | Tranexamic acid (DB00302) | Tranexamic acid is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. | PROTEIN (PLASMINOGEN) (Homo sapiens) | Kringle | ||
| 1bcu | PRL | Proflavine (DB01123) | Proflavine is a topical antiseptic agent used in wound dressings to prevent infections. | ALPHA-THROMBIN (Hirudo medicinalis;homo sapiens) | Trypsin | ||
| 1bzf | TMQ | Trimetrexate (DB01157) | Trimetrexate is a folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. | DIHYDROFOLATE REDUCTASE (Lactobacillus casei) | NA | ||
| 1c3s | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | HDLP (HISTONE DEACETYLASE-LIKE PROTEIN) (Aquifex aeolicus) | Hist_deacetyl | ||
| 1c8l | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | PROTEIN (GLYCOGEN PHOSPHORYLASE) (Oryctolagus cuniculus) | Phosphorylase | ||
| 1cea | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | PLASMINOGEN (Homo sapiens) | Kringle | ||
| 1ceb | AMH | Tranexamic acid (DB00302) | Tranexamic acid is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. | PLASMINOGEN (Homo sapiens) | Kringle | ||
| 1cet | CLQ | Chloroquine (DB00608) | Chloroquine is an antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. | PROTEIN (L-LACTATE DEHYDROGENASE) (Plasmodium falciparum) | Ldh_1_CLdh_1_N | ||
| 1d7o | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER PROTEIN] REDUCTASE (NADH) PRECURSOR (Brassica napus) | adh_short_C2 | ||
| 1d8c | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | MALATE SYNTHASE G (Escherichia coli) | Malate_synthase | ||
| 1dbb | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | IGG1-KAPPA DB3 FAB (HEAVY CHAIN);IGG1-KAPPA DB3 FAB (LIGHT CHAIN) (Mus musculus) | C1-set | ||
| 1dfo | FFO | Levoleucovorin (DB11596) | Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. | SERINE HYDROXYMETHYLTRANSFERASE (Escherichia coli) | SHMT | ||
| 1dit | 2PP | Valproic acid (DB00313) | Valproic acid is an anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. | ALPHA-THROMBIN;PEPTIDE INHIBITOR CVS995 (Homo sapiens) | Trypsin | ||
| 1dss | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | D-GLYCERALDEHYDE-3-PHOSPHATE-DEHYDROGENASE (Palinurus versicolor) | Gp_dh_CGp_dh_N | ||
| 1e6v | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE I BETA SUBUNIT;METHYL-COENZYME M REDUCTASE I GAMMA SUBUNIT (Methanopyrus kandleri) | MCR_alphaMCR_alpha_NMCR_betaMCR_beta_NMCR_gamma | ||
| 1e6w | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE (Rattus norvegicus) | adh_short | ||
| 1e6y | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | METHYL-COENZYME M REDUCTASE I BETA SUBUNIT;METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA;METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri) | MCR_alphaMCR_alpha_NMCR_betaMCR_beta_NMCR_gamma | ||
| 1e7b | HLT | Halothane (DB01159) | Halothane is a general inhalation anesthetic used for the induction and maintenance of general anesthesia. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 1ea1 | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | CYTOCHROME P450 51-LIKE RV0764C (Mycobacterium tuberculosis) | p450 | ||
| 1ee2 | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | ALCOHOL DEHYDROGENASE (Equus caballus) | ADH_NADH_zinc_N | ||
| 1ei6 | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | PHOSPHONOACETATE HYDROLASE (Pseudomonas fluorescens) | Phosphodiest | ||
| 1epb | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN (Rattus norvegicus) | Lipocalin | ||
| 1eqg | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | PROSTAGLANDIN H2 SYNTHASE-1 (Ovis aries) | An_peroxidaseEGF | ||
| 1ewj | BLM | Bleomycin (DB00290) | Bleomycin is a chemotherapy agent used to treat various malignancies, including head and neck malignancy, lymphoma, and testicular tumors, among others. | BLEOMYCIN RESISTANCE DETERMINANT (Klebsiella pneumoniae) | NA | ||
| 1f5l | AMR | Amiloride (DB00594) | Amiloride is a pyrizine compound used to treat hypertension and congestive heart failure. | UROKINASE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens) | Trypsin | ||
| 1ffy | MRC | Mupirocin (DB00410) | Mupirocin is an antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. | ISOLEUCYL-TRNA SYNTHETASE (Staphylococcus aureus;synthetic construct) | Anticodon_1tRNA-synt_1zf-FPG_IleRS | ||
| 1fr6 | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | BETA-LACTAMASE (Citrobacter freundii) | Beta-lactamase | ||
| 1fxh | PAC | Phenylacetic acid (DB09269) | Phenylacetic acid is an agent used as an adjunct to treat acute hyperammonemia and associated encephalopathy in adult and pediatric patients with deficiencies in enzymes of the urea cycle. | PENICILLIN ACYLASE (Escherichia coli) | NA | ||
| 1g0i | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL MONOPHOSPHATASE (Methanocaldococcus jannaschii) | Inositol_P | ||
| 1gm7 | PNN | Benzylpenicillin (DB01053) | Benzylpenicillin is a penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. | PENICILLIN G ACYLASE ALPHA SUBUNIT;PENICILLIN G ACYLASE BETA SUBUNIT (Escherichia coli) | NA | ||
| 1gpk | HUP | Huperzine a (DB04864) | Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of... | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 1gse | EAA | Etacrynic acid (DB00903) | Etacrynic acid is a diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease. | GLUTATHIONE TRANSFERASE (Homo sapiens) | GST_CGST_N | ||
| 1gti | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | GLUTATHIONE S-TRANSFERASE (Mus musculus) | GST_C_3GST_N | ||
| 1h61 | PDN | Prednisone (DB00635) | Prednisone is a corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases. | PENTAERYTHRITOL TETRANITRATE REDUCTASE (Enterobacter cloacae) | Oxidored_FMN | ||
| 1h8s | AIC | Ampicillin (DB00415) | Ampicillin is a penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. | MUTANT AL2 6E7P9G (Mus musculus) | NA | ||
| 1hk4 | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 1hvy | D16 | Raltitrexed (DB00293) | Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. | THYMIDYLATE SYNTHASE (Homo sapiens) | Thymidylat_synt | ||
| 1i0l | 7HP | Allopurinol (DB00437) | Allopurinol is a xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies. | HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (Trypanosoma cruzi) | Pribosyltran | ||
| 1i1e | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | BOTULINUM NEUROTOXIN TYPE B (Clostridium botulinum) | Peptidase_M27Toxin_R_bind_CToxin_R_bind_NToxin_trans | ||
| 1i2w | 1QL | Cefoxitin (DB01331) | Cefoxitin is a semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection. | BETA-LACTAMASE (Bacillus licheniformis) | Beta-lactamase | ||
| 1ibg | OBN | Ouabain (DB01092) | A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell... | IGG2B-KAPPA 40-50 FAB (HEAVY CHAIN);IGG2B-KAPPA 40-50 FAB (LIGHT CHAIN) (Mus musculus) | NA | ||
| 1iev | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | BETA-D-GLUCAN GLUCOHYDROLASE ISOENZYME EXO1 (Hordeum vulgare) | Glyco_hydro_3Glyco_hydro_3_C | ||
| 1igj | DGX | Digoxin (DB00390) | Digoxin is a cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. | IGG2A-KAPPA 26-10 FAB (HEAVY CHAIN);IGG2A-KAPPA 26-10 FAB (LIGHT CHAIN) (Mus musculus) | NA | ||
| 1ihi | IU5 | Ursodeoxycholic acid (DB01586) | Ursodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients. | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Homo sapiens) | Aldo_ket_red | ||
| 1ilp | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | C-X-C CHEMOKINE RECEPTOR TYPE 1;INTERLEUKIN-8 (PRECURSOR) (Homo sapiens;synthetic construct) | IL8 | ||
| 1itu | CIL | Cilastatin (DB01597) | Cilastatin is a renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections. | RENAL DIPEPTIDASE (Homo sapiens) | Peptidase_M19 | ||
| 1iut | PAB | Aminobenzoic acid (DB02362) | Aminobenzoic acid is a drug used to reduce the progression of penile deviation in Peyronie's Disease in adults. | P-HYDROXYBENZOATE HYDROXYLASE (Pseudomonas aeruginosa) | FAD_binding_3 | ||
| 1iwh | PEM | Bezafibrate (DB01393) | Bezafibrate is a lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. | HEMOGLOBIN ALPHA CHAIN (Equus caballus) | Globin | ||
| 1j3j | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Plasmodium falciparum) | DHFR_1 | ||
| 1j96 | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | 3ALPHA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 (Homo sapiens) | Aldo_ket_red | ||
| 1jb0 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM 1 REACTION CENTRE SUBUNIT IX;PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 (Synechococcus elongatus) | PSI_PsaJPsaA_PsaB | ||
| 1jb0 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Synechococcus elongatus) | PsaA_PsaB | ||
| 1jgs | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | MULTIPLE ANTIBIOTIC RESISTANCE PROTEIN MARR (Escherichia coli) | MarR | ||
| 1jif | BLM | Bleomycin (DB00290) | Bleomycin is a chemotherapy agent used to treat various malignancies, including head and neck malignancy, lymphoma, and testicular tumors, among others. | BLEOMYCIN-BINDING PROTEIN (Streptomyces verticillus) | NA | ||
| 1jnn | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN GAMMA-1 CHAIN;MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN KAPPA CHAIN (Mus musculus) | C1-setV-set | ||
| 1jom | FFO | Levoleucovorin (DB11596) | Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. | DIHYDROFOLATE REDUCTASE (Escherichia coli) | DHFR_1 | ||
| 1jqd | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | HISTAMINE N-METHYLTRANSFERASE (Homo sapiens) | Methyltransf_23 | ||
| 1js3 | 142 | Carbidopa (DB00190) | Carbidopa is a dopa decarboxylase inhibitor used in combination with levodopa for the symptomatic treatment of idiopathic Parkinson disease and other conditions associated with parkinsonian symptoms. | DOPA DECARBOXYLASE (Sus scrofa) | Pyridoxal_deC | ||
| 1jt6 | DEQ | Dequalinium (DB04209) | Dequalinium is a quaternary ammonium cation antimicrobial agent used to treat common infections of the mouth and throat that has been studied in the treatment of vaginal candidiasis. | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 1jtx | CVI | Gentian violet cation (DB00406) | Gentian Violet is an antiseptic violet dye used to prevent various infections, including fungal and bacterial infections. | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 1jyl | CDC | Citicoline (DB12153) | Citicoline is an endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. | CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE (Streptococcus pneumoniae) | NTP_transferase | ||
| 1jzs | MRC | Mupirocin (DB00410) | Mupirocin is an antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. | ISOLEUCYL-TRNA SYNTHETASE (Thermus thermophilus) | tRNA-synt_1 | ||
| 1kar | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | HISTIDINOL DEHYDROGENASE (Escherichia coli) | Histidinol_dh | ||
| 1kny | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | KANAMYCIN NUCLEOTIDYLTRANSFERASE (Staphylococcus aureus) | KNTase_C | ||
| 1kpg | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 (Mycobacterium tuberculosis) | CMAS | ||
| 1l8t | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE (Enterococcus faecalis) | APH | ||
| 1lhv | NOG | Levonorgestrel (DB00367) | Levonorgestrel is a progestin found in oral and IUD contraceptives and at higher doses in emergency contraceptives. | SEX HORMONE-BINDING GLOBULIN (Homo sapiens) | Laminin_G_1 | ||
| 1lin | TFP | Trifluoperazine (DB00831) | Trifluoperazine is a phenothiazine used to treat depression, anxiety, and agitation. | CALMODULIN (Bos taurus) | EF-hand_7 | ||
| 1lqp | FCN | Fosfomycin (DB00828) | Fosfomycin is a broad spectrum antibiotic used to treat uncomplicated urinary tract infections. | PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa) | Glyoxalase | ||
| 1m17 | AQ4 | Erlotinib (DB00530) | Erlotinib is an EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 1m4d | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE (Mycobacterium tuberculosis) | Acetyltransf_9 | ||
| 1m4g | RIO | Ribostamycin (DB03615) | Ribostamycin is a broad spectrum aminoglycoside antibiotic on the list of WHO critical antimicrobials for human medicine. | AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE (Mycobacterium tuberculosis) | Acetyltransf_9 | ||
| 1m4i | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE (Mycobacterium tuberculosis) | Acetyltransf_9 | ||
| 1m6e | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | S-ADENOSYL-L-METHIONINE:SALICYLIC ACID CARBOXYL METHYLTRANSFERASE (Clarkia breweri) | Methyltransf_7 | ||
| 1m8d | CLW | Chlorzoxazone (DB00356) | Chlorzoxazone is a drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. | INDUCIBLE NITRIC OXIDE SYNTHASE (Mus musculus) | NO_synthase | ||
| 1m9j | CLW | Chlorzoxazone (DB00356) | Chlorzoxazone is a drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. | ENDOTHELIAL NITRIC-OXIDE SYNTHASE (Homo sapiens) | NO_synthase | ||
| 1maf | HDZ | Nitrogen (DB09152) | Nitrogen is a cryogenic agent used to treat various benign and malignant skin lesions. | METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT) (Paracoccus versutus) | Me-amine-dh_L | ||
| 1mrl | DOL | Dalfopristin (DB01764) | Dalfopristin is an antibiotic used with quinupristin to treat severe or life-threatening infections of vancomycin-resistant Enterococcus faecium (VREF), and skin infections caused by methicillin susceptible staphylococcus aureus or streptococcus pyogenes. | STREPTOGRAMIN A ACETYLTRANSFERASE (Enterococcus faecium) | Hexapep | ||
| 1mrq | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (Homo sapiens) | Aldo_ket_red | ||
| 1mx1 | THA | Tacrine (DB00382) | Tacrine is an anticholinesterase drug used for the management of Alzheimer's disease symptoms. | LIVER CARBOXYLESTERASE I (Homo sapiens) | COesterase | ||
| 1n0s | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | BILIN-BINDING PROTEIN (Pieris brassicae) | Lipocalin | ||
| 1n4f | ASR | Arsanilic acid (DB03006) | An arsenical which has been used as a feed additive for enteric conditions in pigs and poultry. It causes blindness and is ototoxic and nephrotoxic in animals. [PubChem] | LYSOZYME C (Gallus gallus) | Lys | ||
| 1nd4 | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE (Klebsiella pneumoniae) | APH | ||
| 1nki | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa) | Glyoxalase | ||
| 1nx9 | AIC | Ampicillin (DB00415) | Ampicillin is a penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. | ALPHA-AMINO ACID ESTER HYDROLASE (Acetobacter pasteurianus) | PepX_CPeptidase_S15 | ||
| 1oay | FUR | Furazolidone (DB00614) | Furazolidone is a drug for the treatment of infectious diarrhea. | IMMUNOGLOBULIN E (Mus musculus) | V-set | ||
| 1oj7 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | HYPOTHETICAL OXIDOREDUCTASE YQHD (Escherichia coli) | Fe-ADH | ||
| 1osv | CHC | Obeticholic acid (DB05990) | Obeticholic acid is a bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance to UDCA. | BILE ACID RECEPTOR (Rattus norvegicus;synthetic construct) | Hormone_recep | ||
| 1ot7 | IU5 | Ursodeoxycholic acid (DB01586) | Ursodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients. | BILE ACID RECEPTOR (Rattus norvegicus;synthetic construct) | Hormone_recep | ||
| 1oxr | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | PHOSPHOLIPASE A2 ISOFORM 3 (Naja sagittifera) | Phospholip_A2_1 | ||
| 1pb9 | 4AX | Cycloserine (DB00260) | Cycloserine is a broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI). | N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT 1 (Rattus norvegicus) | NA | ||
| 1pbf | BHA | Aminosalicylic acid (DB00233) | Aminosalicylic acid is an aminosalicylate drug used to induce remission in ulcerative colitis. | P-HYDROXYBENZOATE HYDROXYLASE (Pseudomonas fluorescens) | FAD_binding_3 | ||
| 1pj7 | FFO | Levoleucovorin (DB11596) | Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. | N,N-DIMETHYLGLYCINE OXIDASE (Arthrobacter globiformis) | DAOFAO_MGCV_TGCV_T_C | ||
| 1pk2 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | TISSUE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens) | Kringle | ||
| 1pvs | 7HP | Allopurinol (DB00437) | Allopurinol is a xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies. | DNA-3-METHYLADENINE GLYCOSYLASE II (Escherichia coli) | AlkA_NHhH-GPD | ||
| 1pw7 | RAB | Vidarabine (DB00194) | Vidarabine is an antiviral agent used to treat various viral infections. | PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE (Escherichia coli o157:h7) | PNP_UDP_1 | ||
| 1pwy | AC2 | Acyclovir (DB00787) | Acyclovir is a guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster. | PURINE NUCLEOSIDE PHOSPHORYLASE (Homo sapiens) | PNP_UDP_1 | ||
| 1pxx | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 1q0y | MOI | Morphine (DB00295) | Morphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain. | FAB 9B1, HEAVY CHAIN;FAB 9B1, LIGHT CHAIN (Mus musculus) | V-set | ||
| 1q13 | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | PROSTAGLANDIN-E2 9-REDUCTASE (Oryctolagus cuniculus) | Aldo_ket_red | ||
| 1q20 | PLO | Pregnenolone (DB02789) | A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids. | SULFOTRANSFERASE FAMILY, CYTOSOLIC, 2B, MEMBER 1 ISOFORM B (Homo sapiens) | Sulfotransfer_1 | ||
| 1q23 | FUA | Fusidic acid (DB02703) | Fusidic acid is a topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. | CHLORAMPHENICOL ACETYLTRANSFERASE (Escherichia coli) | CAT | ||
| 1q6i | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA (Escherichia coli) | FKBP_CFKBP_N | ||
| 1q7a | OPB | Oxyphenbutazone (DB03585) | Oxyphenbutazone is a nonsteroidal anti-inflammatory drug (NSAID) no longer commonly used for the symptomatic relief of musculoskeletal pain. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 1qca | FUA | Fusidic acid (DB02703) | Fusidic acid is a topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. | TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE (Shigella flexneri) | CAT | ||
| 1qft | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | PROTEIN (FEMALE-SPECIFIC HISTAMINE BINDING PROTEIN 2) (Rhipicephalus appendiculatus) | His_binding | ||
| 1qhy | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | CHLORAMPHENICOL PHOSPHOTRANSFERASE (Streptomyces venezuelae) | CPT | ||
| 1qlu | EUG | Isoeugenol (DB14188) | Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally in the essential oils of plants such as ylang-ylang. It is also a significant dermatologic... | VANILLYL-ALCOHOL OXIDASE (Penicillium simplicissimum) | FAD-oxidase_CFAD_binding_4 | ||
| 1qsg | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (Escherichia coli) | adh_short_C2 | ||
| 1qur | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | BIVALENT INHIBITOR (BZA-2 HIRULOG);HUMAN THROMBIN (BETA CHAIN) (Homo sapiens;synthetic construct) | Trypsin | ||
| 1qvt | PRL | Proflavine (DB01123) | Proflavine is a topical antiseptic agent used in wound dressings to prevent infections. | TRANSCRIPTIONAL REGULATOR QACR (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 1rkw | PNT | Pentamidine (DB00738) | Pentamidine is an antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. | TRANSCRIPTIONAL REGULATOR QACR (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 1rnr | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | RIBONUCLEOTIDE REDUCTASE R1 PROTEIN (Escherichia coli) | Ribonuc_red_sm | ||
| 1rqj | RIS | Risedronic acid (DB00884) | Risedronic acid is a bisphosphonate used to treat osteoporosis and Paget's disease. | GERANYLTRANSTRANSFERASE (Escherichia coli) | polyprenyl_synt | ||
| 1s2c | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 1s3t | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | UREASE ALPHA SUBUNIT (Sporosarcina pasteurii) | Amidohydro_1Urease_alpha | ||
| 1s3z | RIO | Ribostamycin (DB03615) | Ribostamycin is a broad spectrum aminoglycoside antibiotic on the list of WHO critical antimicrobials for human medicine. | AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE (Salmonella enteritidis) | Acetyltransf_1 | ||
| 1s9p | DES | Diethylstilbestrol (DB00255) | A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report... | ESTROGEN-RELATED RECEPTOR GAMMA (Mus musculus) | Hormone_recep | ||
| 1s9q | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | ESTROGEN-RELATED RECEPTOR GAMMA (Mus musculus) | Hormone_recep | ||
| 1sa1 | POD | Podofilox (DB01179) | Podofilox is a topical agent used for the treatment of external genital warts and perianal warts. | TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN (Rattus norvegicus;bos taurus) | TubulinTubulin_C | ||
| 1sgu | MK1 | Indinavir (DB00224) | Indinavir is a protease inhibitor used to treat HIV infection. | POL POLYPROTEIN (Human immunodeficiency virus 1) | RVP | ||
| 1sv9 | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | PHOSPHOLIPASE A2 (Daboia russellii russellii) | Phospholip_A2_1 | ||
| 1sxk | BHA | Aminosalicylic acid (DB00233) | Aminosalicylic acid is an aminosalicylate drug used to induce remission in ulcerative colitis. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii russellii) | Phospholip_A2_1 | ||
| 1t46 | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 1t9u | CPF | Ciprofloxacin (DB00537) | Ciprofloxacin is a second generation fluoroquinolone used to treat various susceptible bacterial infections. | ACRIFLAVINE RESISTANCE PROTEIN B (Escherichia coli) | ACR_tran | ||
| 1tbf | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1tgm | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | PHOSPHOLIPASE A2 (Daboia russellii russellii) | Phospholip_A2_1 | ||
| 1th6 | OIN | Atropine (DB00572) | Atropine is a muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs. | PHOSPHOLIPASE A2 (Daboia russellii russellii) | Phospholip_A2_1 | ||
| 1tpy | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | METHOXY MYCOLIC ACID SYNTHASE 2 (Mycobacterium tuberculosis) | CMAS | ||
| 1tub | TXL | Docetaxel (DB01248) | Docetaxel is a taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer. | TUBULIN (Sus scrofa) | TubulinTubulin_C | ||
| 1tuf | AZ1 | Azelaic acid (DB00548) | Azelaic acid is a saturated dicarboxylic acid used to treat mild to moderate acne vulgaris. | DIAMINOPIMELATE DECARBOXYLASE (Methanocaldococcus jannaschii) | Orn_Arg_deC_NOrn_DAP_Arg_deC | ||
| 1tv5 | A26 | Teriflunomide (DB08880) | Teriflunomide is a pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. | DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum) | DHO_dh | ||
| 1tyl | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | INSULIN (Homo sapiens) | NA | ||
| 1u65 | CP0 | Irinotecan (DB00762) | Irinotecan is an antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum. | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 1u7g | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | PROBABLE AMMONIUM TRANSPORTER (Escherichia coli) | NA | ||
| 1uof | PNN | Benzylpenicillin (DB01053) | Benzylpenicillin is a penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. | DEACETOXYCEPHALOSPORIN C SYNTHETASE (Streptomyces clavuligerus) | 2OG-FeII_OxyDIOX_N | ||
| 1uou | CMU | Tipiracil (DB09343) | Tipiracil is a thymidine phosphorylase inhibitor used as an adjunct treatment of adult patients with certain types of gastric or colorectal malignancies. | THYMIDINE PHOSPHORYLASE (Homo sapiens) | Glycos_trans_3NGlycos_transf_3PYNP_C | ||
| 1upf | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | URACIL PHOSPHORIBOSYLTRANSFERASE (Toxoplasma gondii) | UPRTase | ||
| 1usq | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | DR HEMAGGLUTININ STRUCTURAL SUBUNIT (Escherichia coli) | Adhesin_Dr | ||
| 1uv6 | CCE | Carbamoylcholine (DB00411) | Carbachol is a direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery. | ACETYLCHOLINE-BINDING PROTEIN (Lymnaea stagnalis) | Neur_chan_LBD | ||
| 1uw6 | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | ACETYLCHOLINE-BINDING PROTEIN (Lymnaea stagnalis) | Neur_chan_LBD | ||
| 1v3e | ZMR | Zanamivir (DB00558) | Zanamivir is a neuraminidase inhibitor used to treat influenza A and B. | HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN (Human parainfluenza virus 3) | NA | ||
| 1v3q | 2DI | Didanosine (DB00900) | Didanosine is a reverse transcriptase inhibitor used to treat HIV. | PURINE NUCLEOSIDE PHOSPHORYLASE (Homo sapiens) | PNP_UDP_1 | ||
| 1vm1 | TAZ | Tazobactam (DB01606) | Tazobactam is a beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy. | BETA-LACTAMASE SHV-1 (Klebsiella pneumoniae) | Beta-lactamase2 | ||
| 1vpo | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | ANTI-TESTOSTERONE (HEAVY CHAIN);ANTI-TESTOSTERONE (LIGHT CHAIN) (Mus musculus) | NA | ||
| 1w3r | 2MN | Metronidazole (DB00916) | Metronidazole is a nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections. | NIMA-RELATED PROTEIN (Deinococcus radiodurans) | Pyridox_ox_2 | ||
| 1w6f | ISZ | Isoniazid (DB00951) | Isoniazid is an antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. | ARYLAMINE N-ACETYLTRANSFERASE (Mycobacterium smegmatis) | Acetyltransf_2 | ||
| 1w6r | GNT | Galantamine (DB00674) | Galantamine is a cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 1wop | FFO | Levoleucovorin (DB11596) | Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. | AMINOMETHYLTRANSFERASE (Thermotoga maritima) | GCV_TGCV_T_C | ||
| 1wrk | TFP | Trifluoperazine (DB00831) | Trifluoperazine is a phenothiazine used to treat depression, anxiety, and agitation. | TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES (Homo sapiens) | EF-hand_8 | ||
| 1wsv | THH | Levomefolic acid (DB11256) | Levomefolic acid is a folate supplement used to prevent neural tube defects in pregnancy or folate deficiency. | AMINOMETHYLTRANSFERASE (Homo sapiens) | GCV_TGCV_T_C | ||
| 1x70 | 715 | Sitagliptin (DB01261) | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus. | DIPEPTIDYL PEPTIDASE IV (Homo sapiens) | DPPIV_NPeptidase_S9 | ||
| 1x9q | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | 4M5.3 ANTI-FLUORESCEIN SINGLE CHAIN ANTIBODY FRAGMENT (Homo sapiens) | NA | ||
| 1xih | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | D-XYLOSE ISOMERASE (Streptomyces rubiginosus) | AP_endonuc_2 | ||
| 1xiu | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | RXR-LIKE PROTEIN (Biomphalaria glabrata;synthetic construct) | Hormone_recep | ||
| 1xkk | FMM | Lapatinib (DB01259) | Lapatinib is an antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 1xmu | ROF | Roflumilast (DB01656) | Roflumilast is a selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xoq | ROF | Roflumilast (DB01656) | Roflumilast is a selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 1xos | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xot | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens) | PDEase_I | ||
| 1xoz | CIA | Tadalafil (DB00820) | Tadalafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1xp0 | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 1xql | 4AX | Cycloserine (DB00260) | Cycloserine is a broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI). | ALANINE RACEMASE (Geobacillus stearothermophilus) | Ala_racemase_CAla_racemase_N | ||
| 1xr3 | ISZ | Isoniazid (DB00951) | Isoniazid is an antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. | ACTINORHODIN POLYKETIDE KETOREDUCTASE (Streptomyces coelicolor) | adh_short | ||
| 1xrk | BLM | Bleomycin (DB00290) | Bleomycin is a chemotherapy agent used to treat various malignancies, including head and neck malignancy, lymphoma, and testicular tumors, among others. | BLEOMYCIN RESISTANCE PROTEIN (Streptoalloteichus hindustanus) | Glyoxalase_7 | ||
| 1xz1 | HLT | Halothane (DB01159) | Halothane is a general inhalation anesthetic used for the induction and maintenance of general anesthesia. | FERRITIN LIGHT CHAIN (Equus caballus) | Ferritin | ||
| 1xz3 | ICF | Isoflurane (DB00753) | Isoflurane is an inhaled general anesthetic used in surgery. | FERRITIN LIGHT CHAIN (Equus caballus) | Ferritin | ||
| 1y7i | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | SALICYLIC ACID-BINDING PROTEIN 2 (Nicotiana tabacum) | Abhydrolase_6 | ||
| 1y7v | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | GLUCOSYLCERAMIDASE (Homo sapiens) | Glyco_hydro_30Glyco_hydro_30C | ||
| 1y93 | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | MACROPHAGE METALLOELASTASE (Homo sapiens) | Peptidase_M10 | ||
| 1yhl | RIS | Risedronic acid (DB00884) | Risedronic acid is a bisphosphonate used to treat osteoporosis and Paget's disease. | FARNESYL PYROPHOSPHATE SYNTHASE (Trypanosoma cruzi) | polyprenyl_synt | ||
| 1ymx | 1QL | Cefoxitin (DB01331) | Cefoxitin is a semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection. | BETA-LACTAMASE CTX-M-9 (Escherichia coli) | Beta-lactamase2 | ||
| 1z11 | 8MO | Methoxsalen (DB00553) | Methoxsalen is a furocoumarin used to treat psoriasis and vitiligo. | CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6 (Homo sapiens) | p450 | ||
| 1z9h | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2 (Macaca fascicularis) | GST_N_3 | ||
| 1zr8 | AJM | Ajmaline (DB01426) | Ajmaline is an antiarrhythmic used to manage a variety of forms of tachycardias. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 1zwp | NIM | Nimesulide (DB04743) | Nimesulide is a cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 1zz1 | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE (Alcaligenaceae bacterium) | Hist_deacetyl | ||
| 207l | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | LYSOZYME (Homo sapiens) | Lys | ||
| 2a3r | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | MONOAMINE-SULFATING PHENOL SULFOTRANSFERASE (Homo sapiens) | Sulfotransfer_1 | ||
| 2a68 | RBT | Rifabutin (DB00615) | Rifabutin is an antibiotic used to treat mycobacterium avium complex disease in patients with HIV. | DNA-DIRECTED RNA POLYMERASE BETA CHAIN;RNA POLYMERASE SIGMA FACTOR RPOD (Thermus thermophilus) | RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7Sigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 2a69 | RPT | Rifapentine (DB01201) | Rifapentine is an antibiotic agent used in the treatment of pulmonary tuberculosis. | DNA-DIRECTED RNA POLYMERASE BETA CHAIN;RNA POLYMERASE SIGMA FACTOR RPOD (Thermus thermophilus) | RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7Sigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 2aa6 | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2aax | PDN | Prednisone (DB00635) | Prednisone is a corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2ab2 | SNL | Spironolactone (DB00421) | Spironolactone is an aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 2aba | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | PENTAERYTHRITOL TETRANITRATE REDUCTASE (Enterobacter cloacae) | Oxidored_FMN | ||
| 2ace | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 2ack | EDR | Edrophonium (DB01010) | Edrophonium is a cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis. | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 2aib | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | BETA-ELICITIN CINNAMOMIN (Phytophthora cinnamomi) | Elicitin | ||
| 2aof | FRD | Amphetamine (DB00182) | Amphetamine is a CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). | PEPTIDE INHIBITOR;POL POLYPROTEIN (Human immunodeficiency virus 1;synthetic construct) | RVP | ||
| 2aoj | FRD | Amphetamine (DB00182) | Amphetamine is a CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). | PEPTIDE INHIBITOR;POL POLYPROTEIN (Human immunodeficiency virus type 1 (bh5 isolate);synthetic construct) | RVP | ||
| 2aot | 2PM | Diphenhydramine (DB01075) | Diphenhydramine is a H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes. | HISTAMINE N-METHYLTRANSFERASE (Homo sapiens) | Methyltransf_23 | ||
| 2aou | CQA | Amodiaquine (DB00613) | Amodiaquine is an antimalarial drug. | HISTAMINE N-METHYLTRANSFERASE (Homo sapiens) | Methyltransf_23 | ||
| 2aow | THA | Tacrine (DB00382) | Tacrine is an anticholinesterase drug used for the management of Alzheimer's disease symptoms. | HISTAMINE N-METHYLTRANSFERASE (Homo sapiens) | Methyltransf_23 | ||
| 2avo | MK1 | Indinavir (DB00224) | Indinavir is a protease inhibitor used to treat HIV infection. | POL POLYPROTEIN (Human immunodeficiency virus 1) | RVP | ||
| 2ayl | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | PROSTAGLANDIN G/H SYNTHASE 1 (Ovis aries) | An_peroxidaseEGF | ||
| 2azy | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | PHOSPHOLIPASE A2, MAJOR ISOENZYME (Sus scrofa) | Phospholip_A2_1 | ||
| 2b0q | NMY | Framycetin (DB00452) | Framycetin is an aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus. | AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE (Enterococcus faecalis) | APH | ||
| 2b35 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Mycobacterium tuberculosis) | adh_short_C2 | ||
| 2b60 | RIT | Ritonavir (DB00503) | Ritonavir is an HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | GAG-POL POLYPROTEIN (Human immunodeficiency virus 1) | RVP | ||
| 2bk4 | RAS | Rasagiline (DB01367) | Rasagiline is an irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa. | AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens) | Amino_oxidase | ||
| 2bl9 | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Plasmodium vivax) | DHFR_1 | ||
| 2bxe | 1FL | Diflunisal (DB00861) | Diflunisal is an NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxf | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxg | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxk | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxn | IDB | Iodipamide (DB04711) | Iodipamide is a contrast agent used in cholangiography and cholecystography. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxo | OPB | Oxyphenbutazone (DB03585) | Oxyphenbutazone is a nonsteroidal anti-inflammatory drug (NSAID) no longer commonly used for the symptomatic relief of musculoskeletal pain. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2bxp | P1Z | Phenylbutazone (DB00812) | Phenylbutazone is an NSAID used to treat backache and ankylosing spondylitis. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2byo | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | LIPOPROTEIN LPPX (Mycobacterium tuberculosis) | LppX_LprAFG | ||
| 2coi | GBN | Gabapentin (DB00996) | Gabapentin is an anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. | BRANCHED CHAIN AMINOTRANSFERASE 1, CYTOSOLIC (Homo sapiens) | Aminotran_4 | ||
| 2d06 | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | SULFOTRANSFERASE 1A1 (Homo sapiens) | Sulfotransfer_1 | ||
| 2dcf | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | 6-AMINOHEXANOATE-DIMER HYDROLASE (Flavobacterium sp.) | Beta-lactamase | ||
| 2dm6 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE (Cavia porcellus) | ADH_N_2ADH_zinc_N | ||
| 2dpz | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 2dqy | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | LIVER CARBOXYLESTERASE 1 (Homo sapiens) | COesterase | ||
| 2dxr | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 2e91 | ZOL | Zoledronic acid (DB00399) | Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. | GERANYLGERANYL PYROPHOSPHATE SYNTHETASE (Saccharomyces cerevisiae) | polyprenyl_synt | ||
| 2f0z | ZMR | Zanamivir (DB00558) | Zanamivir is a neuraminidase inhibitor used to treat influenza A and B. | SIALIDASE 2 (Homo sapiens) | BNR_2 | ||
| 2f10 | BCZ | Peramivir (DB06614) | Peramivir is an intravenous antiviral agent used to treat acute uncomplicated influenza in patients aged 2 years and older who are shown to be symptomatic for no more than two days. | SIALIDASE 2 (Homo sapiens) | BNR_2 | ||
| 2f38 | 15M | Bimatoprost (DB00905) | Bimatoprost is a prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 2f94 | BFQ | Ibandronate (DB00710) | Ibandronate is a bisphosphonate used to treat osteoporosis in postmenopausal women. | FARNESYL DIPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 2fbw | CBE | Carboxin (DB04657) | A systemic agricultural fungicide and seed treatment agent. | SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL;SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL;SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL (Gallus gallus) | Fer2_3Fer4_17Sdh_cyt | ||
| 2fn1 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | SALICYLATE SYNTHETASE, IRP9 (Yersinia enterocolitica) | Chorismate_bind | ||
| 2ft9 | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | FATTY ACID-BINDING PROTEIN 2, LIVER (Ambystoma mexicanum) | Lipocalin | ||
| 2fum | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | PROBABLE SERINE/THREONINE-PROTEIN KINASE PKNB (Mycobacterium tuberculosis h37rv) | Pkinase | ||
| 2fxd | DR7 | Atazanavir (DB01072) | Atazanavir is an antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV. | POL PROTEIN (Human immunodeficiency virus 1) | RVP | ||
| 2g7z | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | CONSERVED HYPOTHETICAL PROTEIN SPY1493 (Streptococcus pyogenes) | DegV | ||
| 2gqg | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 2ha2 | SCK | Succinylcholine (DB00202) | Succinylcholine is a depolarizing skeletal muscle relaxant used adjunctly to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures. | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 2ha4 | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 2hcj | TAC | Tetracycline (DB00759) | Tetracycline is an antibiotic used to treat a wide variety of susceptible infections. | PROTEIN CHAIN ELONGATION FACTOR EF-TU (Escherichia coli) | GTP_EFTU_D2GTP_EFTU_D3 | ||
| 2hmp | 211 | Trolamine (DB13747) | Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine... | ACTIN, ALPHA SKELETAL MUSCLE (Oryctolagus cuniculus) | Actin | ||
| 2huo | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL OXYGENASE (Mus musculus) | MIOX | ||
| 2hzq | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | APOLIPOPROTEIN D (Homo sapiens) | Lipocalin | ||
| 2i2z | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2ine | PAC | Phenylacetic acid (DB09269) | Phenylacetic acid is an agent used as an adjunct to treat acute hyperammonemia and associated encephalopathy in adult and pediatric patients with deficiencies in enzymes of the urea cycle. | ALDOSE REDUCTASE (Homo sapiens) | Aldo_ket_red | ||
| 2iya | ZIO | Oleandomycin (DB11442) | Oleandomycin is a macrolide antibiotic, though it is less effective than erythromycin. It is synthesized from strains of Streptomyces antibioticus. | OLEANDOMYCIN GLYCOSYLTRANSFERASE (Streptomyces antibioticus) | UDPGT | ||
| 2iyf | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | OLEANDOMYCIN GLYCOSYLTRANSFERASE (Streptomyces antibioticus) | UDPGT | ||
| 2j0h | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | FICOLIN-2 (Homo sapiens) | Fibrinogen_C | ||
| 2j1g | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | FICOLIN-2 (Homo sapiens) | Fibrinogen_C | ||
| 2j58 | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | OUTER MEMBRANE LIPOPROTEIN WZA (Escherichia coli) | Poly_exportSLBBWza_C | ||
| 2jap | J01 | Clavulanic acid (DB00766) | Clavulanic acid is a beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics. | CLAVALDEHYDE DEHYDROGENASE (Streptomyces clavuligerus) | adh_short | ||
| 2jj8 | AZZ | Zidovudine (DB00495) | Zidovudine is a dideoxynucleoside used in the treatment of HIV infection. | DEOXYNUCLEOSIDE KINASE (Drosophila melanogaster) | NA | ||
| 2jkn | CL8 | Chloramphenicol succinate (DB07565) | Chloramphenicol succinate is a broad-spectrum antibiotic agent used for the treatment of acute and severe infections caused by susceptible bacterial strains. | DR HEMAGGLUTININ STRUCTURAL SUBUNIT (Escherichia coli) | Adhesin_Dr | ||
| 2jn3 | JN3 | Chenodeoxycholic acid (DB06777) | Chenodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis. | FATTY ACID-BINDING PROTEIN, LIVER (Gallus gallus) | Lipocalin | ||
| 2jst | HLT | Halothane (DB01159) | Halothane is a general inhalation anesthetic used for the induction and maintenance of general anesthesia. | FOUR-ALPHA-HELIX BUNDLE (NA) | NA | ||
| 2kaw | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1 (Mus musculus) | PDZ | ||
| 2kce | D16 | Raltitrexed (DB00293) | Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. | THYMIDYLATE SYNTHASE (Escherichia coli) | Thymidylat_synt | ||
| 2kug | HLT | Halothane (DB01159) | Halothane is a general inhalation anesthetic used for the induction and maintenance of general anesthesia. | CALMODULIN (Homo sapiens) | EF-hand_7 | ||
| 2mji | KTR | Ketorolac (DB00465) | Ketorolac is an NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. | FATTY ACID-BINDING PROTEIN, INTESTINAL (Homo sapiens) | Lipocalin | ||
| 2n27 | 4DY | Capsaicin (DB06774) | Capsaicin is a topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain. | CALMODULIN (Homo sapiens) | EF-hand_7 | ||
| 2nnc | HDZ | Nitrogen (DB09152) | Nitrogen is a cryogenic agent used to treat various benign and malignant skin lesions. | SULFUR COVALENTLY-BINDING PROTEIN (Chlorobium limicola) | SoxY | ||
| 2o1o | RIS | Risedronic acid (DB00884) | Risedronic acid is a bisphosphonate used to treat osteoporosis and Paget's disease. | PUTATIVE FARNESYL PYROPHOSPHATE SYNTHASE (Cryptosporidium parvum) | polyprenyl_synt | ||
| 2o2s | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-ACYL CARRIER REDUCTASE (Toxoplasma gondii) | adh_short_C2 | ||
| 2o73 | 2AL | Allantoin (DB11100) | Allantoin is an ingredient used in skin care products to relieve irritation and protect minor cuts, scrapes, and burns. | OHCU DECARBOXYLASE (Danio rerio) | OHCU_decarbox | ||
| 2ocu | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 2okj | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GLUTAMATE DECARBOXYLASE 1 (Homo sapiens) | Pyridoxal_deC | ||
| 2okk | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GLUTAMATE DECARBOXYLASE 2 (Homo sapiens) | Pyridoxal_deC | ||
| 2olv | M0E | Bambermycins (DB11377) | Bambermycins are antibiotic complexes which are retrieved from the organism, Streptomyces bambergiensis. They are used as an additive in food ingested by chickens and swine. The bambermycin complex of antibiotics... | PENICILLIN-BINDING PROTEIN 2 (Staphylococcus aureus) | TransglyTranspeptidase | ||
| 2os9 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | PULMONARY SURFACTANT-ASSOCIATED PROTEIN D (Homo sapiens) | Lectin_CSurfac_D-trimer | ||
| 2ow9 | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | COLLAGENASE 3 (Homo sapiens) | Peptidase_M10 | ||
| 2p16 | GG2 | Apixaban (DB06605) | Apixaban is an anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery. | COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR) (Homo sapiens) | Trypsin | ||
| 2pd3 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Helicobacter pylori) | adh_short_C2 | ||
| 2ph9 | GNT | Galantamine (DB00674) | Galantamine is a cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. | SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica) | Neur_chan_LBD | ||
| 2pk4 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | HUMAN PLASMINOGEN KRINGLE 4 (Homo sapiens) | Kringle | ||
| 2pl0 | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 2pnc | CLU | Clonidine (DB00575) | Clonidine is an alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines. | COPPER AMINE OXIDASE, LIVER ISOZYME (Bos taurus) | Cu_amine_oxidCu_amine_oxidN2Cu_amine_oxidN3 | ||
| 2pws | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 2q58 | ZOL | Zoledronic acid (DB00399) | Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. | FARNESYL PYROPHOSPHATE SYNTHASE (Cryptosporidium parvum) | polyprenyl_synt | ||
| 2qmz | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE (Homo sapiens) | Flavodoxin_2 | ||
| 2qo4 | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | LIVER-BASIC FATTY ACID BINDING PROTEIN (Danio rerio) | Lipocalin_7 | ||
| 2qqt | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | LACTOPEROXIDASE (Bos taurus) | An_peroxidase | ||
| 2qu9 | EUG | Isoeugenol (DB14188) | Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally in the essential oils of plants such as ylang-ylang. It is also a significant dermatologic... | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 2qvd | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russellii pulchella) | Phospholip_A2_1 | ||
| 2r71 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 2rbr | 268 | Phenoxyethanol (DB11304) | Phenoxyethanol is an antiseptic used as a hand disinfectant or preservative in medications. | LYSOZYME (Enterobacteria phage t4) | Phage_lysozyme | ||
| 2rdd | AIC | Ampicillin (DB00415) | Ampicillin is a penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. | ACRIFLAVINE RESISTANCE PROTEIN B (Escherichia coli) | ACR_tran | ||
| 2rgu | 356 | Linagliptin (DB08882) | Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. | DIPEPTIDYL PEPTIDASE 4 (Homo sapiens) | DPPIV_NPeptidase_S9 | ||
| 2rin | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN (Rhizobium meliloti) | OpuAC | ||
| 2rk8 | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP] (Rattus norvegicus) | PEPCK_GTPPEPCK_N | ||
| 2rlc | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CHOLOYLGLYCINE HYDROLASE (Clostridium perfringens) | CBAH | ||
| 2tct | CTC | Chlortetracycline (DB09093) | Chlortetracycline is the first tetracycline antibiotic most commonly used for veterinary purposes. | TETRACYCLINE REPRESSOR (Escherichia coli) | TetR_C_1TetR_N | ||
| 2uuu | PL3 | Cetyl alcohol (DB09494) | Cetyl alcohol, also known as 1-hexadecanol or n-hexadecyl alcohol, is a 16-C fatty alcohol with the chemical formula CH3(CH2)15OH. It can be produced from the reduction of palmitic acid. Cetyl... | ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE (Dictyostelium discoideum) | FAD-oxidase_CFAD_binding_4 | ||
| 2uxo | TAC | Tetracycline (DB00759) | Tetracycline is an antibiotic used to treat a wide variety of susceptible infections. | HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR (Pseudomonas putida) | TetR_C_2TetR_N | ||
| 2uxp | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR (Pseudomonas putida) | TetR_C_2TetR_N | ||
| 2v3d | NBV | Miglustat (DB00419) | Miglustat is a glucosylceramide synthase inhibitor used for the management of mild to moderate type I Gaucher disease for patients who are not candidates for whole enzyme replacement. | GLUCOSYLCERAMIDASE (Homo sapiens) | Glyco_hydro_30Glyco_hydro_30C | ||
| 2v57 | PRL | Proflavine (DB01123) | Proflavine is a topical antiseptic agent used in wound dressings to prevent infections. | TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR (Mycobacterium smegmatis) | TetR_N | ||
| 2v95 | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | CORTICOSTEROID-BINDING GLOBULIN (Rattus norvegicus) | Serpin | ||
| 2vdb | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | SERUM ALBUMIN (Peptostreptococcus magnus;homo sapiens) | Serum_albumin | ||
| 2vdm | AGG | Tirofiban (DB00775) | Tirofiban is a platelet aggregation inhibitor used to prevent thrombotic events in non-ST elevated acute coronary syndrome. | INTEGRIN ALPHA-IIB;INTEGRIN BETA-3 (Homo sapiens;mus musculus) | FG-GAPIntegrin_betaPSI_integrin | ||
| 2vdy | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | CORTICOSTEROID-BINDING GLOBULIN (Homo sapiens) | Serpin | ||
| 2vft | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | XYLITOL OXIDASE (Streptomyces coelicolor) | ALOFAD_binding_4 | ||
| 2vmy | FFO | Levoleucovorin (DB11596) | Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. | SERINE HYDROXYMETHYLTRANSFERASE (Bacillus stearothermophilus) | SHMT | ||
| 2vn1 | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | 70 KDA PEPTIDYLPROLYL ISOMERASE (Plasmodium falciparum) | FKBP_C | ||
| 2vpp | GEO | Gemcitabine (DB00441) | Gemcitabine is a nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. | DEOXYNUCLEOSIDE KINASE (Drosophila melanogaster) | NA | ||
| 2vq5 | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | S-NORCOCLAURINE SYNTHASE (Thalictrum flavum) | Bet_v_1 | ||
| 2vqs | BVD | Brivudine (DB03312) | Brivudine is a drug used to treat herpes zoster. | DEOXYNUCLEOSIDE KINASE (Drosophila melanogaster) | NA | ||
| 2vuf | FUA | Fusidic acid (DB02703) | Fusidic acid is a topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 2vv0 | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 2w3a | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Homo sapiens) | DHFR_1 | ||
| 2w3v | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Mycobacterium avium) | DHFR_1 | ||
| 2w4x | STZ | Streptozocin (DB00428) | Streptozocin is a nitrosourea antineoplastic agent used in the treatment of metastatic pancreatic islet cell carcinoma. | O-GLCNACASE BT_4395 (Bacteroides thetaiotaomicron) | CBM32Glyco_hydro_20bNAGidase | ||
| 2w98 | P1Z | Phenylbutazone (DB00812) | Phenylbutazone is an NSAID used to treat backache and ankylosing spondylitis. | PROSTAGLANDIN REDUCTASE 2 (Homo sapiens) | ADH_N_2ADH_zinc_N | ||
| 2w9h | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Staphylococcus aureus) | DHFR_1 | ||
| 2w9s | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003 (Staphylococcus aureus) | DHFR_1 | ||
| 2wd9 | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL (Homo sapiens) | AMP-bindingAMP-binding_C | ||
| 2wdq | CBE | Carboxin (DB04657) | A systemic agricultural fungicide and seed treatment agent. | SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT;SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT;SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT (Escherichia coli) | Fer2_3Fer4_17Sdh_cyt | ||
| 2wek | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) | ADH_NADH_zinc_N | ||
| 2wey | EV1 | Papaverine (DB01113) | Papaverine is an alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 2wnc | TKT | Tropisetron (DB11699) | Tropisetron is a 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. | SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica) | Neur_chan_LBD | ||
| 2wq5 | MIY | Minocycline (DB01017) | Minocycline is a tetracycline analog used to treat a wide variety of infections in the body. | PHOSPHOLIPASE A2, ACIDIC (Naja naja) | Phospholip_A2_1 | ||
| 2wv2 | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | LANOSTEROL 14-ALPHA-DEMETHYLASE (Trypanosoma brucei) | p450 | ||
| 2wx2 | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | LANOSTEROL 14-ALPHA-DEMETHYLASE (Trypanosoma cruzi) | p450 | ||
| 2wyw | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL CARRIER PROTEIN] REDUCTASE (Thermus thermophilus) | adh_short_C2 | ||
| 2x0y | X0T | Dyphylline (DB00651) | Dyphylline is a theophylline derivative used to treat asthma, bronchospasm, and COPD. | O-GLCNACASE NAGJ (Clostridium perfringens) | Glyco_hydro_20bNAGidase | ||
| 2x1i | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | 4-ALPHA-GLUCANOTRANSFERASE (Thermus brockianus) | Glyco_hydro_77 | ||
| 2x2n | X2N | Posaconazole (DB01263) | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | LANOSTEROL 14-ALPHA-DEMETHYLASE (Trypanosoma brucei) | p450 | ||
| 2x45 | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | ALLERGEN ARG R 1 (Argas reflexus) | His_binding | ||
| 2x7h | PFN | Fenoprofen (DB00573) | Fenoprofen is an anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. | ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens) | ADH_NADH_zinc_N | ||
| 2x8m | X8M | Ipratropium (DB00332) | Ipratropium is an anticholinergic drug used in the control of symptoms related to bronchospasm in chronic obstructive pulmonary disease (COPD). | CHOLINE-BINDING PROTEIN F (Streptococcus pneumoniae) | Choline_bind_1Choline_bind_3 | ||
| 2x8o | OIN | Atropine (DB00572) | Atropine is a muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs. | CHOLINE-BINDING PROTEIN F (Streptococcus pneumoniae) | Choline_bind_1Choline_bind_3 | ||
| 2xat | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | XENOBIOTIC ACETYLTRANSFERASE (Pseudomonas aeruginosa) | Hexapep | ||
| 2xfh | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | ERYTHROMYCIN B/D C-12 HYDROXYLASE (Saccharopolyspora erythraea) | p450 | ||
| 2xin | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | D-XYLOSE ISOMERASE (Actinoplanes missouriensis) | AP_endonuc_2 | ||
| 2xn3 | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | THYROXINE-BINDING GLOBULIN (Homo sapiens) | NA | ||
| 2xn5 | FUN | Furosemide (DB00695) | Furosemide is a loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. | THYROXINE-BINDING GLOBULIN (Homo sapiens) | NA | ||
| 2xn6 | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | THYROXINE-BINDING GLOBULIN (Homo sapiens) | NA | ||
| 2xpv | MIY | Minocycline (DB01017) | Minocycline is a tetracycline analog used to treat a wide variety of infections in the body. | TETRACYCLINE REPRESSOR PROTEIN CLASS D (Escherichia coli) | TetR_C_1TetR_N | ||
| 2xpw | OTC | Oxytetracycline (DB00595) | Oxytetracycline is a tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections. | TETRACYCLINE REPRESSOR PROTEIN CLASS D (Escherichia coli) | TetR_C_1TetR_N | ||
| 2xtk | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CLASS III CHITINASE CHIA1 (Aspergillus fumigatus) | Glyco_hydro_18 | ||
| 2xud | DME | Decamethonium (DB01245) | Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic... | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 2xyt | TC9 | Tubocurarine (DB01199) | Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to... | SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica) | Neur_chan_LBD | ||
| 2xz5 | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica) | Neur_chan_LBD | ||
| 2y05 | RAL | Raloxifene (DB00481) | Raloxifene is a selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women. | PROSTAGLANDIN REDUCTASE 1 (Homo sapiens) | ADH_N_2ADH_zinc_N | ||
| 2y4n | PAC | Phenylacetic acid (DB09269) | Phenylacetic acid is an agent used as an adjunct to treat acute hyperammonemia and associated encephalopathy in adult and pediatric patients with deficiencies in enzymes of the urea cycle. | PHENYLACETATE-COENZYME A LIGASE (Burkholderia cenocepacia) | AMP-bindingAMP-binding_C_2 | ||
| 2y7j | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens) | Pkinase | ||
| 2y7p | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | LYSR-TYPE REGULATORY PROTEIN (Burkholderia sp.) | LysR_substrate | ||
| 2yk1 | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | FAB FRAGMENT, HEAVY CHAIN;FAB FRAGMENT, LIGHT CHAIN (Homo sapiens) | NA | ||
| 2yme | CWB | Granisetron (DB00889) | Granisetron is a 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively. | SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica) | NA | ||
| 2yoe | FL7 | Flurazepam (DB00690) | Flurazepam is a long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. | CYS-LOOP LIGAND-GATED ION CHANNEL (Erwinia chrysanthemi) | NA | ||
| 2z18 | HDZ | Nitrogen (DB09152) | Nitrogen is a cryogenic agent used to treat various benign and malignant skin lesions. | LYSOZYME C (Gallus gallus) | Lys | ||
| 2z2p | DOL | Dalfopristin (DB01764) | Dalfopristin is an antibiotic used with quinupristin to treat severe or life-threatening infections of vancomycin-resistant Enterococcus faecium (VREF), and skin infections caused by methicillin susceptible staphylococcus aureus or streptococcus pyogenes. | VIRGINIAMYCIN B LYASE (Staphylococcus aureus;synthetic construct) | NA | ||
| 2z71 | PNV | Phenoxymethylpenicillin (DB00417) | Phenoxymethylpenicillin is a penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues. | PENICILLIN ACYLASE (Bacillus sphaericus) | CBAH | ||
| 2zb8 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | PROSTAGLANDIN REDUCTASE 2 (Homo sapiens) | ADH_N_2ADH_zinc_N | ||
| 2zmb | PXB | Parecoxib (DB08439) | Parecoxib is a selective COX-2 inhibitor and NSAID used for the short-term management of perioperative pain. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 2zqc | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | BETA-LACTAMASE TOHO-1 (Escherichia coli) | Beta-lactamase2 | ||
| 2zva | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | TYROSINE-PROTEIN KINASE LYN (Mus musculus) | PK_Tyr_Ser-Thr | ||
| 2zw7 | BLM | Bleomycin (DB00290) | Bleomycin is a chemotherapy agent used to treat various malignancies, including head and neck malignancy, lymphoma, and testicular tumors, among others. | BLEOMYCIN ACETYLTRANSFERASE (Streptomyces verticillus) | Acetyltransf_1Glyoxalase_6 | ||
| 3a2q | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | 6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE (Arthrobacter sp.) | Amidase | ||
| 3a3y | OBN | Ouabain (DB01092) | A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell... | NA, K-ATPASE ALPHA SUBUNIT (Squalus acanthias) | Cation_ATPaseCation_ATPase_CCation_ATPase_NE1-E2_ATPase | ||
| 3adx | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 3am5 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-ACP REDUCTASE (Plasmodium falciparum) | adh_short_C2 | ||
| 3aox | EMH | Alectinib (DB11363) | Alectinib is a kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3apv | TP0 | Amitriptyline (DB00321) | Amitriptyline is a tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
| 3apw | DP0 | Disopyramide (DB00280) | Disopyramide is a class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
| 3apx | Z80 | Chlorpromazine (DB00477) | Chlorpromazine is a phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. | ALPHA-1-ACID GLYCOPROTEIN 2 (Homo sapiens) | Lipocalin | ||
| 3aqt | RCO | Resorcinol (DB11085) | Resorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders... | BACTERIAL REGULATORY PROTEINS, TETR FAMILY (Corynebacterium glutamicum) | TetR_N | ||
| 3b00 | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | LAMINARINASE (Thermotoga maritima) | Glyco_hydro_16 | ||
| 3b0w | DGX | Digoxin (DB00390) | Digoxin is a cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. | NUCLEAR RECEPTOR ROR-GAMMA (Homo sapiens) | Hormone_recep | ||
| 3b6h | MXD | Minoxidil (DB00350) | Minoxidil is an antihypertensive vasodilating agent used for resistant hypertension that is symptomatic or has caused end organ damage. | PROSTACYCLIN SYNTHASE (Homo sapiens) | p450 | ||
| 3b9l | AZZ | Zidovudine (DB00495) | Zidovudine is a dideoxynucleoside used in the treatment of HIV infection. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 3bcr | AZZ | Zidovudine (DB00495) | Zidovudine is a dideoxynucleoside used in the treatment of HIV infection. | GLYCOGEN PHOSPHORYLASE, MUSCLE FORM (Oryctolagus cuniculus) | Phosphorylase | ||
| 3bgd | PM6 | Mercaptopurine (DB01033) | Mercaptopurine is an antineoplastic agent used to treat acute lymphocytic leukemia. | THIOPURINE S-METHYLTRANSFERASE (Mus musculus) | TPMT | ||
| 3bpx | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | TRANSCRIPTIONAL REGULATOR (Methanobacterium thermoautotrophicum) | MarR | ||
| 3brf | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A (Caenorhabditis elegans;synthetic construct) | NA | ||
| 3bti | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | HTH-TYPE TRANSCRIPTIONAL REGULATOR QACR (Staphylococcus aureus) | TetR_C_5TetR_N | ||
| 3bu1 | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | LIPOCALIN (Argas monolakensis) | His_binding | ||
| 3c0z | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | HISTONE DEACETYLASE 7A (Homo sapiens) | Hist_deacetyl | ||
| 3c79 | IM4 | Imidacloprid (DB11421) | Imidacloprid is a neonicotinoid, which is a class of neuro-active insecticides modeled after nicotine. Imidacloprid is a patented chemical, Imidacloprid is manufactured by Bayer Cropscience (part of Bayer AG) and... | SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica) | Neur_chan_LBD | ||
| 3c7q | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3cfl | 5CH | Etoricoxib (DB01628) | Etoricoxib is a selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 3cld | GW6 | Fluticasone furoate (DB08906) | Fluticasone furoate is an inhaled corticosteroid that can be used as maintenance treatment of asthma and/or chronic obstructive pulmonary disease (COPD) depending on the product. Also available as a nasal spray to manage symptoms of allergic rhinitis. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3csj | CBL | Chlorambucil (DB00291) | Chlorambucil is a chemotherapy agent used in the management of chronic lymphocytic leukemia and malignant lymphomas. | GLUTATHIONE S-TRANSFERASE P (Homo sapiens) | GST_C_3GST_N | ||
| 3d6y | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 3dcj | THH | Levomefolic acid (DB11256) | Levomefolic acid is a folate supplement used to prevent neural tube defects in pregnancy or folate deficiency. | PROBABLE 5'-PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE PURN (Mycobacterium tuberculosis) | Formyl_trans_N | ||
| 3dds | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | GLYCOGEN PHOSPHORYLASE, LIVER FORM (Homo sapiens) | Phosphorylase | ||
| 3deu | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | TRANSCRIPTIONAL REGULATOR SLYA (Salmonella typhimurium) | MarR | ||
| 3dgq | EAA | Etacrynic acid (DB00903) | Etacrynic acid is a diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease. | GLUTATHIONE S-TRANSFERASE P (Homo sapiens) | GST_C_3GST_N | ||
| 3dmt | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, GLYCOSOMAL (Trypanosoma cruzi) | Gp_dh_CGp_dh_N | ||
| 3dpf | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | NEUTROPHIL COLLAGENASE (Homo sapiens) | Peptidase_M10 | ||
| 3e9x | NIM | Nimesulide (DB04743) | Nimesulide is a cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea. | LACTOTRANSFERRIN' (Bos taurus) | Transferrin | ||
| 3ea2 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | 1-PHOSPHATIDYLINOSITOL PHOSPHODIESTERASE (Bacillus thuringiensis) | PI-PLC-X | ||
| 3eau | PDN | Prednisone (DB00635) | Prednisone is a corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases. | VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT BETA-2 (Rattus norvegicus) | Aldo_ket_red | ||
| 3elz | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | ILEAL BILE ACID-BINDING PROTEIN (Danio rerio) | NA | ||
| 3etd | B1T | Bithionol (DB04813) | Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the... | GLUD1 PROTEIN (Bos taurus) | ELFV_dehydrogELFV_dehydrog_N | ||
| 3ete | H3P | Hexachlorophene (DB00756) | Hexachlorophene is a chlorinated bisphenol antiseptic used as a surgical scrub and skin cleanser. | GLUTAMATE DEHYDROGENASE (Bos taurus) | ELFV_dehydrogELFV_dehydrog_N | ||
| 3ez3 | ZOL | Zoledronic acid (DB00399) | Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. | FARNESYL PYROPHOSPHATE SYNTHASE, PUTATIVE (Plasmodium vivax) | polyprenyl_synt | ||
| 3f4b | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-ACYL CARRIER PROTEIN REDUCTASE (Plasmodium berghei) | adh_short_C2 | ||
| 3f78 | ICF | Isoflurane (DB00753) | Isoflurane is an inhaled general anesthetic used in surgery. | INTEGRIN ALPHA-L (Homo sapiens) | VWA | ||
| 3f8f | DM1 | Daunorubicin (DB00694) | Daunorubicin is an anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia. | TRANSCRIPTIONAL REGULATOR, PADR-LIKE FAMILY (Lactococcus lactis subsp. cremoris) | PadR | ||
| 3fl9 | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (DHFR) (Bacillus anthracis) | DHFR_1 | ||
| 3fo7 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | PHOSPHOLIPASE A2 VRV-PL-VIIIA (Daboia russelli pulchella) | Phospholip_A2_1 | ||
| 3frl | 211 | Trolamine (DB13747) | Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine... | LIPL32 (Leptospira interrogans serovar copenhageni) | Lipl32 | ||
| 3fw1 | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 3g0b | T22 | Alogliptin (DB06203) | Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat hyperglycemia in patients with type 2 diabetes mellitus. | DIPEPTIDYL PEPTIDASE 4 (Homo sapiens) | DPPIV_NPeptidase_S9 | ||
| 3g0e | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | MAST/STEM CELL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3gf2 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 146AA LONG HYPOTHETICAL TRANSCRIPTIONAL REGULATOR (Sulfolobus tokodaii) | MarR_2 | ||
| 3gkz | B40 | Metamfetamine (DB01577) | Metamfetamine is a sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. | ANTI-METHAMPHETAMINE SINGLE CHAIN FV (Mus musculus) | NA | ||
| 3glq | RAB | Vidarabine (DB00194) | Vidarabine is an antiviral agent used to treat various viral infections. | ADENOSYLHOMOCYSTEINASE (Burkholderia pseudomallei 1710b) | AdoHcyaseAdoHcyase_NAD | ||
| 3gvu | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | TYROSINE-PROTEIN KINASE ABL2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3h0a | 9RA | Bexarotene (DB00307) | Bexarotene is a retinoid drug used for cutaneous manifestations of T-cell lymphoma in patients who have not responded well to previous systemic therapy. | RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3h5g | LEI | Penicillamine (DB00859) | Penicillamine is a chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis. | COIL SER L16D-PEN (NA) | NA | ||
| 3hav | SRY | Streptomycin (DB01082) | Streptomycin is an aminoglycoside antibiotic indicated to treat multi-drug resistant mycobacterium tuberculosis and various non-tuberculosis infections. | AMINOGLYCOSIDE PHOSPHOTRANSFERASE (Enterococcus faecium) | APH | ||
| 3hcn | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | FERROCHELATASE, MITOCHONDRIAL (Homo sapiens) | Ferrochelatase | ||
| 3hf0 | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | GCN4-PLI SIDE CHAIN SEQUENCE ON AN (ALPHA-ALPHA-BETA-ALPHA-BETA-ALPHA-BETA) BACKBONE WITH CYCLIC BETA-RESIDUES (NA) | NA | ||
| 3hii | PNT | Pentamidine (DB00738) | Pentamidine is an antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. | AMILORIDE-SENSITIVE AMINE OXIDASE (Homo sapiens) | Cu_amine_oxidCu_amine_oxidN2Cu_amine_oxidN3 | ||
| 3hl4 | CDC | Citicoline (DB12153) | Citicoline is an endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. | CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE A (Rattus norvegicus) | CTP_transf_like | ||
| 3hs7 | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 3ht9 | JZ3 | Guaiacol (DB11359) | Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.... | LYSOZYME (Enterobacteria phage t4) | Phage_lysozyme | ||
| 3huo | PNN | Benzylpenicillin (DB01053) | Benzylpenicillin is a penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. | CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE (Escherichia coli) | Beta-lactamase2 | ||
| 3hyw | PS9 | Octasulfur (DB09353) | Sulfur is an ingredient of various cosmetic preparations for its keratolytic, antifungal, and antibacterial properties. | SULFIDE-QUINONE REDUCTASE (Aquifex aeolicus) | Pyr_redox_2 | ||
| 3hzs | M0E | Bambermycins (DB11377) | Bambermycins are antibiotic complexes which are retrieved from the organism, Streptomyces bambergiensis. They are used as an additive in food ingested by chickens and swine. The bambermycin complex of antibiotics... | MONOFUNCTIONAL GLYCOSYLTRANSFERASE (Staphylococcus aureus subsp. aureus) | Transgly | ||
| 3i52 | KXN | Cianidanol (DB14086) | An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. | PUTATIVE LEUCOANTHOCYANIDIN REDUCTASE 1 (Vitis vinifera) | NmrA | ||
| 3i6n | ISZ | Isoniazid (DB00951) | Isoniazid is an antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. | LACTOPEROXIDASE (Bos taurus) | An_peroxidase | ||
| 3iak | EV1 | Papaverine (DB01113) | Papaverine is an alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 3iaz | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 3ib0 | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 3ib1 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 3ib2 | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 3iba | ZOL | Zoledronic acid (DB00399) | Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. | FARNESYL PYROPHOSPHATE SYNTHASE (Trypanosoma cruzi) | polyprenyl_synt | ||
| 3ihz | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | 70 KDA PEPTIDYLPROLYL ISOMERASE, PUTATIVE (Plasmodium vivax) | FKBP_C | ||
| 3ik3 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Mus musculus) | PK_Tyr_Ser-Thr | ||
| 3ik6 | HCZ | Hydrochlorothiazide (DB00999) | Hydrochlorothiazide is a thiazide diuretic used to treat edema associated with a number of conditions, and hypertension. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3ilu | HFZ | Hydroflumethiazide (DB00774) | Hydroflumethiazide is a thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3ita | AIC | Ampicillin (DB00415) | Ampicillin is a penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. | D-ALANYL-D-ALANINE CARBOXYPEPTIDASE DACC (Escherichia coli) | PBP5_CPeptidase_S11 | ||
| 3ixl | PAC | Phenylacetic acid (DB09269) | Phenylacetic acid is an agent used as an adjunct to treat acute hyperammonemia and associated encephalopathy in adult and pediatric patients with deficiencies in enzymes of the urea cycle. | ARYLMALONATE DECARBOXYLASE (Bordetella bronchiseptica) | Amdase | ||
| 3jqz | LQZ | Lidocaine (DB00281) | Lidocaine is a local anesthetic used in a wide variety of superficial and invasive procedures. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 3jwq | VIA | Sildenafil (DB00203) | Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA (Homo sapiens) | PDEase_I | ||
| 3jz0 | CLY | Clindamycin (DB01190) | Clindamycin is a lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria. | LINCOSAMIDE NUCLEOTIDYLTRANSFERASE (Enterococcus faecium) | NA | ||
| 3k13 | THH | Levomefolic acid (DB11256) | Levomefolic acid is a folate supplement used to prevent neural tube defects in pregnancy or folate deficiency. | 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE (Bacteroides thetaiotaomicron) | Pterin_bind | ||
| 3k5v | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | TYROSINE-PROTEIN KINASE ABL1 (Mus musculus) | PK_Tyr_Ser-Thr | ||
| 3kb7 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | SERINE/THREONINE-PROTEIN KINASE PLK1 (Homo sapiens) | Pkinase | ||
| 3kcx | CQL | Clioquinol (DB04815) | Clioquinol is an antifungal cream used to treat a variety of fungal infections. | HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR (Homo sapiens) | Cupin_8 | ||
| 3kd5 | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | DNA POLYMERASE (Enterobacteria phage rb69;synthetic construct) | DNA_pol_BDNA_pol_B_exo1 | ||
| 3kdm | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | IMMUNOGLOBULIN HEAVY CHAIN;IMMUNOGLOBULIN LIGHT CHAIN (Homo sapiens) | NA | ||
| 3kee | 30B | Simeprevir (DB06290) | Simeprevir is a direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4. | GENOME POLYPROTEIN (Hepatitis c virus;synthetic construct) | Peptidase_S29 | ||
| 3kiv | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | APOLIPOPROTEIN (Homo sapiens) | Kringle | ||
| 3kk6 | CEL | Celecoxib (DB00482) | Celecoxib is an NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. | PROSTAGLANDIN G/H SYNTHASE 1 (Ovis aries) | An_peroxidaseEGF | ||
| 3kp2 | PNN | Benzylpenicillin (DB01053) | Benzylpenicillin is a penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. | TRANSCRIPTIONAL REGULATOR TCAR (Staphylococcus epidermidis rp62a) | MarR_2 | ||
| 3kp3 | AIC | Ampicillin (DB00415) | Ampicillin is a penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. | TRANSCRIPTIONAL REGULATOR TCAR (Staphylococcus epidermidis rp62a) | MarR_2 | ||
| 3kp5 | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | TRANSCRIPTIONAL REGULATOR TCAR (Staphylococcus epidermidis rp62a) | MarR_2 | ||
| 3kp6 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | TRANSCRIPTIONAL REGULATOR TCAR (Staphylococcus epidermidis rp62a) | MarR_2 | ||
| 3kvr | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | URIDINE PHOSPHORYLASE (Bos taurus) | PNP_UDP_1 | ||
| 3kvv | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | URIDINE PHOSPHORYLASE (Escherichia coli) | PNP_UDP_1 | ||
| 3l1m | HQI | Oxyquinoline (DB11145) | Oxyquinoline is a medication used in combination with other medications to restore vaginal pH. | SOLUBLE CYTOCHROME B562 (Escherichia coli) | Cytochrom_B562 | ||
| 3l4d | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | STEROL 14-ALPHA DEMETHYLASE (Leishmania infantum) | p450 | ||
| 3l4w | MIG | Miglitol (DB00491) | Miglitol is an oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates. | MALTASE-GLUCOAMYLASE, INTESTINAL (Homo sapiens) | Glyco_hydro_31NtCtMGAM_NTrefoil | ||
| 3lb3 | 4CH | Parachlorophenol (DB13154) | Parachlorophenol is an antibacterial agent used to prevent infections in root canals. | DEHALOPEROXIDASE A (Amphitrite ornata) | Globin | ||
| 3ld6 | KKK | Ketoconazole (DB01026) | Ketoconazole is a broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. | LANOSTEROL 14-ALPHA DEMETHYLASE (Homo sapiens) | p450 | ||
| 3ln1 | CEL | Celecoxib (DB00482) | Celecoxib is an NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 3ls4 | TCI | Dronabinol (DB00470) | Dronabinol is a synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. | HEAVY CHAIN OF ANTIBODY FAB FRAGMENT;LIGHT CHAIN OF ANTIBODY FAB FRAGMENT (Mus musculus) | NA | ||
| 3lsf | PZI | Piracetam (DB09210) | Piracetam is a nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3ltw | HLZ | Hydralazine (DB01275) | Hydralazine is an antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia . | ARYLAMINE N-ACETYLTRANSFERASE NAT (Mycobacterium marinum) | Acetyltransf_2 | ||
| 3m6b | 1RG | Ertapenem (DB00303) | Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3mdt | VOR | Voriconazole (DB00582) | Voriconazole is a triazole compound used to treat fungal infections. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 3mdv | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 3mes | DME | Decamethonium (DB01245) | Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic... | CHOLINE KINASE (Cryptosporidium parvum) | Choline_kinase | ||
| 3mnp | DEX | Dexamethasone (DB01234) | Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. | GLUCOCORTICOID RECEPTOR (Mus musculus;synthetic construct) | Hormone_recep | ||
| 3mth | MPB | Methylparaben (DB14212) | Methylparaben is used in allergenic testing. | METHYLPARABEN INSULIN (Sus scrofa) | NA | ||
| 3mze | 1QL | Cefoxitin (DB01331) | Cefoxitin is a semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection. | D-ALANYL-D-ALANINE CARBOXYPEPTIDASE DACA (Escherichia coli) | PBP5_CPeptidase_S11 | ||
| 3n45 | ZOL | Zoledronic acid (DB00399) | Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. | FARNESYL PYROPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 3n8x | NIM | Nimesulide (DB04743) | Nimesulide is a cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea. | PROSTAGLANDIN G/H SYNTHASE 1 (Ovis aries) | An_peroxidaseEGF | ||
| 3n8y | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | PROSTAGLANDIN G/H SYNTHASE 1 (Ovis aries) | An_peroxidaseEGF | ||
| 3n8y | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PROSTAGLANDIN G/H SYNTHASE 1 (Ovis aries) | An_peroxidaseEGF | ||
| 3nai | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | RNA DEPENDENT RNA POLYMERASE (Murine norovirus 1) | RdRP_1 | ||
| 3nbl | DXF | Cefuroxime (DB01112) | Cefuroxime is a cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3nbq | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | URIDINE PHOSPHORYLASE 1 (Homo sapiens) | PNP_UDP_1 | ||
| 3nck | NFF | Nafcillin (DB00607) | Nafcillin is a penicillin derivative antibiotic used to treat susceptible staphylococcal infections. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3nde | 9EP | Cefalotin (DB00456) | Cefalotin is a broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3ndv | AIC | Ampicillin (DB00415) | Ampicillin is a penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. | BETA-PEPTIDYL AMINOPEPTIDASE (Sphingosinicella xenopeptidilytica) | Peptidase_S58 | ||
| 3nfz | 3NF | N-acetyltyrosine (DB11102) | N-acetyltyrosine is an amino acid used in total parenteral nutrition. | ASPARTOACYLASE-2 (Mus musculus) | AstE_AspA | ||
| 3nk2 | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | 6-HYDROXY-L-NICOTINE OXIDASE (Arthrobacter nicotinovorans) | Amino_oxidase | ||
| 3nrc | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (NADH) (Francisella tularensis subsp. tularensis) | adh_short_C2 | ||
| 3nrr | D16 | Raltitrexed (DB00293) | Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. | DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Babesia bovis) | DHFR_1Thymidylat_synt | ||
| 3nsq | CHZ | Dantron (DB04816) | Dantron is a drug used to relieve acute and chronic inflammation of the oral cavity and oropharynx. | RETINOID X RECEPTOR, ALPHA (Homo sapiens) | Hormone_recep | ||
| 3nt1 | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 3nt4 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL 2-DEHYDROGENASE/D-CHIRO-INOSITOL 3-DEHYDROGENASE (Bacillus subtilis) | GFO_IDH_MocAGFO_IDH_MocA_C | ||
| 3ny4 | SMX | Cefamandole (DB01326) | Cefamandole is a beta-lactam antibiotic used in the treatment of various infections caused by susceptible strains of bacteria, such as lower respiratory infections, urinary tract infections, skin infections, and bone and joint infections. | BETA-LACTAMASE (Mycobacterium tuberculosis) | Beta-lactamase2 | ||
| 3o02 | JN3 | Chenodeoxycholic acid (DB06777) | Chenodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis. | CELL INVASION PROTEIN SIPD (Salmonella enterica) | NA | ||
| 3o5r | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5 (Homo sapiens) | FKBP_C | ||
| 3o7j | 2AL | Allantoin (DB11100) | Allantoin is an ingredient used in skin care products to relieve irritation and protect minor cuts, scrapes, and burns. | OHCU DECARBOXYLASE (Klebsiella pneumoniae subsp. pneumoniae) | OHCU_decarbox | ||
| 3ogw | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | LACTOPEROXIDASE (Bos taurus) | An_peroxidase | ||
| 3oid | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH] (Bacillus subtilis) | adh_short_C2 | ||
| 3oif | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Bacillus subtilis) | adh_short_C2 | ||
| 3osh | OIN | Atropine (DB00572) | Atropine is a muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs. | PHOSPHOLIPASE A2 ISOFORM 3 (Naja sagittifera) | Phospholip_A2_1 | ||
| 3owx | XRA | Prazosin (DB00457) | Prazosin is an alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 3ozw | KKK | Ketoconazole (DB01026) | Ketoconazole is a broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. | FLAVOHEMOGLOBIN (Ralstonia eutropha) | FAD_binding_6GlobinNAD_binding_1 | ||
| 3p4w | DSF | Desflurane (DB01189) | Desflurane is a general inhalation anesthetic for inpatient and outpatient surgery in adults. | GLR4197 PROTEIN (Gloeobacter violaceus) | Neur_chan_LBD | ||
| 3p73 | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | MHC RFP-Y CLASS I ALPHA CHAIN (Gallus gallus) | C1-setMHC_I | ||
| 3pbs | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa) | PBP_dimerTranspeptidase | ||
| 3peo | CU9 | Metocurine (DB01336) | Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant. Patients on chronic anticonvulsant drugs are relatively resistant to metocurine. | SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica) | Neur_chan_LBD | ||
| 3pgh | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | CYCLOOXYGENASE-2 (Mus musculus) | An_peroxidaseEGF | ||
| 3po7 | ZON | Zonisamide (DB00909) | Zonisamide is a sulfonamide anticonvulsant used to treat partial seizures. | AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens) | Amino_oxidase | ||
| 3pqz | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | CYCLIC PEPTIDE;GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7 (Homo sapiens;synthetic construct) | SH2 | ||
| 3py4 | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | LACTOPEROXIDASE (Bos taurus) | An_peroxidase | ||
| 3q07 | WPP | Piperacillin (DB00319) | Piperacillin is a penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam susceptible, β-lactamase generating strains of several bacteria. | BETA-LACTAMASE (Escherichia coli) | Beta-lactamase2 | ||
| 3q1e | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | 5-HYDROXYISOURATE HYDROLASE (Danio rerio) | Transthyretin | ||
| 3q1l | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | ASPARTATE BETA-SEMIALDEHYDE DEHYDROGENASE (Streptococcus pneumoniae) | Semialdhyde_dhSemialdhyde_dhC | ||
| 3q2a | PAB | Aminobenzoic acid (DB02362) | Aminobenzoic acid is a drug used to reduce the progression of penile deviation in Peyronie's Disease in adults. | TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN A (Pseudomonas mendocina) | Phenol_Hydrox | ||
| 3q2a | PAB | Aminobenzoic acid (DB02362) | Aminobenzoic acid is a drug used to reduce the progression of penile deviation in Peyronie's Disease in adults. | TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN A;TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN E (Pseudomonas mendocina) | Phenol_Hydrox | ||
| 3q5p | TAC | Tetracycline (DB00759) | Tetracycline is an antibiotic used to treat a wide variety of susceptible infections. | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 3q5r | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 3q5s | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR (Bacillus subtilis;synthetic construct) | GyrI-likeMerR | ||
| 3q6j | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | 2-OXOPROPYL-COM REDUCTASE, CARBOXYLATING (Xanthobacter autotrophicus) | Pyr_redoxPyr_redox_dim | ||
| 3qc5 | HDZ | Nitrogen (DB09152) | Nitrogen is a cryogenic agent used to treat various benign and malignant skin lesions. | PLATELET BINDING PROTEIN GSPB (Streptococcus gordonii) | aRib | ||
| 3qel | QEL | Ifenprodil (DB08954) | N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... | GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-2;NMDA GLUTAMATE RECEPTOR SUBUNIT (Xenopus laevis;rattus norvegicus) | ANF_receptor | ||
| 3qf1 | PZE | Piperazine (DB00592) | Piperazine is a medication used to treat roundworm and pinworm. | LACTOPEROXIDASE (Capra hircus) | An_peroxidase | ||
| 3qfx | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Trypanosoma brucei rhodesiense) | DHFR_1 | ||
| 3qt0 | 486 | Mifepristone (DB00834) | Mifepristone is a cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 3r2v | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | PB2 C-TERMINAL SUBUNIT (Influenza a virus) | Flu_PB2 | ||
| 3r43 | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r4x | PZA | Pyrazinamide (DB00339) | Pyrazinamide is an antituberculosis agent used as a component of tuberculosis (TB) treatment. | LACTOPEROXIDASE (Bos taurus) | An_peroxidase | ||
| 3r58 | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r5o | EUG | Isoeugenol (DB14188) | Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally in the essential oils of plants such as ylang-ylang. It is also a significant dermatologic... | LACTOPEROXIDASE (Bos taurus) | An_peroxidase | ||
| 3r6i | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r7m | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3r8g | IZP | Ibuprofen (DB01050) | Ibuprofen is an NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3rav | RAV | Pentobarbital (DB00312) | Pentobarbital is a barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures. | FERRITIN LIGHT CHAIN (Equus caballus) | Ferritin | ||
| 3rcf | BS4 | Sulfabenzamide (DB09355) | Sulfabenzamide is a sulfonamide antibacterial used as an ingredient in various topical and vaginal preparations to treat certain infections, but has been discontinued by the FDA. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL (Homo sapiens) | Pro_isomerase | ||
| 3rd0 | EDP | Thiopental (DB00599) | Thiopental is a barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. | FERRITIN LIGHT CHAIN (Equus caballus) | Ferritin | ||
| 3reo | EUG | Isoeugenol (DB14188) | Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally in the essential oils of plants such as ylang-ylang. It is also a significant dermatologic... | (ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri) | DimerisationMethyltransf_2 | ||
| 3ret | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | SALICYLATE BIOSYNTHESIS PROTEIN PCHB (Pseudomonas aeruginosa) | CM_2 | ||
| 3rgf | BAX | Sorafenib (DB00398) | Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | CYCLIN-DEPENDENT KINASE 8 (Homo sapiens) | Pkinase | ||
| 3rgs | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | CATALASE (Bos taurus) | CatalaseCatalase-rel | ||
| 3rhw | IVM | Ivermectin (DB00602) | Ivermectin is an anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. | AVERMECTIN-SENSITIVE GLUTAMATE-GATED CHLORIDE CHANNEL GLUCL ALPHA (Caenorhabditis elegans;mus musculus) | NA | ||
| 3rox | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | APOLIPOPROTEIN A-I-BINDING PROTEIN (Mus musculus) | YjeF_N | ||
| 3rq0 | 211 | Trolamine (DB13747) | Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine... | GLYCOSYL HYDROLASES FAMILY PROTEIN 16 (Mycobacterium smegmatis) | Glyco_hydro_16 | ||
| 3rqw | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (Dickeya dadantii) | NA | ||
| 3rum | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | MALTOSE-BINDING PERIPLASMIC PROTEIN (Escherichia coli k-12;amycolatopsis lurida) | SBP_bac_1 | ||
| 3run | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | LYSOZYME (Enterobacteria phage t4;streptomyces orientalis) | Phage_lysozyme | ||
| 3s3g | TLT | Tolmetin (DB00500) | Tolmetin is an NSAID used to treat acute flares of various painful conditions and used for the long term management of osteoarthritis, rheumatoid arthritis, and juvenile arthritis. | ALDOSE REDUCTASE (Homo sapiens) | Aldo_ket_red | ||
| 3s5y | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | ALPHA-GALACTOSIDASE A (Homo sapiens) | Melibiase_2Melibiase_2_C | ||
| 3s68 | TCW | Tolcapone (DB00323) | Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease. | CATECHOL O-METHYLTRANSFERASE (Rattus norvegicus) | Methyltransf_3 | ||
| 3sdr | 210 | Pamidronic acid (DB00282) | Pamidronic acid is a bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions. | ALPHA-BISABOLENE SYNTHASE (Abies grandis) | Terpene_synthTerpene_synth_C | ||
| 3sdv | 911 | Etidronic acid (DB01077) | Etidronic acid is a bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis. | ALPHA-BISABOLENE SYNTHASE (Abies grandis) | Terpene_synthTerpene_synth_C | ||
| 3sfe | TMG | Thiabendazole (DB00730) | Thiabendazole is a benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections. | SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL;SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL;SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL (Sus scrofa) | Fer2_3Fer4_17Sdh_cyt | ||
| 3sfu | RBV | Ribavirin (DB00811) | Ribavirin is a guanosine nucleoside used to treat some forms of Hepatitis C. | RNA POLYMERASE (Murine norovirus 1) | RdRP_1 | ||
| 3sm2 | 478 | Amprenavir (DB00701) | Amprenavir is a protease inhibitor used to treat HIV infection. | GAG-PRO-POL POLYPROTEIN (Dg-75 murine leukemia virus) | RVP | ||
| 3soa | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER (Homo sapiens) | CaMKII_ADPkinase | ||
| 3som | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN (Homo sapiens) | MMACHC | ||
| 3sp6 | IL2 | Iloprost (DB01088) | Iloprost is a synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3sp9 | IL2 | Iloprost (DB01088) | Iloprost is a synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA (Homo sapiens) | Hormone_recep | ||
| 3sqg | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE, BETA SUBUNIT;METHYL-COENZYME M REDUCTASE, GAMMA SUBUNIT (Uncultured archaeon) | MCR_alphaMCR_alpha_NMCR_betaMCR_beta_NMCR_gamma | ||
| 3sxr | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3t01 | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | PHOSPHONOACETATE HYDROLASE (Sinorhizobium meliloti) | Phosphodiest | ||
| 3taj | NBO | Nabumetone (DB00461) | Nabumetone is an NSAID used to treat osteoarthritis and rheumatoid arthritis. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 3tc5 | 3T5 | Betamethasone phosphate (DB14669) | Betamethasone phosphate is a fast acting ester prodrug of a corticosteroid used to treat inflammatory conditions. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 (Homo sapiens) | RotamaseWW | ||
| 3teg | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL (Homo sapiens) | FDX-ACBtRNA-synt_2d | ||
| 3teh | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (Thermus thermophilus) | Phe_tRNA-synt_NtRNA-synt_2d | ||
| 3teh | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (Thermus thermophilus) | B3_4B5FDX-ACBtRNA_bindtRNA_synthFbeta | ||
| 3thd | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | BETA-GALACTOSIDASE (Homo sapiens) | BetaGal_dom4_5Glyco_hydro_35 | ||
| 3ti1 | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | CYCLIN-DEPENDENT KINASE 2 (Homo sapiens) | Pkinase | ||
| 3tkd | CYZ | Cyclothiazide (DB00606) | As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides... | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | NA | ||
| 3tq8 | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Coxiella burnetii) | DHFR_1 | ||
| 3ttr | LQZ | Lidocaine (DB00281) | Lidocaine is a local anesthetic used in a wide variety of superficial and invasive procedures. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 3tvx | PNX | Pentoxifylline (DB00806) | Pentoxifylline is a methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A (Homo sapiens) | PDEase_I | ||
| 3twp | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (Mycobacterium tuberculosis) | Glycos_trans_3NGlycos_transf_3 | ||
| 3txi | QPT | Carboplatin (DB00958) | Carboplatin is a alkylating agent used to treat advanced ovarian cancer. | LYSOZYME C (Gallus gallus) | Lys | ||
| 3tz5 | CLT | Phenylbutyric acid (DB06819) | Phenylbutyric acid is an agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy. | [3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL (Rattus norvegicus) | BCDHK_Adom3HATPase_c | ||
| 3u2c | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | ALDOSE REDUCTASE (Homo sapiens) | Aldo_ket_red | ||
| 3u72 | ISZ | Isoniazid (DB00951) | Isoniazid is an antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 3u7s | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | POL POLYPROTEIN (Human immunodeficiency virus 1) | RVP | ||
| 3u9f | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | CHLORAMPHENICOL ACETYLTRANSFERASE (Escherichia coli) | CAT | ||
| 3ub9 | NHY | Hydroxyurea (DB01005) | Hydroxyurea is an antimetabolite used to treat sickle cell anemia crisis. | CHEMORECEPTOR TLPB (Helicobacter pylori) | sCache_2 | ||
| 3ue0 | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | PENICILLIN-BINDING PROTEIN 1A (Acinetobacter baumannii) | PCB_OBTransglyTranspeptidase | ||
| 3ue4 | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3uf8 | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | UBIQUITIN-LIKE PROTEIN SMT3, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (Saccharomyces cerevisiae;burkholderia pseudomallei) | FKBP_Cubiquitin | ||
| 3ugr | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 3uiv | 308 | Amantadine (DB00915) | Amantadine is a medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 3usu | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | LECTIN ALPHA CHAIN;LECTIN BETA CHAIN (Butea monosperma) | Lectin_legB | ||
| 3v1h | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | 1-PHOSPHATIDYLINOSITOL PHOSPHODIESTERASE (Staphylococcus aureus subsp. aureus) | PI-PLC-X | ||
| 3v35 | NTI | Nitazoxanide (DB00507) | Nitazoxanide is a thiazolide anti-infective used to treat infections by protozoa, helminths, anaerobic bacteria, microaerophilic bacteria, and viruses. | ALDOSE REDUCTASE (Homo sapiens) | Aldo_ket_red | ||
| 3v5w | 8PR | Paroxetine (DB00715) | Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. | G-PROTEIN COUPLED RECEPTOR KINASE 2 (Homo sapiens;bos taurus) | PHPkinaseRGS | ||
| 3vet | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | O-CARBAMOYLTRANSFERASE TOBZ (Streptoalloteichus tenebrarius) | Carbam_trans_CCarbam_trans_N | ||
| 3vhu | SNL | Spironolactone (DB00421) | Spironolactone is an aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 3vkx | T3 | Liothyronine (DB00279) | Liothyronine is a thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. | PROLIFERATING CELL NUCLEAR ANTIGEN (Homo sapiens) | PCNA_CPCNA_N | ||
| 3vm4 | IZP | Ibuprofen (DB01050) | Ibuprofen is an NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. | FATTY ACID ALPHA-HYDROXYLASE (Sphingomonas paucimobilis) | p450 | ||
| 3vma | M0E | Bambermycins (DB11377) | Bambermycins are antibiotic complexes which are retrieved from the organism, Streptomyces bambergiensis. They are used as an additive in food ingested by chickens and swine. The bambermycin complex of antibiotics... | PENICILLIN-BINDING PROTEIN 1B (Escherichia coli) | TransglyTranspeptidaseUB2H | ||
| 3vn2 | TLS | Telmisartan (DB00966) | Telmisartan is an ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 3vri | 1KX | Abacavir (DB01048) | Abacavir is an antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. | 10-MER PEPTIDE;HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-57 ALPHA CHAIN (Homo sapiens;synthetic construct) | C1-setMHC_I | ||
| 3vw0 | DEQ | Dequalinium (DB04209) | Dequalinium is a quaternary ammonium cation antimicrobial agent used to treat common infections of the mouth and throat that has been studied in the treatment of vaginal candidiasis. | PUTATIVE REGULATORY PROTEIN (Salmonella typhimurium) | TetR_N | ||
| 3vw1 | CVI | Gentian violet cation (DB00406) | Gentian Violet is an antiseptic violet dye used to prevent various infections, including fungal and bacterial infections. | PUTATIVE REGULATORY PROTEIN (Salmonella typhimurium) | TetR_N | ||
| 3vw2 | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | PUTATIVE REGULATORY PROTEIN (Salmonella typhimurium) | TetR_N | ||
| 3vw7 | VPX | Vorapaxar (DB09030) | Vorapaxar is a platelet aggregation inhibitor used to reduce thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). | PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 3w1w | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | FERROCHELATASE, MITOCHONDRIAL (Homo sapiens) | Ferrochelatase | ||
| 3wfh | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | MAB FAB H FRAGMENT;MAB FAB L FRAGMENT (Mus musculus) | NA | ||
| 3whx | XPG | Alprostadil (DB00770) | Alprostadil is a medication used to treat erectile dysfunction. | MAB FAB H FRAGMENT;MAB FAB L FRAGMENT (Mus musculus) | NA | ||
| 3wip | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | ACETYLCHOLINE-BINDING PROTEIN (Lymnaea stagnalis) | Neur_chan_LBD | ||
| 3wth | IM4 | Imidacloprid (DB11421) | Imidacloprid is a neonicotinoid, which is a class of neuro-active insecticides modeled after nicotine. Imidacloprid is a patented chemical, Imidacloprid is manufactured by Bayer Cropscience (part of Bayer AG) and... | ACETYLCHOLINE-BINDING PROTEIN (Lymnaea stagnalis) | Neur_chan_LBD | ||
| 3wzd | LEV | Lenvatinib (DB09078) | Lenvatinib is a receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3wze | BAX | Sorafenib (DB00398) | Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3zfz | 1W8 | Ceftaroline fosamil (DB06590) | Ceftaroline fosamil is an antibacterial agent used to treat various bacterial infections, such as acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. | PENICILLIN BINDING PROTEIN 2 PRIME (Staphylococcus aureus subsp. aureus mu50) | PBP_dimerTranspeptidase | ||
| 3zg9 | DXF | Cefuroxime (DB01112) | Cefuroxime is a cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo. | PENICILLIN-BINDING PROTEIN 4 (Listeria monocytogenes) | Transpeptidase | ||
| 3zmd | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PUTATIVE TRANSCRIPTIONAL REGULATOR (Streptomyces coelicolor) | MarR_2 | ||
| 3zof | HQE | Hydroquinone (DB09526) | Hydroquinone is a topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. | FLAVOREDOXIN (Thermus thermophilus) | Flavin_Reduct | ||
| 3zos | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 3zuk | 211 | Trolamine (DB13747) | Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine... | ENDOPEPTIDASE, PEPTIDASE FAMILY M13 (Mycobacterium tuberculosis) | Peptidase_M13Peptidase_M13_N | ||
| 4a6z | JZ3 | Guaiacol (DB11359) | Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.... | CYTOCHROME C PEROXIDASE, MITOCHONDRIAL (Saccharomyces cerevisiae) | peroxidase | ||
| 4a97 | ZPC | Eszopiclone (DB00402) | Eszopiclone is a sedative-hypnotic used in the treatment of insomnia, improving both the latency phase and the maintenance phase of sleep. | CYS-LOOP LIGAND-GATED ION CHANNEL (Erwinia chrysanthemi) | NA | ||
| 4ac0 | MIY | Minocycline (DB01017) | Minocycline is a tetracycline analog used to treat a wide variety of infections in the body. | TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN1 0 (Escherichia coli) | TetR_C_1TetR_N | ||
| 4afg | QMR | Varenicline (DB01273) | Varenicline is a partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation. | CAPITELLA TELETA ACHBP (Capitella teleta) | Neur_chan_LBD | ||
| 4ag8 | AXI | Axitinib (DB06626) | Axitinib is an oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4agd | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4ajx | RCO | Resorcinol (DB11085) | Resorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders... | INSULIN (Homo sapiens) | NA | ||
| 4ali | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH] (Staphylococcus aureus) | adh_short_C2 | ||
| 4an2 | EUI | Cobimetinib (DB05239) | Cobimetinib is an antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 4ay8 | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | METHYLCOBALAMIN: COENZYME M METHYLTRANSFERASE (Methanosarcina mazei) | URO-D | ||
| 4bb2 | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CORTICOSTEROID-BINDING GLOBULIN (Homo sapiens) | NA | ||
| 4bds | THA | Tacrine (DB00382) | Tacrine is an anticholinesterase drug used for the management of Alzheimer's disease symptoms. | CHOLINESTERASE (Homo sapiens) | COesterase | ||
| 4bet | CDC | Citicoline (DB12153) | Citicoline is an endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. | PHOSPHOCHOLINE TRANSFERASE ANKX (Legionella pneumophila) | Ank_2Fic | ||
| 4bkj | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4bva | T3 | Liothyronine (DB00279) | Liothyronine is a thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. | THIOMORPHOLINE-CARBOXYLATE DEHYDROGENASE (Mus musculus) | OCD_Mu_crystall | ||
| 4bvv | CPF | Ciprofloxacin (DB00537) | Ciprofloxacin is a second generation fluoroquinolone used to treat various susceptible bacterial infections. | APOLIPOPROTEIN(A) (Homo sapiens) | Kringle | ||
| 4bz6 | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | HISTONE DEACETYLASE 8 (Schistosoma mansoni) | Hist_deacetyl | ||
| 4c1d | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | BETA-LACTAMASE CLASS B VIM-2 (Pseudomonas aeruginosa) | Lactamase_B | ||
| 4c1f | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | BETA-LACTAMASE IMP-1 (Serratia marcescens) | NA | ||
| 4c1h | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | BETA-LACTAMASE 2 (Bacillus cereus) | Lactamase_B | ||
| 4c94 | KXN | Cianidanol (DB14086) | An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. | FRA A 3 ALLERGEN (Fragaria x ananassa) | NA | ||
| 4c9i | KXN | Cianidanol (DB14086) | An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. | MAJOR STRAWBERRY ALLERGEN FRA A 1-E (Fragaria x ananassa) | NA | ||
| 4cox | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | CYCLOOXYGENASE-2 (Mus musculus) | An_peroxidaseEGF | ||
| 4cp3 | RBT | Rifabutin (DB00615) | Rifabutin is an antibiotic used to treat mycobacterium avium complex disease in patients with HIV. | B-CELL LYMPHOMA 6 PROTEIN (Homo sapiens) | NA | ||
| 4csv | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | SRC-ABL TYROSINE KINASE ANCESTOR (Synthetic construct) | NA | ||
| 4cu8 | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | GLYCOSIDE HYDROLASE 2 (Streptococcus pneumoniae tigr4) | DUF4982Glyco_hydro2_C5Glyco_hydro_2Glyco_hydro_2_CGlyco_hydro_2_N | ||
| 4d1j | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | BETA-GALACTOSIDASE, PUTATIVE, BGL35A (Cellvibrio japonicus) | DUF5597Glyco_hydro_42 | ||
| 4da6 | GA2 | Ganciclovir (DB01004) | Ganciclovir is a DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye. | PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE (Bacillus subtilis) | PNP_UDP_1 | ||
| 4da7 | AC2 | Acyclovir (DB00787) | Acyclovir is a guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster. | PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE (Bacillus subtilis) | PNP_UDP_1 | ||
| 4daj | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M3, LYSOZYME (Rattus norvegicus;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 4dbk | BER | Berberine (DB04115) | An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal... | PHOSPHOLIPASE A2, MAJOR ISOENZYME (Sus scrofa) | Phospholip_A2_1 | ||
| 4dki | RB6 | Ceftobiprole (DB04918) | Ceftobiprole is a cephalosporin antibiotic used to treat both community and hospital-acquired pneumonia caused by susceptible bacteria. | PENICILLIN-BINDING PROTEIN 2' (Staphylococcus aureus) | MecA_NPBP_dimerTranspeptidase | ||
| 4dm3 | RCO | Resorcinol (DB11085) | Resorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders... | PHENYLETHANOLAMINE N-METHYLTRANSFERASE (Homo sapiens) | NNMT_PNMT_TEMT | ||
| 4do5 | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | ALPHA-N-ACETYLGALACTOSAMINIDASE (Homo sapiens) | Melibiase_2Melibiase_2_C | ||
| 4dpr | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | LEUKOTRIENE A-4 HYDROLASE (Homo sapiens) | Leuk-A4-hydro_CPeptidase_M1Peptidase_M1_N | ||
| 4dri | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) | FKBP_C | ||
| 4drj | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) | FKBP_C | ||
| 4dx5 | MIY | Minocycline (DB01017) | Minocycline is a tetracycline analog used to treat a wide variety of infections in the body. | ACRIFLAVINE RESISTANCE PROTEIN B (Escherichia coli;synthetic construct) | ACR_tran | ||
| 4dx7 | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | ACRIFLAVINE RESISTANCE PROTEIN B (Escherichia coli;synthetic construct) | ACR_tran | ||
| 4dxu | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 4e2j | MOF | Mometasone furoate (DB14512) | Mometasone furoate is a corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus. | ANCESTRAL GLUCOCORTICOID RECEPTOR 2 (Synthetic construct;synthetic construct) | NA | ||
| 4eb4 | D16 | Raltitrexed (DB00293) | Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. | THYMIDYLATE SYNTHASE (Mus musculus) | Thymidylat_synt | ||
| 4ebk | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE (Pseudomonas aeruginosa) | AadA_CNTP_transf_2 | ||
| 4eis | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | POLYSACCHARIDE MONOOXYGENASE-3 (Neurospora crassa) | AA9 | ||
| 4ejw | SRY | Streptomycin (DB01082) | Streptomycin is an aminoglycoside antibiotic indicated to treat multi-drug resistant mycobacterium tuberculosis and various non-tuberculosis infections. | TRANSCRIPTIONAL REGULATOR TCAR (Staphylococcus epidermidis rp62a) | MarR_2 | ||
| 4em0 | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus) | MarR | ||
| 4em2 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349 (Staphylococcus aureus) | MarR | ||
| 4enh | FVX | Fluvoxamine (DB00176) | Fluvoxamine is a selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 4eoh | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | PYRIDOXAL KINASE (Homo sapiens) | Phos_pyr_kin | ||
| 4eql | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12 (Arabidopsis thaliana) | GH3 | ||
| 4euo | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | ABC TRANSPORTER, SUBSTRATE BINDING PROTEIN (POLYAMINE) (Agrobacterium tumefaciens) | SBP_bac_8 | ||
| 4evy | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | AMINOGLYCOSIDE N(6')-ACETYLTRANSFERASE TYPE 1 (Acinetobacter haemolyticus) | Acetyltransf_1 | ||
| 4ex6 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | ALNB (Streptomyces sp. cm020) | HAD_2 | ||
| 4ey2 | 0RM | Meticillin (DB01603) | One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. | BETA-LACTAMASE NDM-1 (Klebsiella pneumoniae) | Lactamase_B | ||
| 4ey5 | HUP | Huperzine a (DB04864) | Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of... | ACETYLCHOLINESTERASE (Homo sapiens) | COesterase | ||
| 4ey6 | GNT | Galantamine (DB00674) | Galantamine is a cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. | ACETYLCHOLINESTERASE (Homo sapiens) | COesterase | ||
| 4eyb | 0WO | Oxacillin (DB00713) | Oxacillin is a penicillin antibiotic used to treat a number of susceptible bacterial infections. | BETA-LACTAMASE NDM-1 (Klebsiella pneumoniae) | Lactamase_B | ||
| 4eyl | 0RV | Meropenem (DB00760) | Meropenem is a carbapenem antibiotic used to treat a wide variety of infections in the body. | BETA-LACTAMASE NDM-1 (Klebsiella pneumoniae) | Lactamase_B | ||
| 4eyz | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens) | NA | ||
| 4f92 | SAN | Sulfanilamide (DB00259) | Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. | U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE (Homo sapiens) | DEADHelicase_CSec63 | ||
| 4fab | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | IGG2A-KAPPA 4-4-20 FAB (HEAVY CHAIN);IGG2A-KAPPA 4-4-20 FAB (LIGHT CHAIN) (Mus musculus) | C1-set | ||
| 4ffw | 715 | Sitagliptin (DB01261) | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus. | DIPEPTIDYL PEPTIDASE 4 (Rattus norvegicus;mus musculus) | DPPIV_NPeptidase_S9 | ||
| 4fgj | 1PQ | Primaquine (DB01087) | Primaquine is an antimalarial indicated to prevent relapse of vivax malaria. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 4fgl | CLQ | Chloroquine (DB00608) | Chloroquine is an antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 4fgz | CQA | Amodiaquine (DB00613) | Amodiaquine is an antimalarial drug. | PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE (Plasmodium falciparum) | Methyltransf_25 | ||
| 4fh2 | 0RN | Sulbactam (DB09324) | Sulbactam is an beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections. | BETA-LACTAMASE SHV-1 (Klebsiella pneumoniae) | Beta-lactamase2 | ||
| 4fim | CEL | Celecoxib (DB00482) | Celecoxib is an NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 4fjp | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 4fns | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | ALPHA-GALACTOSIDASE AGAA (Geobacillus stearothermophilus) | Glyco_hydro_36CGlyco_hydro_36NMelibiase | ||
| 4for | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 4fox | D16 | Raltitrexed (DB00293) | Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. | THYMIDYLATE SYNTHASE (Mycobacterium tuberculosis) | Thymidylat_synt | ||
| 4fr8 | TNG | Nitroglycerin (DB00727) | Nitroglycerin is a nitrate vasodilator used to treat or prevent angina, treat hypertension, control heart failure in myocardial infarction, and to induce hypotension intraoperatively. | ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL (Homo sapiens) | Aldedh | ||
| 4g05 | JZ3 | Guaiacol (DB11359) | Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.... | VERSATILE PEROXIDASE VPL2 (Pleurotus eryngii) | peroxidase | ||
| 4g1q | T27 | Rilpivirine (DB08864) | Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1). | P51 RT;REVERSE TRANSCRIPTASE/RIBONUCLEASE H (Human immunodeficiency virus type 1) | RVT_1RVT_connectRVT_thumb | ||
| 4g24 | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN AT2G32230, MITOCHONDRIAL (Arabidopsis thaliana) | PPR_longPRORP | ||
| 4g2z | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 4g5j | 0WM | Afatinib (DB08916) | Afatinib is an antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4g77 | TLF | Tolfenamic acid (DB09216) | Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as... | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 4g8z | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Pneumocystis jirovecii) | DHFR_1 | ||
| 4gkh | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB (Acinetobacter baumannii) | APH | ||
| 4grk | KTR | Ketorolac (DB00465) | Ketorolac is an NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 4hvc | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE (Homo sapiens) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 4hvr | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE (Cupriavidus metallidurans) | 3-HAO | ||
| 4hxy | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | PLM1 (Streptomyces sp. hk803) | KR | ||
| 4i1r | LZU | Thioridazine (DB00679) | Thioridazine is a phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. | MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1 (Homo sapiens) | MALT1_IgPeptidase_C14 | ||
| 4i22 | IRE | Gefitinib (DB00317) | Gefitinib is a tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4i24 | 1C9 | Dacomitinib (DB11963) | Dacomitinib is a medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4i30 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | CONCANAVALIN-A (Canavalia lineata) | Lectin_legB | ||
| 4i5x | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 (Homo sapiens) | Aldo_ket_red | ||
| 4iaq | 2GM | Dihydroergotamine (DB00320) | Dihydroergotamine is an ergot alkaloid used in the acute treatment of migraine headache and cluster headache. | CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 4iar | ERM | Ergotamine (DB00696) | Ergotamine is a alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. | CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 4ib4 | ERM | Ergotamine (DB00696) | Ergotamine is a alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. | CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 4ifg | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | CALMODULIN-DOMAIN PROTEIN KINASE 1 (Toxoplasma gondii) | EF-hand_7Pkinase | ||
| 4ii8 | 010 | Benzyl alcohol (DB06770) | Benzyl alcohol is an antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older. | LYSOZYME C (Gallus gallus) | Lys | ||
| 4iqq | D16 | Raltitrexed (DB00293) | Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. | THYMIDYLATE SYNTHASE (Caenorhabditis elegans) | Thymidylat_synt | ||
| 4ir0 | FCN | Fosfomycin (DB00828) | Fosfomycin is a broad spectrum antibiotic used to treat uncomplicated urinary tract infections. | METALLOTHIOL TRANSFERASE FOSB 2 (Bacillus anthracis) | Glyoxalase | ||
| 4irx | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | SUGAR ABC TRANSPORTER, PERIPLASMIC SUGAR-BINDING PROTEIN (Caulobacter crescentus) | Peripla_BP_4 | ||
| 4j03 | FVS | Fulvestrant (DB00947) | Fulvestrant is an estrogen receptor antagonist used to treat HR+ breast cancer that may also be HER2-. | BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens) | Abhydrolase_1Hydrolase | ||
| 4j14 | X2N | Posaconazole (DB01263) | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | CHOLESTEROL 24-HYDROXYLASE (Homo sapiens) | NA | ||
| 4jd6 | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | ENHANCED INTRACELLULAR SURVIVAL PROTEIN (Mycobacterium tuberculosis) | Acetyltransf_17Acetyltransf_9SCP2_2 | ||
| 4jh6 | FCN | Fosfomycin (DB00828) | Fosfomycin is a broad spectrum antibiotic used to treat uncomplicated urinary tract infections. | METALLOTHIOL TRANSFERASE FOSB (Bacillus cereus) | Glyoxalase | ||
| 4jps | 1LT | Alpelisib (DB12015) | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid... | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinase | ||
| 4jq1 | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jq2 | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jq4 | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jqa | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jtq | FLP | Flurbiprofen (DB00712) | Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jtr | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jtr | IZP | Ibuprofen (DB01050) | Ibuprofen is an NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2 (Homo sapiens) | Aldo_ket_red | ||
| 4jvl | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | ESTROGEN SULFOTRANSFERASE (Homo sapiens) | Sulfotransfer_1 | ||
| 4k17 | OHB | Salicylamide (DB08797) | Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... | LEUCINE-RICH REPEAT-CONTAINING PROTEIN 16A (Mus musculus) | Carm_PHLRR_6 | ||
| 4k17 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | LEUCINE-RICH REPEAT-CONTAINING PROTEIN 16A (Mus musculus) | Carm_PHLRR_6 | ||
| 4k7q | ZLD | Linezolid (DB00601) | Linezolid is an oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. | ACRIFLAVINE RESISTANCE PROTEIN B (Escherichia coli) | ACR_tran | ||
| 4k90 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | EXTRACELLULAR METALLOPROTEINASE MEP (Aspergillus fumigatus) | FTPPeptidase_M36 | ||
| 4k90 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | EXTRACELLULAR METALLOPROTEINASE MEP (Aspergillus fumigatus) | FTP | ||
| 4km0 | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | DIHYDROFOLATE REDUCTASE (Mycobacterium tuberculosis) | DHFR_1 | ||
| 4km2 | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Mycobacterium tuberculosis) | DHFR_1 | ||
| 4kpj | 210 | Pamidronic acid (DB00282) | Pamidronic acid is a bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions. | FARNESYL PYROPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 4kuk | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | BLUE-LIGHT PHOTORECEPTOR (Dinoroseobacter shibae) | PAS_9 | ||
| 4kyc | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | MALTOSE-BINDING PERIPLASMIC PROTEIN, PHOSPHOPROTEIN, CHIMERIC CONSTRUCT (Escherichia coli;menangle virus) | SBP_bac_1 | ||
| 4kyk | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | LACTOYLGLUTATHIONE LYASE (Mus musculus) | Glyoxalase | ||
| 4l9q | 9TP | Teniposide (DB00444) | Teniposide is a cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 4laj | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN (Human immunodeficiency virus 1;lama glama;synthetic construct) | NA | ||
| 4lar | 1WE | Dextroamphetamine (DB01576) | Dextroamphetamine is a sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. | SINGLE CHAIN ANTIBODY FRAGMENT SCFV6H4 (Mus musculus) | NA | ||
| 4lax | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4 (Homo sapiens) | FKBP_C | ||
| 4lb2 | DM5 | Idarubicin (DB01177) | Idarubicin is an anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 4lb9 | EVP | Etoposide (DB00773) | Etoposide is a podophyllotoxin derivative used to treat testicular and small cell lung tumors. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 4ldo | ALE | Epinephrine (DB00668) | Epinephrine is a hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. | LYSOZYME, BETA-2 ADRENERGIC RECEPTOR (Enterobacteria phage t4;homo sapiens;lama glama) | 7tm_1Phage_lysozyme | ||
| 4lhm | AZZ | Zidovudine (DB00495) | Zidovudine is a dideoxynucleoside used in the treatment of HIV infection. | THYMIDINE PHOSPHORYLASE (Escherichia coli) | Glycos_trans_3NGlycos_transf_3PYNP_C | ||
| 4lmn | EUI | Cobimetinib (DB05239) | Cobimetinib is an antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 4lnx | T44 | Levothyroxine (DB00451) | Levothyroxine is a synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. | THYROID HORMONE RECEPTOR ALPHA (Homo sapiens) | NA | ||
| 4ltw | 486 | Mifepristone (DB00834) | Mifepristone is a cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation. | ANCESTRAL STEROID RECEPTOR 2 (Ancestral gene) | NA | ||
| 4ltw | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | ANCESTRAL STEROID RECEPTOR 2 (Ancestral gene) | NA | ||
| 4lv9 | 20J | Diazoxide (DB01119) | Diazoxide is a non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions. | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (Homo sapiens) | NAMPT_NNAPRTase | ||
| 4lxz | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | HISTONE DEACETYLASE 2 (Homo sapiens) | Hist_deacetyl | ||
| 4m10 | ICD | Isoxicam (DB08942) | Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4m11 | MXM | Meloxicam (DB00814) | Meloxicam is an NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4m2x | TMQ | Trimetrexate (DB01157) | Trimetrexate is a folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. | DIHYDROFOLATE REDUCTASE (Mycobacterium tuberculosis) | DHFR_1 | ||
| 4m3c | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | SEED LECTIN ALPHA CHAIN;SEED LECTIN BETA CHAIN (Butea monosperma;spatholobus parviflorus) | Lectin_legB | ||
| 4m5m | DX4 | Tioguanine (DB00352) | Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. | 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE (Escherichia coli) | HPPK | ||
| 4m89 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Neisseria meningitidis) | adh_short_C2 | ||
| 4miy | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | INOSITOL 2-DEHYDROGENASE/D-CHIRO-INOSITOL 3-DEHYDROGENASE (Lactobacillus casei) | GFO_IDH_MocAGFO_IDH_MocA_C | ||
| 4mjq | 27R | Bromfenac (DB00963) | Bromfenac is an NSAID used to treat postoperative pain and inflammation of the eye. | DNA POLYMERASE III SUBUNIT BETA (Escherichia coli) | DNA_pol3_betaDNA_pol3_beta_2DNA_pol3_beta_3 | ||
| 4mkc | 4MK | Ceritinib (DB09063) | Ceritinib is an antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4mv7 | PPF | Foscarnet (DB00529) | Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. | BIOTIN CARBOXYLASE (Haemophilus influenzae) | Biotin_carb_CBiotin_carb_NCPSase_L_D2 | ||
| 4mvc | CDC | Citicoline (DB12153) | Citicoline is an endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. | CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE A (Rattus norvegicus) | CTP_transf_like | ||
| 4mwz | CQA | Amodiaquine (DB00613) | Amodiaquine is an antimalarial drug. | PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE (Plasmodium vivax) | Methyltransf_25 | ||
| 4n0z | CPT | Cisplatin (DB00515) | Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. | GLUTAREDOXIN (Plasmodium falciparum) | Glutaredoxin | ||
| 4n6p | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 4ncg | 2KW | Doravirine (DB12301) | Doravirine is a non-nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals to treat HIV-1 infections. | REVERSE TRANSCRIPTASE/RIBONUCLEASE H (Human immunodeficiency virus 1) | RNase_HRVT_1RVT_connectRVT_thumb | ||
| 4nct | 2K2 | Midostaurin (DB06595) | Midostaurin is an antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A (Homo sapiens) | Pkinase | ||
| 4ned | PFN | Fenoprofen (DB00573) | Fenoprofen is an anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. | LACTOTRANSFERRIN (Bos taurus) | Transferrin | ||
| 4nkw | PLO | Pregnenolone (DB02789) | A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids. | STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) | p450 | ||
| 4nkx | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) | p450 | ||
| 4nnr | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2 (Homo sapiens) | FKBP_C | ||
| 4nr0 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] FABI (Pseudomonas aeruginosa) | adh_short_C2 | ||
| 4nsb | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | CHITINASE-3-LIKE PROTEIN 1 (Bubalus bubalis) | Glyco_hydro_18 | ||
| 4ntx | AMR | Amiloride (DB00594) | Amiloride is a pyrizine compound used to treat hypertension and congestive heart failure. | ACID-SENSING ION CHANNEL 1 (Gallus gallus;micrurus tener tener) | ASC | ||
| 4ntx | AMR | Amiloride (DB00594) | Amiloride is a pyrizine compound used to treat hypertension and congestive heart failure. | ACID-SENSING ION CHANNEL 1;BASIC PHOSPHOLIPASE A2 HOMOLOG TX-BETA (Gallus gallus;micrurus tener tener) | ASCPhospholip_A2_1 | ||
| 4o0o | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | RRNA N-GLYCOSIDASE (Momordica balsamina) | RIP | ||
| 4o1z | MXM | Meloxicam (DB00814) | Meloxicam is an NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. | PROSTAGLANDIN G/H SYNTHASE 1 (Ovis aries) | An_peroxidaseEGF | ||
| 4o33 | TZN | Terazosin (DB01162) | Terazosin is an alpha-1 adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia and management of hypertension. | PHOSPHOGLYCERATE KINASE 1 (Homo sapiens) | PGK | ||
| 4o4p | 1C6 | Omeprazole (DB00338) | Omeprazole is a proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection. | BIFUNCTIONAL P-450/NADPH-P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 4o8m | 2Q2 | Gluconic acid (DB13180) | Gluconic Acid is an electrolyte supplement used in total parenteral nutrition. | TRAP DICARBOXYLATE TRANSPORTER, DCTP SUBUNIT (Actinobacillus succinogenes) | DctP | ||
| 4o8z | BBI | Amiodarone (DB01118) | Amiodarone is a class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL (Homo sapiens) | SIR2 | ||
| 4oae | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794 (Pseudomonas aeruginosa) | Acetyltransf_1 | ||
| 4odo | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD (Thermus thermophilus) | FKBP_C | ||
| 4odr | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA (Thermus thermophilus;homo sapiens) | FKBP_C | ||
| 4oir | RFV | Rifamycin (DB11753) | Rifamycin is an antibacterial used to treat traveler's diarrhea. | DNA DIRECTED RNA POLYMERASE SIGMA FACTOR A;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Thermus thermophilus;synthetic construct) | RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7Sigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 4oj4 | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 4okn | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | L-LACTATE DEHYDROGENASE A CHAIN (Homo sapiens) | Ldh_1_CLdh_1_N | ||
| 4or0 | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | SERUM ALBUMIN (Bos taurus) | Serum_albumin | ||
| 4ot4 | CPT | Cisplatin (DB00515) | Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. | RIBONUCLEASE PANCREATIC (Bos taurus) | RnaseA | ||
| 4oty | LUR | Lumiracoxib (DB01283) | Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in... | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4p6w | MOF | Mometasone furoate (DB14512) | Mometasone furoate is a corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4p6x | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 4pa5 | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE (Bacillus subtilis) | TGL | ||
| 4pb1 | RBV | Ribavirin (DB00811) | Ribavirin is a guanosine nucleoside used to treat some forms of Hepatitis C. | NUPC FAMILY PROTEIN (Vibrio cholerae serotype o1) | GateNucleos_tra2_CNucleos_tra2_N | ||
| 4pcd | 2Q2 | Gluconic acid (DB13180) | Gluconic Acid is an electrolyte supplement used in total parenteral nutrition. | C4-DICARBOXYLATE TRANSPORT SYSTEM, SUBSTRATE-BINDING PROTEIN, PUTATIVE (Roseobacter denitrificans) | DctP | ||
| 4pd5 | GEO | Gemcitabine (DB00441) | Gemcitabine is a nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. | NUPC FAMILY PROTEIN (Vibrio cholerae serotype o1) | GateNucleos_tra2_CNucleos_tra2_N | ||
| 4pe5 | QEL | Ifenprodil (DB08954) | N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... | GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1;GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B (Rattus norvegicus) | ANF_receptorLig_chanLig_chan-Glu_bd | ||
| 4ph9 | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | PROSTAGLANDIN G/H SYNTHASE 2 (Mus musculus) | An_peroxidaseEGF | ||
| 4pjv | 2YQ | Talazoparib (DB11760) | Talazoparib is a poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer. | POLY [ADP-RIBOSE] POLYMERASE 2 (Homo sapiens) | PARP | ||
| 4pm5 | CE3 | Cefotaxime (DB00493) | Cefotaxime is a third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. | BETA-LACTAMASE CTX-M-14 (Klebsiella pneumoniae subsp. pneumoniae) | Beta-lactamase2 | ||
| 4po0 | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | SERUM ALBUMIN (Oryctolagus cuniculus) | Serum_albumin | ||
| 4pqa | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE (Neisseria meningitidis) | M20_dimerPeptidase_M20 | ||
| 4q1y | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | ASPARTYL PROTEASE (Human immunodeficiency virus 1) | RVP | ||
| 4qb9 | PAR | Paromomycin (DB01421) | Paromomycin is an aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma. | ENHANCED INTRACELLULAR SURVIVAL PROTEIN (Mycobacterium smegmatis) | Acetyltransf_17Acetyltransf_9SCP2_2 | ||
| 4qc6 | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | BIFUNCTIONAL AAC/APH (Staphylococcus warneri) | Acetyltransf_8 | ||
| 4qd3 | 5AE | Azacitidine (DB00928) | Azacitidine is a pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome. | PEPTIDYL-TRNA HYDROLASE (Pseudomonas aeruginosa) | Pept_tRNA_hydro | ||
| 4qkn | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO (Homo sapiens) | FTO_CTDFTO_NTD | ||
| 4qoo | RCO | Resorcinol (DB11085) | Resorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders... | CATALASE (Bacillus pumilus) | NA | ||
| 4qop | HQE | Hydroquinone (DB09526) | Hydroquinone is a topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. | CATALASE (Bacillus pumilus) | NA | ||
| 4qoq | JZ3 | Guaiacol (DB11359) | Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.... | CATALASE (Bacillus pumilus) | NA | ||
| 4qt3 | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE (Plasmodium falciparum 3d7) | FKBP_C | ||
| 4qu3 | 1RG | Ertapenem (DB00303) | Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. | BETA-LACTAMASE GES-2 (Pseudomonas aeruginosa) | Beta-lactamase2 | ||
| 4r20 | AER | Abiraterone (DB05812) | Abiraterone is an antiandrogen used in the treatment of prostate cancer. | CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2 (Danio rerio) | p450 | ||
| 4r21 | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2 (Danio rerio) | p450 | ||
| 4r7h | P31 | Pexidartinib (DB12978) | Pexidartinib is an antitumor agent that is used for the treatment of rare disease tenosynovial giant cell tumors (TGCT) by inhibiting colony-stimulating factor 1 and its receptor. | MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4r7i | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4r7l | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | LEUKOTRIENE A-4 HYDROLASE (Homo sapiens) | Leuk-A4-hydro_CPeptidase_M1Peptidase_M1_N | ||
| 4rlg | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | PYRIDOXAL-DEPENDENT DECARBOXYLASE (Sphaerobacter thermophilus dsm 20745) | Pyridoxal_deC | ||
| 4rqr | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | GLUTAREDOXIN-1 (Homo sapiens) | Glutaredoxin | ||
| 4ru1 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | MONOSACCHARIDE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN, CUT2 FAMILY (Acidothermus cellulolyticus) | Peripla_BP_4 | ||
| 4rxd | RIS | Risedronic acid (DB00884) | Risedronic acid is a bisphosphonate used to treat osteoporosis and Paget's disease. | FARNESYL PYROPHOSPHATE SYNTHASE (Trypanosoma brucei) | polyprenyl_synt | ||
| 4rxm | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | POSSIBLE SUGAR ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Mannheimia haemolytica) | NA | ||
| 4rzm | LSD | Lasalocid (DB11423) | Lasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis. | EPOXIDE HYDROLASE LASB (Streptomyces lasaliensis) | SnoaL_2 | ||
| 4s0v | SUV | Suvorexant (DB09034) | Suvorexant is a orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance. | HUMAN OREXIN RECEPTOR TYPE 2 FUSION PROTEIN TO P. ABYSII GLYCOGEN SYNTHASE (Homo sapiens;pyrococcus abyssi ge5) | 7tm_1Glycos_transf_1 | ||
| 4s18 | 1PT | Oxaliplatin (DB00526) | Oxaliplatin is a platinum based chemotherapy agent used to treat carcinoma of the colon or rectum or stage III colon cancer. | RIBONUCLEASE PANCREATIC (Bos taurus) | RnaseA | ||
| 4s1y | CPT | Cisplatin (DB00515) | Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 4tt7 | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4tvj | 09L | Olaparib (DB09074) | Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE 2 (Homo sapiens) | PARP | ||
| 4twd | 377 | Memantine (DB01043) | Memantine is an NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's. | CYS-LOOP LIGAND-GATED ION CHANNEL (Dickeya chrysanthemi) | NA | ||
| 4txn | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | URIDINE PHOSPHORYLASE (Schistosoma mansoni) | PNP_UDP_1 | ||
| 4u0i | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4u15 | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARINIC ACETYLCHOLINE RECEPTOR M3 (Rattus norvegicus;enterobacteria phage t4) | 7tm_1 | ||
| 4u16 | 3C0 | Methscopolamine (DB11315) | Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The... | MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARINIC ACETYLCHOLINE RECEPTOR M3 (Rattus norvegicus;enterobacteria phage t4) | 7tm_1 | ||
| 4u7z | 3EW | Selumetinib (DB11689) | Selumetinib is a MEK 1/2 inhibitor used in pediatric patients to treat neurofibromatosis type 1 (NF1) accompanied by symptomatic, inoperable plexiform neurofibromas (PN). | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 4ubs | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | PENTALENIC ACID SYNTHASE (Streptomyces avermitilis ma-4680 = nbrc 14893) | p450 | ||
| 4uda | DEX | Dexamethasone (DB01234) | Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 4ufm | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | GALACTOCEREBROSIDASE (Mus musculus) | Glyco_hydro_59Glyco_hydro_59M | ||
| 4uhx | LZU | Thioridazine (DB00679) | Thioridazine is a phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. | ALDEHYDE OXIDASE (Homo sapiens) | Ald_Xan_dh_CAld_Xan_dh_C2CO_deh_flav_CFAD_binding_5Fer2Fer2_2 | ||
| 4umj | BFQ | Ibandronate (DB00710) | Ibandronate is a bisphosphonate used to treat osteoporosis in postmenopausal women. | GERANYLTRANSTRANSFERASE (Pseudomonas aeruginosa) | polyprenyl_synt | ||
| 4uxq | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | FIBROBLAST GROWTH FACTOR RECEPTOR 4 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4uym | VOR | Voriconazole (DB00582) | Voriconazole is a triazole compound used to treat fungal infections. | 14-ALPHA STEROL DEMETHYLASE (Aspergillus fumigatus) | p450 | ||
| 4v04 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 4w9n | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (Homo sapiens) | ADH_zinc_N | ||
| 4w9n | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (Homo sapiens) | ADH_zinc_N | ||
| 4w9x | 3JW | Baricitinib (DB11817) | Baricitinib is a Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist. | BMP-2-INDUCIBLE PROTEIN KINASE (Homo sapiens) | Pkinase | ||
| 4wa9 | AXI | Axitinib (DB06626) | Axitinib is an oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. | TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | NA | ||
| 4wbg | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | BETA-LACTAMASE (Klebsiella pneumoniae) | Beta-lactamase | ||
| 4wev | SUZ | Sulindac (DB00605) | Sulindac is an NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 (Homo sapiens) | Aldo_ket_red | ||
| 4wg0 | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | NUCLEAR RECEPTOR COACTIVATOR 2 (NA) | NA | ||
| 4wh5 | 3QB | Lincomycin (DB01627) | Lincomycin is an antibiotic indicated only for the treatment of serious infections and is typically reserved for use in cases of penicillin allergy or where penicillin is inappropriate. | LINCOSAMIDE RESISTANCE PROTEIN (Staphylococcus haemolyticus) | Aminoglyc_resit | ||
| 4wql | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | 2''-AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE (Klebsiella pneumoniae) | Aminoglyc_resit | ||
| 4wre | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | PULMONARY SURFACTANT-ASSOCIATED PROTEIN A (Rattus norvegicus) | Lectin_C | ||
| 4wrz | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | URACIL-DNA GLYCOSYLASE (Mycobacterium tuberculosis) | UDG | ||
| 4wvd | IVM | Ivermectin (DB00602) | Ivermectin is an anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. | BILE ACID RECEPTOR (Homo sapiens;synthetic construct) | NA | ||
| 4x1f | 3WF | Ethinylestradiol (DB00977) | Ethinylestradiol is an estradiol used as a contraceptive. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 4x53 | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | CLASS D BETA-LACTAMASE OXA-160 (Acinetobacter baumannii) | Transpeptidase | ||
| 4xcb | HY0 | Hygromycin b (DB11520) | Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. | OXIDASE/HYDROXYLASE (Streptomyces hygroscopicus subsp. hygroscopicus) | PhyH | ||
| 4xe0 | 40L | Idelalisib (DB09054) | Idelalisib is an antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (Mus musculus) | PI3K_C2PI3K_rbdPI3KaPI3_PI4_kinase | ||
| 4xf7 | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | CARBOHYDRATE/PYRIMIDINE KINASE, PFKB FAMILY (Thermococcus kodakaraensis kod1) | NA | ||
| 4xia | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | D-XYLOSE ISOMERASE (Arthrobacter sp.) | AP_endonuc_2 | ||
| 4xiw | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | CARBONIC ANHYDRASE, ALPHA TYPE (Chlamydomonas reinhardtii) | Carb_anhydrase | ||
| 4xux | 4D6 | Vaborbactam (DB12107) | Vaborbactam is a beta lactamase inhibitor used to treat complicated urinary tract infections. | BETA-LACTAMASE (Enterobacter cloacae) | Beta-lactamase | ||
| 4xuz | 4D6 | Vaborbactam (DB12107) | Vaborbactam is a beta lactamase inhibitor used to treat complicated urinary tract infections. | BETA-LACTAMASE (Klebsiella pneumoniae subsp. pneumoniae) | Beta-lactamase2 | ||
| 4xyy | EDN | Ethylenediamine (DB14189) | Ethylenediamine is an organic compound that is used as a building block for the production of many other chemical products. It is also used as an excipient in many pharmacological... | LYSOZYME C (Gallus gallus) | Lys | ||
| 4y03 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PROTEIN POLYBROMO-1 (Homo sapiens) | Bromodomain | ||
| 4y0p | TE4 | Tetracaine (DB09085) | Tetracaine is a local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures. | BETA-LACTOGLOBULIN (Bos taurus) | Lipocalin | ||
| 4y0s | PX9 | Pramocaine (DB09345) | Pramocaine is a local anesthetic and antipruritic agent found in various topical preparations. | BETA-LACTOGLOBULIN (Capra hircus) | Lipocalin | ||
| 4y8w | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | CYTOCHROME P450 21-HYDROXYLASE (Homo sapiens) | NA | ||
| 4ydq | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLINE--TRNA LIGASE (Plasmodium falciparum) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 4yeo | CPT | Cisplatin (DB00515) | Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. | LYSOZYME C (Gallus gallus) | Lys | ||
| 4yfb | PAC | Phenylacetic acid (DB09269) | Phenylacetic acid is an agent used as an adjunct to treat acute hyperammonemia and associated encephalopathy in adult and pediatric patients with deficiencies in enzymes of the urea cycle. | PROTEIN RELATED TO PENICILLIN ACYLASE (Acidovorax sp. mr-s7) | NA | ||
| 4ygf | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | ALPHA-CARBONIC ANHYDRASE (Helicobacter pylori) | Carb_anhydrase | ||
| 4yha | MZM | Methazolamide (DB00703) | Methazolamide is a carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma. | ALPHA-CARBONIC ANHYDRASE (Helicobacter pylori) | Carb_anhydrase | ||
| 4yia | IMN | Indomethacin (DB00328) | Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. | THYROXINE-BINDING GLOBULIN (Homo sapiens) | NA | ||
| 4yji | TYL | Acetaminophen (DB00316) | Acetaminophen is an analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | ARYL ACYLAMIDASE (Bacterium csbl00001) | Amidase | ||
| 4ypm | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | LON PROTEASE (Meiothermus taiwanensis) | Lon_C | ||
| 4yvp | GBM | Glyburide (DB01016) | Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (Homo sapiens) | Aldo_ket_red | ||
| 4yvv | GBM | Glyburide (DB01016) | Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 4yvx | GMR | Glimepiride (DB00222) | Glimepiride is a sulfonylurea drug used to treat type 2 diabetes mellitus. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 4z3g | 4KS | Mequinol (DB09516) | Mequinol is a topical agent used in combination with tretinoin to treat solar lentigines. | PAPG, LECTIN DOMAIN (Escherichia coli) | NA | ||
| 4z69 | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 4zbq | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | SERUM ALBUMIN (Equus caballus) | Serum_albumin | ||
| 4zbr | NPS | Naproxen (DB00788) | Naproxen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | SERUM ALBUMIN (Equus caballus) | Serum_albumin | ||
| 4zcs | CDC | Citicoline (DB12153) | Citicoline is an endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. | CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE (Plasmodium falciparum (isolate 3d7)) | CTP_transf_like | ||
| 4ze1 | X2N | Posaconazole (DB01263) | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | LANOSTEROL 14-ALPHA DEMETHYLASE (Saccharomyces cerevisiae (strain yjm789)) | p450 | ||
| 4zf8 | MYT | Metyrapone (DB01011) | Metyrapone is a steroid 11-beta-monooxygenase inhibitor used to test hypothalamic-pituitary ACTH function. | BIFUNCTIONAL P-450/NADPH-P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 4zfc | GCZ | Gliclazide (DB01120) | Gliclazide is a sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens) | Aldo_ket_red | ||
| 4zj8 | SUV | Suvorexant (DB09034) | Suvorexant is a orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance. | HUMAN OX1R FUSION PROTEIN TO P.ABYSII GLYCOGEN SYNTHASE (Homo sapiens;pyrococcus abyssi (strain ge5 / orsay)) | 7tm_1Glycos_transf_1 | ||
| 4zph | PRL | Proflavine (DB01123) | Proflavine is a topical antiseptic agent used in wound dressings to prevent infections. | ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR;ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1 (Mus musculus) | HLHPASPAS_3 | ||
| 4zs2 | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO (Homo sapiens) | FTO_CTDFTO_NTD | ||
| 4zud | OLM | Olmesartan (DB00275) | Olmesartan is an angiotensin receptor blocker (ARB) used in the treatment of hypertension. | CHIMERA PROTEIN OF SOLUBLE CYTOCHROME B562 AND TYPE-1 ANGIOTENSIN II RECEPTOR (Escherichia coli;homo sapiens) | 7tm_1Cytochrom_B562 | ||
| 4zvm | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 4zz3 | 4DW | Pemetrexed (DB00642) | Pemetrexed is a folate analog used to treat mesothelioma and non-small cell lung cancer. | TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 (Homo sapiens) | Formyl_trans_N | ||
| 5a06 | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | ALDOSE-ALDOSE OXIDOREDUCTASE (Caulobacter crescentus cb15) | GFO_IDH_MocAGFO_IDH_MocA_C | ||
| 5a0y | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | METHYL-COENZYME M REDUCTASE I SUBUNIT ALPHA;METHYL-COENZYME M REDUCTASE I SUBUNIT BETA;METHYL-COENZYME M REDUCTASE I SUBUNIT GAMMA (Methanothermobacter marburgensis) | MCR_alphaMCR_alpha_NMCR_betaMCR_beta_NMCR_gamma | ||
| 5a5z | WJZ | Tiopronin (DB06823) | Tiopronin is a thiol agent indicated for the prevention of kidney stone formation in patients with severe homozygous cystinuria. | BETA-LACTAMASE NDM-1 (Klebsiella pneumoniae) | Lactamase_B | ||
| 5a8w | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | METHYL-COENZYME M II REDUCTASE;METHYL-COENZYME M REDUCTASE II (Methanothermobacter wolfeii) | MCR_alphaMCR_alpha_NMCR_betaMCR_beta_NMCR_gamma | ||
| 5a9u | 5P8 | Lorlatinib (DB12130) | Lorlatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5ain | QMR | Varenicline (DB01273) | Varenicline is a partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation. | SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica) | Neur_chan_LBD | ||
| 5alc | TIQ | Ticagrelor (DB08816) | Ticagrelor is a P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. | ANTI-TICAGRELOR FAB 72, HEAVY CHAIN;ANTI-TICAGRELOR FAB 72, LIGHT CHAIN (Homo sapiens) | NA | ||
| 5axd | RBV | Ribavirin (DB00811) | Ribavirin is a guanosine nucleoside used to treat some forms of Hepatitis C. | ADENOSYLHOMOCYSTEINASE (Mus musculus) | AdoHcyaseAdoHcyase_NAD | ||
| 5axr | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | METALLO-BETA-LACTAMASE (Serratia marcescens) | Lactamase_B | ||
| 5aya | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | METALLO-BETA-LACTAMASE (Serratia marcescens) | Lactamase_B | ||
| 5ayf | C7H | Cyproheptadine (DB00434) | Cyproheptadine is a combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome. | HISTONE-LYSINE N-METHYLTRANSFERASE SETD7 (Homo sapiens) | SET | ||
| 5b1a | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 2;CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL;CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL (Bos taurus) | COX1COX2COX2_TM | ||
| 5b1a | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL (Bos taurus) | COX1COX3COX7a | ||
| 5b8i | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | CALCINEURIN SUBUNIT B, VARIANT;PEPTIDYLPROLYL ISOMERASE;SERINE/THREONINE-PROTEIN PHOSPHATASE (Coccidioides immitis (strain rs)) | EF-hand_5EF-hand_7FKBP_CMetallophos | ||
| 5bpp | A4Z | Bufexamac (DB13346) | Bufexamac is an NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. | LEUKOTRIENE A-4 HYDROLASE (Homo sapiens) | Leuk-A4-hydro_CPeptidase_M1Peptidase_M1_N | ||
| 5bvw | 1N1 | Dasatinib (DB01254) | Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5byk | OAQ | Oxamniquine (DB01096) | An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms... | SULFOTRANSFERASE (Schistosoma mansoni) | Sulfotransfer_4 | ||
| 5cfs | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | AAD(2''),GENTAMICIN 2''-NUCLEOTIDYLTRANSFERASE,GENTAMICIN RESISTANCE PROTEIN (Pseudomonas aeruginosa) | Aminoglyc_resit | ||
| 5cg5 | RIS | Risedronic acid (DB00884) | Risedronic acid is a bisphosphonate used to treat osteoporosis and Paget's disease. | FARNESYL PYROPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 5cp3 | YTZ | Sulfathiazole (DB06147) | Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination... | HEAVY CHAIN OF ANTIGEN-BINDING FRAGMENT OF MONOCLONAL ANTIBODY OF 4C7;LIGHT CHAIN OF ANTIGEN-BINDING FRAGMENT OF MONOCLONAL ANTIBODY OF 4C7 (Mus musculus) | NA | ||
| 5cxv | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M1,ENDOLYSIN,MUSCARINIC ACETYLCHOLINE RECEPTOR M1 (Homo sapiens;enterobacteria phage t4;synthetic construct) | 7tm_1Phage_lysozyme | ||
| 5d0r | B1T | Bithionol (DB04813) | Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the... | ADENYLATE CYCLASE TYPE 10 (Homo sapiens) | Guanylate_cyc | ||
| 5d75 | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3 (Homo sapiens) | FKBP_C | ||
| 5dq8 | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | TRANSCRIPTIONAL ENHANCER FACTOR TEF-4 (Homo sapiens) | YBD | ||
| 5dqf | CZE | Cetirizine (DB00341) | Cetirizine is a selective Histamine-1 antagonist drug used in allergic rhinitis and chronic urticaria. | SERUM ALBUMIN (Equus caballus) | Serum_albumin | ||
| 5dqf | LCR | Levocetirizine (DB06282) | Levocetirizine is an H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria. | SERUM ALBUMIN (Equus caballus) | Serum_albumin | ||
| 5ds3 | 09L | Olaparib (DB09074) | Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARP | ||
| 5dsg | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M4,ENDOLYSIN,ENDOLYSIN,MUSCARINIC ACETYLCHOLINE RECEPTOR M4 (Homo sapiens;enterobacteria phage t4) | 7tm_1 | ||
| 5dv4 | NMY | Framycetin (DB00452) | Framycetin is an aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus. | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE (Homo sapiens) | Exo_endo_phos | ||
| 5dwq | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | HISTONE-ARGININE METHYLTRANSFERASE CARM1;METHYLATED H3 PEPTIDE (Homo sapiens;synthetic construct) | PrmA | ||
| 5dyo | FLU | Fluorescein (DB00693) | Fluorescein is a dye used in angiography or angioscopy of the iris and retina. | FAB 43.1 HEAVY CHAIN;FAB 43.1 LIGHT CHAIN (Mus musculus) | NA | ||
| 5dz2 | 212 | Alendronic acid (DB00630) | Alendronic acid is a bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis. | GERMACRADIENOL/GEOSMIN SYNTHASE (Streptomyces coelicolor (strain atcc baa-471 / a3(2) / m145)) | Terpene_syn_C_2 | ||
| 5e4j | DME | Decamethonium (DB01245) | Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic... | ACETYLCHOLINESTERASE (Torpedo californica) | COesterase | ||
| 5eb5 | 010 | Benzyl alcohol (DB06770) | Benzyl alcohol is an antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older. | HNL ISOENZYME 5 (Prunus dulcis) | GMC_oxred_CGMC_oxred_N | ||
| 5ej0 | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | ENVELOPE PROTEIN H3 (Vaccinia virus (strain western reserve)) | NA | ||
| 5ent | MIY | Minocycline (DB01017) | Minocycline is a tetracycline analog used to treat a wide variety of infections in the body. | MULTIDRUG EFFLUX PUMP SUBUNIT ACRB (Escherichia coli k-12;synthetic construct) | NA | ||
| 5erj | CPT | Cisplatin (DB00515) | Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. | FERRITIN LIGHT CHAIN (Equus caballus) | Ferritin | ||
| 5esg | 1YN | Itraconazole (DB01167) | Itraconazole is an antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis. | LANOSTEROL 14-ALPHA DEMETHYLASE (Saccharomyces cerevisiae (strain yjm789)) | p450 | ||
| 5esm | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | LANOSTEROL 14-ALPHA DEMETHYLASE (Saccharomyces cerevisiae (strain yjm789)) | p450 | ||
| 5evy | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | SALICYLATE HYDROXYLASE (Pseudomonas putida) | FAD_binding_3 | ||
| 5ew8 | 5SF | Erdafitinib (DB12147) | Erdafitinib is a fibroblast growth factor receptor tyrosine kinase inhibitor used to treat locally advanced or metastatic urothelial carcinoma. | FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5eyp | LOC | Colchicine (DB01394) | Colchicine is an alkaloid used in the symptomatic relief of pain in attacks of gout and to treat the inflammatory symptoms of Familial Mediterranean Fever (FMF). | TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN (Synthetic construct;ovis aries) | TubulinTubulin_C | ||
| 5f1a | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5f9z | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | AMINOACYL-TRNA SYNTHETASE (Cryptosporidium parvum) | NA | ||
| 5fbt | 5WQ | Rifampicin (DB01045) | Rifampicin is an antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis. | PHOSPHOENOLPYRUVATE SYNTHASE (Listeria monocytogenes serotype 4b str. f2365) | PEP-utilizersPPDK_N | ||
| 5ff1 | MMZ | Methimazole (DB00763) | Methimazole is a thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism. | LACTOPEROXIDASE (Capra hircus) | An_peroxidase | ||
| 5fpd | PZA | Pyrazinamide (DB00339) | Pyrazinamide is an antituberculosis agent used as a component of tuberculosis (TB) treatment. | HEAT SHOCK-RELATED 70KDA PROTEIN 2 (Homo sapiens) | NA | ||
| 5fse | HQE | Hydroquinone (DB09526) | Hydroquinone is a topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. | UREASE SUBUNIT ALPHA (Sporosarcina pasteurii) | Amidohydro_1Urease_alpha | ||
| 5fto | YMX | Entrectinib (DB11986) | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019... | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5fyr | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | PHOSPHOINOSITOL-SPECIFIC PHOSPHOLIPASE C (Pseudomonas sp.) | PI-PLC-C1 | ||
| 5g2n | 6E2 | Copanlisib (DB12483) | Copanlisib is a medication used to treat relapsed follicular lymphoma who have attempted at least two other treatments. | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens) | PI3K_C2PI3K_rbdPI3KaPI3_PI4_kinase | ||
| 5g44 | YTZ | Sulfathiazole (DB06147) | Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination... | NUCLEAR RECEPTOR ROR-GAMMA (Homo sapiens) | Hormone_recep | ||
| 5g48 | 1FL | Diflunisal (DB00861) | Diflunisal is an NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. | DNA POLYMERASE III SUBUNIT BETA (Helicobacter pylori) | DNA_pol3_betaDNA_pol3_beta_2DNA_pol3_beta_3 | ||
| 5gpg | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3;SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) | FKBP_C | ||
| 5gsn | MMZ | Methimazole (DB00763) | Methimazole is a thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism. | FLAVIN-CONTAINING MONOOXYGENASE (Roseovarius nubinhibens (strain atcc baa-591 / dsm 15170 / ism)) | FMO-like | ||
| 5h2d | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | KLLA0C04147P (Kluyveromyces lactis) | Oxysterol_BP | ||
| 5ha9 | TP0 | Amitriptyline (DB00321) | Amitriptyline is a tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARPPARP_reg | ||
| 5hes | 032 | Vemurafenib (DB08881) | Vemurafenib is a kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation. | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5hkg | RAP | Sirolimus (DB00877) | Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B (Homo sapiens) | FKBP_C | ||
| 5hko | 62W | Mannitol (DB00742) | Mannitol is a sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis. | ABC TRANSPORTER, CARBOHYDRATE UPTAKE TRANSPORTER-2 (CUT2) FAMILY, PERIPLASMIC SUGAR-BINDING PROTEIN (Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)) | Peripla_BP_4 | ||
| 5hlb | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | PENICILLIN-BINDING PROTEIN 1B (Escherichia coli (strain k12)) | TransglyTranspeptidaseUB2H | ||
| 5hpw | 3CJ | Propylthiouracil (DB00550) | Propylthiouracil is a thiourea antithyroid agent used to treat hyperthyroidism. | LACTOPEROXIDASE (Capra hircus) | An_peroxidase | ||
| 5hs1 | VOR | Voriconazole (DB00582) | Voriconazole is a triazole compound used to treat fungal infections. | LANOSTEROL 14-ALPHA DEMETHYLASE (Saccharomyces cerevisiae) | p450 | ||
| 5hss | 64Z | Geraniol (DB14183) | Geraniol is a monoterpene that is found within many essential oils of fruits, vegetables, and herbs including rose oil, citronella, lemongrass, lavender, and other aromatic plants. It is emitted from... | LINALOOL DEHYDRATASE/ISOMERASE (Castellaniella defragrans) | Ldi | ||
| 5hxw | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | L-AMINO ACID DEAMINASE (Proteus vulgaris) | DAO | ||
| 5i3c | AC2 | Acyclovir (DB00787) | Acyclovir is a guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster. | PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE (Escherichia coli o139:h28 (strain e24377a / etec)) | PNP_UDP_1 | ||
| 5i96 | 69Q | Enasidenib (DB13874) | Enasidenib is an isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation. | ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL (Homo sapiens) | Iso_dh | ||
| 5iao | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | BIFUNCTIONAL PROTEIN PYRR (Mycobacterium tuberculosis (strain atcc 25177 / h37ra)) | Pribosyltran | ||
| 5icx | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | CETUXIMAB FAB LIGHT CHAIN;MEDITOPE (Mus musculus;homo sapiens;synthetic construct) | NA | ||
| 5ief | NBV | Miglustat (DB00419) | Miglustat is a glucosylceramide synthase inhibitor used for the management of mild to moderate type I Gaucher disease for patients who are not candidates for whole enzyme replacement. | NEUTRAL ALPHA-GLUCOSIDASE AB (Mus musculus) | Gal_mutarotas_2Glyco_hydro_31 | ||
| 5ifl | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Burkholderia pseudomallei) | adh_short_C2 | ||
| 5ifu | GBM | Glyburide (DB01016) | Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. | PROLINE--TRNA LIGASE (Plasmodium falciparum (isolate 3d7)) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 5igi | ZIT | Azithromycin (DB00207) | Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE (Escherichia coli) | APH | ||
| 5igj | CTY | Clarithromycin (DB01211) | Clarithromycin is a macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. | MACROLIDE 2'-PHOSPHOTRANSFERASE (Escherichia coli) | APH | ||
| 5igs | ZIO | Oleandomycin (DB11442) | Oleandomycin is a macrolide antibiotic, though it is less effective than erythromycin. It is synthesized from strains of Streptomyces antibioticus. | MACROLIDE 2'-PHOSPHOTRANSFERASE (Escherichia coli) | APH | ||
| 5igt | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE (Escherichia coli) | APH | ||
| 5igv | ZIT | Azithromycin (DB00207) | Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE II (Escherichia coli) | APH | ||
| 5igw | CTY | Clarithromycin (DB01211) | Clarithromycin is a macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. | MACROLIDE 2'-PHOSPHOTRANSFERASE II (Escherichia coli) | APH | ||
| 5igz | SPR | Spiramycin (DB06145) | Spiramycin is a macrolide antimicrobial agent used in the treatment of various bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE II (Escherichia coli) | APH | ||
| 5ikq | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5ikr | ID8 | Mefenamic acid (DB00784) | Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5ikt | TLF | Tolfenamic acid (DB09216) | Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as... | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5ikv | FLF | Flufenamic acid (DB02266) | Flufenamic acid is an analgesic drug used to relieve pain associated with rheumatoid diseases. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5iqb | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 5iqd | RIO | Ribostamycin (DB03615) | Ribostamycin is a broad spectrum aminoglycoside antibiotic on the list of WHO critical antimicrobials for human medicine. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 5iqe | NMY | Framycetin (DB00452) | Framycetin is an aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 5iwu | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE II (Escherichia coli) | APH | ||
| 5j0z | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | PROTON-GATED ION CHANNEL (Gloeobacter violaceus (strain pcc 7421)) | NA | ||
| 5j2t | VLB | Vinblastine (DB00570) | Vinblastine is a vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma. | TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN (Rattus norvegicus;gallus gallus;bos taurus) | TubulinTubulin_C | ||
| 5jh7 | 6K9 | Eribulin (DB08871) | Eribulin is a microtubule inhibitor used to treat metastatic breast cancer and metastatic or unresectable liposarcoma. | TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN (Rattus norvegicus;gallus gallus;bos taurus) | TubulinTubulin_C | ||
| 5ji0 | 9CR | Alitretinoin (DB00523) | Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. | RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 5jlc | 1YN | Itraconazole (DB01167) | Itraconazole is an antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis. | LANOSTEROL 14-ALPHA DEMETHYLASE (Candida glabrata (strain atcc 2001 / cbs 138 / jcm 3761 / nbrc 0622 / nrrl y-65)) | p450 | ||
| 5jmn | FUA | Fusidic acid (DB02703) | Fusidic acid is a topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. | MULTIDRUG EFFLUX PUMP SUBUNIT ACRB (Escherichia coli (strain k12);synthetic construct) | ACR_tran | ||
| 5jo9 | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | RIBITOL 2-DEHYDROGENASE (Bradyrhizobium japonicum) | adh_short | ||
| 5jq7 | T0R | Toremifene (DB00539) | Toremifene is a first generation nonsteroidal selective estrogen receptor modulator used to treat certain breast cancers. | ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1;ENVELOPE GLYCOPROTEIN 2 (Ebola virus - mayinga;zaire;1976) | NA | ||
| 5jqb | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1;ENVELOPE GLYCOPROTEIN 2 (Ebola virus - mayinga;zaire;1976) | NA | ||
| 5k1m | 4KS | Mequinol (DB09516) | Mequinol is a topical agent used in combination with tretinoin to treat solar lentigines. | NAD(P)H:FLAVIN OXIDOREDUCTASE SYE4 (Shewanella oneidensis (strain mr-1)) | Oxidored_FMN | ||
| 5k4p | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | PROBABLE PHOSPHATIDYLETHANOLAMINE TRANSFERASE MCR-1 (Escherichia coli bl21(de3)) | Sulfatase | ||
| 5k9d | CE9 | Polidocanol (DB06811) | Polidocanol is a sclerosing agent used for the treatment of uncomplicated spider veins and uncomplicated reticular veins, all less than 3 mm in diameter, in the lower extremity. | DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL (Homo sapiens) | DHO_dh | ||
| 5kir | RCX | Rofecoxib (DB00533) | Rofecoxib is a COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks. | PROSTAGLANDIN G/H SYNTHASE 2 (Homo sapiens) | An_peroxidaseEGF | ||
| 5km8 | L8P | Cidofovir (DB00369) | Cidofovir is an antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. | HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL (Homo sapiens) | HIT | ||
| 5kmw | PNN | Benzylpenicillin (DB01053) | Benzylpenicillin is a penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. | BETA-LACTAMASE TOHO-1 (Escherichia coli) | Beta-lactamase2 | ||
| 5l1f | 6ZP | Perampanel (DB08883) | Perampanel is a non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy. | GLUTAMATE RECEPTOR 2 (Rattus norvegicus) | ANF_receptorLig_chanLig_chan-Glu_bd | ||
| 5l2i | LQQ | Palbociclib (DB09073) | Palbociclib is an endocrine-based chemotherapeutic agent used in combination with other antineoplastic agents to treat HER2-negative and HR-positive advanced or metastatic breast cancer. | CYCLIN-DEPENDENT KINASE 6 (Homo sapiens) | Pkinase | ||
| 5l2s | 6ZV | Abemaciclib (DB12001) | Abemaciclib is a medication used to treat HR+ HER2- advanced or metastatic breast cancer. | CYCLIN-DEPENDENT KINASE 6 (Homo sapiens) | Pkinase | ||
| 5l2t | 6ZZ | Ribociclib (DB11730) | Ribociclib is a kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer. | CYCLIN-DEPENDENT KINASE 6 (Homo sapiens) | Pkinase | ||
| 5l4e | EDP | Thiopental (DB00599) | Thiopental is a barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. | PROTON-GATED ION CHANNEL (Gloeobacter) | Neur_chan_LBD | ||
| 5l7i | VIS | Vismodegib (DB08828) | Vismodegib is a hedgehog pathway inhibitor used to treat patients with locally advanced or metastatic basal cell carcinoma. | SMOOTHENED HOMOLOG,SOLUBLE CYTOCHROME B562,SMOOTHENED HOMOLOG (Homo sapiens;escherichia coli) | FrizzledFz | ||
| 5lbt | 6T0 | Imiquimod (DB00724) | Imiquimod is a toll-like receptor 7 agonist used to treat non hyperkeratotic, non hypertrophic actinic keratosis, basal cell carcinoma, genital or perianal warts, and condyloma acuminata. | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] (Homo sapiens) | Flavodoxin_2 | ||
| 5log | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | PUTATIVE O-METHYLTRANSFERASE (Myxococcus xanthus) | Methyltransf_3 | ||
| 5lpa | 71R | Dihydrostreptomycin (DB11512) | Dihydrostreptomycin is an antibiotic. | STREPTOMYCIN 3''-ADENYLYLTRANSFERASE (Salmonella enterica subsp. enterica serovar typhimurium) | DUF4111NTP_transf_2 | ||
| 5lrv | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | OTU DOMAIN-CONTAINING PROTEIN 7B;POLYUBIQUITIN-B (Homo sapiens;synthetic construct) | OTUubiquitin | ||
| 5luh | SRY | Streptomycin (DB01082) | Streptomycin is an aminoglycoside antibiotic indicated to treat multi-drug resistant mycobacterium tuberculosis and various non-tuberculosis infections. | STREPTOMYCIN 3''-ADENYLYLTRANSFERASE (Salmonella enterica subsp. enterica serovar typhimurium) | DUF4111NTP_transf_2 | ||
| 5lxb | 7A9 | Palonosetron (DB00377) | Palonosetron is a serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting. | SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica) | Neur_chan_LBD | ||
| 5lxm | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | AURORA KINASE A;TARGETING PROTEIN FOR XKLP2 (Homo sapiens;synthetic construct) | Pkinase | ||
| 5lxw | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | LYSOZYME C (Gallus gallus) | Lys | ||
| 5m6g | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | BETA-GLUCOSIDASE (Saccharopolyspora erythraea d) | Glyco_hydro_3Glyco_hydro_3_C | ||
| 5m8w | 4CH | Parachlorophenol (DB13154) | Parachlorophenol is an antibacterial agent used to prevent infections in root canals. | TETRACHLOROETHENE REDUCTIVE DEHALOGENASE CATALYTICALLY ACTIVE SUBUNIT (Sulfurospirillum multivorans) | DehalogenaseFer4_16 | ||
| 5m9x | 7KP | Polydatin (DB11263) | Polydatin, or Piceid, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, polydatin... | SUCROSE PHOSPHORYLASE (Bifidobacterium adolescentis) | Alpha-amylaseDUF1964 | ||
| 5maf | XIN | Nintedanib (DB09079) | Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (Homo sapiens) | Pkinase | ||
| 5mo4 | NIL | Nilotinib (DB04868) | Nilotinib is a kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib. | TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens) | PK_Tyr_Ser-ThrSH2SH3_1 | ||
| 5msy | NH3 | Ammonia (DB11118) | Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium... | GLYCOSIDE HYDROLASE (Bacteroides thetaiotaomicron vpi-5482) | Collagen_bind_2DUF4038 | ||
| 5mwy | YNU | Eplerenone (DB00700) | Eplerenone is an aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure. | MINERALOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 5mzj | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 5mzp | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 5n1q | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT ALPHA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococcus thermolithotrophicus dsm 2095) | MCR_alphaMCR_alpha_NMCR_betaMCR_beta_NMCR_gamma | ||
| 5n3l | E5E | Norepinephrine (DB00368) | Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Cricetulus griseus) | Pkinase | ||
| 5na9 | QPT | Carboplatin (DB00958) | Carboplatin is a alkylating agent used to treat advanced ovarian cancer. | RIBONUCLEASE PANCREATIC (Bos taurus) | RnaseA | ||
| 5nek | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE (Bacillus cereus) | Polysacc_deac_1 | ||
| 5nfp | 8W5 | Budesonide (DB01222) | Budesonide is a corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 5nha | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | XYLOSE ISOMERASE (Piromyces sp. e2) | AP_endonuc_2 | ||
| 5njw | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | BLR6230 PROTEIN (Bradyrhizobium diazoefficiens usda 110) | Lactamase_B | ||
| 5nkn | LOC | Colchicine (DB01394) | Colchicine is an alkaloid used in the symptomatic relief of pain in attacks of gout and to treat the inflammatory symptoms of Familial Mediterranean Fever (FMF). | NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (Homo sapiens) | Lipocalin | ||
| 5nn4 | SC2 | Acetylcysteine (DB06151) | Acetylcysteine is a medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. | LYSOSOMAL ALPHA-GLUCOSIDASE (Homo sapiens) | Gal_mutarotas_2Glyco_hydro_31NtCtMGAM_NTrefoil | ||
| 5nn6 | MIG | Miglitol (DB00491) | Miglitol is an oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates. | LYSOSOMAL ALPHA-GLUCOSIDASE (Homo sapiens) | Gal_mutarotas_2Glyco_hydro_31NtCtMGAM_NTrefoil | ||
| 5nna | BZM | Benzyl benzoate (DB00676) | Benzyl benzoate is a topical treatment for scabies and lice. | ISATIN HYDROLASE A (Labrenzia aggregata) | Cyclase | ||
| 5no9 | 95Z | Glucosamine (DB01296) | Glucosamine is a common ingredient in nutritional supplements used for the relief of joint pain. | 25 KDA PROTEIN ELICITOR (Pythium aphanidermatum) | NPP1 | ||
| 5now | L89 | Amifampridine (DB11640) | Amifampridine is a voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (Homo sapiens) | Pro_isomerase | ||
| 5nr3 | 95E | Ethambutol (DB00330) | Ethambutol is an antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB). | DNA (CYTOSINE-5)-METHYLTRANSFERASE 3B (Homo sapiens) | PWWP | ||
| 5nuk | Z80 | Chlorpromazine (DB00477) | Chlorpromazine is a phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. | BETA-LACTOGLOBULIN (Bos taurus) | Lipocalin | ||
| 5nvp | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | ENVELOPE GLYCOPROTEIN,GP41 (NA) | NA | ||
| 5nz0 | ZLD | Linezolid (DB00601) | Linezolid is an oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. | HTH-TYPE TRANSCRIPTIONAL REGULATOR ETHR (Mycobacterium tuberculosis) | TetR_N | ||
| 5nzx | 9F2 | Ceftriaxone (DB01212) | Ceftriaxone is a broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. | DNA CROSS-LINK REPAIR 1A PROTEIN (Homo sapiens) | DRMBL | ||
| 5nzy | CE3 | Cefotaxime (DB00493) | Cefotaxime is a third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. | DNA CROSS-LINK REPAIR 1A PROTEIN (Homo sapiens) | DRMBL | ||
| 5o1s | 9HB | Dimethyl fumarate (DB08908) | Dimethyl fumarate is a medication used to treat patients with the relapsing-remitting form of multiple sclerosis. | RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 (Mus musculus) | Pkinase | ||
| 5o45 | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | PHE-MEA-9KK-SAR-ASP-VAL-MEA-TYR-SAR-TRP-TYR-LEU-CCS-GLY-NH2;PROGRAMMED CELL DEATH 1 LIGAND 1 (Homo sapiens;synthetic construct) | V-set | ||
| 5o4y | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2 (Homo sapiens;synthetic construct) | NA | ||
| 5o87 | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica) | Neur_chan_LBD | ||
| 5ock | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | CEP1 PEPTIDE (FROM ENOLASE);HUMAN ACPA E4 FAB FRAGMENT - LIGHT CHAIN (Homo sapiens;synthetic construct) | NA | ||
| 5odh | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | HETERODISULFIDE REDUCTASE, SUBUNIT B;HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococcus thermolithotrophicus dsm 2095) | CCGFer4_8 | ||
| 5oh1 | 9UQ | Aminoglutethimide (DB00357) | Aminoglutethimide is an adrenocortical steroid synthesis inhibitor used in the treatment of Cushing's syndrome. | CEREBLON ISOFORM 4 (Magnetospirillum gryphiswaldense) | NA | ||
| 5oh3 | 9V2 | Ethosuximide (DB00593) | Ethosuximide is an anticonvulsant used to treat petit mal seizures. | CEREBLON ISOFORM 4 (Magnetospirillum gryphiswaldense) | NA | ||
| 5oj0 | 9WT | Cefepime (DB01413) | Cefepime is a fourth-generation cephalosporin antibiotic used in the treatment of various bacterial infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections. | PENICILLIN-BINDING PROTEIN 2X (Streptococcus pneumoniae) | PASTAPBP_dimerTranspeptidase | ||
| 5om2 | DXT | Doxycycline (DB00254) | Doxycycline is a tetracycline antibiotic used to treat a wide variety of bacterial infections. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 5om7 | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 5onl | 010 | Benzyl alcohol (DB06770) | Benzyl alcohol is an antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older. | YNDL (Bacillus subtilis) | Gamma_PGA_hydro | ||
| 5oog | A0B | Phloxine b (DB13911) | Phloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to... | FLAVIN REDUCTASE (NADPH) (Homo sapiens) | NAD_binding_10 | ||
| 5ov9 | CVI | Gentian violet cation (DB00406) | Gentian Violet is an antiseptic violet dye used to prevent various infections, including fungal and bacterial infections. | ACETYLCHOLINESTERASE (Mus musculus) | COesterase | ||
| 5oy0 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX (Synechocystis sp. pcc 6803) | PSI_PsaJPsaA_PsaB | ||
| 5oy0 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Synechocystis sp. pcc 6803) | PsaA_PsaB | ||
| 5pah | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | PHENYLALANINE 4-MONOOXYGENASE (Homo sapiens) | NA | ||
| 5phh | LDP | Dopamine (DB00988) | Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. | LYSINE-SPECIFIC DEMETHYLASE 4D (Homo sapiens) | JmjCJmjN | ||
| 5q1s | AWY | Agomelatine (DB06594) | Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine... | DNA CROSS-LINK REPAIR 1A PROTEIN (Homo sapiens) | DRMBL | ||
| 5rf8 | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 5rsu | OHB | Salicylamide (DB08797) | Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5rtm | PZA | Pyrazinamide (DB00339) | Pyrazinamide is an antituberculosis agent used as a component of tuberculosis (TB) treatment. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5rue | BHA | Aminosalicylic acid (DB00233) | Aminosalicylic acid is an aminosalicylate drug used to induce remission in ulcerative colitis. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5rus | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5rvi | CLW | Chlorzoxazone (DB00356) | Chlorzoxazone is a drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5rzb | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | ISOFORM 2 OF BAND 4.1-LIKE PROTEIN 3 (Homo sapiens) | FERM_MFERM_N | ||
| 5s3i | W1P | Edaravone (DB12243) | Edaravone is a free radical scavenger used to delay the progression of ALS. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5s4a | 4AP | Dalfampridine (DB06637) | Dalfampridine is a potassium channel blocker used for the improvement of motor function in patients with multiple sclerosis (MS). | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | Macro | ||
| 5swr | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA;PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_P85_iSH2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinaseSH2 | ||
| 5sxc | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens) | PI3K_C2PI3K_p85BPI3K_rbdPI3KaPI3_PI4_kinase | ||
| 5tiw | OAQ | Oxamniquine (DB01096) | An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms... | SULFOTRANSFERASE (Schistosoma haematobium) | Sulfotransfer_4 | ||
| 5tui | CTC | Chlortetracycline (DB09093) | Chlortetracycline is the first tetracycline antibiotic most commonly used for veterinary purposes. | TETRACYCLINE DESTRUCTASE TET(50) (Uncultured bacterium) | FAD_binding_3 | ||
| 5txi | RB6 | Ceftobiprole (DB04918) | Ceftobiprole is a cephalosporin antibiotic used to treat both community and hospital-acquired pneumonia caused by susceptible bacteria. | PENICILLIN BINDING PROTEIN 4 (Staphylococcus aureus) | DUF1958Peptidase_S11 | ||
| 5ty2 | NFF | Nafcillin (DB00607) | Nafcillin is a penicillin derivative antibiotic used to treat susceptible staphylococcal infections. | PENICILLIN-BINDING PROTEIN 4 (Staphylococcus aureus (strain col)) | DUF1958Peptidase_S11 | ||
| 5tzo | 7V7 | Fentanyl (DB00813) | Fentanyl is an opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. | ENDO-1,4-BETA-XYLANASE A (Bacillus subtilis (strain 168)) | NA | ||
| 5u1r | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | MAIT T-CELL RECEPTOR ALPHA CHAIN;MAIT T-CELL RECEPTOR BETA CHAIN;MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED GENE PROTEIN (Homo sapiens) | C1-setMHC_I | ||
| 5u6n | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | UDP-GLYCOSYLTRANSFERASE 74F2 (Arabidopsis thaliana) | UDPGT | ||
| 5uc1 | 486 | Mifepristone (DB00834) | Mifepristone is a cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation. | GLUCOCORTICOID RECEPTOR (Heterocephalus glaber) | NA | ||
| 5uc3 | 486 | Mifepristone (DB00834) | Mifepristone is a cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation. | GLUCOCORTICOID RECEPTOR (Homo sapiens) | Hormone_recep | ||
| 5uih | 8CV | Phenformin (DB00914) | A biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often... | DIHYDROFOLATE REDUCTASE (Escherichia coli) | DHFR_1 | ||
| 5uxd | ZIT | Azithromycin (DB00207) | Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections. | MACROLIDE 2'-PHOSPHOTRANSFERASE MPHH (Brachybacterium faecium (strain atcc 43885 / dsm 4810 / ncib 9860)) | APH | ||
| 5v02 | 657 | Riluzole (DB00740) | Riluzole is a glutamate antagonist used to treat amyotrophic lateral sclerosis. | CALMODULIN-1;SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 2 (Homo sapiens) | CaMBDEF-hand_7 | ||
| 5v0v | 8QP | Etodolac (DB00749) | Etodolac is an NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain. | SERUM ALBUMIN (Equus caballus) | Serum_albumin | ||
| 5v3c | AMH | Tranexamic acid (DB00302) | Tranexamic acid is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. | QUEUINE TRNA-RIBOSYLTRANSFERASE (Zymomonas mobilis) | TGT | ||
| 5v5z | 1YN | Itraconazole (DB01167) | Itraconazole is an antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis. | LANOSTEROL 14-ALPHA DEMETHYLASE (Candida albicans (strain sc5314 / atcc mya-2876)) | p450 | ||
| 5va6 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | HISTONE H3.1;PROBABLE HISTONE-LYSINE N-METHYLTRANSFERASE ATXR5 (Ricinus communis;synthetic construct) | NA | ||
| 5vc3 | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | WEE1-LIKE PROTEIN KINASE (Homo sapiens) | Pkinase | ||
| 5vdh | IVM | Ivermectin (DB00602) | Ivermectin is an anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. | GLYCINE RECEPTOR SUBUNIT ALPHA-3 (Homo sapiens) | Neur_chan_LBD | ||
| 5vlm | CVI | Gentian violet cation (DB00406) | Gentian Violet is an antiseptic violet dye used to prevent various infections, including fungal and bacterial infections. | REGULATORY PROTEIN TETR (Enterobacter lignolyticus) | TetR_N | ||
| 5vm0 | 9EG | Triclocarban (DB11155) | Triclocarban is an antibacterial agent used in liquid soaps and body washes. | CAMELID NANOBODY VHH T9 (Lama glama) | NA | ||
| 5vm6 | 9EG | Triclocarban (DB11155) | Triclocarban is an antibacterial agent used in liquid soaps and body washes. | SINGLE DOMAIN CAMELID NANOBODY VHH T10 (Lama glama) | NA | ||
| 5w3j | TA1 | Paclitaxel (DB01229) | Paclitaxel is a taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. | TUBULIN BETA CHAIN (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | TubulinTubulin_C | ||
| 5wif | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | SPERMIDINE N1-ACETYLTRANSFERASE (Yersinia pestis) | Acetyltransf_3 | ||
| 5wm2 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | SALICYLATE-AMP LIGASE (Streptomyces gandocaensis) | AMP-bindingAMP-binding_C | ||
| 5wmk | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE (Arabidopsis thaliana) | Aminotran_1_2 | ||
| 5x03 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR (Bacillus subtilis (strain 168)) | Aminotran_1_2 | ||
| 5x2s | PEM | Bezafibrate (DB01393) | Bezafibrate is a lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. | HEMOGLOBIN SUBUNIT ALPHA;HEMOGLOBIN SUBUNIT BETA (Homo sapiens) | Globin | ||
| 5x7z | BHA | Aminosalicylic acid (DB00233) | Aminosalicylic acid is an aminosalicylate drug used to induce remission in ulcerative colitis. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887 (Mycobacterium tuberculosis h37rv) | MarR | ||
| 5x80 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887 (Mycobacterium tuberculosis h37rv) | MarR | ||
| 5xip | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLYL-TRNA SYNTHETASE, PUTATIVE (Eimeria tenella) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 5xiq | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLYL-TRNA SYNTHETASE (PRORS) (Toxoplasma gondii (strain atcc 50611 / me49)) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 5xpr | K86 | Bosentan (DB00559) | Bosentan is a dual endothelin receptor antagonist used to treat pulmonary arterial hypertension. | ENDOTHELIN B RECEPTOR,ENDOLYSIN,ENDOTHELIN B RECEPTOR (Homo sapiens;enterobacteria phage t4) | 7tm_1 | ||
| 5xu8 | DX4 | Tioguanine (DB00352) | Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. | UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2 (Homo sapiens;bos taurus) | UCH | ||
| 5y2o | 8N6 | Pioglitazone (DB01132) | Pioglitazone is a thiazolidinedione used adjunctively with diet and exercise to normalize glycemic levels in adults with type 2 diabetes mellitus. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 5y5c | HXA | Doconexent (DB03756) | Doconexent is an omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. | BETA-LACTOGLOBULIN (Bos taurus) | Lipocalin | ||
| 5y7p | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | BILE SALT HYDROLASE (Lactobacillus salivarius) | CBAH | ||
| 5y80 | IRE | Gefitinib (DB00317) | Gefitinib is a tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria. | CYCLIN-G-ASSOCIATED KINASE (Homo sapiens;lama glama) | Pkinase | ||
| 5y9a | AR3 | Cytarabine (DB00987) | Cytarabine is a pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia. | PEPTIDYL-TRNA HYDROLASE (Acinetobacter baumannii (strain atcc 19606 / dsm 30007 / cip 70.34 / jcm 6841 / nbrc 109757 / ncimb 12457 / nctc 12156 / 81)) | Pept_tRNA_hydro | ||
| 5ycs | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] FABI (Bacillus cereus (strain atcc 14579 / dsm 31 / jcm 2152 / nbrc 15305 / ncimb 9373 / nrrl b-3711)) | adh_short_C2 | ||
| 5yj1 | 6EL | Thalidomide (DB01041) | Thalidomide is a medication used to treat newly diagnosed multiple myeloma and erythema nodosum leprosum. | PROTEIN CEREBLON (Mus musculus) | NA | ||
| 5yjs | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | VICILIN-LIKE ANTIMICROBIAL PEPTIDES 2-2 (Capsicum annuum) | Cupin_1 | ||
| 5yk2 | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | ABC1 | ||
| 5yoq | CLT | Phenylbutyric acid (DB06819) | Phenylbutyric acid is an agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 5ypi | 8YF | Imipenem (DB01598) | Imipenem is a carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. | METALLO-BETA-LACTAMASE NDM-1 (Escherichia coli) | Lactamase_B | ||
| 5ys0 | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | MEMBRANE-ANCHORED LIPID-BINDING PROTEIN YSP2 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | VASt | ||
| 5yu9 | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 5z0f | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | MELC;TYROSINASE (Streptomyces castaneoglobisporus) | MelC1Tyrosinase | ||
| 5z79 | PAB | Aminobenzoic acid (DB02362) | Aminobenzoic acid is a drug used to reduce the progression of penile deviation in Peyronie's Disease in adults. | HYDROXYMETHYLDIHYDROPTERIN PYROPHOSPHOKINASE-DIHYDROPTEROATE SYNTHASE, PUTATIVE (NA) | HPPKPterin_bind | ||
| 5zio | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | METALLO-BETA-LACTAMASE TYPE 2 (Klebsiella pneumoniae) | Lactamase_B | ||
| 5zj8 | 9DC | Dimercaprol (DB06782) | Dimercaprol is a chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium. | METALLO-BETA-LACTAMASE TYPE 2 (Klebsiella pneumoniae) | Lactamase_B | ||
| 5zkc | 3C0 | Methscopolamine (DB11315) | Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The... | MUSCARINIC ACETYLCHOLINE RECEPTOR M2,APO-CYTOCHROME B562,MUSCARINIC ACETYLCHOLINE RECEPTOR M2 (Homo sapiens) | 7tm_1 | ||
| 5znc | QI9 | Quinine (DB00468) | Quinine is an alkaloid used to treat uncomplicated Plasmodium falciparum malaria. | PURINE NUCLEOSIDE PHOSPHORYLASE (Plasmodium falciparum) | PNP_UDP_1 | ||
| 5zni | YMZ | Mefloquine (DB00358) | Mefloquine is an antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. | PURINE NUCLEOSIDE PHOSPHORYLASE (Plasmodium falciparum) | PNP_UDP_1 | ||
| 5znj | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLINE--TRNA LIGASE (Staphylococcus aureus) | NA | ||
| 5zsf | 6T0 | Imiquimod (DB00724) | Imiquimod is a toll-like receptor 7 agonist used to treat non hyperkeratotic, non hypertrophic actinic keratosis, basal cell carcinoma, genital or perianal warts, and condyloma acuminata. | TOLL-LIKE RECEPTOR 7 (Macaca mulatta) | LRR_5LRR_8 | ||
| 5zv2 | LEV | Lenvatinib (DB09078) | Lenvatinib is a receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. | FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6a0m | PAC | Phenylacetic acid (DB09269) | Phenylacetic acid is an agent used as an adjunct to treat acute hyperammonemia and associated encephalopathy in adult and pediatric patients with deficiencies in enzymes of the urea cycle. | 4-HYDROXYMANDELATE OXIDASE (Amycolatopsis orientalis) | FMN_dh | ||
| 6a7p | 9SC | Aripiprazole (DB01238) | Aripiprazole is an atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 6a93 | 8NU | Risperidone (DB00734) | Risperidone is a second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. | 5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 6a94 | ZOT | Zotepine (DB09225) | Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. It has been used as an antipsychotic in Japan, India... | 5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 6a96 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-5,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-5;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Lama glama;homo sapiens) | Neur_chan_LBDNeur_chan_memb | ||
| 6agn | 9Y6 | Cinnamaldehyde (DB14184) | Cinnamaldehyde is a naturally occurring flavonoid that gives the spice cinnamon its flavour and odour. It occurs naturally in the bark of cinnamon trees and other species of the genus... | LYSOZYME C (Gallus gallus) | Lys | ||
| 6ah9 | TCL | Triclosan (DB08604) | Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Acinetobacter baumannii atcc 19606 = cip 70.34 = jcm 6841) | adh_short_C2 | ||
| 6aji | AY6 | Rimonabant (DB06155) | Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite.... | DRUG EXPORTERS OF THE RND SUPERFAMILY-LIKE PROTEIN,ENDOLYSIN (Mycobacterium smegmatis (strain atcc 700084 / mc(2)155);enterobacteria phage t4) | MMPLPhage_lysozyme | ||
| 6ak3 | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6ak4 | PD9 | Entacapone (DB00494) | Entacapone is a selective reversible catechol-O-methyltransferase inhibitor for the treatment of Parkinson's disease. | ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO (Homo sapiens) | FTO_CTDFTO_NTD | ||
| 6aog | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasma gondii) | Thymidylat_synt | ||
| 6ap6 | TLF | Tolfenamic acid (DB09216) | Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as... | PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia hybrida) | Abhydrolase_6 | ||
| 6avs | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | LYSINE-SPECIFIC DEMETHYLASE 8 (Homo sapiens) | Cupin_8 | ||
| 6ay4 | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | CYP51, STEROL 14ALPHA-DEMETHYLASE (Naegleria fowleri) | p450 | ||
| 6ay6 | VOR | Voriconazole (DB00582) | Voriconazole is a triazole compound used to treat fungal infections. | CYP51, STEROL 14ALPHA-DEMETHYLASE (Naegleria fowleri) | p450 | ||
| 6ayb | KKK | Ketoconazole (DB01026) | Ketoconazole is a broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. | CYP51, STEROL 14ALPHA-DEMETHYLASE (Naegleria fowleri) | p450 | ||
| 6b1e | LF7 | Vildagliptin (DB04876) | Vildagliptin is a once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus. | DIPEPTIDYL PEPTIDASE 4 (Homo sapiens) | DPPIV_NPeptidase_S9 | ||
| 6b5z | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | FRUCTOSE-1,6-BISPHOSPHATASE/INOSITOL-1-MONOPHOSPHATASE (Archaeoglobus fulgidus (strain atcc 49558 / vc-16 / dsm 4304 / jcm 9628 / nbrc 100126)) | Inositol_P | ||
| 6b6d | 9F2 | Ceftriaxone (DB01212) | Ceftriaxone is a broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. | BETA-LACTAMASE (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | Beta-lactamase2 | ||
| 6b82 | AER | Abiraterone (DB05812) | Abiraterone is an antiandrogen used in the treatment of prostate cancer. | CYTOCHROME P450, FAMILY 17, SUBFAMILY A, POLYPEPTIDE 1 (Danio rerio) | p450 | ||
| 6b89 | NOV | Novobiocin (DB01051) | Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... | LIPOPOLYSACCHARIDE EXPORT SYSTEM ATP-BINDING PROTEIN LPTB (Escherichia coli (strain k12)) | ABC_tranBCA_ABC_TP_C | ||
| 6baa | GBM | Glyburide (DB01016) | Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. | ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Rattus norvegicus;cricetus cricetus) | ABC_membraneABC_tran | ||
| 6beb | RFV | Rifamycin (DB11753) | Rifamycin is an antibacterial used to treat traveler's diarrhea. | SCAFFOLD PROTEIN D13 (Vaccinia virus wr) | Pox_Rif | ||
| 6bec | RBT | Rifabutin (DB00615) | Rifabutin is an antibiotic used to treat mycobacterium avium complex disease in patients with HIV. | SCAFFOLD PROTEIN D13 (Vaccinia virus wr) | Pox_Rif | ||
| 6bee | RXM | Rifaximin (DB01220) | Rifaximin is a rifamycin-based non-systemic antibiotic used for the treatment of gastrointestinal bacterial infections, such as traveler's diarrhea and irritable bowel syndrome, and reduction of overt hepatic encephalopathy recurrence in adults. | SCAFFOLD PROTEIN D13 (Vaccinia virus wr) | Pox_Rif | ||
| 6beh | RPT | Rifapentine (DB01201) | Rifapentine is an antibiotic agent used in the treatment of pulmonary tuberculosis. | SCAFFOLD PROTEIN D13 (Vaccinia virus (strain western reserve)) | Pox_Rif | ||
| 6bfh | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE ACETYLTRANSFERASE (Escherichia coli) | Acetyltransf_8 | ||
| 6bjd | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | CALPAIN-3 (Homo sapiens) | Peptidase_C2 | ||
| 6bqg | ERM | Ergotamine (DB00696) | Ergotamine is a alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. | 5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 6bzo | FI8 | Fidaxomicin (DB08874) | Fidaxomicin is a macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection. | DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA';RNA POLYMERASE SIGMA FACTOR SIGA;RNA POLYMERASE-BINDING PROTEIN RBPA (Mycobacterium tuberculosis;synthetic construct) | RNA_pol_Rpb1_1RNA_pol_Rpb1_2RNA_pol_Rpb1_3RNA_pol_Rpb1_4RNA_pol_Rpb1_5RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7RbpASigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 6c79 | CE3 | Cefotaxime (DB00493) | Cefotaxime is a third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. | BETA-LACTAMASE TOHO-1 (Escherichia coli) | Beta-lactamase2 | ||
| 6ca3 | MIG | Miglitol (DB00491) | Miglitol is an oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates. | GLYCOSYL HYDROLASE, FAMILY 31 (Blautia obeum atcc 29174) | Gal_mutarotas_2Glyco_hydro_31 | ||
| 6cav | 84D | Dibekacin (DB13270) | Dibekacin is an aminoglycoside antibiotic marketed in Japan . | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 6cay | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | STEROL-BINDING PROTEIN (Saccharomyces cerevisiae) | VASt | ||
| 6cgd | AKN | Amikacin (DB00479) | Amikacin is an aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria. | BIFUNCTIONAL AAC/APH (Staphylococcus aureus) | APH | ||
| 6ci6 | NBO | Nabumetone (DB00461) | Nabumetone is an NSAID used to treat osteoarthritis and rheumatoid arthritis. | SERUM ALBUMIN (Equus caballus) | Serum_albumin | ||
| 6cm4 | 8NU | Risperidone (DB00734) | Risperidone is a second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. | D(2) DOPAMINE RECEPTOR, ENDOLYSIN CHIMERA (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6cnj | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6cww | 211 | Trolamine (DB13747) | Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine... | METHYL-ACCEPTING CHEMOTAXIS PROTEIN (Caldanaerobacter subterraneus) | HNOB | ||
| 6dcm | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | PLASMINOGEN (Homo sapiens) | NA | ||
| 6de9 | FUN | Furosemide (DB00695) | Furosemide is a loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. | CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens) | zf-CDGSH | ||
| 6dew | 64Z | Geraniol (DB14183) | Geraniol is a monoterpene that is found within many essential oils of fruits, vegetables, and herbs including rose oil, citronella, lemongrass, lavender, and other aromatic plants. It is emitted from... | UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL (Homo sapiens) | COQ9 | ||
| 6dgo | GD4 | Troglitazone (DB00197) | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 6djz | GMJ | Haloperidol (DB00502) | Haloperidol is an antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. | SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens) | ERG2_Sigma1R | ||
| 6dk1 | GM4 | Pentazocine (DB00652) | Pentazocine is an analgesic used to treat moderate to severe pain. | SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens) | ERG2_Sigma1R | ||
| 6drx | H8G | Lisuride (DB00589) | An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at... | 5HT2B RECEPTOR, BRIL CHIMERA (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6dry | H8D | Methylergometrine (DB00353) | Methylergometrine is an ergot alkaloid used to prevent and control uterine atony and hemorrhage before and after delivery. | 5HT2B RECEPTOR, BRIL CHIMERA (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6drz | H8J | Methysergide (DB00247) | Methysergide is an ergot alkaloid used for the prophylaxis of migraine and cluster headaches. | 5HT2B RECEPTOR, BRIL CHIMERA (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6dw0 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1 (Rattus norvegicus) | Neur_chan_LBDNeur_chan_memb | ||
| 6dw1 | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1 (Rattus norvegicus) | Neur_chan_LBDNeur_chan_memb | ||
| 6e5z | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1 (Homo sapiens) | DJ-1_PfpI | ||
| 6ebp | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE, BETA SUBUNIT (Aerococcus urinae (strain acs-120-v-col10a)) | Ribonuc_red_sm | ||
| 6eg9 | 0LI | Ponatinib (DB08901) | Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). | INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6eku | ZMR | Zanamivir (DB00558) | Zanamivir is a neuraminidase inhibitor used to treat influenza A and B. | SIALIDASE (Vibrio cholerae serotype o1) | Sial-lect-inser | ||
| 6ep4 | DME | Decamethonium (DB01245) | Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic... | CHOLINESTERASE (Homo sapiens) | COesterase | ||
| 6eqp | BUW | Profenamine (DB00392) | Profenamine is an antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease. | CHOLINESTERASE (Homo sapiens) | COesterase | ||
| 6esm | PZE | Piperazine (DB00592) | Piperazine is a medication used to treat roundworm and pinworm. | MATRIX METALLOPROTEINASE-9 (Homo sapiens) | Peptidase_M10 | ||
| 6euh | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | BETA-GLUCANASE (Bacteroides thetaiotaomicron (strain atcc 29148 / dsm 2079 / nctc 10582 / e50 / vpi-5482)) | Glyco_hydro_43 | ||
| 6f6i | 8PR | Paroxetine (DB00715) | Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. | ENVELOPE GLYCOPROTEIN;ENVELOPE GLYCOPROTEIN,GP,GP1 (Ebola virus) | NA | ||
| 6f6n | SRE | Sertraline (DB01104) | Sertraline is a selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. | ENVELOPE GLYCOPROTEIN;ENVELOPE GLYCOPROTEIN,ENVELOPE GLYCOPROTEIN,GP1 (Zaire ebolavirus (strain mayinga-76);ebola virus) | NA | ||
| 6f6s | CXQ | Benzatropine (DB00245) | Benzatropine is an anticholinergic drug used to treat Parkinson's disease (PD) and extrapyramidal symptoms, except tardive dyskinesia. | ENVELOPE GLYCOPROTEIN;ENVELOPE GLYCOPROTEIN,ENVELOPE GLYCOPROTEIN,GP1 (Zaire ebolavirus (strain mayinga-76);ebola virus) | NA | ||
| 6fbv | FI8 | Fidaxomicin (DB08874) | Fidaxomicin is a macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection. | DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA';RNA POLYMERASE SIGMA FACTOR SIGA (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | RNA_pol_Rpb1_1RNA_pol_Rpb1_2RNA_pol_Rpb1_3RNA_pol_Rpb1_4RNA_pol_Rpb1_5RNA_pol_Rpb2_1RNA_pol_Rpb2_2RNA_pol_Rpb2_3RNA_pol_Rpb2_45RNA_pol_Rpb2_6RNA_pol_Rpb2_7Sigma70_r1_2Sigma70_r2Sigma70_r3Sigma70_r4 | ||
| 6fdy | DB8 | Bosutinib (DB06616) | Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments. | SERINE/THREONINE-PROTEIN KINASE ULK3 (Homo sapiens) | Pkinase | ||
| 6fpl | TAC | Tetracycline (DB00759) | Tetracycline is an antibiotic used to treat a wide variety of susceptible infections. | TETRACYCLINE REPRESSOR PROTEIN CLASS D (Escherichia coli) | TetR_C_1TetR_N | ||
| 6ftp | DM2 | Doxorubicin (DB00997) | Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 6fu4 | HSM | Histamine (DB05381) | Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains. | PROBABLE CHEMOTAXIS TRANSDUCER (Pseudomonas aeruginosa pao1) | NA | ||
| 6fux | SRY | Streptomycin (DB01082) | Streptomycin is an aminoglycoside antibiotic indicated to treat multi-drug resistant mycobacterium tuberculosis and various non-tuberculosis infections. | AMINOGLYCOSIDE PHOSPHOTRANSFERASE (Streptomyces rimosus subsp. rimosus atcc 10970) | APH | ||
| 6g31 | ZOL | Zoledronic acid (DB00399) | Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. | GERANYLGERANYL PYROPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 6g4e | ACA | Aminocaproic acid (DB00513) | Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively. | ASPARTATE AMINOTRANSFERASE FAMILY PROTEIN (Pseudomonas sp) | Aminotran_3 | ||
| 6g88 | RB6 | Ceftobiprole (DB04918) | Ceftobiprole is a cephalosporin antibiotic used to treat both community and hospital-acquired pneumonia caused by susceptible bacteria. | LOW AFFINITY PENICILLIN-BINDING PROTEIN 5 (PBP5) (Enterococcus faecium) | MecA_NPBP_dimerTranspeptidase | ||
| 6g9b | IXX | Imipramine (DB00458) | Imipramine is a tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. | ENVELOPE GLYCOPROTEIN;ENVELOPE GLYCOPROTEIN,ENVELOPE GLYCOPROTEIN (Zaire ebolavirus (strain mayinga-76)) | NA | ||
| 6g9i | CXX | Clomipramine (DB01242) | Clomipramine is a tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. | ENVELOPE GLYCOPROTEIN (Ebola virus - mayinga;zaire;1976;human immunodeficiency virus 1) | NA | ||
| 6gh9 | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 (Homo sapiens) | UCH | ||
| 6gp2 | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE BETA CHAIN (Mesoplasma florum (strain atcc 33453 / nbrc 100688 / nctc 11704 / l1)) | Ribonuc_red_sm | ||
| 6gsg | RCO | Resorcinol (DB11085) | Resorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders... | CATECHOL OXIDASE (Aspergillus oryzae (strain atcc 42149 / rib 40)) | Tyrosinase | ||
| 6gyj | FGT | Phenolphthalein (DB04824) | Phenolphthalein is a drug used for symptomatic relief of constipation and bowel cleansing prior to medical procedures. | THYMIDYLATE SYNTHASE (Mus musculus) | Thymidylat_synt | ||
| 6h1l | FJQ | Tioconazole (DB01007) | Tioconazole is an imidazole antifungal used to treat vulvovaginal candidiasis. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6h1o | VOR | Voriconazole (DB00582) | Voriconazole is a triazole compound used to treat fungal infections. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6h1s | TPF | Fluconazole (DB00196) | Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6h1t | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium) | p450 | ||
| 6hco | FY5 | Estrone sulfate (DB04574) | Estrone sulfate is an estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 6hdr | CC9 | Curcumin (DB11672) | Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in Curcuma xanthorrhiza oil. It is a highly pleiotropic molecule that exhibits antibacterial,... | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2 (Homo sapiens) | Pkinase | ||
| 6hgf | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 6hgg | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 6hgk | STR | Progesterone (DB00396) | Progesterone is a hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 6hgl | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | ALPHA-1-ANTICHYMOTRYPSIN (Homo sapiens) | NA | ||
| 6hj2 | P06 | Dabrafenib (DB08912) | Dabrafenib is a kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 6hl1 | JN3 | Chenodeoxycholic acid (DB06777) | Chenodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis. | BILE ACID RECEPTOR (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 6hlo | GBQ | Aprepitant (DB00673) | Aprepitant is a substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. | SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR (Homo sapiens;pyrococcus abyssi ge5) | 7tm_1Glycos_transf_1 | ||
| 6hn1 | DIF | Diclofenac (DB00586) | Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | ALBUMIN (Capra hircus) | Serum_albumin | ||
| 6huj | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6huo | 08H | Alprazolam (DB00404) | Alprazolam is a triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6huo | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6hup | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6hup | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Bos taurus;homo sapiens;lama glama) | Neur_chan_LBDNeur_chan_memb | ||
| 6hwm | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT (Thermus thermophilus) | CLP_protease | ||
| 6icn | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | METHYLXANTHINE N1-DEMETHYLASE NDMA (Pseudomonas putida) | RieskeVanA_C | ||
| 6ico | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | METHYLXANTHINE N1-DEMETHYLASE NDMA (Pseudomonas putida) | RieskeVanA_C | ||
| 6ie9 | JN3 | Chenodeoxycholic acid (DB06777) | Chenodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis. | REGULATORY PROTEIN (Salmonella typhimurium (strain 14028s / sgsc 2262)) | TetR_N | ||
| 6ijx | JMS | Meclofenamic acid (DB00939) | Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. | ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (Homo sapiens) | Aldo_ket_red | ||
| 6itq | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | ANTI-CORTISOL CAMELID ANTIBODY (Camelus bactrianus) | NA | ||
| 6iwg | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | BETA-2-MICROGLOBULIN (Macaca mulatta;synthetic construct) | C1-set | ||
| 6iwl | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (Moraxella catarrhalis (strain bbh18)) | adh_short_C2 | ||
| 6j20 | GBQ | Aprepitant (DB00673) | Aprepitant is a substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. | SUBSTANCE-P RECEPTOR,ENDOLYSIN (Homo sapiens;enterobacteria phage t4) | 7tm_1 | ||
| 6j2m | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP53 (Arabidopsis thaliana) | FKBP_C | ||
| 6jb3 | BJX | Repaglinide (DB00912) | Repaglinide is a antihyperglycemic used to improve glycemic control in diabetes. | ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 ISOFORM X2 (Mesocricetus auratus) | ABC_membraneABC_tran | ||
| 6jdw | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | PROTEIN (L-ARGININE:GLYCINE AMIDINOTRANSFERASE) (Homo sapiens) | NA | ||
| 6jok | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6jol | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6jp5 | C5U | Nifedipine (DB01115) | Nifedipine is a dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension. | VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S (Oryctolagus cuniculus) | CAC1F_CCa_chan_IQGPHHIon_trans | ||
| 6jpb | C9F | Diltiazem (DB00343) | Diltiazem is a calcium channel blocker used to treat hypertension and to manage chronic stable angina. | VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S (Oryctolagus cuniculus) | CAC1F_CCa_chan_IQGPHHIon_trans | ||
| 6jqr | C6F | Gilteritinib (DB12141) | Gilteritinib is an AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. | RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3 (NA) | PK_Tyr_Ser-Thr | ||
| 6jqx | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | SALICYLATE DECARBOXYLASE (Cutaneotrichosporon moniliiforme) | Amidohydro_2 | ||
| 6juw | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL;CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL (Bos taurus) | COX8 | ||
| 6jzy | PL3 | Cetyl alcohol (DB09494) | Cetyl alcohol, also known as 1-hexadecanol or n-hexadecyl alcohol, is a 16-C fatty alcohol with the chemical formula CH3(CH2)15OH. It can be produced from the reduction of palmitic acid. Cetyl... | ALDEHYDE DECARBONYLASE (Synechococcus elongatus pcc 7942) | Ald_deCOase | ||
| 6k41 | CZX | Dexmedetomidine (DB00633) | Dexmedetomidine is an alpha-2 agonist used for sedation during various procedures. | ALPHA-2A ADRENERGIC RECEPTOR,ENDOLYSIN,ALPHA-2B ADRENERGIC RECEPTOR,ALPHA-2B ADRENERGIC RECEPTOR (Homo sapiens;mus musculus;bos taurus;enterobacteria phage rb59) | 7tm_1 | ||
| 6k61 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX (Nostoc sp. pcc 7120) | PSI_PsaJPsaA_PsaB | ||
| 6k61 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 1 (Nostoc sp. pcc 7120) | PsaA_PsaB | ||
| 6k7s | D16 | Raltitrexed (DB00293) | Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. | THYMIDYLATE SYNTHASE (Penaeus vannamei) | Thymidylat_synt | ||
| 6kgu | AZR | Aztreonam (DB00355) | Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. | PENICILLIN-BINDING PROTEIN PBPB (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | PBP_dimerTranspeptidase | ||
| 6ko8 | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | PUTATIVE REGULATORY PROTEIN (Salmonella enterica subsp. enterica serovar typhimurium str. 14028s) | TetR_N | ||
| 6krf | JZ3 | Guaiacol (DB11359) | Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.... | MYOGLOBIN (Physeter macrocephalus) | Globin | ||
| 6ktl | INS | Inositol (DB13178) | Inositol is an ingredient found in a variety of nutritional products. | SCYLLO-INOSITOL DEHYDROGENASE WITH L-GLUCOSE DEHYDROGENASE ACTIVITY (Paracoccus laeviglucosivorans) | GFO_IDH_MocAGFO_IDH_MocA_C | ||
| 6ktn | STI | Imatinib (DB00619) | Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 6l35 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Physcomitrium patens) | PsaA_PsaB | ||
| 6l4m | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | VICILIN (Solanum lycopersicum) | Cupin_1 | ||
| 6l6e | E6L | Avanafil (DB06237) | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction. | CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens) | PDEase_I | ||
| 6lgm | 9HB | Dimethyl fumarate (DB08908) | Dimethyl fumarate is a medication used to treat patients with the relapsing-remitting form of multiple sclerosis. | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Mus musculus) | Gp_dh_CGp_dh_N | ||
| 6lqa | QDN | Quinidine (DB00908) | Quinidine is a medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. | SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA (Homo sapiens) | Ion_transNa_trans_assocNa_trans_cytopl | ||
| 6lud | YY3 | Osimertinib (DB09330) | Osimertinib is a tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6luq | GMJ | Haloperidol (DB00502) | Haloperidol is an antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. | CHIMERA OF D(2) DOPAMINE RECEPTOR AND ENDOLYSIN (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6ly4 | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE (Bacillus megaterium (strain atcc 14581 / dsm 32 / jcm 2506 / nbrc 15308 / ncimb 9376 / nctc 10342 / vkm b-512)) | p450 | ||
| 6m11 | B49 | Sunitinib (DB01268) | Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | RIBONUCLEASE L (Sus scrofa) | Ank_2Ank_3Ank_4PkinaseRibonuc_2-5A | ||
| 6mdq | TES | Testosterone (DB00624) | Testosterone is a hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. | SERUM ALBUMIN (Equus caballus) | Serum_albumin | ||
| 6me2 | JEV | Ramelteon (DB00980) | Ramelteon is a melatonin receptor agonist used to treat insomnia. | CHIMERA PROTEIN OF MELATONIN RECEPTOR TYPE 1A AND GLGA GLYCOGEN SYNTHASE (Homo sapiens;pyrococcus abyssi ge5) | 7tm_1Glycos_transf_1 | ||
| 6me5 | AWY | Agomelatine (DB06594) | Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine... | CHIMERA PROTEIN OF MELATONIN RECEPTOR TYPE 1A AND GLGA GLYCOGEN SYNTHASE (Homo sapiens;pyrococcus abyssi ge5) | 7tm_1Glycos_transf_1 | ||
| 6me9 | JEV | Ramelteon (DB00980) | Ramelteon is a melatonin receptor agonist used to treat insomnia. | SOLUBLE CYTOCHROME B562,MELATONIN RECEPTOR TYPE 1B,RUBREDOXIN (Escherichia coli;homo sapiens;clostridium pasteurianum) | 7tm_1Cytochrom_B562Rubredoxin | ||
| 6mev | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6 (Homo sapiens) | JmjC | ||
| 6mke | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYLPROLYL ISOMERASE (Naegleria fowleri) | FKBP_C | ||
| 6mn4 | AM2 | Apramycin (DB04626) | Apramycin is an aminoglycoside antibiotic for veterinary use that is used to treat infections in animals. | AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA (Escherichia coli) | Antibiotic_NAT | ||
| 6mne | J3Z | Estrone (DB00655) | Estrone is an estrogen used to treat perimenopausal and postmenopausal symptoms. | ESTRADIOL 17-BETA-DEHYDROGENASE 1 (Homo sapiens) | adh_short | ||
| 6mp4 | TCI | Dronabinol (DB00470) | Dronabinol is a synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. | FATTY ACID-BINDING PROTEIN, LIVER (Homo sapiens) | Lipocalin_7 | ||
| 6mqf | AIN | Acetylsalicylic acid (DB00945) | Aspirin is a salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | BASIC PHOSPHOLIPASE A2 HOMOLOG 2 (Bothrops moojeni) | Phospholip_A2_1 | ||
| 6mwf | SFY | Sulfapyridine (DB00891) | Sulfapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. | 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia pseudomallei (strain 1710b)) | YgbB | ||
| 6mwj | AZM | Acetazolamide (DB00819) | Acetazolamide is a carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. | 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia pseudomallei (strain 1710b)) | YgbB | ||
| 6mx8 | 6GY | Brigatinib (DB12267) | Brigatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 6mxt | K5Y | Salmeterol (DB00938) | Salmeterol is a long-acting beta-2 adrenergic receptor agonist used to treat asthma and COPD. | ENDOLYSIN, BETA-2 ADRENERGIC RECEPTOR CHIMERA (Enterobacteria phage t4;homo sapiens;lama glama) | 7tm_1Phage_lysozyme | ||
| 6n2w | 30Z | Masoprocol (DB00179) | A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in... | ARACHIDONATE 5-LIPOXYGENASE (Homo sapiens) | LipoxygenasePLAT | ||
| 6nmb | AMH | Tranexamic acid (DB00302) | Tranexamic acid is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. | UROKINASE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens) | Trypsin | ||
| 6np4 | TOY | Tobramycin (DB00684) | Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections. | AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE (Enterobacter cloacae) | Antibiotic_NAT | ||
| 6nwk | DEX | Dexamethasone (DB01234) | Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | NA | ||
| 6nwl | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | GLUCOCORTICOID RECEPTOR (Homo sapiens;synthetic construct) | NA | ||
| 6o0k | LBM | Venetoclax (DB11581) | Venetoclax is a BCL-2 inhibitor used to treat chronic lymphocytic leukemia, small lymphocytic lymphoma, or acute myeloid leukemia. | APOPTOSIS REGULATOR BCL-2 (Homo sapiens) | BH4Bcl-2 | ||
| 6o2p | VX7 | Ivacaftor (DB08820) | Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used alone or in combination products to treat cystic fibrosis in patients who have specific genetic mutations that are responsive to the medication. | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (Homo sapiens) | ABC_membraneABC_tranCFTR_R | ||
| 6o5u | KAN | Kanamycin (DB01172) | Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. | AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE (Enterobacteriaceae) | Antibiotic_NAT | ||
| 6och | M4Y | Parthenolide (DB13063) | Parthenolide has been used in trials studying the diagnostic of Allergic Contact Dermatitis. | TUBULINYL-TYR CARBOXYPEPTIDASE 1 (Homo sapiens) | NA | ||
| 6ock | 9KL | Dexketoprofen (DB09214) | Dexketoprofen is an NSAID that is the R(-)-enantiomer of racemic ketoprofen with analgesic and anti-inflammatory properties used for the treatment of mild to moderate pain. | SERUM ALBUMIN (Oryctolagus cuniculus) | Serum_albumin | ||
| 6ohu | CTX | Tamoxifen (DB00675) | Tamoxifen is a selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women. | 3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE (Homo sapiens) | EBP | ||
| 6oi3 | NMM | Tilarginine (DB11815) | Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. | MONOMETHYL H3R2 PEPTIDE;WD REPEAT-CONTAINING PROTEIN 5 (Homo sapiens;synthetic construct) | WD40 | ||
| 6ol9 | 0HK | Tiotropium (DB01409) | Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). | MUSCARINIC ACETYLCHOLINE RECEPTOR M5, T4 LYSOZYME FUSION (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6on3 | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | L-DOPA EXTRADIOL DIOXYGENASE (Streptomyces sclerotialus) | Glyoxalase | ||
| 6opv | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | PROTEASE NL4-3 (Human immunodeficiency virus 1) | RVP | ||
| 6ot4 | HAE | Acetohydroxamic acid (DB00551) | Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract. | SOLUBLE CYTOCHROME B562 (Escherichia coli) | Cytochrom_B562 | ||
| 6p54 | 9F2 | Ceftriaxone (DB01212) | Ceftriaxone is a broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. | PROBABLE PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PENA (Neisseria gonorrhoeae) | Transpeptidase | ||
| 6p6l | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 1a (isolate 1)) | Peptidase_S29 | ||
| 6p6s | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 3a (isolate nzl1)) | Peptidase_S29 | ||
| 6p6v | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 5a (isolate sa13)) | Peptidase_S29 | ||
| 6p6z | O31 | Glecaprevir (DB13879) | Glecaprevir is a Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. | NON-STRUCTURAL PROTEIN 4A,SERINE PROTEASE NS3 (Hepatitis c virus genotype 4a (isolate ed43)) | Peptidase_S29 | ||
| 6p99 | 1RG | Ertapenem (DB00303) | Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. | BETA-LACTAMASE (Klebsiella pneumoniae) | Transpeptidase | ||
| 6p9c | O6P | Doripenem (DB06211) | Doripenem is an antibiotic of the penem class used to treat complicated intra-abdominal and urinary tract infections. | BETA-LACTAMASE (Klebsiella pneumoniae) | Transpeptidase | ||
| 6pah | DAH | Levodopa (DB01235) | Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. | PHENYLALANINE 4-MONOOXYGENASE (Homo sapiens) | NA | ||
| 6pej | SOR | Sorbitol (DB01638) | Sorbitol is a product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. | SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE) (Sinorhizobium meliloti 1021) | adh_short_C2 | ||
| 6plx | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GLYCINE RECEPTOR SUBUNIT ALPHAZ1 (Danio rerio) | Neur_chan_LBDNeur_chan_memb | ||
| 6pnj | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTRE SUBUNIT IX / PSAJ (Fischerella thermalis pcc 7521) | PSI_PsaJPsaA_PsaB | ||
| 6pnj | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Fischerella thermalis pcc 7521) | PsaA_PsaB | ||
| 6po4 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Haemophilus influenzae pittii) | PNP_UDP_1 | ||
| 6pq8 | J01 | Clavulanic acid (DB00766) | Clavulanic acid is a beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics. | BETA-LACTAMASE (Escherichia coli) | Beta-lactamase2 | ||
| 6ps3 | CVD | Carvedilol (DB01136) | Carvedilol is a non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. | FUSION PROTEIN OF BETA-2 ADRENERGIC RECEPTOR AND T4 LYSOZYME (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6ps6 | TIM | Timolol (DB00373) | Timolol is a non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. | FUSION PROTEIN OF BETA-2 ADRENERGIC RECEPTOR AND T4 LYSOZYME (Homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6pub | CVI | Gentian violet cation (DB00406) | Gentian Violet is an antiseptic violet dye used to prevent various infections, including fungal and bacterial infections. | CHLORAMPHENICOL ACETYLTRANSFERASE (Vibrio cholerae serotype o1 (strain atcc 39315 / el tor inaba n16961)) | Hexapep | ||
| 6pv7 | NCT | Nicotine (DB00184) | Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. | FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 AND SOLUBLE CYTOCHROME B562;FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4 AND SOLUBLE CYTOCHROME B562 (Homo sapiens;escherichia coli o11;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6pyf | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | SEX HORMONE-BINDING GLOBULIN (Homo sapiens) | Laminin_G_1 | ||
| 6q6o | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | NUCLEAR RECEPTOR ROR-GAMMA (Homo sapiens) | Hormone_recep | ||
| 6qex | TA1 | Paclitaxel (DB01229) | Paclitaxel is a taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. | MULTIDRUG RESISTANCE PROTEIN 1 (Homo sapiens;mus musculus) | ABC_membraneABC_tran | ||
| 6qvl | 4DW | Pemetrexed (DB00642) | Pemetrexed is a folate analog used to treat mesothelioma and non-small cell lung cancer. | SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL (Homo sapiens) | SHMT | ||
| 6qwj | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 (Chroococcidiopsis sp. ts-821) | PsaA_PsaB | ||
| 6qwj | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Chroococcidiopsis sp. ts-821) | PsaA_PsaB | ||
| 6qya | FFO | Levoleucovorin (DB11596) | Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. | THYMIDYLATE SYNTHASE (Enterococcus faecalis) | Thymidylat_synt | ||
| 6qyq | FFO | Levoleucovorin (DB11596) | Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. | THYMIDYLATE SYNTHASE (Homo sapiens) | Thymidylat_synt | ||
| 6r4l | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1-RELATED PROTEIN 1 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | NPC1_NPatched | ||
| 6r4n | ERG | Ergosterol (DB04038) | A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... | PHOSPHATIDYLGLYCEROL/PHOSPHATIDYLINOSITOL TRANSFER PROTEIN (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | E1_DerP2_DerF2 | ||
| 6r4v | BFQ | Ibandronate (DB00710) | Ibandronate is a bisphosphonate used to treat osteoporosis in postmenopausal women. | GERANYLGERANYL PYROPHOSPHATE SYNTHASE (Homo sapiens) | polyprenyl_synt | ||
| 6r7s | SAS | Sulfasalazine (DB00795) | Sulfasalazine is an anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis. | SERUM ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 6r7u | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | MIROLYSIN (Tannerella forsythia) | Peptidase_M43 | ||
| 6rgx | DXT | Doxycycline (DB00254) | Doxycycline is a tetracycline antibiotic used to treat a wide variety of bacterial infections. | TETRACYCLINE REPRESSOR PROTEIN CLASS D (Escherichia coli) | TetR_C_1TetR_N | ||
| 6rum | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | GFP-LAMA-G97 A GFP ENHANCER NANOBODY WITH CPDHFR INSERTION (Lama glama;escherichia coli (strain k12)) | NA | ||
| 6rwm | KLQ | Bictegravir (DB11799) | Bictegravir is an integrase inhibitor used to treat HIV infections. | POL PROTEIN (Simian immunodeficiency virus) | IN_DBD_CIntegrase_Znrve | ||
| 6rwn | DLU | Dolutegravir (DB08930) | Dolutegravir is an antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents. | POL PROTEIN (Simian immunodeficiency virus) | IN_DBD_CIntegrase_Znrve | ||
| 6rxb | MIY | Minocycline (DB01017) | Minocycline is a tetracycline analog used to treat a wide variety of infections in the body. | TETRACYCLINE REPRESSOR PROTEIN CLASS G (Acinetobacter baumannii (strain aye)) | TetR_C_1TetR_N | ||
| 6rz5 | ZLK | Zafirlukast (DB00549) | Zafirlukast is a leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma. | CYSTEINYL LEUKOTRIENE RECEPTOR 1,SOLUBLE CYTOCHROME B562,CYSTEINYL LEUKOTRIENE RECEPTOR 1 (Homo sapiens;escherichia coli) | 7tm_1 | ||
| 6rzr | 8YF | Imipenem (DB01598) | Imipenem is a carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. | BETA-LACTAMASE (Pseudomonas aeruginosa) | NA | ||
| 6sf9 | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | FARNESYL DIPHOSPHATE SYNTHASE (Trypanosoma cruzi) | polyprenyl_synt | ||
| 6sk4 | THH | Levomefolic acid (DB11256) | Levomefolic acid is a folate supplement used to prevent neural tube defects in pregnancy or folate deficiency. | METHYLCORRINOID:TETRAHYDROFOLATE METHYLTRANSFERASE (Desulfitobacterium hafniense y51) | MtrH | ||
| 6skr | 1RG | Ertapenem (DB00303) | Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. | BETA-LACTAMASE (Escherichia coli) | Transpeptidase | ||
| 6sl5 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 (Dunaliella salina) | PsaA_PsaB | ||
| 6sl5 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Dunaliella salina) | PsaA_PsaB | ||
| 6sm7 | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | 3-SULFOLACTALDEHYDE REDUCTASE (Escherichia coli) | NAD_binding_11NAD_binding_2 | ||
| 6ssi | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | CYS-LOOP LIGAND-GATED ION CHANNEL (Dickeya chrysanthemi;lama glama) | NA | ||
| 6tbe | NOV | Novobiocin (DB01051) | Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... | MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3A (Homo sapiens) | NA | ||
| 6td0 | 4D6 | Vaborbactam (DB12107) | Vaborbactam is a beta lactamase inhibitor used to treat complicated urinary tract infections. | CARBAPENEM-HYDROLYZING BETA-LACTAMASE KPC (Klebsiella pneumoniae) | Beta-lactamase2 | ||
| 6tfb | N6W | Carbamazepine (DB00564) | Carbamazepine is an anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. | FRIZZLED-8 (Mus musculus) | Fz | ||
| 6tsh | DGJ | Migalastat (DB05018) | Migalastat is an alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. | BETA-GALACTOSIDASE (Escherichia coli) | Bgal_small_NDUF4981Glyco_hydro_2Glyco_hydro_2_CGlyco_hydro_2_N | ||
| 6ttn | HYO | Hyoscyamine (DB00424) | Hyoscyamine is an anticholinergic indicated to treat functional gastrointestinal disorders, biliary and renal colic, and acute rhinitis. | HYOSCYAMINE 6 BETA-HYDROXYLASE (Datura metel) | 2OG-FeII_OxyDIOX_N | ||
| 6tuz | TEP | Theophylline (DB00277) | Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. | PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM (Homo sapiens) | PAE | ||
| 6tv4 | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM (Homo sapiens) | PAE | ||
| 6tz6 | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | CALCINEURIN SUBUNIT B;FK506-BINDING PROTEIN 1;SERINE/THREONINE-PROTEIN PHOSPHATASE (Candida albicans (strain wo-1);candida albicans (strain sc5314 / atcc mya-2876)) | EF-hand_7FKBP_CMetallophos | ||
| 6tz8 | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | CALCINEURIN SUBUNIT B;FK506-BINDING PROTEIN 1;SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT A1 (Cryptococcus neoformans var. grubii serotype a (strain h99 / atcc 208821 / cbs 10515 / fgsc 9487)) | EF-hand_7FKBP_CMetallophos | ||
| 6u10 | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | PUTATIVE METALLO-BETA-LACTAMASE L1 (BETA-LACTAMASE TYPE II) (EC 3.5.2.6) (PENICILLINASE) (Stenotrophomonas maltophilia (strain k279a)) | Lactamase_B | ||
| 6u4r | 9KL | Dexketoprofen (DB09214) | Dexketoprofen is an NSAID that is the R(-)-enantiomer of racemic ketoprofen with analgesic and anti-inflammatory properties used for the treatment of mild to moderate pain. | SERUM ALBUMIN (Equus caballus) | Serum_albumin | ||
| 6u4x | IBP | Dexibuprofen (DB09213) | Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. | SERUM ALBUMIN (Equus caballus) | Serum_albumin | ||
| 6u88 | P0T | Cannabidiol (DB09061) | Cannabidiol is an active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. | TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 2 (Rattus norvegicus) | Ank_2Ion_trans | ||
| 6ug0 | HDZ | Nitrogen (DB09152) | Nitrogen is a cryogenic agent used to treat various benign and malignant skin lesions. | NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN (Azotobacter vinelandii) | Oxidored_nitro | ||
| 6ulb | QA1 | Danazol (DB01406) | Danazol is a synthetic steroid and pituitary gonadotropin inhibitor used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts. | SEX HORMONE-BINDING GLOBULIN (Homo sapiens) | Laminin_G_1 | ||
| 6un1 | TJ7 | Temocillin (DB12343) | Temocillin has been investigated in Infection, Liver Dysfunction, and Urinary Tract Infection. | PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI (Pseudomonas aeruginosa) | PBP_dimerTranspeptidase | ||
| 6un3 | XT8 | Ticarcillin (DB01607) | Ticarcillin is a beta lactam antibiotic used to treat a variety of infections in the body. | PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI (Pseudomonas aeruginosa) | PBP_dimerTranspeptidase | ||
| 6un8 | NMY | Framycetin (DB00452) | Framycetin is an aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus. | AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE (Staphylococcus aureus) | KNTase_C | ||
| 6unb | TJ7 | Temocillin (DB12343) | Temocillin has been investigated in Infection, Liver Dysfunction, and Urinary Tract Infection. | BETA-LACTAMASE (Escherichia coli) | Beta-lactamase2 | ||
| 6ur8 | QMR | Varenicline (DB01273) | Varenicline is a partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation. | CHIMERA OF SOLUBLE CYTOCHROME B562 (BRIL) AND NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 (Homo sapiens;escherichia coli) | Neur_chan_LBDNeur_chan_memb | ||
| 6uw2 | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | OBTUSIFOLIOL 14ALPHADEMETHYLASE (Acanthamoeba castellanii str. neff) | p450 | ||
| 6ux0 | QKM | Isavuconazole (DB11633) | Isavuconazole is an triazole antifungal with broad spectrum of activity and good safety profile . It is approved by the FDA and EMA for the treatment of invasive aspergillosis and... | OBTUSIFOLIOL 14ALPHADEMETHYLASE (Acanthamoeba castellanii str. neff) | p450 | ||
| 6uxj | FFO | Levoleucovorin (DB11596) | Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. | SERINE HYDROXYMETHYLTRANSFERASE (Glycine max) | SHMT | ||
| 6uyh | HFG | Halofuginone (DB04866) | Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis... | PROLYL-TRNA SYNTHETASE (Naegleria fowleri) | HGTP_anticodonProRS-C_1tRNA-synt_2b | ||
| 6uz0 | K4D | Flecainide (DB01195) | Flecainide is a class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT). | SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA,GREEN FLUORESCENT PROTEIN (Rattus norvegicus;aequorea victoria) | GFPIon_transNa_trans_assoc | ||
| 6v1r | ACH | Acetylcholine (DB03128) | Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. | IACHSNFR FLUORESCENT ACETYLCHOLINE SENSOR V9 PRECURSOR BINDING PROTEIN (Thermoanaerobacter sp. x513) | NA | ||
| 6v61 | X8Z | Captopril (DB01197) | Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. | BETA-LACTAMASE (NA) | Lactamase_B | ||
| 6v7h | 4D6 | Vaborbactam (DB12107) | Vaborbactam is a beta lactamase inhibitor used to treat complicated urinary tract infections. | BETA-LACTAMASE (Escherichia coli) | Beta-lactamase2 | ||
| 6vje | RB6 | Ceftobiprole (DB04918) | Ceftobiprole is a cephalosporin antibiotic used to treat both community and hospital-acquired pneumonia caused by susceptible bacteria. | PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI (Pseudomonas aeruginosa) | PBP_dimerTranspeptidase | ||
| 6vkk | RPB | Rucaparib (DB12332) | Rucaparib is an anti-cancer agent used to treat recurrent ovarian, fallopian tube, or peritoneal cancer. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARPPARP_reg | ||
| 6vkt | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | EFFLUX PUMP MEMBRANE TRANSPORTER (Neisseria gonorrhoeae) | ACR_tran | ||
| 6vm3 | IVM | Ivermectin (DB00602) | Ivermectin is an anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. | GLYCINE RECEPTOR SUBUNIT ALPHAZ1 (Danio rerio) | Neur_chan_LBDNeur_chan_memb | ||
| 6vms | 08Y | Bromocriptine (DB01200) | Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. | ENDOLYSIN,D(2) DOPAMINE RECEPTOR,D(2) DOPAMINE RECEPTOR (Rattus norvegicus;homo sapiens;enterobacteria phage t4) | 7tm_1Phage_lysozyme | ||
| 6vrx | FK5 | Tacrolimus (DB00864) | Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. | PEPTIDYLPROLYL ISOMERASE (Mucor circinelloides) | FKBP_C | ||
| 6vrz | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | MULTIDRUG TRANSPORTER MDFA (Escherichia coli) | MFS_1 | ||
| 6vta | AKN | Amikacin (DB00479) | Amikacin is an aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria. | AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE (NA) | NA | ||
| 6w6q | 017 | Darunavir (DB01264) | Darunavir is a HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. | HTLV-1 PROTEASE (Human t-cell leukemia virus type i) | RVP | ||
| 6w70 | GG2 | Apixaban (DB06605) | Apixaban is an anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery. | DE NOVO DESIGNED ABLE (Synthetic construct) | NA | ||
| 6w9k | TUA | Prednisolone (DB00860) | Prednisolone is a glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers. | GLUCOCORTICOID RECEPTOR (Synthetic construct;synthetic construct) | Hormone_recep | ||
| 6whf | 9EP | Cefalotin (DB00456) | Cefalotin is a broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract. | BETA-LACTAMASE (Escherichia coli) | Beta-lactamase | ||
| 6wjc | OIN | Atropine (DB00572) | Atropine is a muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs. | MUSCARINIC ACETYLCHOLINE RECEPTOR M1,ENDOLYSIN FUSION (Homo sapiens;enterobacteria phage t4;dendroaspis angusticeps) | 7tm_1Phage_lysozyme | ||
| 6wl5 | 16A | Cetrimonium (DB01718) | Cetrimonium is a compound that can be used as a topical antiseptic. | ECMRR TRANSCRIPTIONAL REGULATOR (Escherichia coli) | NA | ||
| 6wpg | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | REGULATORY PROTEIN NPR4 (Arabidopsis thaliana) | NA | ||
| 6wr1 | AER | Abiraterone (DB05812) | Abiraterone is an antiandrogen used in the treatment of prostate cancer. | STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) | p450 | ||
| 6wv6 | UAS | Phenindione (DB00498) | An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects.... | VITAMIN K EPOXIDE REDUCTASE, TERMINI RESTRAINED BY GREEN FLUORESCENT PROTEIN (Aequorea victoria;homo sapiens) | GFPVKOR | ||
| 6wv8 | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | VITAMIN K EPOXIDE REDUCTASE-LIKE PROTEIN, TERMINI RESTRAINED BY GREEN FLUORESCENT PROTEIN (Escherichia virus rb43;takifugu rubripes;aequorea victoria) | VKOR | ||
| 6wwr | TA1 | Paclitaxel (DB01229) | Paclitaxel is a taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. | TUBULIN BETA-2B CHAIN (Mus musculus;sus scrofa) | TubulinTubulin_C | ||
| 6wxc | CMU | Tipiracil (DB09343) | Tipiracil is a thymidine phosphorylase inhibitor used as an adjunct treatment of adult patients with certain types of gastric or colorectal malignancies. | URIDYLATE-SPECIFIC ENDORIBONUCLEASE (Severe acute respiratory syndrome coronavirus 2) | CoV_NSP15_CCoV_NSP15_MCoV_NSP15_N | ||
| 6x10 | GMJ | Haloperidol (DB00502) | Haloperidol is an antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. | N-ACETYLTRANSFERASE EIS (NA) | NA | ||
| 6x27 | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | LON PROTEASE HOMOLOG, MITOCHONDRIAL (Homo sapiens) | NA | ||
| 6x3t | ABU | Gamma-aminobutyric acid (DB02530) | The most common inhibitory neurotransmitter in the central nervous system. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3u | FYP | Flumazenil (DB01205) | Flumazenil is a benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBD | ||
| 6x3v | V8D | Etomidate (DB00292) | Etomidate is a short-acting intravenous anesthetic indicated for the induction of anesthesia and supplementation of subpotent anesthesia during short operative procedures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3w | UQA | Phenobarbital (DB01174) | Phenobarbital is a long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 (Homo sapiens;mus musculus) | Neur_chan_LBDNeur_chan_memb | ||
| 6x3x | DZP | Diazepam (DB00829) | Diazepam is a long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 (Homo sapiens;mus musculus) | Neur_chan_LBD | ||
| 6x7q | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | CHLORAMPHENICOL ACETYLTRANSFERASE 3 (NA) | NA | ||
| 6xg5 | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Escherichia coli (strain k12)) | DHFR_1 | ||
| 6xic | DHL | Cysteamine (DB00847) | Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. | PEPTIDE 40;PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (Homo sapiens;synthetic construct) | Peptidase_S8 | ||
| 6xk0 | DEX | Dexamethasone (DB01234) | Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. | ALBUMIN (Equus caballus) | Serum_albumin | ||
| 6xz0 | SCM | Spectinomycin (DB00919) | Spectinomycin is an aminocyclitol antibiotic used to treat susceptible strains of Neisseria gonorrhoeae. | STREPTOMYCIN 3''-ADENYLYLTRANSFERASE (Enterococcus faecalis) | DUF4111Polbeta | ||
| 6y08 | 08D | Sulfamethoxazole (DB01015) | Sulfamethoxazole is an oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract. | THYMIDYLATE SYNTHASE (Mus musculus) | Thymidylat_synt | ||
| 6y0f | 356 | Linagliptin (DB08882) | Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. | PROLYL ENDOPEPTIDASE FAP (Homo sapiens) | DPPIV_N | ||
| 6ycr | CCS | Carbocisteine (DB04339) | Carbocisteine is a expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. | FFIVIRDRVFR(CCS)G(NH2);PROGRAMMED CELL DEATH 1 LIGAND 1 (Homo sapiens;synthetic construct) | V-set | ||
| 6yk1 | D95 | Artesunate (DB09274) | Artesunate is artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. | PYRIDOXAL KINASE (Mus musculus) | Phos_pyr_kin | ||
| 6ymo | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | 14-3-3 PROTEIN ZETA/DELTA (Homo sapiens;synthetic construct) | 14-3-3 | ||
| 6yz4 | 1E8 | Ibrutinib (DB09053) | Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7 (Homo sapiens) | Pkinase | ||
| 6za5 | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | SALICYLATE SYNTHASE (Mycobacterium tuberculosis (strain atcc 25618 / h37rv)) | Chorismate_bind | ||
| 6zkk | 970 | Rotenone (DB11457) | Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also... | MITOCHONDRIAL COMPLEX I, 49 KDA SUBUNIT;MITOCHONDRIAL COMPLEX I, PSST SUBUNIT (Ovis aries) | NA | ||
| 6zkm | 970 | Rotenone (DB11457) | Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also... | MITOCHONDRIAL COMPLEX I, 49 KDA SUBUNIT;MITOCHONDRIAL COMPLEX I, PSST SUBUNIT (Ovis aries) | NA | ||
| 6zkm | 970 | Rotenone (DB11457) | Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also... | MITOCHONDRIAL COMPLEX I, PSST SUBUNIT;NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1 (Ovis aries) | NADHdh | ||
| 6zo9 | RBT | Rifabutin (DB00615) | Rifabutin is an antibiotic used to treat mycobacterium avium complex disease in patients with HIV. | MULTIDRUG EFFLUX PUMP SUBUNIT ACRB (Escherichia coli k-12;synthetic construct) | ACR_tran | ||
| 6zoc | ERY | Erythromycin (DB00199) | Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections. | MULTIDRUG EFFLUX PUMP SUBUNIT ACRB (Escherichia coli k-12;synthetic construct) | ACR_tran | ||
| 6zu4 | 115 | Fluvastatin (DB01095) | Fluvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6 (Homo sapiens) | SIR2 | ||
| 7a1u | FUA | Fusidic acid (DB02703) | Fusidic acid is a topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7a69 | R1Q | Vincristine (DB00541) | Vincristine is a vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. | MULTIDRUG RESISTANCE PROTEIN 1 (Homo sapiens;mus musculus) | ABC_membraneABC_tran | ||
| 7aem | 6GY | Brigatinib (DB12267) | Brigatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. | EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | ||
| 7aqi | QEL | Ifenprodil (DB08954) | N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7awc | BRL | Rosiglitazone (DB00412) | Rosiglitazone is a thiazolidinedione indicated as an adjunct to diet and exercise to maintain glycemic control in type 2 diabetes. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) | Hormone_recep | ||
| 7awr | S7W | Tegafur (DB09256) | Tegafur is an antineoplastic agent used in combination with other anticancer medications to treat advanced gastric and colorectal cancers. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7aww | CLU | Clonidine (DB00575) | Clonidine is an alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7axa | CL6 | Clotrimazole (DB00257) | Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 7axh | 27J | Zeranol (DB11478) | Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x... | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 7axk | EST | Estradiol (DB00783) | Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 (Homo sapiens) | Hormone_recep | ||
| 7bcr | 2Q2 | Gluconic acid (DB13180) | Gluconic Acid is an electrolyte supplement used in total parenteral nutrition. | PUTATIVE TRAP TRANSPORTER SOLUTE RECEPTOR DCTP (Advenella mimigardefordensis dpn7) | DctP | ||
| 7bni | SAL | Salicylic acid (DB00936) | Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. | LYSOSTAPHIN (Staphylococcus simulans) | SH3_5 | ||
| 7bpz | PEM | Bezafibrate (DB01393) | Bezafibrate is a lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 7bq0 | F5A | Fenofibric acid (DB13873) | Fenofibric acid is a fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia. | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens;synthetic construct) | Hormone_recep | ||
| 7br3 | F5O | Elagolix (DB11979) | Elagolix is a gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis. | GONADOTROPIN-RELEASING HORMONE RECEPTOR,GLGA GLYCOGEN SYNTHASE,GONADOTROPIN-RELEASING HORMONE RECEPTOR (Homo sapiens;pyrococcus abyssi (strain ge5 / orsay)) | 7tm_1Glycos_transf_1 | ||
| 7brn | ALE | Epinephrine (DB00668) | Epinephrine is a hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. | AUTOPHAGY-RELATED PROTEIN 40,AUTOPHAGY-RELATED PROTEIN 8 (Saccharomyces cerevisiae s288c) | ATG8 | ||
| 7bts | ALE | Epinephrine (DB00668) | Epinephrine is a hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. | LYSOZYME-BETA-1 ADRENERGIC RECEPTOR CHIMERA (Enterobacteria phage t4;homo sapiens;vicugna pacos) | Phage_lysozyme | ||
| 7bu6 | E5E | Norepinephrine (DB00368) | Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. | ENDOLYSIN,ENDOLYSIN,ENDOLYSIN,BETA-1 ADRENERGIC RECEPTOR CHIMERA (Enterobacteria phage t4;homo sapiens;camelidae mixed library) | Phage_lysozyme | ||
| 7bvc | 95E | Ethambutol (DB00330) | Ethambutol is an antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB). | INTEGRAL MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBB (Mycolicibacterium smegmatis mc2 155) | Arabino_trans_CArabino_trans_NArabinose_trans | ||
| 7bve | 95E | Ethambutol (DB00330) | Ethambutol is an antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB). | INTEGRAL MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBC (Mycolicibacterium smegmatis (strain atcc 700084 / mc(2)155);mycolicibacterium smegmatis mc2 155) | Arabino_trans_CArabino_trans_NArabinose_trans | ||
| 7bvf | 95E | Ethambutol (DB00330) | Ethambutol is an antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB). | PROBABLE ARABINOSYLTRANSFERASE B (Mycobacterium tuberculosis h37rv;mycolicibacterium smegmatis mc2 155) | Arabino_trans_CArabino_trans_NArabinose_trans | ||
| 7bym | FBX | Ezogabine (DB04953) | Ezogabine is an antiepileptic agent used as an adjuvant treatment of partial-onset seizures. | GREEN FLUORESCENT PROTEIN,POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 (Aequorea victoria;homo sapiens) | GFPIon_transKCNQ_channel | ||
| 7c4g | CLM | Chloramphenicol (DB00446) | Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. | N-ACETYLTRANSFERASE (Legionella pneumophila) | Acetyltransf_1 | ||
| 7cbq | A9L | Apremilast (DB05676) | Apremilast is a non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis. | CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens) | PDEase_I | ||
| 7cia | MPB | Methylparaben (DB14212) | Methylparaben is used in allergenic testing. | UDP-3-O-ACYL-N-ACETYLGLUCOSAMINE DEACETYLASE (Pseudomonas aeruginosa pao1) | LpxC | ||
| 7clz | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | PUTATIVE HYDROLASE (Streptomyces ambofaciens (strain atcc 23877 / 3486 / dsm 40053 / jcm 4204 / nbrc 12836 / nrrl b-2516)) | Abhydrolase_1 | ||
| 7cmu | G6L | Pramipexole (DB00413) | Pramipexole is a non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS). | SOLUBLE CYTOCHROME B562,D(3) DOPAMINE RECEPTOR (Homo sapiens;mus musculus;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 7coh | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 2;CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL (Bos taurus) | COX1COX2COX2_TM | ||
| 7cr2 | FBX | Ezogabine (DB04953) | Ezogabine is an antiepileptic agent used as an adjuvant treatment of partial-onset seizures. | POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2 (Homo sapiens) | Ion_transKCNQ_channel | ||
| 7cx2 | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | PROSTAGLANDIN E2 RECEPTOR EP2 SUBTYPE (Homo sapiens;synthetic construct) | 7tm_1 | ||
| 7d77 | HCY | Hydrocortisone (DB00741) | Hydrocortisone is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. | ADHESION G PROTEIN-COUPLED RECEPTOR G3; GPR97 (Homo sapiens;synthetic construct) | NA | ||
| 7d7k | CFF | Caffeine (DB00201) | Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7d7m | P2E | Dinoprostone (DB00917) | Dinoprostone is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. | PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE (Homo sapiens;lama glama) | 7tm_1 | ||
| 7d8j | URF | Fluorouracil (DB00544) | Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. | SINGLE-STRANDED DNA-BINDING PROTEIN (Staphylococcus aureus (strain ed98)) | SSB | ||
| 7daf | GZX | Ixabepilone (DB04845) | Ixabepilone is a microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines. | TUBULIN BETA CHAIN (Mus musculus;gallus gallus;sus scrofa) | TubulinTubulin_C | ||
| 7dbl | MOA | Mycophenolic acid (DB01024) | Mycophenolic acid is an immunosuppressant used to prevent organ transplant rejections. | ACYL-COA HYDROLASE MPAH' (Penicillium brevicompactum) | NA | ||
| 7ddh | DGX | Digoxin (DB00390) | Digoxin is a cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. | SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1;SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1 (Sus scrofa) | Cation_ATPaseCation_ATPase_CCation_ATPase_NE1-E2_ATPaseNa_K-ATPase | ||
| 7ddi | F9R | Digitoxin (DB01396) | Digitoxin is a cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure. | SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1;SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1 (Sus scrofa) | Cation_ATPaseCation_ATPase_CCation_ATPase_NE1-E2_ATPaseNa_K-ATPase | ||
| 7ddj | OBN | Ouabain (DB01092) | A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell... | SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1 (Sus scrofa) | Cation_ATPaseCation_ATPase_CCation_ATPase_NE1-E2_ATPase | ||
| 7dkz | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX (Pisum sativum) | PSI_PsaJPsaA_PsaB | ||
| 7dkz | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Pisum sativum) | PsaA_PsaB | ||
| 7dwq | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P740 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX (NA) | NA | ||
| 7dwq | PQN | Phylloquinone (DB01022) | Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. | PHOTOSYSTEM I P740 CHLOROPHYLL A APOPROTEIN A2;PHOTOSYSTEM I PROTEIN PSA27 (NA) | NA | ||
| 7e2z | 9SC | Aripiprazole (DB01238) | Aripiprazole is an atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. | SOLUBLE CYTOCHROME B562,5-HYDROXYTRYPTAMINE RECEPTOR 1A (Homo sapiens;escherichia coli) | 7tm_1Cytochrom_B562 | ||
| 7eov | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | CYTOSOLIC SULFOTRANSFERASE SULT2A8 (Mus musculus) | Sulfotransfer_1 | ||
| 7jm2 | AM2 | Apramycin (DB04626) | Apramycin is an aminoglycoside antibiotic for veterinary use that is used to treat infections in animals. | AMINOCYCLITOL ACETYLTRANSFERASE APMA (Staphylococcus aureus) | NA | ||
| 7jpx | 6UB | Levamlodipine (DB09237) | Levamlodipine is a calcium channel blocker used to treat hypertension. | VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S (Oryctolagus cuniculus) | CAC1F_CCa_chan_IQGPHHIon_trans | ||
| 7jsn | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA (Bos taurus) | GAFPDEase_I | ||
| 7jsn | VDN | Vardenafil (DB00862) | Vardenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA (Bos taurus) | GAFPDEase_I | ||
| 7ju7 | G65 | Masitinib (DB11526) | Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the... | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7jur | QOM | Trametinib (DB08911) | Trametinib is a kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1;KINASE SUPPRESSOR OF RAS 2 (Homo sapiens;oryctolagus cuniculus) | PK_Tyr_Ser-ThrPkinase | ||
| 7jvr | 08Y | Bromocriptine (DB01200) | Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. | SOLUBLE CYTOCHROME B562,D(2) DOPAMINE RECEPTOR (Escherichia coli;homo sapiens;synthetic construct) | 7tm_1 | ||
| 7jvu | SHH | Vorinostat (DB02546) | Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | HISTONE DEACETYLASE 8 (Homo sapiens) | Hist_deacetyl | ||
| 7jwn | 9KL | Dexketoprofen (DB09214) | Dexketoprofen is an NSAID that is the R(-)-enantiomer of racemic ketoprofen with analgesic and anti-inflammatory properties used for the treatment of mild to moderate pain. | ALBUMIN (Homo sapiens) | Serum_albumin | ||
| 7k12 | 1FL | Diflunisal (DB00861) | Diflunisal is an NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. | 2-AMINO-3-CARBOXYMUCONATE 6-SEMIALDEHYDE DECARBOXYLASE (Pseudomonas fluorescens) | Amidohydro_2 | ||
| 7k6d | SV6 | Telaprevir (DB05521) | Telaprevir is an NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections. | 3C-LIKE PROTEINASE (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7kep | FYG | Avibactam (DB09060) | Avibactam is a non-β-lactam β-lactamase inhibitor used in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and hospital or ventilator-acquired pneumonia. | BETA-LACTAMASE (Clostridioides difficile) | Transpeptidase | ||
| 7kes | AM2 | Apramycin (DB04626) | Apramycin is an aminoglycoside antibiotic for veterinary use that is used to treat infections in animals. | AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE (Uncultured bacterium) | Antibiotic_NAT | ||
| 7kgn | 1RG | Ertapenem (DB00303) | Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. | L,D-TRANSPEPTIDASE (Salmonella enterica) | PG_binding_1ScaffoldYkuD | ||
| 7kk3 | 2YQ | Talazoparib (DB11760) | Talazoparib is a poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARPPARP_reg | ||
| 7kk4 | 09L | Olaparib (DB09074) | Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARPPARP_reg | ||
| 7kk5 | 3JD | Niraparib (DB11793) | Niraparib is a poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE 1 (Homo sapiens) | PARPPARP_reg | ||
| 7kkn | 2YQ | Talazoparib (DB11760) | Talazoparib is a poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer. | POLY [ADP-RIBOSE] POLYMERASE (Homo sapiens) | PARP | ||
| 7kko | 09L | Olaparib (DB09074) | Olaparib is a chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE (Homo sapiens) | PARP | ||
| 7kkp | 3JD | Niraparib (DB11793) | Niraparib is a poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy. | POLY [ADP-RIBOSE] POLYMERASE (Homo sapiens) | PARP | ||
| 7krz | BO2 | Bortezomib (DB00188) | Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | LON PROTEASE HOMOLOG, MITOCHONDRIAL (Homo sapiens;escherichia coli bl21(de3)) | AAA | ||
| 7kxt | XB7 | Astemizole (DB00637) | Astemizole is a second generation antihistamine used to treat allergy symptoms. | POLYCOMB PROTEIN EED (Homo sapiens) | WD40 | ||
| 7llf | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | NON-STRUCTURAL PROTEIN 3 (Severe acute respiratory syndrome coronavirus 2) | NA | ||
| 7lnl | 8YF | Imipenem (DB01598) | Imipenem is a carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. | CARBAPENEM-HYDROLYZING BETA-LACTAMASE KPC (Klebsiella pneumoniae) | Beta-lactamase2 | ||
| 7lr0 | 4DY | Capsaicin (DB06774) | Capsaicin is a topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain. | OSM-9-LIKE TRP CHANNEL 1 (Ictidomys tridecemlineatus) | Ank_2Ion_trans | ||
| 7lw6 | RLT | Raltegravir (DB06817) | Raltegravir is an antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals. | POLYMERASE ACIDIC PROTEIN (Influenza a virus (a/luxembourg/43/2009(h1n1))) | NA | ||
| 7m0u | QO7 | Binimetinib (DB11967) | Binimetinib is a medication used to treat metastatic melanoma with specific mutations. | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens) | Pkinase | ||
| 7m4p | YQM | Eravacycline (DB12329) | Eravacycline is a tetracycline antibiotic used to treat complicated intra-abdominal infections. | EFFLUX PUMP MEMBRANE TRANSPORTER (Acinetobacter baumannii) | ACR_tran | ||
| 7nay | BO3 | Boric acid (DB11326) | Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing,... | L-LACTATE DEHYDROGENASE (Selenomonas ruminantium) | Ldh_1_CLdh_1_N | ||
| 7nez | TTC | Topotecan (DB01030) | Topotecan is an antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 7nfd | MIX | Mitoxantrone (DB01204) | Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. | ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (Homo sapiens;mus musculus) | ABC2_membraneABC2_membrane_7ABC_tran | ||
| 7nkg | COM | Coenzyme m (DB09110) | Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract. | METHYL-COENZYME M REDUCTASE ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE BETA SUBUNIT;METHYL-COENZYME M REDUCTASE GAMMA SUBUNIT (Methermicoccus shengliensis dsm 18856) | NA | ||
| 7o0k | CHD | Cholic acid (DB02659) | Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. | FATTY ACID-BINDING PROTEIN, LIVER (Gallus gallus) | Lipocalin | ||
| 7ocf | CYZ | Cyclothiazide (DB00606) | As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides... | ISOFORM FLIP OF GLUTAMATE RECEPTOR 1;ISOFORM FLIP OF GLUTAMATE RECEPTOR 2 (NA) | NA | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |