Ligand ID: 115

Drugbank ID:
Fluvastatin
(DB01095)

Indication:
Fluvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.

LIST OF BINDING INTERFACES for query '115'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
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DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1HWI_A_115A2	1hwi	115	Fluvastatin (DB01095)	Homo sapiens	HMG-COA REDUCTASE	HMG-CoA_red	22	GLU B 559 GLY B 560 CYS B 561 LEU B 562 SER B 565 ARG A 590 MET A 657 SER A 661 VAL A 683 SER A 684 ASN A 686 CYS A 688 ASP A 690 LYS A 691 LYS A 692 LYS B 735 ALA B 751 HIS B 752 ASN B 755 LEU B 853 ALA B 856 LEU B 857	115 A   2		Details
6ZU4_B_115B403	6zu4	115	Fluvastatin (DB01095)	Homo sapiens	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6	SIR2	14	LYS B  15 ILE B  61 PRO B  62 PHE B  64 VAL B  70 TRP B  71 GLU B  74 PRO B  80 PHE B  82 PHE B  86 VAL B 115 MET B 157 ILE B 185 TRP B 188	115 B 403		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1HWI_A_115A2","1hwi","115","Fluvastatin (DB01095)","Homo sapiens","HMG-COA REDUCTASE","HMG-CoA_red",22,"GLU B 559;GLY B 560;CYS B 561;LEU B 562;SER B 565;ARG A 590;MET A 657;SER A 661;VAL A 683;SER A 684;ASN A 686;CYS A 688;ASP A 690;LYS A 691;LYS A 692;LYS B 735;ALA B 751;HIS B 752;ASN B 755;LEU B 853;ALA B 856;LEU B 857","115 A 2\r"],["6ZU4_B_115B403","6zu4","115","Fluvastatin (DB01095)","Homo sapiens","NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6","SIR2",14,"LYS B 15;ILE B 61;PRO B 62;PHE B 64;VAL B 70;TRP B 71;GLU B 74;PRO B 80;PHE B 82;PHE B 86;VAL B 115;MET B 157;ILE B 185;TRP B 188","115 B 403\r"]]