Ligand ID: ROF

Drugbank ID:
Roflumilast
(DB01656)

Indication:
Roflumilast is a selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis.


LIST OF BINDING INTERFACES for query 'ROF'

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DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details
1XMU_A_ROFA1011xmu ROFRoflumilast
(DB01656) 		Homo sapiens CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B PDEase_I 18TYR A 233
HIS A 234
THR A 345
MET A 347
ASP A 392
LEU A 393
ASN A 395
PRO A 396
TYR A 403
TRP A 406
THR A 407
ILE A 410
MET A 411
PHE A 414
MET A 431
SER A 442
GLN A 443
PHE A 446
ROF A 101
1XOQ_A_ROFA5021xoq ROFRoflumilast
(DB01656) 		Homo sapiens CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D PDEase_I 18TYR A 159
HIS A 160
THR A 271
MET A 273
ASP A 318
LEU A 319
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
GLN A 369
PHE A 372
ROF A 502
DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details