Ligand ID: TCW

Drugbank ID:
Tolcapone
(DB00323)

Indication:
Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease.

LIST OF BINDING INTERFACES for query 'DB00323'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3S68_A_TCWA227	3s68	TCW	Tolcapone (DB00323)	Rattus norvegicus	CATECHOL O-METHYLTRANSFERASE	Methyltransf_3	16	TRP A  38 MET A  40 ASN A  41 VAL A  42 LYS A  46 ASP A 141 HIS A 142 TRP A 143 LYS A 144 TYR A 147 ASP A 169 ASN A 170 VAL A 173 PRO A 174 LEU A 198 GLU A 199	TCW A 227		Details
4D7B_A_TCWA1126	4d7b	TCW	Tolcapone (DB00323)	Homo sapiens	TRANSTHYRETIN	Transthyretin	10	LYS B  15 LEU B  17 THR B 106 ALA B 108 ALA B 109 LEU B 110 SER B 117 THR B 118 THR B 119 VAL B 121	TCW A1126		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3S68_A_TCWA227","3s68","TCW","Tolcapone (DB00323)","Rattus norvegicus","CATECHOL O-METHYLTRANSFERASE","Methyltransf_3",16,"TRP A 38;MET A 40;ASN A 41;VAL A 42;LYS A 46;ASP A 141;HIS A 142;TRP A 143;LYS A 144;TYR A 147;ASP A 169;ASN A 170;VAL A 173;PRO A 174;LEU A 198;GLU A 199","TCW A 227\r"],["4D7B_A_TCWA1126","4d7b","TCW","Tolcapone (DB00323)","Homo sapiens","TRANSTHYRETIN","Transthyretin",10,"LYS B 15;LEU B 17;THR B 106;ALA B 108;ALA B 109;LEU B 110;SER B 117;THR B 118;THR B 119;VAL B 121","TCW A1126\r"]]