Ligand ID: CHC

Drugbank ID:
Obeticholic acid
(DB05990)

Indication:
Obeticholic acid is a bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance to UDCA.


LIST OF BINDING INTERFACES for query 'DB05990'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
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DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details
1OSV_A_CHCA2021osv CHCObeticholic acid
(DB05990) 		Rattus norvegicus;
synthetic construct 		BILE ACID RECEPTOR Hormone_recep 21MET A 262
LEU A 284
MET A 287
ALA A 288
HIS A 291
MET A 325
PHE A 326
ARG A 328
SER A 329
ILE A 332
PHE A 333
LEU A 345
ILE A 349
TYR A 358
ILE A 359
MET A 362
PHE A 363
TYR A 366
HIS A 444
TRP A 451
TRP A 466
CHC A 202
DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details