Results: Ligand

Ligand ID: ERY

Drugbank ID:
Erythromycin
(DB00199)

Indication:
Erythromycin is a macrolide antibiotic used to treat and prevent a variety of bacterial infections.

LIST OF BINDING INTERFACES for query 'DB00199'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
2IYF_A_ERYA1400	2iyf	ERY	Erythromycin (DB00199)	Streptomyces antibioticus	OLEANDOMYCIN GLYCOSYLTRANSFERASE	UDPGT	18	ALA A 16 HIS A 19 TRP A 73 ASN A 80 VAL A 81 PHE A 84 ILE A 111 THR A 112 TYR A 114 ARG A 117 ASN A 133 LEU A 134 VAL A 135 ALA A 136 TYR A 140 ALA A 182 SER A 183 ASP A 329	ERY A1400
2J0D_A_ERYA1498	2j0d	ERY	Erythromycin (DB00199)	Homo sapiens	CYTOCHROME P450 3A4	p450	17	PHE A 57 ARG A 105 ARG A 106 PHE A 108 SER A 119 ILE A 120 PHE A 213 PHE A 220 PHE A 241 ILE A 301 PHE A 304 ALA A 305 THR A 309 ALA A 370 ARG A 372 GLU A 374 LEU A 482	ERY A1498
3FRQ_A_ERYA195	3frq	ERY	Erythromycin (DB00199)	Escherichia coli	REPRESSOR PROTEIN MPHR(A)	TetR_N	23	THR A 17 LEU A 20 LYS A 21 MET A 59 GLY A 62 GLN A 65 VAL A 66 TYR A 69 LEU A 89 SER A 92 MET A 93 ASN A 102 TYR A 103 ILE A 105 SER A 106 ARG A 122 ASN A 123 VAL A 126 HIS A 147 ILE A 150 ALA A 151 THR A 154 MET B 155	ERY A 195
5IGT_A_ERYA402	5igt	ERY	Erythromycin (DB00199)	Escherichia coli	MACROLIDE 2'-PHOSPHOTRANSFERASE	APH	23	MET A 103 ILE A 105 SER A 109 SER A 110 PRO A 112 VAL A 115 ASP A 200 LEU A 201 TYR A 202 VAL A 203 HIS A 205 SER A 221 GLU A 222 ILE A 230 ALA A 233 ALA A 234 MET A 237 VAL A 238 LEU A 270 GLY A 273 THR A 276 TYR A 277 PHE A 280	ERY A 402
5IWU_A_ERYA404	5iwu	ERY	Erythromycin (DB00199)	Escherichia coli	MACROLIDE 2'-PHOSPHOTRANSFERASE II	APH	24	ILE A 103 HIS A 105 GLY A 108 ASN A 109 TYR A 110 TRP A 112 GLY A 199 ASP A 200 VAL A 201 HIS A 202 HIS A 205 THR A 221 GLU A 222 HIS A 230 ILE A 233 PHE A 234 ARG A 237 ALA A 238 TYR A 273 SER A 276 ILE A 277 PHE A 280 TYR A 289 MET A 292	ERY A 404
5YK2_A_ERYA501	5yk2	ERY	Erythromycin (DB00199)	Mycobacterium tuberculosis (strain atcc 25618 / h37rv)	PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER	ABC1	16	ASP A 195 GLU A 196 GLU A 199 ARG A 200 MET A 203 GLY A 285 ASP A 286 GLY A 306 ALA A 307 VAL A 308 ALA A 309 PRO A 310 ALA A 403 ILE A 407 ARG A 410 VAL A 411	ERY A 501
6VKT_B_ERYB1101	6vkt	ERY	Erythromycin (DB00199)	Neisseria gonorrhoeae	EFFLUX PUMP MEMBRANE TRANSPORTER	ACR_tran	17	PHE B 136 ILE B 139 MET B 141 ARG B 174 PHE B 176 SER B 275 THR B 277 GLY B 286 ALA B 288 TYR B 325 THR B 327 PHE B 568 ILE B 605 VAL B 607 PHE B 610 PHE B 612 PHE B 623	ERY B1101
6ZOC_A_ERYA1203	6zoc	ERY	Erythromycin (DB00199)	Escherichia coli k-12; synthetic construct	MULTIDRUG EFFLUX PUMP SUBUNIT ACRB	ACR_tran	23	SER A 79 ASN A 81 THR A 91 SER A 134 SER A 135 PHE A 136 LYS A 292 MET A 573 MET A 575 PHE A 615 PRO A 616 ILE A 626 LEU A 668 VAL A 672 GLU A 673 GLY A 675 ASP A 681 GLU A 683 ASN A 719 GLU A 826 THR A 860 GLY A 861 MET A 862	ERY A1203
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["2IYF_A_ERYA1400","2iyf","ERY","Erythromycin (DB00199)","Streptomyces antibioticus","OLEANDOMYCIN GLYCOSYLTRANSFERASE","UDPGT",18,"ALA A  16;HIS A  19;TRP A  73;ASN A  80;VAL A  81;PHE A  84;ILE A 111;THR A 112;TYR A 114;ARG A 117;ASN A 133;LEU A 134;VAL A 135;ALA A 136;TYR A 140;ALA A 182;SER A 183;ASP A 329","ERY A1400\r"],["2J0D_A_ERYA1498","2j0d","ERY","Erythromycin (DB00199)","Homo sapiens","CYTOCHROME P450 3A4","p450",17,"PHE A  57;ARG A 105;ARG A 106;PHE A 108;SER A 119;ILE A 120;PHE A 213;PHE A 220;PHE A 241;ILE A 301;PHE A 304;ALA A 305;THR A 309;ALA A 370;ARG A 372;GLU A 374;LEU A 482","ERY A1498\r"],["3FRQ_A_ERYA195","3frq","ERY","Erythromycin (DB00199)","Escherichia coli","REPRESSOR PROTEIN MPHR(A)","TetR_N",23,"THR A  17;LEU A  20;LYS A  21;MET A  59;GLY A  62;GLN A  65;VAL A  66;TYR A  69;LEU A  89;SER A  92;MET A  93;ASN A 102;TYR A 103;ILE A 105;SER A 106;ARG A 122;ASN A 123;VAL A 126;HIS A 147;ILE A 150;ALA A 151;THR A 154;MET B 155","ERY A 195\r"],["5IGT_A_ERYA402","5igt","ERY","Erythromycin (DB00199)","Escherichia coli","MACROLIDE 2'-PHOSPHOTRANSFERASE","APH",23,"MET A 103;ILE A 105;SER A 109;SER A 110;PRO A 112;VAL A 115;ASP A 200;LEU A 201;TYR A 202;VAL A 203;HIS A 205;SER A 221;GLU A 222;ILE A 230;ALA A 233;ALA A 234;MET A 237;VAL A 238;LEU A 270;GLY A 273;THR A 276;TYR A 277;PHE A 280","ERY A 402\r"],["5IWU_A_ERYA404","5iwu","ERY","Erythromycin (DB00199)","Escherichia coli","MACROLIDE 2'-PHOSPHOTRANSFERASE II","APH",24,"ILE A 103;HIS A 105;GLY A 108;ASN A 109;TYR A 110;TRP A 112;GLY A 199;ASP A 200;VAL A 201;HIS A 202;HIS A 205;THR A 221;GLU A 222;HIS A 230;ILE A 233;PHE A 234;ARG A 237;ALA A 238;TYR A 273;SER A 276;ILE A 277;PHE A 280;TYR A 289;MET A 292","ERY A 404\r"],["5YK2_A_ERYA501","5yk2","ERY","Erythromycin (DB00199)","Mycobacterium tuberculosis (strain atcc 25618 \/ h37rv)","PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER","ABC1",16,"ASP A 195;GLU A 196;GLU A 199;ARG A 200;MET A 203;GLY A 285;ASP A 286;GLY A 306;ALA A 307;VAL A 308;ALA A 309;PRO A 310;ALA A 403;ILE A 407;ARG A 410;VAL A 411","ERY A 501\r"],["6VKT_B_ERYB1101","6vkt","ERY","Erythromycin (DB00199)","Neisseria gonorrhoeae","EFFLUX PUMP MEMBRANE TRANSPORTER","ACR_tran",17,"PHE B 136;ILE B 139;MET B 141;ARG B 174;PHE B 176;SER B 275;THR B 277;GLY B 286;ALA B 288;TYR B 325;THR B 327;PHE B 568;ILE B 605;VAL B 607;PHE B 610;PHE B 612;PHE B 623","ERY B1101\r"],["6ZOC_A_ERYA1203","6zoc","ERY","Erythromycin (DB00199)","Escherichia coli k-12;synthetic construct","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","ACR_tran",23,"SER A  79;ASN A  81;THR A  91;SER A 134;SER A 135;PHE A 136;LYS A 292;MET A 573;MET A 575;PHE A 615;PRO A 616;ILE A 626;LEU A 668;VAL A 672;GLU A 673;GLY A 675;ASP A 681;GLU A 683;ASN A 719;GLU A 826;THR A 860;GLY A 861;MET A 862","ERY A1203\r"]]