Ligand ID: P06

Drugbank ID:
Dabrafenib
(DB08912)

Indication:
Dabrafenib is a kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.

LIST OF BINDING INTERFACES for query 'DB08912'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4XV2_A_P06A801	4xv2	P06	Dabrafenib (DB08912)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE B-RAF	NA	22	ILE A 463 GLY A 464 SER A 465 GLY A 466 PHE A 468 VAL A 471 ALA A 481 LYS A 483 LEU A 505 LEU A 514 LEU A 515 PHE A 516 ILE A 527 THR A 529 GLN A 530 TRP A 531 CYS A 532 PHE A 583 ILE A 592 GLY A 593 ASP A 594 PHE A 595	P06 A 801		Details
6HJ2_A_P06A501	6hj2	P06	Dabrafenib (DB08912)	Homo sapiens	NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2	Hormone_recep	18	LEU A 209 VAL A 211 MET A 243 SER A 247 PHE A 251 PHE A 281 CYS A 284 GLN A 285 PHE A 288 TRP A 299 TYR A 306 MET A 323 HIS A 407 THR A 408 LEU A 411 PHE A 420 MET A 425 PHE A 429	P06 A 501		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4XV2_A_P06A801","4xv2","P06","Dabrafenib (DB08912)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE B-RAF","NA",22,"ILE A 463;GLY A 464;SER A 465;GLY A 466;PHE A 468;VAL A 471;ALA A 481;LYS A 483;LEU A 505;LEU A 514;LEU A 515;PHE A 516;ILE A 527;THR A 529;GLN A 530;TRP A 531;CYS A 532;PHE A 583;ILE A 592;GLY A 593;ASP A 594;PHE A 595","P06 A 801\r"],["6HJ2_A_P06A501","6hj2","P06","Dabrafenib (DB08912)","Homo sapiens","NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2","Hormone_recep",18,"LEU A 209;VAL A 211;MET A 243;SER A 247;PHE A 251;PHE A 281;CYS A 284;GLN A 285;PHE A 288;TRP A 299;TYR A 306;MET A 323;HIS A 407;THR A 408;LEU A 411;PHE A 420;MET A 425;PHE A 429","P06 A 501\r"]]