Results: Ligand

Ligand ID: TOY

Drugbank ID:
Tobramycin
(DB00684)

Indication:
Tobramycin is an aminoglycoside antibiotic used to treat cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, bone, and skin structure infections.

LIST OF BINDING INTERFACES for query 'TOY'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1M4D_A_TOYA500	1m4d	TOY	Tobramycin (DB00684)	Mycobacterium tuberculosis	AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE	Acetyltransf_9	16	PHE A 32 ASP A 35 PHE A 36 ASP A 40 VAL A 81 GLU A 82 GLY A 83 SER A 117 SER A 118 SER A 119 ALA A 120 ASP A 151 ASP A 152 THR A 155 ASP A 179 TRP A 181	TOY A 500
3SG8_A_TOYA305	3sg8	TOY	Tobramycin (DB00684)	Enterococcus casseliflavus	APH(2'')-ID	APH	13	ASN A 32 ASP A 197 SER A 199 ASP A 201 HIS A 202 ASP A 220 GLU A 235 GLU A 238 GLU A 239 TRP A 271 GLU A 274 TYR A 278 TRP A 287	TOY A 305
3VET_A_TOYA604	3vet	TOY	Tobramycin (DB00684)	Streptoalloteichus tenebrarius	O-CARBAMOYLTRANSFERASE TOBZ	Carbam_trans_C Carbam_trans_N	11	ASP A 12 HIS A 14 TYR A 42 PHE A 169 GLU A 172 GLU A 176 GLY A 182 ASP A 183 TRP A 227 ASP A 228 TYR A 230	TOY A 604
4EBK_A_TOYA301	4ebk	TOY	Tobramycin (DB00684)	Pseudomonas aeruginosa	AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE	AadA_C NTP_transf_2	9	ASP B 40 GLU B 51 TYR B 53 ALA B 70 GLU A 122 GLU A 124 GLU A 126 ASP A 127 GLU A 130	TOY A 301
4EVY_A_TOYA201	4evy	TOY	Tobramycin (DB00684)	Acinetobacter haemolyticus	AMINOGLYCOSIDE N(6')-ACETYLTRANSFERASE TYPE 1	Acetyltransf_1	15	ARG A 18 TRP A 22 SER A 23 ASP A 24 GLU A 32 TYR B 65 ASN B 67 PHE A 76 GLU A 78 GLY A 79 ASP A 114 ALA A 115 ALA A 116 GLU B 135 VAL B 137	TOY A 201
4JD6_A_TOYA501	4jd6	TOY	Tobramycin (DB00684)	Mycobacterium tuberculosis	ENHANCED INTRACELLULAR SURVIVAL PROTEIN	Acetyltransf_17 Acetyltransf_9 SCP2_2	16	PHE A 24 ASP A 26 ILE A 28 TRP A 36 LEU A 82 SER A 83 PHE A 84 VAL A 85 LEU A 118 HIS A 119 ALA A 120 SER A 121 TYR A 126 GLU A 203 GLU A 401 PHE A 402	TOY A 501
5CFS_A_TOYA203	5cfs	TOY	Tobramycin (DB00684)	Pseudomonas aeruginosa	AAD(2''),GENTAMICIN 2''-NUCLEOTIDYLTRANSFERASE,GENTAMICIN RESISTANCE PROTEIN	Aminoglyc_resit	9	ASP A 44 ASP A 46 TYR A 74 ASP A 86 GLU A 88 ILE A 99 ALA A 100 ASP A 131 TYR A 134	TOY A 203
6NP4_A_TOYA301	6np4	TOY	Tobramycin (DB00684)	Enterobacter cloacae	AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE	Antibiotic_NAT	22	PHE A 77 SER A 79 SER A 83 TYR A 85 GLU A 86 TYR A 113 PHE A 116 ASP A 136 TYR A 159 ASP A 183 ALA A 184 THR A 186 HIS A 189 SER A 225 ASN A 226 GLY A 227 ALA A 234 PRO A 235 GLY A 237 ASP A 239 VAL A 241 GLU A 242	TOY A 301
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1M4D_A_TOYA500","1m4d","TOY","Tobramycin (DB00684)","Mycobacterium tuberculosis","AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE","Acetyltransf_9",16,"PHE A  32;ASP A  35;PHE A  36;ASP A  40;VAL A  81;GLU A  82;GLY A  83;SER A 117;SER A 118;SER A 119;ALA A 120;ASP A 151;ASP A 152;THR A 155;ASP A 179;TRP A 181","TOY A 500\r"],["3SG8_A_TOYA305","3sg8","TOY","Tobramycin (DB00684)","Enterococcus casseliflavus","APH(2'')-ID","APH",13,"ASN A  32;ASP A 197;SER A 199;ASP A 201;HIS A 202;ASP A 220;GLU A 235;GLU A 238;GLU A 239;TRP A 271;GLU A 274;TYR A 278;TRP A 287","TOY A 305\r"],["3VET_A_TOYA604","3vet","TOY","Tobramycin (DB00684)","Streptoalloteichus tenebrarius","O-CARBAMOYLTRANSFERASE TOBZ","Carbam_trans_C;Carbam_trans_N",11,"ASP A  12;HIS A  14;TYR A  42;PHE A 169;GLU A 172;GLU A 176;GLY A 182;ASP A 183;TRP A 227;ASP A 228;TYR A 230","TOY A 604\r"],["4EBK_A_TOYA301","4ebk","TOY","Tobramycin (DB00684)","Pseudomonas aeruginosa","AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE","AadA_C;NTP_transf_2",9,"ASP B  40;GLU B  51;TYR B  53;ALA B  70;GLU A 122;GLU A 124;GLU A 126;ASP A 127;GLU A 130","TOY A 301\r"],["4EVY_A_TOYA201","4evy","TOY","Tobramycin (DB00684)","Acinetobacter haemolyticus","AMINOGLYCOSIDE N(6')-ACETYLTRANSFERASE TYPE 1","Acetyltransf_1",15,"ARG A  18;TRP A  22;SER A  23;ASP A  24;GLU A  32;TYR B  65;ASN B  67;PHE A  76;GLU A  78;GLY A  79;ASP A 114;ALA A 115;ALA A 116;GLU B 135;VAL B 137","TOY A 201\r"],["4JD6_A_TOYA501","4jd6","TOY","Tobramycin (DB00684)","Mycobacterium tuberculosis","ENHANCED INTRACELLULAR SURVIVAL PROTEIN","Acetyltransf_17;Acetyltransf_9;SCP2_2",16,"PHE A  24;ASP A  26;ILE A  28;TRP A  36;LEU A  82;SER A  83;PHE A  84;VAL A  85;LEU A 118;HIS A 119;ALA A 120;SER A 121;TYR A 126;GLU A 203;GLU A 401;PHE A 402","TOY A 501\r"],["5CFS_A_TOYA203","5cfs","TOY","Tobramycin (DB00684)","Pseudomonas aeruginosa","AAD(2''),GENTAMICIN 2''-NUCLEOTIDYLTRANSFERASE,GENTAMICIN RESISTANCE PROTEIN","Aminoglyc_resit",9,"ASP A  44;ASP A  46;TYR A  74;ASP A  86;GLU A  88;ILE A  99;ALA A 100;ASP A 131;TYR A 134","TOY A 203\r"],["6NP4_A_TOYA301","6np4","TOY","Tobramycin (DB00684)","Enterobacter cloacae","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE","Antibiotic_NAT",22,"PHE A  77;SER A  79;SER A  83;TYR A  85;GLU A  86;TYR A 113;PHE A 116;ASP A 136;TYR A 159;ASP A 183;ALA A 184;THR A 186;HIS A 189;SER A 225;ASN A 226;GLY A 227;ALA A 234;PRO A 235;GLY A 237;ASP A 239;VAL A 241;GLU A 242","TOY A 301\r"]]