Results: Ligand

Ligand ID: 1N1

Drugbank ID:
Dasatinib
(DB01254)

Indication:
Dasatinib is a tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy.

LIST OF BINDING INTERFACES for query 'DB01254'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
2GQG_A_1N1A501	2gqg	1N1	Dasatinib (DB01254)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1	PK_Tyr_Ser-Thr	21	LEU A 248 GLY A 249 TYR A 253 VAL A 256 ALA A 269 VAL A 270 LYS A 271 GLU A 286 MET A 290 VAL A 299 ILE A 313 THR A 315 GLU A 316 PHE A 317 MET A 318 THR A 319 TYR A 320 GLY A 321 LEU A 370 ALA A 380 ASP A 381	1N1 A 501
2Y6O_A_1N1A1892	2y6o	1N1	Dasatinib (DB01254)	Mus musculus	EPHRIN TYPE-A RECEPTOR 4	PK_Tyr_Ser-Thr	21	LYS A 625 ILE A 627 GLY A 628 VAL A 635 ALA A 651 ILE A 652 LYS A 653 GLU A 670 MET A 674 ILE A 683 ILE A 697 THR A 699 GLU A 700 TYR A 701 MET A 702 GLU A 703 ASN A 704 GLY A 705 LYS A 713 LEU A 753 SER A 763	1N1 A1892
2ZVA_A_1N1A513	2zva	1N1	Dasatinib (DB01254)	Mus musculus	TYROSINE-PROTEIN KINASE LYN	PK_Tyr_Ser-Thr	19	LEU A 253 VAL A 261 ALA A 273 VAL A 274 LYS A 275 GLU A 290 MET A 294 VAL A 303 ILE A 317 THR A 319 GLU A 320 PHE A 321 MET A 322 ALA A 323 LYS A 324 GLY A 325 LEU A 374 ALA A 384 ASP A 385	1N1 A 513
3G5D_A_1N1A1	3g5d	1N1	Dasatinib (DB01254)	Gallus gallus	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	PK_Tyr_Ser-Thr	19	LEU A 273 VAL A 281 ALA A 293 ILE A 294 LYS A 295 GLU A 310 MET A 314 VAL A 323 ILE A 336 THR A 338 GLU A 339 TYR A 340 MET A 341 SER A 342 LYS A 343 GLY A 344 LEU A 393 ALA A 403 ASP A 404	1N1 A 1
3K54_A_1N1A1	3k54	1N1	Dasatinib (DB01254)	Homo sapiens	TYROSINE-PROTEIN KINASE BTK	PK_Tyr_Ser-Thr	20	LEU A 408 PHE A 413 VAL A 416 ALA A 428 ILE A 429 LYS A 430 GLU A 445 MET A 449 VAL A 458 ILE A 472 THR A 474 GLU A 475 TYR A 476 MET A 477 ALA A 478 ASN A 479 GLY A 480 LEU A 528 SER A 538 ASP A 539	1N1 A 1
3LFA_A_1N1A361	3lfa	1N1	Dasatinib (DB01254)	Homo sapiens	MITOGEN-ACTIVATED PROTEIN KINASE 14	Pkinase	18	VAL A 30 GLY A 31 VAL A 38 ALA A 51 VAL A 52 LYS A 53 GLU A 71 LEU A 75 ILE A 84 LEU A 104 VAL A 105 THR A 106 HIS A 107 LEU A 108 MET A 109 GLY A 110 LEU A 167 ASP A 168	1N1 A 361
3OHT_A_1N1A1000	3oht	1N1	Dasatinib (DB01254)	Salmo salar	P38A	Pkinase	20	VAL A 31 GLY A 32 SER A 33 VAL A 39 ALA A 52 VAL A 53 LYS A 54 GLU A 72 LEU A 76 ILE A 85 LEU A 105 THR A 107 HIS A 108 LEU A 109 MET A 110 GLY A 111 ASN A 116 LEU A 168 ASP A 169 PHE A 170	1N1 A1000
3OHT_A_1N1A2000	3oht	1N1	Dasatinib (DB01254)	Salmo salar	P38A	Pkinase	16	ASP A 146 ILE A 147 ILE A 148 ARG A 150 ARG B 190 ILE B 194 TRP A 198 MET A 199 TYR A 201 ASN A 202 VAL A 205 ILE B 230 SER B 253 GLU B 255 ALA B 256 TYR B 259	1N1 A2000
3SXR_A_1N1A1	3sxr	1N1	Dasatinib (DB01254)	Homo sapiens	CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX	PK_Tyr_Ser-Thr	19	LEU A 423 GLY A 424 VAL A 431 ALA A 443 VAL A 444 LYS A 445 MET A 464 VAL A 473 ILE A 487 THR A 489 GLU A 490 TYR A 491 ILE A 492 SER A 493 ASN A 494 GLY A 495 LEU A 543 SER A 553 PHE A 555	1N1 A 1
4QMS_A_1N1A401	4qms	1N1	Dasatinib (DB01254)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE 24	Pkinase	23	ILE A 30 GLY A 31 LYS A 32 VAL A 38 ALA A 51 ILE A 52 LYS A 53 GLU A 70 THR A 83 ILE A 97 MET A 99 GLU A 100 TYR A 101 LEU A 102 GLY A 103 GLY A 104 GLY A 105 LEU A 151 ALA A 161 ASP A 162 TYR A 291 LYS A 292 LYS A 295	1N1 A 401
5BVW_A_1N1A1009	5bvw	1N1	Dasatinib (DB01254)	Homo sapiens	EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1	PK_Tyr_Ser-Thr	19	LEU A 616 VAL A 624 ALA A 653 VAL A 654 LYS A 655 GLU A 672 MET A 676 ILE A 685 MET A 699 THR A 701 ASP A 702 TYR A 703 MET A 704 GLU A 705 ASN A 706 GLY A 707 LEU A 773 ALA A 783 PHE A 785	1N1 A1009
5H2U_A_1N1A501	5h2u	1N1	Dasatinib (DB01254)	Homo sapiens	PROTEIN-TYROSINE KINASE 6	PK_Tyr_Ser-Thr	21	ARG A 195 LEU A 197 VAL A 205 ALA A 217 ILE A 218 LYS A 219 LEU A 248 ILE A 262 ILE A 263 THR A 264 GLU A 265 LEU A 266 MET A 267 ALA A 268 LYS A 269 GLY A 270 GLU A 274 LEU A 319 GLY A 329 ASP A 330 LEU A 333	1N1 A 501
5I9Y_A_1N1A1001	5i9y	1N1	Dasatinib (DB01254)	Homo sapiens	EPHRIN TYPE-A RECEPTOR 2	PK_Tyr_Ser-Thr	21	ILE A 619 VAL A 627 ALA A 644 ILE A 645 LYS A 646 GLU A 663 MET A 667 ILE A 676 ILE A 690 THR A 692 GLU A 693 TYR A 694 MET A 695 GLU A 696 ASN A 697 GLY A 698 LYS A 702 GLU A 706 LEU A 746 SER A 756 ASP A 757	1N1 A1001
5OWR_A_1N1A401	5owr	1N1	Dasatinib (DB01254)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE 10	Pkinase	16	LEU A 42 ALA A 63 LYS A 65 GLU A 81 VAL A 94 ILE A 110 GLU A 111 PHE A 112 CYS A 113 PRO A 114 GLY A 115 GLY A 116 LEU A 164 ALA A 174 ASP A 175 VAL A 314	1N1 A 401
5VCV_A_1N1A404	5vcv	1N1	Dasatinib (DB01254)	Homo sapiens	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE	Pkinase	23	LEU A 116 GLY A 117 VAL A 124 ALA A 137 VAL A 138 LYS A 139 GLU A 157 HIS A 161 VAL A 171 LEU A 185 GLN A 186 THR A 187 GLU A 188 LEU A 189 CYS A 190 GLY A 191 PRO A 192 SER A 193 GLN A 196 PHE A 240 GLY A 250 ASP A 251 PHE A 252	1N1 A 404
6FNM_A_1N1A1001	6fnm	1N1	Dasatinib (DB01254)	Homo sapiens	EPHRIN TYPE-B RECEPTOR 4	PK_Tyr_Ser-Thr	22	ILE A 621 GLY A 622 VAL A 629 ALA A 645 ILE A 646 LYS A 647 GLU A 664 MET A 668 ILE A 677 ILE A 691 LEU A 692 THR A 693 GLU A 694 PHE A 695 MET A 696 GLU A 697 ASN A 698 GLY A 699 PHE A 704 LEU A 707 LEU A 747 SER A 757	1N1 A1001
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["2GQG_A_1N1A501","2gqg","1N1","Dasatinib (DB01254)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","PK_Tyr_Ser-Thr",21,"LEU A 248;GLY A 249;TYR A 253;VAL A 256;ALA A 269;VAL A 270;LYS A 271;GLU A 286;MET A 290;VAL A 299;ILE A 313;THR A 315;GLU A 316;PHE A 317;MET A 318;THR A 319;TYR A 320;GLY A 321;LEU A 370;ALA A 380;ASP A 381","1N1 A 501\r"],["2Y6O_A_1N1A1892","2y6o","1N1","Dasatinib (DB01254)","Mus musculus","EPHRIN TYPE-A RECEPTOR 4","PK_Tyr_Ser-Thr",21,"LYS A 625;ILE A 627;GLY A 628;VAL A 635;ALA A 651;ILE A 652;LYS A 653;GLU A 670;MET A 674;ILE A 683;ILE A 697;THR A 699;GLU A 700;TYR A 701;MET A 702;GLU A 703;ASN A 704;GLY A 705;LYS A 713;LEU A 753;SER A 763","1N1 A1892\r"],["2ZVA_A_1N1A513","2zva","1N1","Dasatinib (DB01254)","Mus musculus","TYROSINE-PROTEIN KINASE LYN","PK_Tyr_Ser-Thr",19,"LEU A 253;VAL A 261;ALA A 273;VAL A 274;LYS A 275;GLU A 290;MET A 294;VAL A 303;ILE A 317;THR A 319;GLU A 320;PHE A 321;MET A 322;ALA A 323;LYS A 324;GLY A 325;LEU A 374;ALA A 384;ASP A 385","1N1 A 513\r"],["3G5D_A_1N1A1","3g5d","1N1","Dasatinib (DB01254)","Gallus gallus","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","PK_Tyr_Ser-Thr",19,"LEU A 273;VAL A 281;ALA A 293;ILE A 294;LYS A 295;GLU A 310;MET A 314;VAL A 323;ILE A 336;THR A 338;GLU A 339;TYR A 340;MET A 341;SER A 342;LYS A 343;GLY A 344;LEU A 393;ALA A 403;ASP A 404","1N1 A   1\r"],["3K54_A_1N1A1","3k54","1N1","Dasatinib (DB01254)","Homo sapiens","TYROSINE-PROTEIN KINASE BTK","PK_Tyr_Ser-Thr",20,"LEU A 408;PHE A 413;VAL A 416;ALA A 428;ILE A 429;LYS A 430;GLU A 445;MET A 449;VAL A 458;ILE A 472;THR A 474;GLU A 475;TYR A 476;MET A 477;ALA A 478;ASN A 479;GLY A 480;LEU A 528;SER A 538;ASP A 539","1N1 A   1\r"],["3LFA_A_1N1A361","3lfa","1N1","Dasatinib (DB01254)","Homo sapiens","MITOGEN-ACTIVATED PROTEIN KINASE 14","Pkinase",18,"VAL A  30;GLY A  31;VAL A  38;ALA A  51;VAL A  52;LYS A  53;GLU A  71;LEU A  75;ILE A  84;LEU A 104;VAL A 105;THR A 106;HIS A 107;LEU A 108;MET A 109;GLY A 110;LEU A 167;ASP A 168","1N1 A 361\r"],["3OHT_A_1N1A1000","3oht","1N1","Dasatinib (DB01254)","Salmo salar","P38A","Pkinase",20,"VAL A  31;GLY A  32;SER A  33;VAL A  39;ALA A  52;VAL A  53;LYS A  54;GLU A  72;LEU A  76;ILE A  85;LEU A 105;THR A 107;HIS A 108;LEU A 109;MET A 110;GLY A 111;ASN A 116;LEU A 168;ASP A 169;PHE A 170","1N1 A1000\r"],["3OHT_A_1N1A2000","3oht","1N1","Dasatinib (DB01254)","Salmo salar","P38A","Pkinase",16,"ASP A 146;ILE A 147;ILE A 148;ARG A 150;ARG B 190;ILE B 194;TRP A 198;MET A 199;TYR A 201;ASN A 202;VAL A 205;ILE B 230;SER B 253;GLU B 255;ALA B 256;TYR B 259","1N1 A2000\r"],["3SXR_A_1N1A1","3sxr","1N1","Dasatinib (DB01254)","Homo sapiens","CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX","PK_Tyr_Ser-Thr",19,"LEU A 423;GLY A 424;VAL A 431;ALA A 443;VAL A 444;LYS A 445;MET A 464;VAL A 473;ILE A 487;THR A 489;GLU A 490;TYR A 491;ILE A 492;SER A 493;ASN A 494;GLY A 495;LEU A 543;SER A 553;PHE A 555","1N1 A   1\r"],["4QMS_A_1N1A401","4qms","1N1","Dasatinib (DB01254)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE 24","Pkinase",23,"ILE A  30;GLY A  31;LYS A  32;VAL A  38;ALA A  51;ILE A  52;LYS A  53;GLU A  70;THR A  83;ILE A  97;MET A  99;GLU A 100;TYR A 101;LEU A 102;GLY A 103;GLY A 104;GLY A 105;LEU A 151;ALA A 161;ASP A 162;TYR A 291;LYS A 292;LYS A 295","1N1 A 401\r"],["5BVW_A_1N1A1009","5bvw","1N1","Dasatinib (DB01254)","Homo sapiens","EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1","PK_Tyr_Ser-Thr",19,"LEU A 616;VAL A 624;ALA A 653;VAL A 654;LYS A 655;GLU A 672;MET A 676;ILE A 685;MET A 699;THR A 701;ASP A 702;TYR A 703;MET A 704;GLU A 705;ASN A 706;GLY A 707;LEU A 773;ALA A 783;PHE A 785","1N1 A1009\r"],["5H2U_A_1N1A501","5h2u","1N1","Dasatinib (DB01254)","Homo sapiens","PROTEIN-TYROSINE KINASE 6","PK_Tyr_Ser-Thr",21,"ARG A 195;LEU A 197;VAL A 205;ALA A 217;ILE A 218;LYS A 219;LEU A 248;ILE A 262;ILE A 263;THR A 264;GLU A 265;LEU A 266;MET A 267;ALA A 268;LYS A 269;GLY A 270;GLU A 274;LEU A 319;GLY A 329;ASP A 330;LEU A 333","1N1 A 501\r"],["5I9Y_A_1N1A1001","5i9y","1N1","Dasatinib (DB01254)","Homo sapiens","EPHRIN TYPE-A RECEPTOR 2","PK_Tyr_Ser-Thr",21,"ILE A 619;VAL A 627;ALA A 644;ILE A 645;LYS A 646;GLU A 663;MET A 667;ILE A 676;ILE A 690;THR A 692;GLU A 693;TYR A 694;MET A 695;GLU A 696;ASN A 697;GLY A 698;LYS A 702;GLU A 706;LEU A 746;SER A 756;ASP A 757","1N1 A1001\r"],["5OWR_A_1N1A401","5owr","1N1","Dasatinib (DB01254)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE 10","Pkinase",16,"LEU A  42;ALA A  63;LYS A  65;GLU A  81;VAL A  94;ILE A 110;GLU A 111;PHE A 112;CYS A 113;PRO A 114;GLY A 115;GLY A 116;LEU A 164;ALA A 174;ASP A 175;VAL A 314","1N1 A 401\r"],["5VCV_A_1N1A404","5vcv","1N1","Dasatinib (DB01254)","Homo sapiens","MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE","Pkinase",23,"LEU A 116;GLY A 117;VAL A 124;ALA A 137;VAL A 138;LYS A 139;GLU A 157;HIS A 161;VAL A 171;LEU A 185;GLN A 186;THR A 187;GLU A 188;LEU A 189;CYS A 190;GLY A 191;PRO A 192;SER A 193;GLN A 196;PHE A 240;GLY A 250;ASP A 251;PHE A 252","1N1 A 404\r"],["6FNM_A_1N1A1001","6fnm","1N1","Dasatinib (DB01254)","Homo sapiens","EPHRIN TYPE-B RECEPTOR 4","PK_Tyr_Ser-Thr",22,"ILE A 621;GLY A 622;VAL A 629;ALA A 645;ILE A 646;LYS A 647;GLU A 664;MET A 668;ILE A 677;ILE A 691;LEU A 692;THR A 693;GLU A 694;PHE A 695;MET A 696;GLU A 697;ASN A 698;GLY A 699;PHE A 704;LEU A 707;LEU A 747;SER A 757","1N1 A1001\r"]]