Ligand ID: 4DW

Drugbank ID:
Pemetrexed
(DB00642)

Indication:
Pemetrexed is a folate analog used to treat mesothelioma and non-small cell lung cancer.

LIST OF BINDING INTERFACES for query 'DB00642'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4ZZ3_A_4DWA1101	4zz3	4DW	Pemetrexed (DB00642)	Homo sapiens	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3	Formyl_trans_N	15	LEU A 892 PHE A 895 MET A 896 ARG A 897 ILE A 898 LEU A 899 VAL A 904 ASN A 913 HIS A 944 VAL A 946 ALA A 947 GLU A 948 ASP A 949 VAL A 950 ASP A 951	4DW A1101		Details
6QVL_B_4DWB602	6qvl	4DW	Pemetrexed (DB00642)	Homo sapiens	SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL	SHMT	14	GLU B  98 TYR B 105 TYR B 106 LEU A 166 LEU A 172 TYR A 176 LYS A 181 ILE A 183 SER A 226 ALA A 227 PHE B 317 PHE B 320 PRO B 321 ARG A 425	4DW B 602		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4ZZ3_A_4DWA1101","4zz3","4DW","Pemetrexed (DB00642)","Homo sapiens","TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3","Formyl_trans_N",15,"LEU A 892;PHE A 895;MET A 896;ARG A 897;ILE A 898;LEU A 899;VAL A 904;ASN A 913;HIS A 944;VAL A 946;ALA A 947;GLU A 948;ASP A 949;VAL A 950;ASP A 951","4DW A1101\r"],["6QVL_B_4DWB602","6qvl","4DW","Pemetrexed (DB00642)","Homo sapiens","SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL","SHMT",14,"GLU B 98;TYR B 105;TYR B 106;LEU A 166;LEU A 172;TYR A 176;LYS A 181;ILE A 183;SER A 226;ALA A 227;PHE B 317;PHE B 320;PRO B 321;ARG A 425","4DW B 602\r"]]