Results: Ligand

Ligand ID: RBT

Drugbank ID:
Rifabutin
(DB00615)

Indication:
Rifabutin is an antibiotic used to treat mycobacterium avium complex disease in patients with HIV.

LIST OF BINDING INTERFACES for query 'DB00615'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
2A68_C_RBTC8001	2a68	RBT	Rifabutin (DB00615)	Thermus thermophilus	DNA-DIRECTED RNA POLYMERASE BETA CHAIN; RNA POLYMERASE SIGMA FACTOR RPOD	RNA_pol_Rpb2_1 RNA_pol_Rpb2_2 RNA_pol_Rpb2_3 RNA_pol_Rpb2_45 RNA_pol_Rpb2_6 RNA_pol_Rpb2_7 Sigma70_r1_2 Sigma70_r2 Sigma70_r3 Sigma70_r4	19	ARG C 134 ASP F 323 LYS F 325 SER C 389 GLN C 390 LEU C 391 SER C 392 GLN C 393 PHE C 394 LYS C 395 ASP C 396 ARG C 405 HIS C 406 ARG C 409 SER C 411 LEU C 413 PRO C 444 ILE C 452 GLN C 633	RBT C8001
4CP3_B_RBTB1129	4cp3	RBT	Rifabutin (DB00615)	Homo sapiens	B-CELL LYMPHOMA 6 PROTEIN	NA	12	ASN A 21 ARG A 24 LEU A 25 ARG A 28 MET B 51 ALA B 52 CYS B 53 SER B 54 GLY B 55 TYR B 58 SER B 59 GLN B 113	RBT B1129
6BEC_C_RBTC601	6bec	RBT	Rifabutin (DB00615)	Vaccinia virus wr	SCAFFOLD PROTEIN D13	Pox_Rif	18	VAL B 24 VAL A 24 GLN C 27 GLU A 165 GLU C 165 PHE A 168 PHE B 168 PHE C 168 PRO A 483 PRO C 483 PRO B 483 ILE C 485 PHE B 486 PHE A 486 PHE C 486 PHE A 487 PHE B 487 PHE C 487	RBT C 601
6ZO9_B_RBTB1111	6zo9	RBT	Rifabutin (DB00615)	Escherichia coli k-12; synthetic construct	MULTIDRUG EFFLUX PUMP SUBUNIT ACRB	ACR_tran	19	MET B 575 GLN B 577 ALA B 618 PHE B 664 PHE B 666 THR B 676 THR B 678 GLY B 679 PHE B 680 ASP B 681 SER B 715 ARG B 717 PRO B 718 ASN B 719 GLY B 720 GLU B 826 LEU B 828 GLY B 829 GLN B 830	RBT B1111
6ZO9_B_RBTB1112	6zo9	RBT	Rifabutin (DB00615)	Escherichia coli k-12; synthetic construct	MULTIDRUG EFFLUX PUMP SUBUNIT ACRB	ACR_tran	23	TYR B 77 GLN B 89 SER B 132 SER B 134 SER B 135 PHE B 136 MET B 573 MET B 575 PHE B 617 ALA B 618 PHE B 666 LEU B 668 PRO B 669 VAL B 672 GLU B 673 LEU B 674 GLY B 675 THR B 676 ASN B 719 ARG B 815 GLU B 826 GLY B 861 MET B 862	RBT B1112
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["2A68_C_RBTC8001","2a68","RBT","Rifabutin (DB00615)","Thermus thermophilus","DNA-DIRECTED RNA POLYMERASE BETA CHAIN;RNA POLYMERASE SIGMA FACTOR RPOD","RNA_pol_Rpb2_1;RNA_pol_Rpb2_2;RNA_pol_Rpb2_3;RNA_pol_Rpb2_45;RNA_pol_Rpb2_6;RNA_pol_Rpb2_7;Sigma70_r1_2;Sigma70_r2;Sigma70_r3;Sigma70_r4",19,"ARG C 134;ASP F 323;LYS F 325;SER C 389;GLN C 390;LEU C 391;SER C 392;GLN C 393;PHE C 394;LYS C 395;ASP C 396;ARG C 405;HIS C 406;ARG C 409;SER C 411;LEU C 413;PRO C 444;ILE C 452;GLN C 633","RBT C8001\r"],["4CP3_B_RBTB1129","4cp3","RBT","Rifabutin (DB00615)","Homo sapiens","B-CELL LYMPHOMA 6 PROTEIN","NA",12,"ASN A  21;ARG A  24;LEU A  25;ARG A  28;MET B  51;ALA B  52;CYS B  53;SER B  54;GLY B  55;TYR B  58;SER B  59;GLN B 113","RBT B1129\r"],["6BEC_C_RBTC601","6bec","RBT","Rifabutin (DB00615)","Vaccinia virus wr","SCAFFOLD PROTEIN D13","Pox_Rif",18,"VAL B  24;VAL A  24;GLN C  27;GLU A 165;GLU C 165;PHE A 168;PHE B 168;PHE C 168;PRO A 483;PRO C 483;PRO B 483;ILE C 485;PHE B 486;PHE A 486;PHE C 486;PHE A 487;PHE B 487;PHE C 487","RBT C 601\r"],["6ZO9_B_RBTB1111","6zo9","RBT","Rifabutin (DB00615)","Escherichia coli k-12;synthetic construct","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","ACR_tran",19,"MET B 575;GLN B 577;ALA B 618;PHE B 664;PHE B 666;THR B 676;THR B 678;GLY B 679;PHE B 680;ASP B 681;SER B 715;ARG B 717;PRO B 718;ASN B 719;GLY B 720;GLU B 826;LEU B 828;GLY B 829;GLN B 830","RBT B1111\r"],["6ZO9_B_RBTB1112","6zo9","RBT","Rifabutin (DB00615)","Escherichia coli k-12;synthetic construct","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","ACR_tran",23,"TYR B  77;GLN B  89;SER B 132;SER B 134;SER B 135;PHE B 136;MET B 573;MET B 575;PHE B 617;ALA B 618;PHE B 666;LEU B 668;PRO B 669;VAL B 672;GLU B 673;LEU B 674;GLY B 675;THR B 676;ASN B 719;ARG B 815;GLU B 826;GLY B 861;MET B 862","RBT B1112\r"]]