Results: Ligand

Ligand ID: KAN

Drugbank ID:
Kanamycin
(DB01172)

Indication:
Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria.

LIST OF BINDING INTERFACES for query 'DB01172'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1KNY_A_KANA558	1kny	KAN	Kanamycin (DB01172)	Staphylococcus aureus	KANAMYCIN NUCLEOTIDYLTRANSFERASE	KNTase_C	8	GLU B 67 GLU B 76 SER A 94 ASP A 95 GLU A 141 GLU A 142 GLU A 145 TYR A 146	KAN A 558
1L8T_A_KANA1	1l8t	KAN	Kanamycin (DB01172)	Enterococcus faecalis	AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE	APH	14	MET A 26 SER A 27 GLU A 157 ASN A 158 TRP A 159 GLU A 160 ASP A 190 ASP A 208 ARG A 226 SER A 227 GLU A 230 ASP A 261 GLU A 262 PHE A 264	KAN A 1
1M4I_A_KANA500	1m4i	KAN	Kanamycin (DB01172)	Mycobacterium tuberculosis	AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE	Acetyltransf_9	16	PHE A 32 ASP A 35 PHE A 36 ASP A 40 VAL A 81 GLU A 82 GLY A 83 SER A 117 SER A 118 SER A 119 ALA A 120 ASP A 151 ASP A 152 THR A 155 ASP A 179 TRP A 181	KAN A 500
1ND4_A_KANA1300	1nd4	KAN	Kanamycin (DB01172)	Klebsiella pneumoniae	AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE	APH	13	ASP A 157 LEU A 158 ASP A 159 GLU A 160 ASP A 190 ASN A 195 ARG A 211 ARG A 226 ASP A 227 GLU A 230 ASP A 261 GLU A 262 PHE A 264	KAN A1300
3KP5_A_KANA2001	3kp5	KAN	Kanamycin (DB01172)	Staphylococcus epidermidis rp62a	TRANSCRIPTIONAL REGULATOR TCAR	MarR_2	17	GLU B 13 LYS B 14 ILE B 16 ASN B 17 VAL A 19 ASN A 20 THR A 23 LEU A 27 GLN A 31 ALA A 38 GLU A 39 SER A 41 HIS A 42 ASN A 45 GLN A 61 GLN B 61 ARG A 110	KAN A2001
3Q5R_A_KANA2002	3q5r	KAN	Kanamycin (DB01172)	Bacillus subtilis; synthetic construct	MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR	GyrI-like MerR	15	PRO A 144 GLU A 145 VAL A 147 LEU A 148 ASN A 149 TYR A 152 TYR A 170 ILE A 182 TYR A 187 PHE A 224 PRO A 226 TYR A 229 GLU A 253 ILE A 255 TYR A 268	KAN A2002
3U6T_A_KANA4699	3u6t	KAN	Kanamycin (DB01172)	Momordica balsamina	RIBOSOME INACTIVATING PROTEIN	RIP	14	VAL A 69 TYR A 70 ILE A 71 MET A 72 PHE A 83 GLU A 85 SER A 108 GLY A 109 ASN A 110 TYR A 111 ILE A 155 ALA A 159 GLU A 160 ARG A 163	KAN A4699
4DFB_A_KANA401	4dfb	KAN	Kanamycin (DB01172)	Enterococcus casseliflavus; streptomyces kanamyceticus	APH(2"")-ID	APH	10	ASN A 32 ASP A 197 SER A 199 HIS A 202 ASP A 220 GLU A 235 GLU A 239 TRP A 271 TYR A 278 TRP A 287	KAN A 401
4EM0_B_KANB302	4em0	KAN	Kanamycin (DB01172)	Staphylococcus aureus	UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349	MarR	11	TYR B 52 TYR B 55 LEU B 56 THR B 59 TYR B 70 TRP B 73 LEU B 74 ARG B 77 ARG B 94 VAL B 145 GLN B 149	KAN B 302
4GKH_A_KANA301	4gkh	KAN	Kanamycin (DB01172)	Acinetobacter baumannii	AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB	APH	14	SER B 2 HIS B 3 GLN A 35 ASP A 165 PHE A 166 ASP A 167 ASP A 198 ASP A 202 ARG A 219 ASN A 234 CYS A 235 ASP A 268 GLU A 269 PHE A 271	KAN A 301
4OKN_B_KANB403	4okn	KAN	Kanamycin (DB01172)	Homo sapiens	L-LACTATE DEHYDROGENASE A CHAIN	Ldh_1_C Ldh_1_N	12	ASP B 52 VAL B 53 TYR B 83 ALA B 96 GLY B 97 ALA B 98 ARG B 99 ARG B 112 ASN B 115 ILE B 116 PHE B 119 ILE B 120	KAN B 403
4QC6_A_KANA201	4qc6	KAN	Kanamycin (DB01172)	Staphylococcus warneri	BIFUNCTIONAL AAC/APH	Acetyltransf_8	16	PHE A 33 TYR A 34 GLY A 35 HIS A 49 TYR A 50 GLU A 52 TRP A 54 TYR A 72 GLN A 74 TYR A 79 ASP A 99 ASP A 136 PRO A 137 HIS A 138 GLU A 163 HIS A 165	KAN A 201
4WQL_A_KANA203	4wql	KAN	Kanamycin (DB01172)	Klebsiella pneumoniae	2''-AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE	Aminoglyc_resit	11	ASP A 44 ASP A 46 TYR A 74 ASP A 86 GLU A 88 ILE A 99 ALA A 100 GLU A 101 ASP A 131 TYR A 134 GLU A 138	KAN A 203
5IQB_A_KANA600	5iqb	KAN	Kanamycin (DB01172)	Staphylococcus aureus	BIFUNCTIONAL AAC/APH	APH	14	ASP A 374 SER A 376 ASN A 378 HIS A 379 ASP A 396 TYR A 408 GLU A 411 SER A 413 GLU A 415 GLU A 416 GLU A 445 TYR A 448 GLU A 451 ARG A 475	KAN A 600
6BFH_A_KANA201	6bfh	KAN	Kanamycin (DB01172)	Escherichia coli	AMINOGLYCOSIDE ACETYLTRANSFERASE	Acetyltransf_8	12	PHE A 32 TYR A 33 ASP A 34 TRP A 53 GLN A 73 TYR A 75 LEU A 81 GLU A 84 TYR A 85 ASP A 98 ASP A 135 GLU A 162	KAN A 201
6CTZ_A_KANA404	6ctz	KAN	Kanamycin (DB01172)	Enterococcus gallinarum	GENTAMICIN RESISTANCE PROTEIN	APH	16	PHE A 31 GLU A 102 ASP A 196 SER A 198 ASP A 200 ASP A 221 TYR A 233 GLU A 236 ASP A 237 ASP A 269 GLN A 270 SER A 272 TYR A 273 GLU A 276 GLU A 288 LEU A 292	KAN A 404
6O5U_A_KANA301	6o5u	KAN	Kanamycin (DB01172)	Enterobacteriaceae	AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE	Antibiotic_NAT	21	PHE A 77 SER A 79 SER A 83 TYR A 85 GLU A 86 TYR A 113 PHE A 116 ASP A 136 TYR A 159 ASP A 183 THR A 186 HIS A 189 SER A 225 ASN A 226 ALA A 233 ALA A 234 PRO A 235 GLY A 237 ASP A 239 VAL A 241 GLU A 242	KAN A 301
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1KNY_A_KANA558","1kny","KAN","Kanamycin (DB01172)","Staphylococcus aureus","KANAMYCIN NUCLEOTIDYLTRANSFERASE","KNTase_C",8,"GLU B  67;GLU B  76;SER A  94;ASP A  95;GLU A 141;GLU A 142;GLU A 145;TYR A 146","KAN A 558\r"],["1L8T_A_KANA1","1l8t","KAN","Kanamycin (DB01172)","Enterococcus faecalis","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE","APH",14,"MET A  26;SER A  27;GLU A 157;ASN A 158;TRP A 159;GLU A 160;ASP A 190;ASP A 208;ARG A 226;SER A 227;GLU A 230;ASP A 261;GLU A 262;PHE A 264","KAN A   1\r"],["1M4I_A_KANA500","1m4i","KAN","Kanamycin (DB01172)","Mycobacterium tuberculosis","AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE","Acetyltransf_9",16,"PHE A  32;ASP A  35;PHE A  36;ASP A  40;VAL A  81;GLU A  82;GLY A  83;SER A 117;SER A 118;SER A 119;ALA A 120;ASP A 151;ASP A 152;THR A 155;ASP A 179;TRP A 181","KAN A 500\r"],["1ND4_A_KANA1300","1nd4","KAN","Kanamycin (DB01172)","Klebsiella pneumoniae","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE","APH",13,"ASP A 157;LEU A 158;ASP A 159;GLU A 160;ASP A 190;ASN A 195;ARG A 211;ARG A 226;ASP A 227;GLU A 230;ASP A 261;GLU A 262;PHE A 264","KAN A1300\r"],["3KP5_A_KANA2001","3kp5","KAN","Kanamycin (DB01172)","Staphylococcus epidermidis rp62a","TRANSCRIPTIONAL REGULATOR TCAR","MarR_2",17,"GLU B  13;LYS B  14;ILE B  16;ASN B  17;VAL A  19;ASN A  20;THR A  23;LEU A  27;GLN A  31;ALA A  38;GLU A  39;SER A  41;HIS A  42;ASN A  45;GLN A  61;GLN B  61;ARG A 110","KAN A2001\r"],["3Q5R_A_KANA2002","3q5r","KAN","Kanamycin (DB01172)","Bacillus subtilis;synthetic construct","MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR","GyrI-like;MerR",15,"PRO A 144;GLU A 145;VAL A 147;LEU A 148;ASN A 149;TYR A 152;TYR A 170;ILE A 182;TYR A 187;PHE A 224;PRO A 226;TYR A 229;GLU A 253;ILE A 255;TYR A 268","KAN A2002\r"],["3U6T_A_KANA4699","3u6t","KAN","Kanamycin (DB01172)","Momordica balsamina","RIBOSOME INACTIVATING PROTEIN","RIP",14,"VAL A  69;TYR A  70;ILE A  71;MET A  72;PHE A  83;GLU A  85;SER A 108;GLY A 109;ASN A 110;TYR A 111;ILE A 155;ALA A 159;GLU A 160;ARG A 163","KAN A4699\r"],["4DFB_A_KANA401","4dfb","KAN","Kanamycin (DB01172)","Enterococcus casseliflavus;streptomyces kanamyceticus","APH(2\"\")-ID","APH",10,"ASN A  32;ASP A 197;SER A 199;HIS A 202;ASP A 220;GLU A 235;GLU A 239;TRP A 271;TYR A 278;TRP A 287","KAN A 401\r"],["4EM0_B_KANB302","4em0","KAN","Kanamycin (DB01172)","Staphylococcus aureus","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","MarR",11,"TYR B  52;TYR B  55;LEU B  56;THR B  59;TYR B  70;TRP B  73;LEU B  74;ARG B  77;ARG B  94;VAL B 145;GLN B 149","KAN B 302\r"],["4GKH_A_KANA301","4gkh","KAN","Kanamycin (DB01172)","Acinetobacter baumannii","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","APH",14,"SER B   2;HIS B   3;GLN A  35;ASP A 165;PHE A 166;ASP A 167;ASP A 198;ASP A 202;ARG A 219;ASN A 234;CYS A 235;ASP A 268;GLU A 269;PHE A 271","KAN A 301\r"],["4OKN_B_KANB403","4okn","KAN","Kanamycin (DB01172)","Homo sapiens","L-LACTATE DEHYDROGENASE A CHAIN","Ldh_1_C;Ldh_1_N",12,"ASP B  52;VAL B  53;TYR B  83;ALA B  96;GLY B  97;ALA B  98;ARG B  99;ARG B 112;ASN B 115;ILE B 116;PHE B 119;ILE B 120","KAN B 403\r"],["4QC6_A_KANA201","4qc6","KAN","Kanamycin (DB01172)","Staphylococcus warneri","BIFUNCTIONAL AAC\/APH","Acetyltransf_8",16,"PHE A  33;TYR A  34;GLY A  35;HIS A  49;TYR A  50;GLU A  52;TRP A  54;TYR A  72;GLN A  74;TYR A  79;ASP A  99;ASP A 136;PRO A 137;HIS A 138;GLU A 163;HIS A 165","KAN A 201\r"],["4WQL_A_KANA203","4wql","KAN","Kanamycin (DB01172)","Klebsiella pneumoniae","2''-AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE","Aminoglyc_resit",11,"ASP A  44;ASP A  46;TYR A  74;ASP A  86;GLU A  88;ILE A  99;ALA A 100;GLU A 101;ASP A 131;TYR A 134;GLU A 138","KAN A 203\r"],["5IQB_A_KANA600","5iqb","KAN","Kanamycin (DB01172)","Staphylococcus aureus","BIFUNCTIONAL AAC\/APH","APH",14,"ASP A 374;SER A 376;ASN A 378;HIS A 379;ASP A 396;TYR A 408;GLU A 411;SER A 413;GLU A 415;GLU A 416;GLU A 445;TYR A 448;GLU A 451;ARG A 475","KAN A 600\r"],["6BFH_A_KANA201","6bfh","KAN","Kanamycin (DB01172)","Escherichia coli","AMINOGLYCOSIDE ACETYLTRANSFERASE","Acetyltransf_8",12,"PHE A  32;TYR A  33;ASP A  34;TRP A  53;GLN A  73;TYR A  75;LEU A  81;GLU A  84;TYR A  85;ASP A  98;ASP A 135;GLU A 162","KAN A 201\r"],["6CTZ_A_KANA404","6ctz","KAN","Kanamycin (DB01172)","Enterococcus gallinarum","GENTAMICIN RESISTANCE PROTEIN","APH",16,"PHE A  31;GLU A 102;ASP A 196;SER A 198;ASP A 200;ASP A 221;TYR A 233;GLU A 236;ASP A 237;ASP A 269;GLN A 270;SER A 272;TYR A 273;GLU A 276;GLU A 288;LEU A 292","KAN A 404\r"],["6O5U_A_KANA301","6o5u","KAN","Kanamycin (DB01172)","Enterobacteriaceae","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE","Antibiotic_NAT",21,"PHE A  77;SER A  79;SER A  83;TYR A  85;GLU A  86;TYR A 113;PHE A 116;ASP A 136;TYR A 159;ASP A 183;THR A 186;HIS A 189;SER A 225;ASN A 226;ALA A 233;ALA A 234;PRO A 235;GLY A 237;ASP A 239;VAL A 241;GLU A 242","KAN A 301\r"]]