Results: Ligand

Ligand ID: ACH

Drugbank ID:
Acetylcholine
(DB03128)

Indication:
Acetylcholine is a parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.

LIST OF BINDING INTERFACES for query 'DB03128'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
2ACE_A_ACHA998	2ace	ACH	Acetylcholine (DB03128)	Torpedo californica	ACETYLCHOLINESTERASE	COesterase	14	TRP A 84 GLY A 117 GLY A 118 GLY A 119 GLU A 199 SER A 200 ALA A 201 TRP A 233 PHE A 288 PHE A 290 PHE A 330 PHE A 331 HIS A 440 GLY A 441	ACH A 998
2HA4_A_ACHA545	2ha4	ACH	Acetylcholine (DB03128)	Mus musculus	ACETYLCHOLINESTERASE	COesterase	8	TYR A 72 ASP A 74 TYR A 124 TRP A 286 PHE A 297 TYR A 337 PHE A 338 TYR A 341	ACH A 545
2HA4_A_ACHA546	2ha4	ACH	Acetylcholine (DB03128)	Mus musculus	ACETYLCHOLINESTERASE	COesterase	12	TRP A 86 GLY A 120 GLY A 121 GLY A 122 TYR A 124 TYR A 133 GLU A 202 ALA A 203 TYR A 337 PHE A 338 HIS A 447 GLY A 448	ACH A 546
2J0H_A_ACHA1290	2j0h	ACH	Acetylcholine (DB03128)	Homo sapiens	FICOLIN-2	Fibrinogen_C	5	ASP A 111 THR A 112 ASP A 113 GLY A 114 GLY A 115	ACH A1290
2RIN_A_ACHA1	2rin	ACH	Acetylcholine (DB03128)	Rhizobium meliloti	PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	OpuAC	11	TRP A 43 ASP A 45 TRP A 90 MET A 94 TYR A 119 ILE A 152 GLU A 153 ASN A 156 ASP A 157 GLY A 158 TRP A 205	ACH A 1
2XZ5_A_ACHA1210	2xz5	ACH	Acetylcholine (DB03128)	Aplysia californica	SOLUBLE ACETYLCHOLINE RECEPTOR	Neur_chan_LBD	9	TYR A 91 ILE B 116 SER A 144 TRP A 145 VAL A 146 TYR A 186 CYS A 188 CYS A 189 TYR A 193	ACH A1210
2XZ5_A_ACHA1211	2xz5	ACH	Acetylcholine (DB03128)	Aplysia californica	SOLUBLE ACETYLCHOLINE RECEPTOR	Neur_chan_LBD	10	THR B 34 GLN B 36 GLN B 55 TYR A 91 ILE B 116 TRP A 145 SER B 165 TYR A 186 SER A 187 CYS A 188	ACH A1211
3Q5S_A_ACHA1289	3q5s	ACH	Acetylcholine (DB03128)	Bacillus subtilis; synthetic construct	MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR	GyrI-like MerR	8	VAL A 147 ASN A 149 TYR A 152 TYR A 170 TYR A 187 GLU A 253 ILE A 255 TYR A 268	ACH A1289
3RQW_A_ACHA323	3rqw	ACH	Acetylcholine (DB03128)	Dickeya dadantii	ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI	NA	12	PHE A 19 TYR A 38 VAL A 40 GLU B 77 ILE B 79 ASN A 103 GLU B 131 PRO B 132 PHE B 133 TYR B 175 LEU B 178 PHE B 188	ACH A 323
3WIP_A_ACHA301	3wip	ACH	Acetylcholine (DB03128)	Lymnaea stagnalis	ACETYLCHOLINE-BINDING PROTEIN	Neur_chan_LBD	12	TRP B 53 TYR A 89 ARG B 104 LEU B 112 MET B 114 SER A 142 TRP A 143 THR A 144 TYR A 185 CYS A 187 CYS A 188 TYR A 192	ACH A 301
6V1R_A_ACHA301	6v1r	ACH	Acetylcholine (DB03128)	Thermoanaerobacter sp. x513	IACHSNFR FLUORESCENT ACETYLCHOLINE SENSOR V9 PRECURSOR BINDING PROTEIN	NA	10	ILE A 10 PHE A 12 VAL A 43 TYR A 65 ASN A 109 THR A 110 TYR A 111 PHE A 145 TRP A 190 TYR A 214	ACH A 301
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["2ACE_A_ACHA998","2ace","ACH","Acetylcholine (DB03128)","Torpedo californica","ACETYLCHOLINESTERASE","COesterase",14,"TRP A  84;GLY A 117;GLY A 118;GLY A 119;GLU A 199;SER A 200;ALA A 201;TRP A 233;PHE A 288;PHE A 290;PHE A 330;PHE A 331;HIS A 440;GLY A 441","ACH A 998\r"],["2HA4_A_ACHA545","2ha4","ACH","Acetylcholine (DB03128)","Mus musculus","ACETYLCHOLINESTERASE","COesterase",8,"TYR A  72;ASP A  74;TYR A 124;TRP A 286;PHE A 297;TYR A 337;PHE A 338;TYR A 341","ACH A 545\r"],["2HA4_A_ACHA546","2ha4","ACH","Acetylcholine (DB03128)","Mus musculus","ACETYLCHOLINESTERASE","COesterase",12,"TRP A  86;GLY A 120;GLY A 121;GLY A 122;TYR A 124;TYR A 133;GLU A 202;ALA A 203;TYR A 337;PHE A 338;HIS A 447;GLY A 448","ACH A 546\r"],["2J0H_A_ACHA1290","2j0h","ACH","Acetylcholine (DB03128)","Homo sapiens","FICOLIN-2","Fibrinogen_C",5,"ASP A 111;THR A 112;ASP A 113;GLY A 114;GLY A 115","ACH A1290\r"],["2RIN_A_ACHA1","2rin","ACH","Acetylcholine (DB03128)","Rhizobium meliloti","PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN","OpuAC",11,"TRP A  43;ASP A  45;TRP A  90;MET A  94;TYR A 119;ILE A 152;GLU A 153;ASN A 156;ASP A 157;GLY A 158;TRP A 205","ACH A   1\r"],["2XZ5_A_ACHA1210","2xz5","ACH","Acetylcholine (DB03128)","Aplysia californica","SOLUBLE ACETYLCHOLINE RECEPTOR","Neur_chan_LBD",9,"TYR A  91;ILE B 116;SER A 144;TRP A 145;VAL A 146;TYR A 186;CYS A 188;CYS A 189;TYR A 193","ACH A1210\r"],["2XZ5_A_ACHA1211","2xz5","ACH","Acetylcholine (DB03128)","Aplysia californica","SOLUBLE ACETYLCHOLINE RECEPTOR","Neur_chan_LBD",10,"THR B  34;GLN B  36;GLN B  55;TYR A  91;ILE B 116;TRP A 145;SER B 165;TYR A 186;SER A 187;CYS A 188","ACH A1211\r"],["3Q5S_A_ACHA1289","3q5s","ACH","Acetylcholine (DB03128)","Bacillus subtilis;synthetic construct","MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR","GyrI-like;MerR",8,"VAL A 147;ASN A 149;TYR A 152;TYR A 170;TYR A 187;GLU A 253;ILE A 255;TYR A 268","ACH A1289\r"],["3RQW_A_ACHA323","3rqw","ACH","Acetylcholine (DB03128)","Dickeya dadantii","ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI","NA",12,"PHE A  19;TYR A  38;VAL A  40;GLU B  77;ILE B  79;ASN A 103;GLU B 131;PRO B 132;PHE B 133;TYR B 175;LEU B 178;PHE B 188","ACH A 323\r"],["3WIP_A_ACHA301","3wip","ACH","Acetylcholine (DB03128)","Lymnaea stagnalis","ACETYLCHOLINE-BINDING PROTEIN","Neur_chan_LBD",12,"TRP B  53;TYR A  89;ARG B 104;LEU B 112;MET B 114;SER A 142;TRP A 143;THR A 144;TYR A 185;CYS A 187;CYS A 188;TYR A 192","ACH A 301\r"],["6V1R_A_ACHA301","6v1r","ACH","Acetylcholine (DB03128)","Thermoanaerobacter sp. x513","IACHSNFR FLUORESCENT ACETYLCHOLINE SENSOR V9 PRECURSOR BINDING PROTEIN","NA",10,"ILE A  10;PHE A  12;VAL A  43;TYR A  65;ASN A 109;THR A 110;TYR A 111;PHE A 145;TRP A 190;TYR A 214","ACH A 301\r"]]