Ligand ID: SHH

Drugbank ID:
Vorinostat
(DB02546)

Indication:
Vorinostat is a histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies.

LIST OF BINDING INTERFACES for query 'SHH'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1C3S_A_SHHA952	1c3s	SHH	Vorinostat (DB02546)	Aquifex aeolicus	HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)	Hist_deacetyl	14	ASN A  20 PRO A  22 TYR A  91 HIS A 131 HIS A 132 GLY A 140 PHE A 141 ASP A 168 HIS A 170 PHE A 198 ASP A 258 LEU A 265 GLY A 295 TYR A 297	SHH A 952		Details
1ZZ1_A_SHHA2452	1zz1	SHH	Vorinostat (DB02546)	Alcaligenaceae bacterium	HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE	Hist_deacetyl	15	LEU A  21 ASP A  98 ILE A 100 HIS A 142 HIS A 143 GLY A 151 PHE A 152 ASP A 180 HIS A 182 PHE A 208 ASP A 268 LEU A 275 GLY A 310 TYR A 312 PHE D 341	SHH A2452		Details
3C0Z_A_SHHA301	3c0z	SHH	Vorinostat (DB02546)	Homo sapiens	HISTONE DEACETYLASE 7A	Hist_deacetyl	9	HIS A 669 HIS A 670 GLY A 678 PHE A 679 ASP A 707 HIS A 709 PHE A 738 ASP A 801 GLY A 841	SHH A 301		Details
4BZ6_A_SHHA700	4bz6	SHH	Vorinostat (DB02546)	Schistosoma mansoni	HISTONE DEACETYLASE 8	Hist_deacetyl	13	LYS A  20 ASP A 100 HIS A 141 HIS A 142 GLY A 150 ASP A 186 HIS A 188 PHE A 216 ASP A 285 PRO A 291 HIS A 292 GLY A 339 TYR A 341	SHH A 700		Details
4LXZ_A_SHHA407	4lxz	SHH	Vorinostat (DB02546)	Homo sapiens	HISTONE DEACETYLASE 2	Hist_deacetyl	16	GLY A  32 HIS A  33 PRO A  34 GLU A 103 ASP A 104 HIS A 145 HIS A 146 GLY A 154 PHE A 155 ASP A 181 HIS A 183 PHE A 210 ASP A 269 LEU A 276 GLY A 306 TYR A 308	SHH A 407		Details
4R7L_A_SHHA709	4r7l	SHH	Vorinostat (DB02546)	Homo sapiens	LEUKOTRIENE A-4 HYDROLASE	Leuk-A4-hydro_C Peptidase_M1 Peptidase_M1_N	18	GLN A 134 GLN A 136 ALA A 137 TYR A 267 GLY A 269 MET A 270 GLU A 271 HIS A 295 GLU A 296 HIS A 299 TRP A 311 PHE A 314 GLU A 318 LEU A 369 PRO A 374 ALA A 377 TYR A 378 TYR A 383	SHH A 709		Details
5EEI_A_SHHA2004	5eei	SHH	Vorinostat (DB02546)	Danio rerio	HDAC6 PROTEIN	Hist_deacetyl	18	HIS A 463 PRO A 464 SER A 531 PRO A 571 HIS A 573 HIS A 574 GLY A 582 PHE A 583 CYS A 584 ASP A 612 HIS A 614 PHE A 643 ASP A 705 LEU A 712 GLU A 742 GLY A 743 GLY A 744 TYR A 745	SHH A2004		Details
7JVU_A_SHHA404	7jvu	SHH	Vorinostat (DB02546)	Homo sapiens	HISTONE DEACETYLASE 8	Hist_deacetyl	16	TYR A 100 HIS A 142 HIS A 143 GLY A 151 PHE B 152 PHE A 152 ASP A 178 HIS A 180 PHE A 208 ASP A 267 PRO B 273 MET A 274 MET B 274 GLY A 304 TYR B 306 TYR A 306	SHH A 404		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1C3S_A_SHHA952","1c3s","SHH","Vorinostat (DB02546)","Aquifex aeolicus","HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)","Hist_deacetyl",14,"ASN A 20;PRO A 22;TYR A 91;HIS A 131;HIS A 132;GLY A 140;PHE A 141;ASP A 168;HIS A 170;PHE A 198;ASP A 258;LEU A 265;GLY A 295;TYR A 297","SHH A 952\r"],["1ZZ1_A_SHHA2452","1zz1","SHH","Vorinostat (DB02546)","Alcaligenaceae bacterium","HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE","Hist_deacetyl",15,"LEU A 21;ASP A 98;ILE A 100;HIS A 142;HIS A 143;GLY A 151;PHE A 152;ASP A 180;HIS A 182;PHE A 208;ASP A 268;LEU A 275;GLY A 310;TYR A 312;PHE D 341","SHH A2452\r"],["3C0Z_A_SHHA301","3c0z","SHH","Vorinostat (DB02546)","Homo sapiens","HISTONE DEACETYLASE 7A","Hist_deacetyl",9,"HIS A 669;HIS A 670;GLY A 678;PHE A 679;ASP A 707;HIS A 709;PHE A 738;ASP A 801;GLY A 841","SHH A 301\r"],["4BZ6_A_SHHA700","4bz6","SHH","Vorinostat (DB02546)","Schistosoma mansoni","HISTONE DEACETYLASE 8","Hist_deacetyl",13,"LYS A 20;ASP A 100;HIS A 141;HIS A 142;GLY A 150;ASP A 186;HIS A 188;PHE A 216;ASP A 285;PRO A 291;HIS A 292;GLY A 339;TYR A 341","SHH A 700\r"],["4LXZ_A_SHHA407","4lxz","SHH","Vorinostat (DB02546)","Homo sapiens","HISTONE DEACETYLASE 2","Hist_deacetyl",16,"GLY A 32;HIS A 33;PRO A 34;GLU A 103;ASP A 104;HIS A 145;HIS A 146;GLY A 154;PHE A 155;ASP A 181;HIS A 183;PHE A 210;ASP A 269;LEU A 276;GLY A 306;TYR A 308","SHH A 407\r"],["4R7L_A_SHHA709","4r7l","SHH","Vorinostat (DB02546)","Homo sapiens","LEUKOTRIENE A-4 HYDROLASE","Leuk-A4-hydro_C;Peptidase_M1;Peptidase_M1_N",18,"GLN A 134;GLN A 136;ALA A 137;TYR A 267;GLY A 269;MET A 270;GLU A 271;HIS A 295;GLU A 296;HIS A 299;TRP A 311;PHE A 314;GLU A 318;LEU A 369;PRO A 374;ALA A 377;TYR A 378;TYR A 383","SHH A 709\r"],["5EEI_A_SHHA2004","5eei","SHH","Vorinostat (DB02546)","Danio rerio","HDAC6 PROTEIN","Hist_deacetyl",18,"HIS A 463;PRO A 464;SER A 531;PRO A 571;HIS A 573;HIS A 574;GLY A 582;PHE A 583;CYS A 584;ASP A 612;HIS A 614;PHE A 643;ASP A 705;LEU A 712;GLU A 742;GLY A 743;GLY A 744;TYR A 745","SHH A2004\r"],["7JVU_A_SHHA404","7jvu","SHH","Vorinostat (DB02546)","Homo sapiens","HISTONE DEACETYLASE 8","Hist_deacetyl",16,"TYR A 100;HIS A 142;HIS A 143;GLY A 151;PHE B 152;PHE A 152;ASP A 178;HIS A 180;PHE A 208;ASP A 267;PRO B 273;MET A 274;MET B 274;GLY A 304;TYR B 306;TYR A 306","SHH A 404\r"]]