Ligand ID: DIF

Drugbank ID:
Diclofenac
(DB00586)

Indication:
Diclofenac is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.

LIST OF BINDING INTERFACES for query 'DB00586'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1DVX_B_DIFB125	1dvx	DIF	Diclofenac (DB00586)	Homo sapiens	TRANSTHYRETIN	Transthyretin	20	LYS A  15 LYS B  15 LEU B  17 LEU A  17 ALA A 108 ALA B 108 ALA B 109 ALA A 109 LEU A 110 LEU B 110 SER B 115 SER A 115 SER B 117 SER A 117 THR B 118 THR A 118 THR B 119 THR A 119 VAL B 121 VAL A 121	DIF B 125		Details
1NR6_A_DIFA501	1nr6	DIF	Diclofenac (DB00586)	Oryctolagus cuniculus	CYTOCHROME P450 2C5	p450	13	LEU A 103 ALA A 113 PHE A 114 VAL A 205 LEU A 208 ASP A 290 GLY A 293 ALA A 294 GLU A 297 THR A 298 LEU A 359 LEU A 363 PHE A 473	DIF A 501		Details
1PXX_A_DIFA701	1pxx	DIF	Diclofenac (DB00586)	Mus musculus	PROSTAGLANDIN G/H SYNTHASE 2	An_peroxidase EGF	17	ARG A 120 PHE A 205 TYR A 348 VAL A 349 LEU A 352 SER A 353 TYR A 355 PHE A 381 LEU A 384 TYR A 385 TRP A 387 MET A 522 VAL A 523 GLY A 526 ALA A 527 SER A 530 LEU A 531	DIF A 701		Details
1SV9_A_DIFA701	1sv9	DIF	Diclofenac (DB00586)	Daboia russellii russellii	PHOSPHOLIPASE A2	Phospholip_A2_1	12	LEU A   2 PHE A   5 ALA A  18 ILE A  19 TYR A  22 CYS A  29 GLY A  30 CYS A  45 HIS A  48 ASP A  49 LYS A  69 PHE A 106	DIF A 701		Details
2WEK_A_DIFA1373	2wek	DIF	Diclofenac (DB00586)	Homo sapiens	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2	ADH_N ADH_zinc_N	11	ASN A  75 SER A  77 TYR A  86 PHE A  98 MET A 124 VAL A 155 ILE A 269 TYR A 275 PHE A 304 LEU A 305 ASN A 306	DIF A1373		Details
2WEK_A_DIFA1374	2wek	DIF	Diclofenac (DB00586)	Homo sapiens	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2	ADH_N ADH_zinc_N	9	TYR A  81 TYR A  86 PHE A  98 MET A 124 ALA A 125 PRO A 126 ILE A 139 ASN A 306 LEU A 309	DIF A1374		Details
2WEK_A_DIFA1375	2wek	DIF	Diclofenac (DB00586)	Homo sapiens	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2	ADH_N ADH_zinc_N	9	MET A 124 SER A 138 ILE A 139 ALA A 140 THR A 141 LEU A 309 SER A 310 TYR A 312 GLN A 313	DIF A1375		Details
2WEK_A_DIFA1376	2wek	DIF	Diclofenac (DB00586)	Homo sapiens	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2	ADH_N ADH_zinc_N	9	TYR A 161 LEU A 164 LYS A 165 LEU A 170 LEU A 192 LYS A 195 ALA A 196 HIS A 318 MET A 322	DIF A1376		Details
3IB0_A_DIFA701	3ib0	DIF	Diclofenac (DB00586)	Bos taurus	LACTOTRANSFERRIN	Transferrin	7	PRO A 593 GLU A 658 GLU A 659 TYR A 660 LEU A 661 GLY A 662 THR A 663	DIF A 701		Details
3N8Y_A_DIFA701	3n8y	DIF	Diclofenac (DB00586)	Ovis aries	PROSTAGLANDIN G/H SYNTHASE 1	An_peroxidase EGF	16	PHE A 205 TYR A 348 VAL A 349 LEU A 352 SER A 353 TYR A 355 LEU A 384 TYR A 385 TRP A 387 PHE A 518 MET A 522 ILE A 523 GLY A 526 ALA A 527 SER A 530 LEU A 531	DIF A 701		Details
4OJ4_A_DIFA501	4oj4	DIF	Diclofenac (DB00586)	Homo sapiens	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA	Hormone_recep	15	ILE A 281 GLY A 284 CYS A 285 ARG A 288 SER A 289 ILE A 326 LEU A 330 LEU A 333 VAL A 339 LEU A 340 ILE A 341 SER A 342 GLU A 343 PHE A 363 MET A 364	DIF A 501		Details
4UBS_A_DIFA502	4ubs	DIF	Diclofenac (DB00586)	Streptomyces avermitilis ma-4680 = nbrc 14893	PENTALENIC ACID SYNTHASE	p450	11	ARG A  70 VAL A  85 VAL A  90 LEU A  93 LEU A 177 LEU A 178 ARG A 190 SER A 233 THR A 236 LEU A 237 ILE A 240	DIF A 502		Details
4UBS_A_DIFA503	4ubs	DIF	Diclofenac (DB00586)	Streptomyces avermitilis ma-4680 = nbrc 14893	PENTALENIC ACID SYNTHASE	p450	11	LEU A  93 LEU A 178 ALA A 241 THR A 245 ALA A 288 ASP A 289 GLY A 290 LEU A 291 LEU A 292 ARG A 293 ILE A 392	DIF A 503		Details
4Z69_A_DIFA1006	4z69	DIF	Diclofenac (DB00586)	Homo sapiens	SERUM ALBUMIN	Serum_albumin	11	ILE A 142 HIS A 146 PHE A 149 LEU A 154 PHE A 157 TYR A 161 LEU A 185 ARG A 186 GLY A 189 LYS A 190 SER A 193	DIF A1006		Details
4Z69_A_DIFA1007	4z69	DIF	Diclofenac (DB00586)	Homo sapiens	SERUM ALBUMIN	Serum_albumin	13	LYS A 199 TRP A 214 ARG A 218 LEU A 219 ARG A 222 PHE A 223 LEU A 238 ARG A 257 LEU A 260 ILE A 264 SER A 287 ILE A 290 ALA A 291	DIF A1007		Details
4Z69_A_DIFA1008	4z69	DIF	Diclofenac (DB00586)	Homo sapiens	SERUM ALBUMIN	Serum_albumin	14	LYS A 199 SER A 202 LEU A 203 PHE A 206 GLY A 207 ALA A 210 PHE A 211 TRP A 214 HIS A 242 VAL A 344 LEU A 347 SER A 480 LEU A 481 VAL A 482	DIF A1008		Details
4ZBQ_A_DIFA601	4zbq	DIF	Diclofenac (DB00586)	Equus caballus	SERUM ALBUMIN	Serum_albumin	16	LEU A 386 VAL A 387 ASN A 390 CYS A 391 PHE A 402 LEU A 406 ARG A 409 LEU A 429 VAL A 432 GLY A 433 CYS A 437 SER A 448 GLU A 449 LEU A 452 ARG A 484 SER A 488	DIF A 601		Details
4ZBQ_A_DIFA602	4zbq	DIF	Diclofenac (DB00586)	Equus caballus	SERUM ALBUMIN	Serum_albumin	11	LEU A 393 VAL A 397 ASP A 401 ASN A 404 ALA A 405 VAL A 408 LYS A 540 GLU A 541 LEU A 543 LYS A 544 LEU A 547	DIF A 602		Details
5U1R_C_DIFC305	5u1r	DIF	Diclofenac (DB00586)	Homo sapiens	MAIT T-CELL RECEPTOR ALPHA CHAIN; MAIT T-CELL RECEPTOR BETA CHAIN; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED GENE PROTEIN	C1-set MHC_I	15	LEU C   5 TYR C   7 ARG C   9 SER C  24 LYS C  43 HIS C  58 TYR C  62 LEU C  65 LEU C  66 TRP C  69 TYR D  95 ILE C  96 GLU E  99 TRP C 156 TRP C 164	DIF C 305		Details
6HN1_A_DIFA601	6hn1	DIF	Diclofenac (DB00586)	Capra hircus	ALBUMIN	Serum_albumin	15	PRO A 383 LEU A 386 ILE A 387 ASN A 390 PHE A 402 LEU A 406 ARG A 409 TYR A 410 LEU A 429 VAL A 432 THR A 448 GLU A 449 LEU A 452 ARG A 484 SER A 488	DIF A 601		Details
6HN1_A_DIFA602	6hn1	DIF	Diclofenac (DB00586)	Capra hircus	ALBUMIN	Serum_albumin	12	TYR A 400 GLY A 401 ASN A 404 ALA A 405 VAL A 408 LYS A 524 LEU A 528 LEU A 543 LYS A 544 MET A 547 GLU A 548 VAL A 551	DIF A 602		Details
6HN1_A_DIFA603	6hn1	DIF	Diclofenac (DB00586)	Capra hircus	ALBUMIN	Serum_albumin	10	GLN A  20 LEU A  24 PHE A  36 VAL A  40 VAL A  43 LYS A  44 ASP A 129 LYS A 131 LYS A 132 GLY A 135	DIF A 603		Details
6HN1_A_DIFA604	6hn1	DIF	Diclofenac (DB00586)	Capra hircus	ALBUMIN	Serum_albumin	12	LEU A 115 LYS A 116 PRO A 117 LEU A 122 TYR A 137 GLU A 140 VAL A 141 TYR A 160 ILE A 181 MET A 184 ARG A 185 VAL A 188	DIF A 604		Details
6HN1_A_DIFA605	6hn1	DIF	Diclofenac (DB00586)	Capra hircus	ALBUMIN	Serum_albumin	11	ARG A 208 LYS A 211 ALA A 212 VAL A 215 PHE A 227 THR A 231 VAL A 234 THR A 235 ASP A 323 VAL A 324 GLY A 327	DIF A 605		Details
6HN1_A_DIFA606	6hn1	DIF	Diclofenac (DB00586)	Capra hircus	ALBUMIN	Serum_albumin	16	PHE A 501 ASP A 502 GLY A 503 SER A 505 PHE A 506 THR A 507 PHE A 508 ALA A 527 GLU A 530 LEU A 531 VAL A 546 MET A 547 PHE A 550 LEU A 574 VAL A 575 THR A 578	DIF A 606		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1DVX_B_DIFB125","1dvx","DIF","Diclofenac (DB00586)","Homo sapiens","TRANSTHYRETIN","Transthyretin",20,"LYS A 15;LYS B 15;LEU B 17;LEU A 17;ALA A 108;ALA B 108;ALA B 109;ALA A 109;LEU A 110;LEU B 110;SER B 115;SER A 115;SER B 117;SER A 117;THR B 118;THR A 118;THR B 119;THR A 119;VAL B 121;VAL A 121","DIF B 125\r"],["1NR6_A_DIFA501","1nr6","DIF","Diclofenac (DB00586)","Oryctolagus cuniculus","CYTOCHROME P450 2C5","p450",13,"LEU A 103;ALA A 113;PHE A 114;VAL A 205;LEU A 208;ASP A 290;GLY A 293;ALA A 294;GLU A 297;THR A 298;LEU A 359;LEU A 363;PHE A 473","DIF A 501\r"],["1PXX_A_DIFA701","1pxx","DIF","Diclofenac (DB00586)","Mus musculus","PROSTAGLANDIN G\/H SYNTHASE 2","An_peroxidase;EGF",17,"ARG A 120;PHE A 205;TYR A 348;VAL A 349;LEU A 352;SER A 353;TYR A 355;PHE A 381;LEU A 384;TYR A 385;TRP A 387;MET A 522;VAL A 523;GLY A 526;ALA A 527;SER A 530;LEU A 531","DIF A 701\r"],["1SV9_A_DIFA701","1sv9","DIF","Diclofenac (DB00586)","Daboia russellii russellii","PHOSPHOLIPASE A2","Phospholip_A2_1",12,"LEU A 2;PHE A 5;ALA A 18;ILE A 19;TYR A 22;CYS A 29;GLY A 30;CYS A 45;HIS A 48;ASP A 49;LYS A 69;PHE A 106","DIF A 701\r"],["2WEK_A_DIFA1373","2wek","DIF","Diclofenac (DB00586)","Homo sapiens","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","ADH_N;ADH_zinc_N",11,"ASN A 75;SER A 77;TYR A 86;PHE A 98;MET A 124;VAL A 155;ILE A 269;TYR A 275;PHE A 304;LEU A 305;ASN A 306","DIF A1373\r"],["2WEK_A_DIFA1374","2wek","DIF","Diclofenac (DB00586)","Homo sapiens","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","ADH_N;ADH_zinc_N",9,"TYR A 81;TYR A 86;PHE A 98;MET A 124;ALA A 125;PRO A 126;ILE A 139;ASN A 306;LEU A 309","DIF A1374\r"],["2WEK_A_DIFA1375","2wek","DIF","Diclofenac (DB00586)","Homo sapiens","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","ADH_N;ADH_zinc_N",9,"MET A 124;SER A 138;ILE A 139;ALA A 140;THR A 141;LEU A 309;SER A 310;TYR A 312;GLN A 313","DIF A1375\r"],["2WEK_A_DIFA1376","2wek","DIF","Diclofenac (DB00586)","Homo sapiens","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","ADH_N;ADH_zinc_N",9,"TYR A 161;LEU A 164;LYS A 165;LEU A 170;LEU A 192;LYS A 195;ALA A 196;HIS A 318;MET A 322","DIF A1376\r"],["3IB0_A_DIFA701","3ib0","DIF","Diclofenac (DB00586)","Bos taurus","LACTOTRANSFERRIN","Transferrin",7,"PRO A 593;GLU A 658;GLU A 659;TYR A 660;LEU A 661;GLY A 662;THR A 663","DIF A 701\r"],["3N8Y_A_DIFA701","3n8y","DIF","Diclofenac (DB00586)","Ovis aries","PROSTAGLANDIN G\/H SYNTHASE 1","An_peroxidase;EGF",16,"PHE A 205;TYR A 348;VAL A 349;LEU A 352;SER A 353;TYR A 355;LEU A 384;TYR A 385;TRP A 387;PHE A 518;MET A 522;ILE A 523;GLY A 526;ALA A 527;SER A 530;LEU A 531","DIF A 701\r"],["4OJ4_A_DIFA501","4oj4","DIF","Diclofenac (DB00586)","Homo sapiens","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","Hormone_recep",15,"ILE A 281;GLY A 284;CYS A 285;ARG A 288;SER A 289;ILE A 326;LEU A 330;LEU A 333;VAL A 339;LEU A 340;ILE A 341;SER A 342;GLU A 343;PHE A 363;MET A 364","DIF A 501\r"],["4UBS_A_DIFA502","4ubs","DIF","Diclofenac (DB00586)","Streptomyces avermitilis ma-4680 = nbrc 14893","PENTALENIC ACID SYNTHASE","p450",11,"ARG A 70;VAL A 85;VAL A 90;LEU A 93;LEU A 177;LEU A 178;ARG A 190;SER A 233;THR A 236;LEU A 237;ILE A 240","DIF A 502\r"],["4UBS_A_DIFA503","4ubs","DIF","Diclofenac (DB00586)","Streptomyces avermitilis ma-4680 = nbrc 14893","PENTALENIC ACID SYNTHASE","p450",11,"LEU A 93;LEU A 178;ALA A 241;THR A 245;ALA A 288;ASP A 289;GLY A 290;LEU A 291;LEU A 292;ARG A 293;ILE A 392","DIF A 503\r"],["4Z69_A_DIFA1006","4z69","DIF","Diclofenac (DB00586)","Homo sapiens","SERUM ALBUMIN","Serum_albumin",11,"ILE A 142;HIS A 146;PHE A 149;LEU A 154;PHE A 157;TYR A 161;LEU A 185;ARG A 186;GLY A 189;LYS A 190;SER A 193","DIF A1006\r"],["4Z69_A_DIFA1007","4z69","DIF","Diclofenac (DB00586)","Homo sapiens","SERUM ALBUMIN","Serum_albumin",13,"LYS A 199;TRP A 214;ARG A 218;LEU A 219;ARG A 222;PHE A 223;LEU A 238;ARG A 257;LEU A 260;ILE A 264;SER A 287;ILE A 290;ALA A 291","DIF A1007\r"],["4Z69_A_DIFA1008","4z69","DIF","Diclofenac (DB00586)","Homo sapiens","SERUM ALBUMIN","Serum_albumin",14,"LYS A 199;SER A 202;LEU A 203;PHE A 206;GLY A 207;ALA A 210;PHE A 211;TRP A 214;HIS A 242;VAL A 344;LEU A 347;SER A 480;LEU A 481;VAL A 482","DIF A1008\r"],["4ZBQ_A_DIFA601","4zbq","DIF","Diclofenac (DB00586)","Equus caballus","SERUM ALBUMIN","Serum_albumin",16,"LEU A 386;VAL A 387;ASN A 390;CYS A 391;PHE A 402;LEU A 406;ARG A 409;LEU A 429;VAL A 432;GLY A 433;CYS A 437;SER A 448;GLU A 449;LEU A 452;ARG A 484;SER A 488","DIF A 601\r"],["4ZBQ_A_DIFA602","4zbq","DIF","Diclofenac (DB00586)","Equus caballus","SERUM ALBUMIN","Serum_albumin",11,"LEU A 393;VAL A 397;ASP A 401;ASN A 404;ALA A 405;VAL A 408;LYS A 540;GLU A 541;LEU A 543;LYS A 544;LEU A 547","DIF A 602\r"],["5U1R_C_DIFC305","5u1r","DIF","Diclofenac (DB00586)","Homo sapiens","MAIT T-CELL RECEPTOR ALPHA CHAIN;MAIT T-CELL RECEPTOR BETA CHAIN;MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED GENE PROTEIN","C1-set;MHC_I",15,"LEU C 5;TYR C 7;ARG C 9;SER C 24;LYS C 43;HIS C 58;TYR C 62;LEU C 65;LEU C 66;TRP C 69;TYR D 95;ILE C 96;GLU E 99;TRP C 156;TRP C 164","DIF C 305\r"],["6HN1_A_DIFA601","6hn1","DIF","Diclofenac (DB00586)","Capra hircus","ALBUMIN","Serum_albumin",15,"PRO A 383;LEU A 386;ILE A 387;ASN A 390;PHE A 402;LEU A 406;ARG A 409;TYR A 410;LEU A 429;VAL A 432;THR A 448;GLU A 449;LEU A 452;ARG A 484;SER A 488","DIF A 601\r"],["6HN1_A_DIFA602","6hn1","DIF","Diclofenac (DB00586)","Capra hircus","ALBUMIN","Serum_albumin",12,"TYR A 400;GLY A 401;ASN A 404;ALA A 405;VAL A 408;LYS A 524;LEU A 528;LEU A 543;LYS A 544;MET A 547;GLU A 548;VAL A 551","DIF A 602\r"],["6HN1_A_DIFA603","6hn1","DIF","Diclofenac (DB00586)","Capra hircus","ALBUMIN","Serum_albumin",10,"GLN A 20;LEU A 24;PHE A 36;VAL A 40;VAL A 43;LYS A 44;ASP A 129;LYS A 131;LYS A 132;GLY A 135","DIF A 603\r"],["6HN1_A_DIFA604","6hn1","DIF","Diclofenac (DB00586)","Capra hircus","ALBUMIN","Serum_albumin",12,"LEU A 115;LYS A 116;PRO A 117;LEU A 122;TYR A 137;GLU A 140;VAL A 141;TYR A 160;ILE A 181;MET A 184;ARG A 185;VAL A 188","DIF A 604\r"],["6HN1_A_DIFA605","6hn1","DIF","Diclofenac (DB00586)","Capra hircus","ALBUMIN","Serum_albumin",11,"ARG A 208;LYS A 211;ALA A 212;VAL A 215;PHE A 227;THR A 231;VAL A 234;THR A 235;ASP A 323;VAL A 324;GLY A 327","DIF A 605\r"],["6HN1_A_DIFA606","6hn1","DIF","Diclofenac (DB00586)","Capra hircus","ALBUMIN","Serum_albumin",16,"PHE A 501;ASP A 502;GLY A 503;SER A 505;PHE A 506;THR A 507;PHE A 508;ALA A 527;GLU A 530;LEU A 531;VAL A 546;MET A 547;PHE A 550;LEU A 574;VAL A 575;THR A 578","DIF A 606\r"]]