Ligand ID: BO2

Drugbank ID:
Bortezomib
(DB00188)

Indication:
Bortezomib is a proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies.

LIST OF BINDING INTERFACES for query 'BO2'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4FWD_A_BO2A801	4fwd	BO2	Bortezomib (DB00188)	Meiothermus taiwanensis	TTC1975 PEPTIDASE	AAA_32 Lon_C	16	LEU A 502 VAL A 503 VAL A 504 VAL A 505 GLU A 506 PHE A 542 PHE A 571 VAL A 576 SER A 577 ILE A 578 GLU A 579 GLY A 580 ASP A 581 SER A 582 ALA A 583 LYS A 625	BO2 A 801		Details
4QVP_H_BO2H301	4qvp	BO2	Bortezomib (DB00188)	Saccharomyces cerevisiae	PROTEASOME SUBUNIT BETA TYPE-2; PROTEASOME SUBUNIT BETA TYPE-3	Pr_beta_C Proteasome	17	THR H   1 ARG H  19 SER H  20 THR H  21 GLN H  22 ALA H  27 CYS H  31 LYS H  33 GLY H  45 ALA H  46 GLY H  47 THR H  48 ALA H  49 THR H  52 ASP I 124 CYS I 128 GLY H 168	BO2 H 301		Details
4QVP_K_BO2K301	4qvp	BO2	Bortezomib (DB00188)	Saccharomyces cerevisiae	PROTEASOME SUBUNIT BETA TYPE-5; PROTEASOME SUBUNIT BETA TYPE-6	Proteasome	17	THR K   1 ARG K  19 ALA K  20 THR K  21 ALA K  22 ALA K  27 VAL K  31 LYS K  33 THR K  45 ALA K  46 GLY K  47 GLY K  48 ALA K  49 GLN K  53 ASP L 126 SER K 131 TYR K 170	BO2 K 301		Details
4QVP_N_BO2N201	4qvp	BO2	Bortezomib (DB00188)	Saccharomyces cerevisiae	PROTEASOME SUBUNIT BETA TYPE-1; PROTEASOME SUBUNIT BETA TYPE-2	Pr_beta_C	17	THR N   1 ARG N  19 THR N  20 THR N  21 THR N  22 ALA N  27 THR N  31 LYS N  33 ARG N  45 SER N  46 GLY N  47 SER N  48 ALA N  49 THR N  52 HIS H 114 SER H 118 SER N 168	BO2 N 201		Details
4YPM_A_BO2A801	4ypm	BO2	Bortezomib (DB00188)	Meiothermus taiwanensis	LON PROTEASE	Lon_C	17	LEU A 600 ALA A 601 TRP A 602 THR A 603 THR A 608 LEU A 610 MET A 633 THR A 672 PRO A 673 LYS A 674 ASP A 675 GLY A 676 PRO A 677 SER A 678 ALA A 679 GLY A 716 LYS A 721	BO2 A 801		Details
5L5F_K_BO2K301	5l5f	BO2	Bortezomib (DB00188)	Saccharomyces cerevisiae (strain atcc 204508 / s288c); homo sapiens; saccharomyces cerevisiae	PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6; PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5	Proteasome	17	THR K   1 ARG K  19 ALA K  20 SER K  21 ALA K  22 SER K  27 VAL K  31 LYS K  33 MET K  45 SER K  46 GLY K  47 CYS K  48 ALA K  49 ASP L 126 SER L 130 SER K 130 TYR K 169	BO2 K 301		Details
5L5Z_K_BO2K301	5l5z	BO2	Bortezomib (DB00188)	Homo sapiens; saccharomyces cerevisiae (strain atcc 204508 / s288c); saccharomyces cerevisiae	PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5; PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6	Proteasome	16	THR K   1 ARG K  19 ALA K  20 THR K  21 ALA K  22 ALA K  27 VAL K  31 LYS K  33 MET K  45 ALA K  46 GLY K  47 ALA K  49 ASP L 126 SER L 130 SER K 130 TYR K 169	BO2 K 301		Details
5LF3_H_BO2H306	5lf3	BO2	Bortezomib (DB00188)	Homo sapiens	PROTEASOME SUBUNIT BETA TYPE-3; PROTEASOME SUBUNIT BETA TYPE-7	Pr_beta_C Proteasome	17	THR H   1 ARG H  19 ALA H  20 THR H  21 GLU H  22 CYS H  31 LYS H  33 GLY H  45 ALA H  46 GLY H  47 THR H  48 ALA H  49 THR H  52 ASP I 124 CYS I 128 SER H 129 GLY H 168	BO2 H 306		Details
5LF3_K_BO2K305	5lf3	BO2	Bortezomib (DB00188)	Homo sapiens	PROTEASOME SUBUNIT BETA TYPE-1; PROTEASOME SUBUNIT BETA TYPE-5	Proteasome	17	THR K   1 ARG K  19 ALA K  20 THR K  21 ALA K  22 ALA K  27 VAL K  31 LYS K  33 MET K  45 ALA K  46 GLY K  47 GLY K  48 ALA K  49 ASP L 125 SER L 129 SER K 130 TYR K 169	BO2 K 305		Details
5LF3_N_BO2N304	5lf3	BO2	Bortezomib (DB00188)	Homo sapiens	PROTEASOME SUBUNIT BETA TYPE-6; PROTEASOME SUBUNIT BETA TYPE-7	Pr_beta_C	18	THR N   1 ARG N  19 THR N  20 THR N  21 THR N  22 THR N  31 LYS N  33 ARG N  45 SER N  46 GLY N  47 SER N  48 ALA N  49 THR N  52 MET N  95 TYR H 114 SER H 118 SER N 130 SER N 169	BO2 N 304		Details
6HWM_A_BO2A301	6hwm	BO2	Bortezomib (DB00188)	Thermus thermophilus	ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT	CLP_protease	17	PRO A  66 GLY A  67 GLY A  68 GLU A  69 VAL A  70 ALA A  96 SER A  97 MET A  98 VAL A 101 HIS A 122 GLN A 123 PRO A 124 TRP A 125 GLY A 126 GLY A 127 ILE A 142 LEU A 149	BO2 A 301		Details
6TD5_H_BO2H301	6td5	BO2	Bortezomib (DB00188)	Leishmania donovani	PROTEASOME SUBUNIT BETA	NA	17	THR H  55 ARG H  73 THR H  74 SER H  75 SER H  76 VAL H  81 SER H  85 LYS H  87 ARG H  99 SER H 100 GLY H 101 SER H 102 ALA H 103 THR H 106 ALA I 143 SER I 147 SER H 223	BO2 H 301		Details
6TD5_I_BO2I301	6td5	BO2	Bortezomib (DB00188)	Leishmania donovani	PROTEASOME SUBUNIT BETA	Proteasome	16	THR I  30 ASP I  46 ARG I  48 ALA I  49 THR I  50 GLU I  51 ALA I  56 LYS I  62 GLY I  74 ALA I  75 GLY I  76 THR I  77 SER I  78 THR I  81 CYS J 131 TYR I 197	BO2 I 301		Details
6TD5_L_BO2L401	6td5	BO2	Bortezomib (DB00188)	Leishmania donovani	PROTEASOME SUBUNIT BETA	Proteasome	18	THR L 100 ARG L 118 ALA L 119 SER L 120 THR L 121 ALA L 126 VAL L 130 LYS L 132 LEU L 144 ALA L 145 GLY L 146 GLY L 147 ALA L 148 CYS L 151 SER L 195 ASP M 251 SER M 255 ALA L 268	BO2 L 401		Details
6X27_A_BO2A1001	6x27	BO2	Bortezomib (DB00188)	Homo sapiens	LON PROTEASE HOMOLOG, MITOCHONDRIAL	NA	17	LEU A 768 ALA A 769 TRP A 770 THR A 771 SER A 776 LEU A 778 MET A 810 THR A 849 PRO A 850 LYS A 851 ASP A 852 GLY A 853 PRO A 854 SER A 855 ALA A 856 GLY A 893 LYS A 898	BO2 A1001		Details
7KRZ_A_BO2A1002	7krz	BO2	Bortezomib (DB00188)	Homo sapiens; escherichia coli bl21(de3)	LON PROTEASE HOMOLOG, MITOCHONDRIAL	AAA	17	LEU A 768 ALA A 769 TRP A 770 THR A 771 SER A 776 LEU A 778 MET A 810 THR A 849 PRO A 850 LYS A 851 ASP A 852 GLY A 853 PRO A 854 SER A 855 ALA A 856 GLY A 893 LYS A 898	BO2 A1002		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4FWD_A_BO2A801","4fwd","BO2","Bortezomib (DB00188)","Meiothermus taiwanensis","TTC1975 PEPTIDASE","AAA_32;Lon_C",16,"LEU A 502;VAL A 503;VAL A 504;VAL A 505;GLU A 506;PHE A 542;PHE A 571;VAL A 576;SER A 577;ILE A 578;GLU A 579;GLY A 580;ASP A 581;SER A 582;ALA A 583;LYS A 625","BO2 A 801\r"],["4QVP_H_BO2H301","4qvp","BO2","Bortezomib (DB00188)","Saccharomyces cerevisiae","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","Pr_beta_C;Proteasome",17,"THR H 1;ARG H 19;SER H 20;THR H 21;GLN H 22;ALA H 27;CYS H 31;LYS H 33;GLY H 45;ALA H 46;GLY H 47;THR H 48;ALA H 49;THR H 52;ASP I 124;CYS I 128;GLY H 168","BO2 H 301\r"],["4QVP_K_BO2K301","4qvp","BO2","Bortezomib (DB00188)","Saccharomyces cerevisiae","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","Proteasome",17,"THR K 1;ARG K 19;ALA K 20;THR K 21;ALA K 22;ALA K 27;VAL K 31;LYS K 33;THR K 45;ALA K 46;GLY K 47;GLY K 48;ALA K 49;GLN K 53;ASP L 126;SER K 131;TYR K 170","BO2 K 301\r"],["4QVP_N_BO2N201","4qvp","BO2","Bortezomib (DB00188)","Saccharomyces cerevisiae","PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-2","Pr_beta_C",17,"THR N 1;ARG N 19;THR N 20;THR N 21;THR N 22;ALA N 27;THR N 31;LYS N 33;ARG N 45;SER N 46;GLY N 47;SER N 48;ALA N 49;THR N 52;HIS H 114;SER H 118;SER N 168","BO2 N 201\r"],["4YPM_A_BO2A801","4ypm","BO2","Bortezomib (DB00188)","Meiothermus taiwanensis","LON PROTEASE","Lon_C",17,"LEU A 600;ALA A 601;TRP A 602;THR A 603;THR A 608;LEU A 610;MET A 633;THR A 672;PRO A 673;LYS A 674;ASP A 675;GLY A 676;PRO A 677;SER A 678;ALA A 679;GLY A 716;LYS A 721","BO2 A 801\r"],["5L5F_K_BO2K301","5l5f","BO2","Bortezomib (DB00188)","Saccharomyces cerevisiae (strain atcc 204508 \/ s288c);homo sapiens;saccharomyces cerevisiae","PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5","Proteasome",17,"THR K 1;ARG K 19;ALA K 20;SER K 21;ALA K 22;SER K 27;VAL K 31;LYS K 33;MET K 45;SER K 46;GLY K 47;CYS K 48;ALA K 49;ASP L 126;SER L 130;SER K 130;TYR K 169","BO2 K 301\r"],["5L5Z_K_BO2K301","5l5z","BO2","Bortezomib (DB00188)","Homo sapiens;saccharomyces cerevisiae (strain atcc 204508 \/ s288c);saccharomyces cerevisiae","PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6","Proteasome",16,"THR K 1;ARG K 19;ALA K 20;THR K 21;ALA K 22;ALA K 27;VAL K 31;LYS K 33;MET K 45;ALA K 46;GLY K 47;ALA K 49;ASP L 126;SER L 130;SER K 130;TYR K 169","BO2 K 301\r"],["5LF3_H_BO2H306","5lf3","BO2","Bortezomib (DB00188)","Homo sapiens","PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7","Pr_beta_C;Proteasome",17,"THR H 1;ARG H 19;ALA H 20;THR H 21;GLU H 22;CYS H 31;LYS H 33;GLY H 45;ALA H 46;GLY H 47;THR H 48;ALA H 49;THR H 52;ASP I 124;CYS I 128;SER H 129;GLY H 168","BO2 H 306\r"],["5LF3_K_BO2K305","5lf3","BO2","Bortezomib (DB00188)","Homo sapiens","PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-5","Proteasome",17,"THR K 1;ARG K 19;ALA K 20;THR K 21;ALA K 22;ALA K 27;VAL K 31;LYS K 33;MET K 45;ALA K 46;GLY K 47;GLY K 48;ALA K 49;ASP L 125;SER L 129;SER K 130;TYR K 169","BO2 K 305\r"],["5LF3_N_BO2N304","5lf3","BO2","Bortezomib (DB00188)","Homo sapiens","PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-7","Pr_beta_C",18,"THR N 1;ARG N 19;THR N 20;THR N 21;THR N 22;THR N 31;LYS N 33;ARG N 45;SER N 46;GLY N 47;SER N 48;ALA N 49;THR N 52;MET N 95;TYR H 114;SER H 118;SER N 130;SER N 169","BO2 N 304\r"],["6HWM_A_BO2A301","6hwm","BO2","Bortezomib (DB00188)","Thermus thermophilus","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT","CLP_protease",17,"PRO A 66;GLY A 67;GLY A 68;GLU A 69;VAL A 70;ALA A 96;SER A 97;MET A 98;VAL A 101;HIS A 122;GLN A 123;PRO A 124;TRP A 125;GLY A 126;GLY A 127;ILE A 142;LEU A 149","BO2 A 301\r"],["6TD5_H_BO2H301","6td5","BO2","Bortezomib (DB00188)","Leishmania donovani","PROTEASOME SUBUNIT BETA","NA",17,"THR H 55;ARG H 73;THR H 74;SER H 75;SER H 76;VAL H 81;SER H 85;LYS H 87;ARG H 99;SER H 100;GLY H 101;SER H 102;ALA H 103;THR H 106;ALA I 143;SER I 147;SER H 223","BO2 H 301\r"],["6TD5_I_BO2I301","6td5","BO2","Bortezomib (DB00188)","Leishmania donovani","PROTEASOME SUBUNIT BETA","Proteasome",16,"THR I 30;ASP I 46;ARG I 48;ALA I 49;THR I 50;GLU I 51;ALA I 56;LYS I 62;GLY I 74;ALA I 75;GLY I 76;THR I 77;SER I 78;THR I 81;CYS J 131;TYR I 197","BO2 I 301\r"],["6TD5_L_BO2L401","6td5","BO2","Bortezomib (DB00188)","Leishmania donovani","PROTEASOME SUBUNIT BETA","Proteasome",18,"THR L 100;ARG L 118;ALA L 119;SER L 120;THR L 121;ALA L 126;VAL L 130;LYS L 132;LEU L 144;ALA L 145;GLY L 146;GLY L 147;ALA L 148;CYS L 151;SER L 195;ASP M 251;SER M 255;ALA L 268","BO2 L 401\r"],["6X27_A_BO2A1001","6x27","BO2","Bortezomib (DB00188)","Homo sapiens","LON PROTEASE HOMOLOG, MITOCHONDRIAL","NA",17,"LEU A 768;ALA A 769;TRP A 770;THR A 771;SER A 776;LEU A 778;MET A 810;THR A 849;PRO A 850;LYS A 851;ASP A 852;GLY A 853;PRO A 854;SER A 855;ALA A 856;GLY A 893;LYS A 898","BO2 A1001\r"],["7KRZ_A_BO2A1002","7krz","BO2","Bortezomib (DB00188)","Homo sapiens;escherichia coli bl21(de3)","LON PROTEASE HOMOLOG, MITOCHONDRIAL","AAA",17,"LEU A 768;ALA A 769;TRP A 770;THR A 771;SER A 776;LEU A 778;MET A 810;THR A 849;PRO A 850;LYS A 851;ASP A 852;GLY A 853;PRO A 854;SER A 855;ALA A 856;GLY A 893;LYS A 898","BO2 A1002\r"]]