Results: Ligand

Ligand ID: DB8

Drugbank ID:
Bosutinib
(DB06616)

Indication:
Bosutinib is an antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments.

LIST OF BINDING INTERFACES for query 'DB06616'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3SOA_A_DB8A445	3soa	DB8	Bosutinib (DB06616)	Homo sapiens	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER	CaMKII_AD Pkinase	10	LEU A 19 GLY A 20 VAL A 27 ALA A 40 MET A 42 GLU A 60 PHE A 89 VAL A 92 THR A 93 PHE A 157	DB8 A 445
3UE4_A_DB8A601	3ue4	DB8	Bosutinib (DB06616)	Homo sapiens	TYROSINE-PROTEIN KINASE ABL1	PK_Tyr_Ser-Thr	20	LEU A 248 VAL A 256 ALA A 269 VAL A 270 LYS A 271 GLU A 286 MET A 290 VAL A 299 ILE A 313 ILE A 314 THR A 315 GLU A 316 PHE A 317 MET A 318 THR A 319 TYR A 320 GLY A 321 LEU A 370 ALA A 380 PHE A 382	DB8 A 601
4MXO_A_DB8A601	4mxo	DB8	Bosutinib (DB06616)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	PK_Tyr_Ser-Thr	20	LEU A 273 VAL A 281 ALA A 293 ILE A 294 LYS A 295 GLU A 310 MET A 314 VAL A 323 ILE A 336 VAL A 337 THR A 338 GLU A 339 TYR A 340 MET A 341 SER A 342 LYS A 343 GLY A 344 LEU A 393 ALA A 403 ASP A 404	DB8 A 601
4QMN_A_DB8A401	4qmn	DB8	Bosutinib (DB06616)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE 24	Pkinase	20	ILE A 30 GLY A 31 VAL A 38 ALA A 51 ILE A 52 LYS A 53 GLU A 70 LEU A 74 THR A 83 ILE A 97 MET A 99 GLU A 100 TYR A 101 LEU A 102 GLY A 103 GLY A 105 LEU A 151 ALA A 161 ASP A 162 LYS A 295	DB8 A 401
5AJQ_A_DB8A800	5ajq	DB8	Bosutinib (DB06616)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE 10	Pkinase	24	LEU A 42 GLY A 43 VAL A 50 ALA A 63 ALA A 64 LYS A 65 VAL A 94 ILE A 108 ILE A 110 GLU A 111 PHE A 112 CYS A 113 PRO A 114 GLY A 115 GLY A 116 GLU A 124 GLY A 161 ASN A 162 LEU A 164 ALA A 174 ASP A 175 VAL A 178 SER A 179 ALA A 310	DB8 A 800
5I9X_A_DB8A1001	5i9x	DB8	Bosutinib (DB06616)	Homo sapiens	EPHRIN TYPE-A RECEPTOR 2	PK_Tyr_Ser-Thr	21	ILE A 619 GLY A 620 VAL A 627 ALA A 644 ILE A 645 LYS A 646 GLU A 663 MET A 667 ILE A 676 ILE A 690 THR A 692 GLU A 693 TYR A 694 MET A 695 GLU A 696 ASN A 697 GLY A 698 GLU A 706 LEU A 746 SER A 756 ASP A 757	DB8 A1001
5VC3_A_DB8A601	5vc3	DB8	Bosutinib (DB06616)	Homo sapiens	WEE1-LIKE PROTEIN KINASE	Pkinase	24	GLU A 303 ILE A 305 GLY A 306 VAL A 313 LYS A 315 ALA A 326 LYS A 328 GLU A 346 VAL A 360 ILE A 374 ASN A 376 GLU A 377 TYR A 378 CYS A 379 ASN A 380 GLY A 381 GLY A 382 SER A 383 ASP A 386 SER A 430 ASN A 431 PHE A 433 GLY A 462 ASP A 463	DB8 A 601
5VCY_A_DB8A401	5vcy	DB8	Bosutinib (DB06616)	Homo sapiens	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE	Pkinase	24	LEU A 116 GLY A 117 VAL A 124 LYS A 126 ALA A 137 VAL A 138 LYS A 139 GLU A 157 HIS A 161 VAL A 171 LEU A 185 GLN A 186 THR A 187 GLU A 188 LEU A 189 CYS A 190 GLY A 191 PRO A 192 SER A 193 GLN A 196 ASN A 238 PHE A 240 GLY A 250 ASP A 251	DB8 A 401
6FDY_U_DB8U301	6fdy	DB8	Bosutinib (DB06616)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE ULK3	Pkinase	18	LEU U 20 GLY U 21 VAL U 28 ALA U 42 ILE U 43 LYS U 44 VAL U 75 MET U 91 GLU U 92 PHE U 93 CYS U 94 ALA U 95 GLY U 97 GLN U 141 ASN U 142 LEU U 144 ALA U 156 ASP U 157	DB8 U 301
6FDY_U_DB8U302	6fdy	DB8	Bosutinib (DB06616)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE ULK3	Pkinase	9	LEU U 173 PRO U 177 MET U 180 VAL U 185 PHE U 218 SER U 219 LEU U 221 GLU U 222 ILE U 225	DB8 U 302
6OP9_A_DB8A1101	6op9	DB8	Bosutinib (DB06616)	Homo sapiens	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3	PK_Tyr_Ser-Thr	20	LEU A 696 GLY A 697 VAL A 704 CYS A 721 ILE A 722 LYS A 723 VAL A 753 LEU A 766 VAL A 767 THR A 768 GLN A 769 TYR A 770 LEU A 771 PRO A 772 GLY A 774 ASN A 820 LEU A 822 ALA A 832 ASP A 833 VAL A 836	DB8 A1101
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3SOA_A_DB8A445","3soa","DB8","Bosutinib (DB06616)","Homo sapiens","CALCIUM\/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER","CaMKII_AD;Pkinase",10,"LEU A  19;GLY A  20;VAL A  27;ALA A  40;MET A  42;GLU A  60;PHE A  89;VAL A  92;THR A  93;PHE A 157","DB8 A 445\r"],["3UE4_A_DB8A601","3ue4","DB8","Bosutinib (DB06616)","Homo sapiens","TYROSINE-PROTEIN KINASE ABL1","PK_Tyr_Ser-Thr",20,"LEU A 248;VAL A 256;ALA A 269;VAL A 270;LYS A 271;GLU A 286;MET A 290;VAL A 299;ILE A 313;ILE A 314;THR A 315;GLU A 316;PHE A 317;MET A 318;THR A 319;TYR A 320;GLY A 321;LEU A 370;ALA A 380;PHE A 382","DB8 A 601\r"],["4MXO_A_DB8A601","4mxo","DB8","Bosutinib (DB06616)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","PK_Tyr_Ser-Thr",20,"LEU A 273;VAL A 281;ALA A 293;ILE A 294;LYS A 295;GLU A 310;MET A 314;VAL A 323;ILE A 336;VAL A 337;THR A 338;GLU A 339;TYR A 340;MET A 341;SER A 342;LYS A 343;GLY A 344;LEU A 393;ALA A 403;ASP A 404","DB8 A 601\r"],["4QMN_A_DB8A401","4qmn","DB8","Bosutinib (DB06616)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE 24","Pkinase",20,"ILE A  30;GLY A  31;VAL A  38;ALA A  51;ILE A  52;LYS A  53;GLU A  70;LEU A  74;THR A  83;ILE A  97;MET A  99;GLU A 100;TYR A 101;LEU A 102;GLY A 103;GLY A 105;LEU A 151;ALA A 161;ASP A 162;LYS A 295","DB8 A 401\r"],["5AJQ_A_DB8A800","5ajq","DB8","Bosutinib (DB06616)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE 10","Pkinase",24,"LEU A  42;GLY A  43;VAL A  50;ALA A  63;ALA A  64;LYS A  65;VAL A  94;ILE A 108;ILE A 110;GLU A 111;PHE A 112;CYS A 113;PRO A 114;GLY A 115;GLY A 116;GLU A 124;GLY A 161;ASN A 162;LEU A 164;ALA A 174;ASP A 175;VAL A 178;SER A 179;ALA A 310","DB8 A 800\r"],["5I9X_A_DB8A1001","5i9x","DB8","Bosutinib (DB06616)","Homo sapiens","EPHRIN TYPE-A RECEPTOR 2","PK_Tyr_Ser-Thr",21,"ILE A 619;GLY A 620;VAL A 627;ALA A 644;ILE A 645;LYS A 646;GLU A 663;MET A 667;ILE A 676;ILE A 690;THR A 692;GLU A 693;TYR A 694;MET A 695;GLU A 696;ASN A 697;GLY A 698;GLU A 706;LEU A 746;SER A 756;ASP A 757","DB8 A1001\r"],["5VC3_A_DB8A601","5vc3","DB8","Bosutinib (DB06616)","Homo sapiens","WEE1-LIKE PROTEIN KINASE","Pkinase",24,"GLU A 303;ILE A 305;GLY A 306;VAL A 313;LYS A 315;ALA A 326;LYS A 328;GLU A 346;VAL A 360;ILE A 374;ASN A 376;GLU A 377;TYR A 378;CYS A 379;ASN A 380;GLY A 381;GLY A 382;SER A 383;ASP A 386;SER A 430;ASN A 431;PHE A 433;GLY A 462;ASP A 463","DB8 A 601\r"],["5VCY_A_DB8A401","5vcy","DB8","Bosutinib (DB06616)","Homo sapiens","MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE","Pkinase",24,"LEU A 116;GLY A 117;VAL A 124;LYS A 126;ALA A 137;VAL A 138;LYS A 139;GLU A 157;HIS A 161;VAL A 171;LEU A 185;GLN A 186;THR A 187;GLU A 188;LEU A 189;CYS A 190;GLY A 191;PRO A 192;SER A 193;GLN A 196;ASN A 238;PHE A 240;GLY A 250;ASP A 251","DB8 A 401\r"],["6FDY_U_DB8U301","6fdy","DB8","Bosutinib (DB06616)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE ULK3","Pkinase",18,"LEU U  20;GLY U  21;VAL U  28;ALA U  42;ILE U  43;LYS U  44;VAL U  75;MET U  91;GLU U  92;PHE U  93;CYS U  94;ALA U  95;GLY U  97;GLN U 141;ASN U 142;LEU U 144;ALA U 156;ASP U 157","DB8 U 301\r"],["6FDY_U_DB8U302","6fdy","DB8","Bosutinib (DB06616)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE ULK3","Pkinase",9,"LEU U 173;PRO U 177;MET U 180;VAL U 185;PHE U 218;SER U 219;LEU U 221;GLU U 222;ILE U 225","DB8 U 302\r"],["6OP9_A_DB8A1101","6op9","DB8","Bosutinib (DB06616)","Homo sapiens","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3","PK_Tyr_Ser-Thr",20,"LEU A 696;GLY A 697;VAL A 704;CYS A 721;ILE A 722;LYS A 723;VAL A 753;LEU A 766;VAL A 767;THR A 768;GLN A 769;TYR A 770;LEU A 771;PRO A 772;GLY A 774;ASN A 820;LEU A 822;ALA A 832;ASP A 833;VAL A 836","DB8 A1101\r"]]