Results: Ligand

Ligand ID: RAP

Drugbank ID:
Sirolimus
(DB00877)

Indication:
Sirolimus is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis.

LIST OF BINDING INTERFACES for query 'RAP'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1FKB_A_RAPA108	1fkb	RAP	Sirolimus (DB00877)	Homo sapiens	FK506 BINDING PROTEIN	FKBP_C	14	TYR A 26 PHE A 36 ASP A 37 PHE A 46 GLN A 53 GLU A 54 VAL A 55 ILE A 56 TRP A 59 TYR A 82 HIS A 87 ILE A 90 ILE A 91 PHE A 99	RAP A 108
2VCD_A_RAPA138	2vcd	RAP	Sirolimus (DB00877)	Legionella pneumophila subsp. pneumophila (strain philadelphia 1 / atcc 33152 / dsm 7513)	OUTER MEMBRANE PROTEIN MIP	FKBP_C	31	THR A 50 VAL A 53 TYR A 55 GLY A 57 PHE A 65 ASP A 66 SER A 67 THR A 68 ALA A 75 THR A 76 PHE A 77 GLN A 78 VAL A 79 SER A 80 GLN A 81 VAL A 82 ILE A 83 PRO A 84 TRP A 86 LEU A 90 LEU A 107 ALA A 108 TYR A 109 GLY A 110 VAL A 114 GLY A 115 GLY A 116 ILE A 118 LEU A 124 PHE A 126 ILE A 128	RAP A 138
4DRI_A_RAPA201	4dri	RAP	Sirolimus (DB00877)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5; SERINE/THREONINE-PROTEIN KINASE MTOR	FKBP_C	25	TYR A 57 PHE A 67 ASP A 68 ARG A 73 PHE A 77 GLY A 84 GLN A 85 VAL A 86 ILE A 87 TRP A 90 TYR A 113 SER A 118 ILE A 122 PHE A 130 LEU B2031 GLU B2032 SER B2035 ARG B2036 PHE B2039 GLY B2040 THR B2098 TRP B2101 ASP B2102 TYR B2105 PHE B2108	RAP A 201
4DRJ_A_RAPA201	4drj	RAP	Sirolimus (DB00877)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4; SERINE/THREONINE-PROTEIN KINASE MTOR	FKBP_C	24	TYR A 57 PHE A 67 ASP A 68 PHE A 77 GLY A 84 GLU A 85 VAL A 86 ILE A 87 TRP A 90 TYR A 113 LYS A 121 ILE A 122 PHE A 130 LEU B2031 GLU B2032 SER B2035 ARG B2036 PHE B2039 GLY B2040 THR B2098 TRP B2101 ASP B2102 TYR B2105 PHE B2108	RAP A 201
4QT3_A_RAPA202	4qt3	RAP	Sirolimus (DB00877)	Plasmodium falciparum 3d7	FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE	FKBP_C	14	TYR A 44 PHE A 55 ASP A 56 PHE A 59 PHE A 65 GLY A 72 GLU A 73 VAL A 74 ILE A 75 TRP A 78 TYR A 101 CYS A 106 ILE A 110 PHE A 118	RAP A 202
5FLC_C_RAPC999	5flc	RAP	Sirolimus (DB00877)	Homo sapiens; spodoptera frugiperda	FKBP; SERINE/THREONINE-PROTEIN KINASE MTOR	FAT FATC FRB_dom PI3_PI4_kinase	9	GLU B2032 SER B2035 ARG B2036 PHE B2039 GLY B2040 THR B2098 TRP B2101 TYR B2105 PHE B2108	RAP C 999
5GPG_A_RAPA301	5gpg	RAP	Sirolimus (DB00877)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3; SERINE/THREONINE-PROTEIN KINASE MTOR	FKBP_C	24	TYR A 135 PHE A 145 ASP A 146 LEU A 162 GLY A 169 LYS A 170 VAL A 171 ILE A 172 TRP A 175 TYR A 198 ALA A 206 ILE A 208 PHE A 216 LEU B2031 GLU B2032 SER B2035 ARG B2036 PHE B2039 GLY B2040 THR B2098 TRP B2101 ASP B2102 TYR B2105 PHE B2108	RAP A 301
5HKG_A_RAPA201	5hkg	RAP	Sirolimus (DB00877)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B	FKBP_C	14	TYR A 26 PHE A 36 ASP A 37 PHE A 46 GLN A 53 GLU A 54 VAL A 55 ILE A 56 PHE A 59 TYR A 82 HIS A 87 VAL A 90 ILE A 91 PHE A 99	RAP A 201
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1FKB_A_RAPA108","1fkb","RAP","Sirolimus (DB00877)","Homo sapiens","FK506 BINDING PROTEIN","FKBP_C",14,"TYR A  26;PHE A  36;ASP A  37;PHE A  46;GLN A  53;GLU A  54;VAL A  55;ILE A  56;TRP A  59;TYR A  82;HIS A  87;ILE A  90;ILE A  91;PHE A  99","RAP A 108\r"],["2VCD_A_RAPA138","2vcd","RAP","Sirolimus (DB00877)","Legionella pneumophila subsp. pneumophila (strain philadelphia 1 \/ atcc 33152 \/ dsm 7513)","OUTER MEMBRANE PROTEIN MIP","FKBP_C",31,"THR A  50;VAL A  53;TYR A  55;GLY A  57;PHE A  65;ASP A  66;SER A  67;THR A  68;ALA A  75;THR A  76;PHE A  77;GLN A  78;VAL A  79;SER A  80;GLN A  81;VAL A  82;ILE A  83;PRO A  84;TRP A  86;LEU A  90;LEU A 107;ALA A 108;TYR A 109;GLY A 110;VAL A 114;GLY A 115;GLY A 116;ILE A 118;LEU A 124;PHE A 126;ILE A 128","RAP A 138\r"],["4DRI_A_RAPA201","4dri","RAP","Sirolimus (DB00877)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5;SERINE\/THREONINE-PROTEIN KINASE MTOR","FKBP_C",25,"TYR A  57;PHE A  67;ASP A  68;ARG A  73;PHE A  77;GLY A  84;GLN A  85;VAL A  86;ILE A  87;TRP A  90;TYR A 113;SER A 118;ILE A 122;PHE A 130;LEU B2031;GLU B2032;SER B2035;ARG B2036;PHE B2039;GLY B2040;THR B2098;TRP B2101;ASP B2102;TYR B2105;PHE B2108","RAP A 201\r"],["4DRJ_A_RAPA201","4drj","RAP","Sirolimus (DB00877)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4;SERINE\/THREONINE-PROTEIN KINASE MTOR","FKBP_C",24,"TYR A  57;PHE A  67;ASP A  68;PHE A  77;GLY A  84;GLU A  85;VAL A  86;ILE A  87;TRP A  90;TYR A 113;LYS A 121;ILE A 122;PHE A 130;LEU B2031;GLU B2032;SER B2035;ARG B2036;PHE B2039;GLY B2040;THR B2098;TRP B2101;ASP B2102;TYR B2105;PHE B2108","RAP A 201\r"],["4QT3_A_RAPA202","4qt3","RAP","Sirolimus (DB00877)","Plasmodium falciparum 3d7","FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE","FKBP_C",14,"TYR A  44;PHE A  55;ASP A  56;PHE A  59;PHE A  65;GLY A  72;GLU A  73;VAL A  74;ILE A  75;TRP A  78;TYR A 101;CYS A 106;ILE A 110;PHE A 118","RAP A 202\r"],["5FLC_C_RAPC999","5flc","RAP","Sirolimus (DB00877)","Homo sapiens;spodoptera frugiperda","FKBP;SERINE\/THREONINE-PROTEIN KINASE MTOR","FAT;FATC;FRB_dom;PI3_PI4_kinase",9,"GLU B2032;SER B2035;ARG B2036;PHE B2039;GLY B2040;THR B2098;TRP B2101;TYR B2105;PHE B2108","RAP C 999\r"],["5GPG_A_RAPA301","5gpg","RAP","Sirolimus (DB00877)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3;SERINE\/THREONINE-PROTEIN KINASE MTOR","FKBP_C",24,"TYR A 135;PHE A 145;ASP A 146;LEU A 162;GLY A 169;LYS A 170;VAL A 171;ILE A 172;TRP A 175;TYR A 198;ALA A 206;ILE A 208;PHE A 216;LEU B2031;GLU B2032;SER B2035;ARG B2036;PHE B2039;GLY B2040;THR B2098;TRP B2101;ASP B2102;TYR B2105;PHE B2108","RAP A 301\r"],["5HKG_A_RAPA201","5hkg","RAP","Sirolimus (DB00877)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B","FKBP_C",14,"TYR A  26;PHE A  36;ASP A  37;PHE A  46;GLN A  53;GLU A  54;VAL A  55;ILE A  56;PHE A  59;TYR A  82;HIS A  87;VAL A  90;ILE A  91;PHE A  99","RAP A 201\r"]]