Results: Ligand

Ligand ID: AZR

Drugbank ID:
Aztreonam
(DB00355)

Indication:
Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria.

LIST OF BINDING INTERFACES for query 'DB00355'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1FR6_A_AZRA362	1fr6	AZR	Aztreonam (DB00355)	Citrobacter freundii	BETA-LACTAMASE	Beta-lactamase	20	GLY A 63 SER A 64 LYS A 67 LEU A 119 GLN A 120 VAL B 121 PRO B 122 ASP B 123 ASP B 124 TYR A 150 ASN A 152 TYR A 221 LEU A 293 LYS A 315 THR A 316 GLY A 317 SER A 318 THR A 319 GLY A 320 ASN A 346	AZR A 362
2ZQC_A_AZRA301	2zqc	AZR	Aztreonam (DB00355)	Escherichia coli	BETA-LACTAMASE TOHO-1	Beta-lactamase2	17	CYS A 69 SER A 70 ASN A 104 TYR A 105 SER A 130 ASN A 132 PRO A 167 ASN A 170 THR A 171 THR A 216 LYS A 234 THR A 235 GLY A 236 SER A 237 GLY A 238 ASP A 240 ASN A 274	AZR A 301
3PBS_A_AZRA999	3pbs	AZR	Aztreonam (DB00355)	Pseudomonas aeruginosa	PENICILLIN-BINDING PROTEIN 3	PBP_dimer Transpeptidase	18	GLU A 291 GLY A 293 SER A 294 VAL A 333 SER A 349 ASN A 351 GLY A 408 TYR A 409 LYS A 484 SER A 485 GLY A 486 THR A 487 ALA A 488 ARG A 489 TYR A 503 TYR A 532 PHE A 533 GLY A 534	AZR A 999
3UE0_A_AZRA998	3ue0	AZR	Aztreonam (DB00355)	Acinetobacter baumannii	PENICILLIN-BINDING PROTEIN 1A	PCB_OB Transgly Transpeptidase	17	GLN A 431 GLY A 433 SER A 434 SER A 470 SER A 487 ASN A 489 LEU A 526 GLY A 527 LYS A 669 THR A 670 GLY A 671 THR A 672 THR A 673 ASN A 674 ASP A 675 ALA A 676 TYR A 707	AZR A 998
4WBG_A_AZRA1001	4wbg	AZR	Aztreonam (DB00355)	Klebsiella pneumoniae	BETA-LACTAMASE	Beta-lactamase	18	GLY A 64 SER A 65 LYS A 68 LEU A 120 GLN A 121 TYR A 151 ASN A 153 VAL A 213 TYR A 223 ILE A 292 LYS A 312 THR A 313 GLY A 314 SER A 315 SER A 316 ASN A 317 ASN A 340 ILE A 343	AZR A1001
4X53_A_AZRA301	4x53	AZR	Aztreonam (DB00355)	Acinetobacter baumannii	CLASS D BETA-LACTAMASE OXA-160	Transpeptidase	16	VAL A 78 ALA A 80 SER A 81 TYR A 112 SER A 128 ASP A 130 TRP A 167 GLY A 170 LYS A 218 SER A 219 GLY A 220 TRP A 221 GLY A 222 MET A 223 GLN A 228 ARG A 261	AZR A 301
5HLB_A_AZRA902	5hlb	AZR	Aztreonam (DB00355)	Escherichia coli (strain k12)	PENICILLIN-BINDING PROTEIN 1B	Transgly Transpeptidase UB2H	18	SER A 507 GLY A 509 SER A 510 LYS A 513 ASP A 553 SER A 572 ASN A 574 LEU A 611 GLY A 612 THR A 682 THR A 699 GLY A 700 THR A 701 THR A 702 ASN A 703 ASN A 704 TYR A 734 GLY A 735	AZR A 902
6KGU_A_AZRA701	6kgu	AZR	Aztreonam (DB00355)	Mycobacterium tuberculosis (strain atcc 25618 / h37rv)	PENICILLIN-BINDING PROTEIN PBPB	PBP_dimer Transpeptidase	18	GLU A 383 GLY A 385 SER A 386 ALA A 424 SER A 441 ASN A 443 ILE A 499 GLY A 500 GLN A 501 THR A 578 LYS A 592 THR A 593 GLY A 594 THR A 595 ALA A 596 GLN A 597 TYR A 606 TYR A 611	AZR A 701
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1FR6_A_AZRA362","1fr6","AZR","Aztreonam (DB00355)","Citrobacter freundii","BETA-LACTAMASE","Beta-lactamase",20,"GLY A  63;SER A  64;LYS A  67;LEU A 119;GLN A 120;VAL B 121;PRO B 122;ASP B 123;ASP B 124;TYR A 150;ASN A 152;TYR A 221;LEU A 293;LYS A 315;THR A 316;GLY A 317;SER A 318;THR A 319;GLY A 320;ASN A 346","AZR A 362\r"],["2ZQC_A_AZRA301","2zqc","AZR","Aztreonam (DB00355)","Escherichia coli","BETA-LACTAMASE TOHO-1","Beta-lactamase2",17,"CYS A  69;SER A  70;ASN A 104;TYR A 105;SER A 130;ASN A 132;PRO A 167;ASN A 170;THR A 171;THR A 216;LYS A 234;THR A 235;GLY A 236;SER A 237;GLY A 238;ASP A 240;ASN A 274","AZR A 301\r"],["3PBS_A_AZRA999","3pbs","AZR","Aztreonam (DB00355)","Pseudomonas aeruginosa","PENICILLIN-BINDING PROTEIN 3","PBP_dimer;Transpeptidase",18,"GLU A 291;GLY A 293;SER A 294;VAL A 333;SER A 349;ASN A 351;GLY A 408;TYR A 409;LYS A 484;SER A 485;GLY A 486;THR A 487;ALA A 488;ARG A 489;TYR A 503;TYR A 532;PHE A 533;GLY A 534","AZR A 999\r"],["3UE0_A_AZRA998","3ue0","AZR","Aztreonam (DB00355)","Acinetobacter baumannii","PENICILLIN-BINDING PROTEIN 1A","PCB_OB;Transgly;Transpeptidase",17,"GLN A 431;GLY A 433;SER A 434;SER A 470;SER A 487;ASN A 489;LEU A 526;GLY A 527;LYS A 669;THR A 670;GLY A 671;THR A 672;THR A 673;ASN A 674;ASP A 675;ALA A 676;TYR A 707","AZR A 998\r"],["4WBG_A_AZRA1001","4wbg","AZR","Aztreonam (DB00355)","Klebsiella pneumoniae","BETA-LACTAMASE","Beta-lactamase",18,"GLY A  64;SER A  65;LYS A  68;LEU A 120;GLN A 121;TYR A 151;ASN A 153;VAL A 213;TYR A 223;ILE A 292;LYS A 312;THR A 313;GLY A 314;SER A 315;SER A 316;ASN A 317;ASN A 340;ILE A 343","AZR A1001\r"],["4X53_A_AZRA301","4x53","AZR","Aztreonam (DB00355)","Acinetobacter baumannii","CLASS D BETA-LACTAMASE OXA-160","Transpeptidase",16,"VAL A  78;ALA A  80;SER A  81;TYR A 112;SER A 128;ASP A 130;TRP A 167;GLY A 170;LYS A 218;SER A 219;GLY A 220;TRP A 221;GLY A 222;MET A 223;GLN A 228;ARG A 261","AZR A 301\r"],["5HLB_A_AZRA902","5hlb","AZR","Aztreonam (DB00355)","Escherichia coli (strain k12)","PENICILLIN-BINDING PROTEIN 1B","Transgly;Transpeptidase;UB2H",18,"SER A 507;GLY A 509;SER A 510;LYS A 513;ASP A 553;SER A 572;ASN A 574;LEU A 611;GLY A 612;THR A 682;THR A 699;GLY A 700;THR A 701;THR A 702;ASN A 703;ASN A 704;TYR A 734;GLY A 735","AZR A 902\r"],["6KGU_A_AZRA701","6kgu","AZR","Aztreonam (DB00355)","Mycobacterium tuberculosis (strain atcc 25618 \/ h37rv)","PENICILLIN-BINDING PROTEIN PBPB","PBP_dimer;Transpeptidase",18,"GLU A 383;GLY A 385;SER A 386;ALA A 424;SER A 441;ASN A 443;ILE A 499;GLY A 500;GLN A 501;THR A 578;LYS A 592;THR A 593;GLY A 594;THR A 595;ALA A 596;GLN A 597;TYR A 606;TYR A 611","AZR A 701\r"]]