Ligand ID: CYZ

Drugbank ID:
Cyclothiazide
(DB00606)

Indication:
As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides...


LIST OF BINDING INTERFACES for query 'DB00606'
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DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details
3TKD_A_CYZA2663tkd CYZCyclothiazide
(DB00606) 		Rattus norvegicus GLUTAMATE RECEPTOR 2 NA 21TYR A  35
THR B  91
ILE B  92
THR B  93
LYS A 104
PRO B 105
PRO A 105
PHE A 106
MET A 107
SER A 108
SER B 217
LYS B 218
GLY B 219
GLY A 219
VAL A 238
LEU A 239
SER A 242
GLU A 243
LEU A 247
ASP A 248
LYS A 251
CYZ A 266
7OCF_A_CYZA14017ocf CYZCyclothiazide
(DB00606) 		NA ISOFORM FLIP OF GLUTAMATE RECEPTOR 1;
ISOFORM FLIP OF GLUTAMATE RECEPTOR 2 		NA 12LYS A 489
PRO A 490
PHE A 491
MET A 492
SER A 493
SER B 729
LYS B 730
LEU A 747
SER A 750
LEU A 755
ASP A 756
LYS A 759
CYZ A1401
7OCF_B_CYZB14017ocf CYZCyclothiazide
(DB00606) 		NA ISOFORM FLIP OF GLUTAMATE RECEPTOR 1;
ISOFORM FLIP OF GLUTAMATE RECEPTOR 2 		NA 14ILE A 477
LYS B 493
SER A 493
PRO B 494
PHE B 495
MET B 496
SER B 497
SER A 725
LYS A 726
GLY A 727
SER B 754
LEU B 759
ASP B 760
LYS B 763
CYZ B1401
DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details