Results: Ligand

Ligand ID: 486

Drugbank ID:
Mifepristone
(DB00834)

Indication:
Mifepristone is a cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation.

LIST OF BINDING INTERFACES for query 'DB00834'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
2W8Y_A_486A1000	2w8y	486	Mifepristone (DB00834)	Homo sapiens	PROGESTERONE RECEPTOR	Hormone_recep	23	LEU A 715 LEU A 718 ASN A 719 LEU A 721 GLY A 722 GLU A 723 GLN A 725 LEU A 726 TRP A 755 MET A 756 MET A 759 VAL A 760 LEU A 763 ARG A 766 PHE A 778 PHE A 794 LEU A 797 MET A 801 LEU A 887 TYR A 890 CYS A 891 MET A 909 VAL A 912	486 A1000
3QT0_A_486A4	3qt0	486	Mifepristone (DB00834)	Homo sapiens	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA	Hormone_recep	21	LYS A 265 GLY A 284 CYS A 285 GLN A 286 ARG A 288 SER A 289 ALA A 292 ILE A 326 TYR A 327 MET A 329 LEU A 330 LEU A 333 VAL A 339 ILE A 341 MET A 348 LEU A 353 PHE A 363 MET A 364 LYS A 367 HIS A 449 TYR A 473	486 A 4
4LTW_A_486A302	4ltw	486	Mifepristone (DB00834)	Ancestral gene	ANCESTRAL STEROID RECEPTOR 2	NA	14	LEU A 42 VAL A 43 VAL A 46 LYS A 50 PHE A 55 LEU A 60 GLN A 63 MET A 64 ILE A 67 GLN A 68 MET A 224 GLU A 227 ILE A 228 ALA A 231	486 A 302
4LTW_A_486A303	4ltw	486	Mifepristone (DB00834)	Ancestral gene	ANCESTRAL STEROID RECEPTOR 2	NA	13	THR A 27 LEU A 31 ALA A 109 MET A 110 ASP A 112 LEU A 113 GLY A 202 GLN A 205 PHE A 206 TYR A 209 THR A 210 LEU A 217 VAL A 219	486 A 303
5UC1_A_486A801	5uc1	486	Mifepristone (DB00834)	Heterocephalus glaber	GLUCOCORTICOID RECEPTOR	NA	22	TRP B 553 MET B 556 THR B 557 LEU A 559 ASN B 560 ASN A 560 LEU A 562 GLY A 563 GLY A 564 GLN A 566 VAL A 567 TRP A 596 MET A 597 MET A 600 ALA A 601 LEU A 604 ARG A 607 PHE A 619 GLN B 638 GLN A 638 CYS A 639 MET A 642	486 A 801
5UC3_A_486A801	5uc3	486	Mifepristone (DB00834)	Homo sapiens	GLUCOCORTICOID RECEPTOR	Hormone_recep	23	MET A 560 LEU A 563 ASN A 564 LEU A 566 GLY A 567 GLY A 568 GLN A 570 VAL A 571 TRP A 600 MET A 601 MET A 604 ALA A 605 LEU A 608 ARG A 611 PHE A 623 MET A 639 GLN A 642 CYS A 643 MET A 646 LEU A 732 TYR A 735 CYS A 736 THR A 739	486 A 801
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["2W8Y_A_486A1000","2w8y","486","Mifepristone (DB00834)","Homo sapiens","PROGESTERONE RECEPTOR","Hormone_recep",23,"LEU A 715;LEU A 718;ASN A 719;LEU A 721;GLY A 722;GLU A 723;GLN A 725;LEU A 726;TRP A 755;MET A 756;MET A 759;VAL A 760;LEU A 763;ARG A 766;PHE A 778;PHE A 794;LEU A 797;MET A 801;LEU A 887;TYR A 890;CYS A 891;MET A 909;VAL A 912","486 A1000\r"],["3QT0_A_486A4","3qt0","486","Mifepristone (DB00834)","Homo sapiens","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","Hormone_recep",21,"LYS A 265;GLY A 284;CYS A 285;GLN A 286;ARG A 288;SER A 289;ALA A 292;ILE A 326;TYR A 327;MET A 329;LEU A 330;LEU A 333;VAL A 339;ILE A 341;MET A 348;LEU A 353;PHE A 363;MET A 364;LYS A 367;HIS A 449;TYR A 473","486 A   4\r"],["4LTW_A_486A302","4ltw","486","Mifepristone (DB00834)","Ancestral gene","ANCESTRAL STEROID RECEPTOR 2","NA",14,"LEU A  42;VAL A  43;VAL A  46;LYS A  50;PHE A  55;LEU A  60;GLN A  63;MET A  64;ILE A  67;GLN A  68;MET A 224;GLU A 227;ILE A 228;ALA A 231","486 A 302\r"],["4LTW_A_486A303","4ltw","486","Mifepristone (DB00834)","Ancestral gene","ANCESTRAL STEROID RECEPTOR 2","NA",13,"THR A  27;LEU A  31;ALA A 109;MET A 110;ASP A 112;LEU A 113;GLY A 202;GLN A 205;PHE A 206;TYR A 209;THR A 210;LEU A 217;VAL A 219","486 A 303\r"],["5UC1_A_486A801","5uc1","486","Mifepristone (DB00834)","Heterocephalus glaber","GLUCOCORTICOID RECEPTOR","NA",22,"TRP B 553;MET B 556;THR B 557;LEU A 559;ASN B 560;ASN A 560;LEU A 562;GLY A 563;GLY A 564;GLN A 566;VAL A 567;TRP A 596;MET A 597;MET A 600;ALA A 601;LEU A 604;ARG A 607;PHE A 619;GLN B 638;GLN A 638;CYS A 639;MET A 642","486 A 801\r"],["5UC3_A_486A801","5uc3","486","Mifepristone (DB00834)","Homo sapiens","GLUCOCORTICOID RECEPTOR","Hormone_recep",23,"MET A 560;LEU A 563;ASN A 564;LEU A 566;GLY A 567;GLY A 568;GLN A 570;VAL A 571;TRP A 600;MET A 601;MET A 604;ALA A 605;LEU A 608;ARG A 611;PHE A 623;MET A 639;GLN A 642;CYS A 643;MET A 646;LEU A 732;TYR A 735;CYS A 736;THR A 739","486 A 801\r"]]