Ligand ID: A26

Drugbank ID:
Teriflunomide
(DB08880)

Indication:
Teriflunomide is a pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis.

LIST OF BINDING INTERFACES for query 'DB08880'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1D3H_A_A26A397	1d3h	A26	Teriflunomide (DB08880)	Homo sapiens	DIHYDROOROTATE DEHYDROGENASE	DHO_dh	15	MET A  43 PRO A  52 ALA A  55 HIS A  56 ALA A  59 THR A  63 PHE A  98 MET A 111 VAL A 134 ARG A 136 TYR A 356 LEU A 359 THR A 360 GLY A 363 PRO A 364	A26 A 397		Details
1TV5_A_A26A1001	1tv5	A26	Teriflunomide (DB08880)	Plasmodium falciparum	DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL	DHO_dh	16	TYR A 168 PHE A 171 LEU A 172 CYS A 175 GLY A 181 CYS A 184 HIS A 185 PHE A 188 PHE A 227 ILE A 263 ARG A 265 TYR A 528 LEU A 531 VAL A 532 GLY A 535 MET A 536	A26 A1001		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1D3H_A_A26A397","1d3h","A26","Teriflunomide (DB08880)","Homo sapiens","DIHYDROOROTATE DEHYDROGENASE","DHO_dh",15,"MET A 43;PRO A 52;ALA A 55;HIS A 56;ALA A 59;THR A 63;PHE A 98;MET A 111;VAL A 134;ARG A 136;TYR A 356;LEU A 359;THR A 360;GLY A 363;PRO A 364","A26 A 397\r"],["1TV5_A_A26A1001","1tv5","A26","Teriflunomide (DB08880)","Plasmodium falciparum","DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL","DHO_dh",16,"TYR A 168;PHE A 171;LEU A 172;CYS A 175;GLY A 181;CYS A 184;HIS A 185;PHE A 188;PHE A 227;ILE A 263;ARG A 265;TYR A 528;LEU A 531;VAL A 532;GLY A 535;MET A 536","A26 A1001\r"]]