Ligand ID: ACA

Drugbank ID:
Aminocaproic acid
(DB00513)

Indication:
Aminocaproic acid is an antifibrinolytic agent used to induce clotting postoperatively.

LIST OF BINDING INTERFACES for query 'ACA'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1CEA_A_ACAA90	1cea	ACA	Aminocaproic acid (DB00513)	Homo sapiens	PLASMINOGEN	Kringle	10	THR B  12 ARG A  34 PHE A  35 ASP A  54 ASP A  56 TRP A  61 TYR A  63 ARG A  70 TYR A  71 TYR A  73	ACA A  90		Details
1ILP_C_ACAC7	1ilp	ACA	Aminocaproic acid (DB00513)	Homo sapiens; synthetic construct	C-X-C CHEMOKINE RECEPTOR TYPE 1; INTERLEUKIN-8 (PRECURSOR)	IL8	23	MET C   1 TRP C   2 ASP C   3 PHE C   4 ASP C   5 ASP C   6 MET C   8 PRO C   9 PRO C  10 ALA C  11 TYR A  13 LYS A  15 PRO A  16 PHE A  17 HIS A  18 PRO A  19 LYS A  20 PHE A  21 LEU A  43 SER A  44 ASP A  45 GLY A  46 ARG A  47	ACA C   7		Details
1PK2_A_ACAA91	1pk2	ACA	Aminocaproic acid (DB00513)	Homo sapiens	TISSUE-TYPE PLASMINOGEN ACTIVATOR	Kringle	11	LYS A  39 VAL A  40 TYR A  41 PRO A  62 ASP A  63 ASP A  65 TRP A  69 HIS A  71 LEU A  78 THR A  79 TRP A  80	ACA A  91		Details
2DCF_A_ACAA501	2dcf	ACA	Aminocaproic acid (DB00513)	Flavobacterium sp.	6-AMINOHEXANOATE-DIMER HYDROLASE	Beta-lactamase	8	ALA A 112 LYS A 115 TYR A 170 TYR A 215 TRP A 331 ILE A 343 GLY A 344 ILE A 345	ACA A 501		Details
2DCF_A_ACAA502	2dcf	ACA	Aminocaproic acid (DB00513)	Flavobacterium sp.	6-AMINOHEXANOATE-DIMER HYDROLASE	Beta-lactamase	16	MET A 111 ALA A 112 LYS A 115 GLU A 168 TYR A 170 VAL A 177 ASP A 181 TRP A 186 TYR A 215 SER A 217 PHE A 264 ASN A 266 GLY A 267 ILE A 343 GLY A 344 ILE A 345	ACA A 502		Details
2PK4_A_ACAA100	2pk4	ACA	Aminocaproic acid (DB00513)	Homo sapiens	HUMAN PLASMINOGEN KRINGLE 4	Kringle	7	LYS A  35 ASP A  55 ASP A  57 TRP A  62 PHE A  64 ARG A  71 TRP A  72	ACA A 100		Details
3A2Q_A_ACAA601	3a2q	ACA	Aminocaproic acid (DB00513)	Arthrobacter sp.	6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE	Amidase	13	LEU A  74 MET A 123 GLY A 124 ASN A 125 SER A 150 ASN A 169 ALA A 171 ALA A 174 ASP A 202 VAL A 206 CYS A 316 ILE A 320 GLN A 411	ACA A 601		Details
3A2Q_A_ACAA602	3a2q	ACA	Aminocaproic acid (DB00513)	Arthrobacter sp.	6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE	Amidase	14	GLY A 124 ASN A 125 GLN A 126 VAL A 127 SER A 150 ASP A 170 ALA A 171 ALA A 172 GLY A 173 ALA A 174 CYS A 316 GLN A 411 PHE A 414 LEU A 422	ACA A 602		Details
3KIV_A_ACAA100	3kiv	ACA	Aminocaproic acid (DB00513)	Homo sapiens	APOLIPOPROTEIN	Kringle	8	HIS A  33 ARG A  35 ASP A  55 ASP A  57 TRP A  62 PHE A  64 ARG A  71 TRP A  72	ACA A 100		Details
4DXU_A_ACAA711	4dxu	ACA	Aminocaproic acid (DB00513)	Bos taurus	LACTOTRANSFERRIN	Transferrin	10	GLU A 431 GLY A 432 VAL A 591 ALA A 592 PRO A 593 LEU A 661 GLY A 662 THR A 663 GLU A 664 TYR A 665	ACA A 711		Details
4G24_A_ACAA1004	4g24	ACA	Aminocaproic acid (DB00513)	Arabidopsis thaliana	PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN AT2G32230, MITOCHONDRIAL	PPR_long PRORP	8	ALA A 401 ASN A 402 LEU A 405 VAL A 406 ASN A 407 ASP A 475 ASP A 493 GLU A 494	ACA A1004		Details
4HXY_B_ACAB502	4hxy	ACA	Aminocaproic acid (DB00513)	Streptomyces sp. hk803	PLM1	KR	8	VAL B 277 SER B 319 GLN B 329 TYR B 332 TRP B 358 MET B 366 LEU B 367 ASP B 371	ACA B 502		Details
4LAJ_B_ACAB512	4laj	ACA	Aminocaproic acid (DB00513)	Human immunodeficiency virus 1; lama glama; synthetic construct	HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN	NA	8	ASP B  57 PRO B 214 HIS B 216 ARG B 252 ASN A 300 ASN A 301 ARG A 440 GLY A 441	ACA B 512		Details
5I73_A_ACAA709	5i73	ACA	Aminocaproic acid (DB00513)	Homo sapiens; mus musculus	SODIUM-DEPENDENT SEROTONIN TRANSPORTER	SNF	3	GLN A 246 ASP A 247 GLY A 249	ACA A 709		Details
5NVP_A_ACAA18	5nvp	ACA	Aminocaproic acid (DB00513)	NA	ENVELOPE GLYCOPROTEIN,GP41	NA	19	GLY A  14 SER A  15 LYS A  16 LYS A  17 LYS A  19 ASN A  20 GLU A  21 GLN A  22 GLU A  23 LEU A  24 LEU A  25 GLU A  26 LEU A  27 ASP A  28 LYS A  29 TRP A  30 ALA A  31 LEU A  33 TRP A  34	ACA A  18		Details
5OCK_A_ACAA0	5ock	ACA	Aminocaproic acid (DB00513)	Homo sapiens; synthetic construct	CEP1 PEPTIDE (FROM ENOLASE); HUMAN ACPA E4 FAB FRAGMENT - LIGHT CHAIN	NA	4	CYS A   1 LYS A   2 ASN L  67 SER L  68	ACA A   0		Details
6DCM_A_ACAA101	6dcm	ACA	Aminocaproic acid (DB00513)	Homo sapiens	PLASMINOGEN	NA	7	TYR A  35 ASP A  54 ASP A  56 TRP A  61 PHE A  63 ARG A  70 TRP A  71	ACA A 101		Details
6G4E_A_ACAA502	6g4e	ACA	Aminocaproic acid (DB00513)	Pseudomonas sp	ASPARTATE AMINOTRANSFERASE FAMILY PROTEIN	Aminotran_3	9	TYR A  20 TRP A  58 PHE B  86 TYR A 151 ALA A 230 LYS A 287 THR B 324 ARG A 417 MET A 419	ACA A 502		Details
6NK0_A_ACAA302	6nk0	ACA	Aminocaproic acid (DB00513)	Homo sapiens; synthetic construct	EPHRIN TYPE-A RECEPTOR 2	NA	9	ASP A  78 TRP A  80 TYR A 122 LYS A 136 ARG A 137 PHE A 139 THR A 140 LYS A 141 GLN A 183	ACA A 302		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1CEA_A_ACAA90","1cea","ACA","Aminocaproic acid (DB00513)","Homo sapiens","PLASMINOGEN","Kringle",10,"THR B 12;ARG A 34;PHE A 35;ASP A 54;ASP A 56;TRP A 61;TYR A 63;ARG A 70;TYR A 71;TYR A 73","ACA A 90\r"],["1ILP_C_ACAC7","1ilp","ACA","Aminocaproic acid (DB00513)","Homo sapiens;synthetic construct","C-X-C CHEMOKINE RECEPTOR TYPE 1;INTERLEUKIN-8 (PRECURSOR)","IL8",23,"MET C 1;TRP C 2;ASP C 3;PHE C 4;ASP C 5;ASP C 6;MET C 8;PRO C 9;PRO C 10;ALA C 11;TYR A 13;LYS A 15;PRO A 16;PHE A 17;HIS A 18;PRO A 19;LYS A 20;PHE A 21;LEU A 43;SER A 44;ASP A 45;GLY A 46;ARG A 47","ACA C 7\r"],["1PK2_A_ACAA91","1pk2","ACA","Aminocaproic acid (DB00513)","Homo sapiens","TISSUE-TYPE PLASMINOGEN ACTIVATOR","Kringle",11,"LYS A 39;VAL A 40;TYR A 41;PRO A 62;ASP A 63;ASP A 65;TRP A 69;HIS A 71;LEU A 78;THR A 79;TRP A 80","ACA A 91\r"],["2DCF_A_ACAA501","2dcf","ACA","Aminocaproic acid (DB00513)","Flavobacterium sp.","6-AMINOHEXANOATE-DIMER HYDROLASE","Beta-lactamase",8,"ALA A 112;LYS A 115;TYR A 170;TYR A 215;TRP A 331;ILE A 343;GLY A 344;ILE A 345","ACA A 501\r"],["2DCF_A_ACAA502","2dcf","ACA","Aminocaproic acid (DB00513)","Flavobacterium sp.","6-AMINOHEXANOATE-DIMER HYDROLASE","Beta-lactamase",16,"MET A 111;ALA A 112;LYS A 115;GLU A 168;TYR A 170;VAL A 177;ASP A 181;TRP A 186;TYR A 215;SER A 217;PHE A 264;ASN A 266;GLY A 267;ILE A 343;GLY A 344;ILE A 345","ACA A 502\r"],["2PK4_A_ACAA100","2pk4","ACA","Aminocaproic acid (DB00513)","Homo sapiens","HUMAN PLASMINOGEN KRINGLE 4","Kringle",7,"LYS A 35;ASP A 55;ASP A 57;TRP A 62;PHE A 64;ARG A 71;TRP A 72","ACA A 100\r"],["3A2Q_A_ACAA601","3a2q","ACA","Aminocaproic acid (DB00513)","Arthrobacter sp.","6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE","Amidase",13,"LEU A 74;MET A 123;GLY A 124;ASN A 125;SER A 150;ASN A 169;ALA A 171;ALA A 174;ASP A 202;VAL A 206;CYS A 316;ILE A 320;GLN A 411","ACA A 601\r"],["3A2Q_A_ACAA602","3a2q","ACA","Aminocaproic acid (DB00513)","Arthrobacter sp.","6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE","Amidase",14,"GLY A 124;ASN A 125;GLN A 126;VAL A 127;SER A 150;ASP A 170;ALA A 171;ALA A 172;GLY A 173;ALA A 174;CYS A 316;GLN A 411;PHE A 414;LEU A 422","ACA A 602\r"],["3KIV_A_ACAA100","3kiv","ACA","Aminocaproic acid (DB00513)","Homo sapiens","APOLIPOPROTEIN","Kringle",8,"HIS A 33;ARG A 35;ASP A 55;ASP A 57;TRP A 62;PHE A 64;ARG A 71;TRP A 72","ACA A 100\r"],["4DXU_A_ACAA711","4dxu","ACA","Aminocaproic acid (DB00513)","Bos taurus","LACTOTRANSFERRIN","Transferrin",10,"GLU A 431;GLY A 432;VAL A 591;ALA A 592;PRO A 593;LEU A 661;GLY A 662;THR A 663;GLU A 664;TYR A 665","ACA A 711\r"],["4G24_A_ACAA1004","4g24","ACA","Aminocaproic acid (DB00513)","Arabidopsis thaliana","PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN AT2G32230, MITOCHONDRIAL","PPR_long;PRORP",8,"ALA A 401;ASN A 402;LEU A 405;VAL A 406;ASN A 407;ASP A 475;ASP A 493;GLU A 494","ACA A1004\r"],["4HXY_B_ACAB502","4hxy","ACA","Aminocaproic acid (DB00513)","Streptomyces sp. hk803","PLM1","KR",8,"VAL B 277;SER B 319;GLN B 329;TYR B 332;TRP B 358;MET B 366;LEU B 367;ASP B 371","ACA B 502\r"],["4LAJ_B_ACAB512","4laj","ACA","Aminocaproic acid (DB00513)","Human immunodeficiency virus 1;lama glama;synthetic construct","HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN","NA",8,"ASP B 57;PRO B 214;HIS B 216;ARG B 252;ASN A 300;ASN A 301;ARG A 440;GLY A 441","ACA B 512\r"],["5I73_A_ACAA709","5i73","ACA","Aminocaproic acid (DB00513)","Homo sapiens;mus musculus","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","SNF",3,"GLN A 246;ASP A 247;GLY A 249","ACA A 709\r"],["5NVP_A_ACAA18","5nvp","ACA","Aminocaproic acid (DB00513)","NA","ENVELOPE GLYCOPROTEIN,GP41","NA",19,"GLY A 14;SER A 15;LYS A 16;LYS A 17;LYS A 19;ASN A 20;GLU A 21;GLN A 22;GLU A 23;LEU A 24;LEU A 25;GLU A 26;LEU A 27;ASP A 28;LYS A 29;TRP A 30;ALA A 31;LEU A 33;TRP A 34","ACA A 18\r"],["5OCK_A_ACAA0","5ock","ACA","Aminocaproic acid (DB00513)","Homo sapiens;synthetic construct","CEP1 PEPTIDE (FROM ENOLASE);HUMAN ACPA E4 FAB FRAGMENT - LIGHT CHAIN","NA",4,"CYS A 1;LYS A 2;ASN L 67;SER L 68","ACA A 0\r"],["6DCM_A_ACAA101","6dcm","ACA","Aminocaproic acid (DB00513)","Homo sapiens","PLASMINOGEN","NA",7,"TYR A 35;ASP A 54;ASP A 56;TRP A 61;PHE A 63;ARG A 70;TRP A 71","ACA A 101\r"],["6G4E_A_ACAA502","6g4e","ACA","Aminocaproic acid (DB00513)","Pseudomonas sp","ASPARTATE AMINOTRANSFERASE FAMILY PROTEIN","Aminotran_3",9,"TYR A 20;TRP A 58;PHE B 86;TYR A 151;ALA A 230;LYS A 287;THR B 324;ARG A 417;MET A 419","ACA A 502\r"],["6NK0_A_ACAA302","6nk0","ACA","Aminocaproic acid (DB00513)","Homo sapiens;synthetic construct","EPHRIN TYPE-A RECEPTOR 2","NA",9,"ASP A 78;TRP A 80;TYR A 122;LYS A 136;ARG A 137;PHE A 139;THR A 140;LYS A 141;GLN A 183","ACA A 302\r"]]