Results: Ligand

Ligand ID: URF

Drugbank ID:
Fluorouracil
(DB00544)

Indication:
Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment.

LIST OF BINDING INTERFACES for query 'URF'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1H7X_A_URFA1033	1h7x	URF	Fluorouracil (DB00544)	Sus scrofa	DIHYDROPYRIMIDINE DEHYDROGENASE	DHO_dh Fer4_20 Fer4_21 Pyr_redox_2	9	ASN A 609 GLU A 611 LEU A 612 ILE A 613 ASN A 668 SER A 670 ASN A 736 THR A 737 GLY A 764	URF A1033
1UPF_D_URFD999	1upf	URF	Fluorouracil (DB00544)	Toxoplasma gondii	URACIL PHOSPHORIBOSYLTRANSFERASE	UPRTase	9	MET D 166 ALA D 168 LEU D 223 TYR D 227 TYR D 228 ILE D 229 GLY D 234 ASP D 235 PHE D 236	URF D 999
3KVR_A_URFA2001	3kvr	URF	Fluorouracil (DB00544)	Bos taurus	URIDINE PHOSPHORYLASE	PNP_UDP_1	13	THR A 140 SER A 141 GLY A 142 PHE A 212 GLN A 216 ARG A 218 ILE A 246 GLU A 247 MET A 248 LEU A 271 LEU A 272 ARG A 274 ILE A 280	URF A2001
3KVV_A_URFA254	3kvv	URF	Fluorouracil (DB00544)	Escherichia coli	URIDINE PHOSPHORYLASE	PNP_UDP_1	11	THR A 94 THR A 95 GLY A 96 PHE A 162 GLN A 166 ARG A 168 TYR A 195 GLU A 196 MET A 197 ILE A 220 VAL A 221	URF A 254
3NAI_A_URFA521	3nai	URF	Fluorouracil (DB00544)	Murine norovirus 1	RNA DEPENDENT RNA POLYMERASE	RdRP_1	5	ARG A 185 ASP A 245 ASP A 346 ASP A 347 ARG A 395	URF A 521
3NBQ_A_URFA400	3nbq	URF	Fluorouracil (DB00544)	Homo sapiens	URIDINE PHOSPHORYLASE 1	PNP_UDP_1	13	THR A 141 SER A 142 GLY A 143 PHE A 213 GLN A 217 ARG A 219 ILE A 247 GLU A 248 MET A 249 LEU A 272 LEU A 273 ARG A 275 ILE A 281	URF A 400
4O0O_A_URFA303	4o0o	URF	Fluorouracil (DB00544)	Momordica balsamina	RRNA N-GLYCOSIDASE	RIP	10	VAL A 69 TYR A 70 ILE A 71 GLY A 109 ASN A 110 TYR A 111 ILE A 155 ALA A 159 GLU A 160 ARG A 163	URF A 303
4TXN_A_URFA302	4txn	URF	Fluorouracil (DB00544)	Schistosoma mansoni	URIDINE PHOSPHORYLASE	PNP_UDP_1	13	THR A 124 SER A 125 GLY A 126 PHE A 197 GLN A 201 ARG A 203 MET A 231 GLU A 232 MET A 233 ALA A 256 VAL A 257 ARG A 259 ILE A 265	URF A 302
4WRZ_A_URFA302	4wrz	URF	Fluorouracil (DB00544)	Mycobacterium tuberculosis	URACIL-DNA GLYCOSYLASE	UDG	10	GLY A 66 GLN A 67 ASP A 68 PRO A 69 TYR A 70 SER A 80 PHE A 81 SER A 93 ASN A 127 HIS A 191	URF A 302
5IAO_A_URFA301	5iao	URF	Fluorouracil (DB00544)	Mycobacterium tuberculosis (strain atcc 25177 / h37ra)	BIFUNCTIONAL PROTEIN PYRR	Pribosyltran	6	ARG A 58 ASP A 120 VAL A 176 HIS A 177 VAL A 178 ARG A 179	URF A 301
5SXC_A_URFA1101	5sxc	URF	Fluorouracil (DB00544)	Homo sapiens	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM	PI3K_C2 PI3K_p85B PI3K_rbd PI3Ka PI3_PI4_kinase	4	GLU A 620 LYS A 621 ASP A 625 LYS A 656	URF A1101
6KLK_A_URFA501	6klk	URF	Fluorouracil (DB00544)	Pseudomonas aeruginosa (strain atcc 15692 / dsm 22644 / cip 104116 / jcm 14847 / lmg 12228 / 1c / prs 101 / pao1)	D-HYDANTOINASE/DIHYDROPYRIMIDINASE	Amidohydro_1	14	HIS A 61 LEU A 64 PHE A 66 PHE A 152 TYR A 155 HIS A 183 HIS A 239 MET A 288 SER A 289 PRO A 290 ASP A 316 CYS A 318 ASN A 337 GLY A 338	URF A 501
6L0B_A_URFA403	6l0b	URF	Fluorouracil (DB00544)	Saccharomyces cerevisiae	DIHYDROOROTASE	NA	13	HIS A 16 ARG A 18 ASN A 43 THR A 105 THR A 106 HIS A 137 HIS A 180 LYS A 230 ASP A 258 ALA A 260 HIS A 262 ALA A 275 GLY A 276	URF A 403
7D8J_B_URFB301	7d8j	URF	Fluorouracil (DB00544)	Staphylococcus aureus (strain ed98)	SINGLE-STRANDED DNA-BINDING PROTEIN	SSB	4	THR B 12 LYS B 13 THR B 30 PHE B 48	URF B 301
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1H7X_A_URFA1033","1h7x","URF","Fluorouracil (DB00544)","Sus scrofa","DIHYDROPYRIMIDINE DEHYDROGENASE","DHO_dh;Fer4_20;Fer4_21;Pyr_redox_2",9,"ASN A 609;GLU A 611;LEU A 612;ILE A 613;ASN A 668;SER A 670;ASN A 736;THR A 737;GLY A 764","URF A1033\r"],["1UPF_D_URFD999","1upf","URF","Fluorouracil (DB00544)","Toxoplasma gondii","URACIL PHOSPHORIBOSYLTRANSFERASE","UPRTase",9,"MET D 166;ALA D 168;LEU D 223;TYR D 227;TYR D 228;ILE D 229;GLY D 234;ASP D 235;PHE D 236","URF D 999\r"],["3KVR_A_URFA2001","3kvr","URF","Fluorouracil (DB00544)","Bos taurus","URIDINE PHOSPHORYLASE","PNP_UDP_1",13,"THR A 140;SER A 141;GLY A 142;PHE A 212;GLN A 216;ARG A 218;ILE A 246;GLU A 247;MET A 248;LEU A 271;LEU A 272;ARG A 274;ILE A 280","URF A2001\r"],["3KVV_A_URFA254","3kvv","URF","Fluorouracil (DB00544)","Escherichia coli","URIDINE PHOSPHORYLASE","PNP_UDP_1",11,"THR A  94;THR A  95;GLY A  96;PHE A 162;GLN A 166;ARG A 168;TYR A 195;GLU A 196;MET A 197;ILE A 220;VAL A 221","URF A 254\r"],["3NAI_A_URFA521","3nai","URF","Fluorouracil (DB00544)","Murine norovirus 1","RNA DEPENDENT RNA POLYMERASE","RdRP_1",5,"ARG A 185;ASP A 245;ASP A 346;ASP A 347;ARG A 395","URF A 521\r"],["3NBQ_A_URFA400","3nbq","URF","Fluorouracil (DB00544)","Homo sapiens","URIDINE PHOSPHORYLASE 1","PNP_UDP_1",13,"THR A 141;SER A 142;GLY A 143;PHE A 213;GLN A 217;ARG A 219;ILE A 247;GLU A 248;MET A 249;LEU A 272;LEU A 273;ARG A 275;ILE A 281","URF A 400\r"],["4O0O_A_URFA303","4o0o","URF","Fluorouracil (DB00544)","Momordica balsamina","RRNA N-GLYCOSIDASE","RIP",10,"VAL A  69;TYR A  70;ILE A  71;GLY A 109;ASN A 110;TYR A 111;ILE A 155;ALA A 159;GLU A 160;ARG A 163","URF A 303\r"],["4TXN_A_URFA302","4txn","URF","Fluorouracil (DB00544)","Schistosoma mansoni","URIDINE PHOSPHORYLASE","PNP_UDP_1",13,"THR A 124;SER A 125;GLY A 126;PHE A 197;GLN A 201;ARG A 203;MET A 231;GLU A 232;MET A 233;ALA A 256;VAL A 257;ARG A 259;ILE A 265","URF A 302\r"],["4WRZ_A_URFA302","4wrz","URF","Fluorouracil (DB00544)","Mycobacterium tuberculosis","URACIL-DNA GLYCOSYLASE","UDG",10,"GLY A  66;GLN A  67;ASP A  68;PRO A  69;TYR A  70;SER A  80;PHE A  81;SER A  93;ASN A 127;HIS A 191","URF A 302\r"],["5IAO_A_URFA301","5iao","URF","Fluorouracil (DB00544)","Mycobacterium tuberculosis (strain atcc 25177 \/ h37ra)","BIFUNCTIONAL PROTEIN PYRR","Pribosyltran",6,"ARG A  58;ASP A 120;VAL A 176;HIS A 177;VAL A 178;ARG A 179","URF A 301\r"],["5SXC_A_URFA1101","5sxc","URF","Fluorouracil (DB00544)","Homo sapiens","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","PI3K_C2;PI3K_p85B;PI3K_rbd;PI3Ka;PI3_PI4_kinase",4,"GLU A 620;LYS A 621;ASP A 625;LYS A 656","URF A1101\r"],["6KLK_A_URFA501","6klk","URF","Fluorouracil (DB00544)","Pseudomonas aeruginosa (strain atcc 15692 \/ dsm 22644 \/ cip 104116 \/ jcm 14847 \/ lmg 12228 \/ 1c \/ prs 101 \/ pao1)","D-HYDANTOINASE\/DIHYDROPYRIMIDINASE","Amidohydro_1",14,"HIS A  61;LEU A  64;PHE A  66;PHE A 152;TYR A 155;HIS A 183;HIS A 239;MET A 288;SER A 289;PRO A 290;ASP A 316;CYS A 318;ASN A 337;GLY A 338","URF A 501\r"],["6L0B_A_URFA403","6l0b","URF","Fluorouracil (DB00544)","Saccharomyces cerevisiae","DIHYDROOROTASE","NA",13,"HIS A  16;ARG A  18;ASN A  43;THR A 105;THR A 106;HIS A 137;HIS A 180;LYS A 230;ASP A 258;ALA A 260;HIS A 262;ALA A 275;GLY A 276","URF A 403\r"],["7D8J_B_URFB301","7d8j","URF","Fluorouracil (DB00544)","Staphylococcus aureus (strain ed98)","SINGLE-STRANDED DNA-BINDING PROTEIN","SSB",4,"THR B  12;LYS B  13;THR B  30;PHE B  48","URF B 301\r"]]