Ligand ID: AXI

Drugbank ID:
Axitinib
(DB06626)

Indication:
Axitinib is an oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.

LIST OF BINDING INTERFACES for query 'DB06626'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
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DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4AG8_A_AXIA2000	4ag8	AXI	Axitinib (DB06626)	Homo sapiens	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	PK_Tyr_Ser-Thr	20	LEU A 840 VAL A 848 ALA A 866 VAL A 867 LYS A 868 GLU A 885 LEU A 889 VAL A 899 VAL A 914 VAL A 916 GLU A 917 PHE A 918 CYS A 919 LYS A 920 PHE A 921 GLY A 922 LEU A1035 CYS A1045 ASP A1046 PHE A1047	AXI A2000		Details
4WA9_B_AXIB9000	4wa9	AXI	Axitinib (DB06626)	Homo sapiens	TYROSINE-PROTEIN KINASE ABL1	NA	16	LEU B 248 GLY B 249 TYR B 253 VAL B 256 ALA B 269 LYS B 271 THR B 315 GLU B 316 PHE B 317 MET B 318 THR B 319 GLY B 321 ASN B 368 LEU B 370 ALA B 380 PHE B 382	AXI B9000		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4AG8_A_AXIA2000","4ag8","AXI","Axitinib (DB06626)","Homo sapiens","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","PK_Tyr_Ser-Thr",20,"LEU A 840;VAL A 848;ALA A 866;VAL A 867;LYS A 868;GLU A 885;LEU A 889;VAL A 899;VAL A 914;VAL A 916;GLU A 917;PHE A 918;CYS A 919;LYS A 920;PHE A 921;GLY A 922;LEU A1035;CYS A1045;ASP A1046;PHE A1047","AXI A2000\r"],["4WA9_B_AXIB9000","4wa9","AXI","Axitinib (DB06626)","Homo sapiens","TYROSINE-PROTEIN KINASE ABL1","NA",16,"LEU B 248;GLY B 249;TYR B 253;VAL B 256;ALA B 269;LYS B 271;THR B 315;GLU B 316;PHE B 317;MET B 318;THR B 319;GLY B 321;ASN B 368;LEU B 370;ALA B 380;PHE B 382","AXI B9000\r"]]