Ligand ID: 08Y

Drugbank ID:
Bromocriptine
(DB01200)

Indication:
Bromocriptine is a dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome.

LIST OF BINDING INTERFACES for query '08Y'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3UA1_A_08YA600	3ua1	08Y	Bromocriptine (DB01200)	Homo sapiens	CYTOCHROME P450 3A4	p450	22	TYR A  53 PHE A  57 ASP A  76 ARG A 105 ARG A 106 PRO A 107 PHE A 108 SER A 119 ILE A 120 ARG A 212 PHE A 213 PHE A 215 THR A 224 ILE A 301 PHE A 304 ALA A 305 THR A 309 ALA A 370 MET A 371 ARG A 372 LEU A 373 GLU A 374	08Y A 600		Details
6VMS_R_08YR601	6vms	08Y	Bromocriptine (DB01200)	Rattus norvegicus; homo sapiens; enterobacteria phage t4	ENDOLYSIN,D(2) DOPAMINE RECEPTOR,D(2) DOPAMINE RECEPTOR	7tm_1 Phage_lysozyme	23	LEU R  94 PHE R 110 VAL R 111 ASP R 114 VAL R 115 CYS R 118 THR R 119 ILE R 122 CYS R 182 ILE R 183 ILE R 184 VAL R 190 SER R 193 SER R 197 TRP R 386 PHE R 389 PHE R 390 HIS R 393 PRO R 405 TYR R 408 SER R 409 THR R 412 TYR R 416	08Y R 601		Details
7JVR_R_08YR500	7jvr	08Y	Bromocriptine (DB01200)	Escherichia coli; homo sapiens; synthetic construct	SOLUBLE CYTOCHROME B562,D(2) DOPAMINE RECEPTOR	7tm_1	21	LEU R  94 PHE R 110 VAL R 111 ASP R 114 VAL R 115 CYS R 118 THR R 119 ILE R 122 ILE R 183 ILE R 184 VAL R 190 SER R 193 SER R 194 SER R 197 TRP R 386 PHE R 389 PHE R 390 HIS R 393 TYR R 408 THR R 412 TYR R 416	08Y R 500		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3UA1_A_08YA600","3ua1","08Y","Bromocriptine (DB01200)","Homo sapiens","CYTOCHROME P450 3A4","p450",22,"TYR A 53;PHE A 57;ASP A 76;ARG A 105;ARG A 106;PRO A 107;PHE A 108;SER A 119;ILE A 120;ARG A 212;PHE A 213;PHE A 215;THR A 224;ILE A 301;PHE A 304;ALA A 305;THR A 309;ALA A 370;MET A 371;ARG A 372;LEU A 373;GLU A 374","08Y A 600\r"],["6VMS_R_08YR601","6vms","08Y","Bromocriptine (DB01200)","Rattus norvegicus;homo sapiens;enterobacteria phage t4","ENDOLYSIN,D(2) DOPAMINE RECEPTOR,D(2) DOPAMINE RECEPTOR","7tm_1;Phage_lysozyme",23,"LEU R 94;PHE R 110;VAL R 111;ASP R 114;VAL R 115;CYS R 118;THR R 119;ILE R 122;CYS R 182;ILE R 183;ILE R 184;VAL R 190;SER R 193;SER R 197;TRP R 386;PHE R 389;PHE R 390;HIS R 393;PRO R 405;TYR R 408;SER R 409;THR R 412;TYR R 416","08Y R 601\r"],["7JVR_R_08YR500","7jvr","08Y","Bromocriptine (DB01200)","Escherichia coli;homo sapiens;synthetic construct","SOLUBLE CYTOCHROME B562,D(2) DOPAMINE RECEPTOR","7tm_1",21,"LEU R 94;PHE R 110;VAL R 111;ASP R 114;VAL R 115;CYS R 118;THR R 119;ILE R 122;ILE R 183;ILE R 184;VAL R 190;SER R 193;SER R 194;SER R 197;TRP R 386;PHE R 389;PHE R 390;HIS R 393;TYR R 408;THR R 412;TYR R 416","08Y R 500\r"]]