Results: Ligand

Ligand ID: TCL

Drugbank ID:
Triclosan
(DB08604)

Indication:
Triclosan is an antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew.

LIST OF BINDING INTERFACES for query 'TCL'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1D7O_A_TCLA502	1d7o	TCL	Triclosan (DB08604)	Brassica napus	ENOYL-[ACYL-CARRIER PROTEIN] REDUCTASE (NADH) PRECURSOR	adh_short_C2	11	ALA A 138 ASN A 139 GLY A 140 VAL A 143 TYR A 188 TYR A 198 MET A 202 LYS A 206 PRO A 235 PHE A 246 ILE A 247	TCL A 502
1QSG_A_TCLA1302	1qsg	TCL	Triclosan (DB08604)	Escherichia coli	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE	adh_short_C2	14	GLY A 93 PHE A 94 ALA A 95 LEU A 100 TYR A 146 TYR A 156 MET A 159 LYS A 163 PRO A 191 ALA A 196 ALA A 197 ILE A 200 PHE A 203 MET A 206	TCL A1302
2B35_A_TCLA300	2b35	TCL	Triclosan (DB08604)	Mycobacterium tuberculosis	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]	adh_short_C2	9	GLY A 96 PHE A 97 MET A 98 MET A 103 PHE A 149 TYR A 158 MET A 161 LYS A 165 PRO A 193	TCL A 300
2O2S_A_TCLA705	2o2s	TCL	Triclosan (DB08604)	Toxoplasma gondii	ENOYL-ACYL CARRIER REDUCTASE	adh_short_C2	14	ALA A 129 ASN A 130 GLY A 131 VAL A 134 TYR A 179 TYR A 189 MET A 193 LYS A 197 PRO A 226 ALA A 231 ALA A 232 ILE A 235 PHE A 243 ILE A 244	TCL A 705
2PD3_A_TCLA2414	2pd3	TCL	Triclosan (DB08604)	Helicobacter pylori	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]	adh_short_C2	12	ALA A 93 PHE A 94 ALA A 95 TYR A 145 TYR A 155 MET A 158 LYS A 162 PRO A 190 ALA A 195 SER A 196 ILE A 199 PHE A 202	TCL A2414
2WYW_A_TCLA1261	2wyw	TCL	Triclosan (DB08604)	Thermus thermophilus	ENOYL-[ACYL CARRIER PROTEIN] REDUCTASE	adh_short_C2	15	ALA A 95 PHE A 96 ALA A 97 MET A 102 TYR A 147 TYR A 157 MET A 160 LYS A 164 PRO A 192 ALA A 197 ALA A 198 SER A 200 ILE A 201 PHE A 204 MET A 207	TCL A1261
3AM5_A_TCLA802	3am5	TCL	Triclosan (DB08604)	Plasmodium falciparum	ENOYL-ACP REDUCTASE	adh_short_C2	14	ALA A 217 ASN A 218 ALA A 219 VAL A 222 TYR A 267 TYR A 277 MET A 281 LYS A 285 PRO A 314 ALA A 319 ALA A 320 ILE A 323 PHE A 368 ILE A 369	TCL A 802
3F4B_A_TCLA400	3f4b	TCL	Triclosan (DB08604)	Plasmodium berghei	ENOYL-ACYL CARRIER PROTEIN REDUCTASE	adh_short_C2	14	ALA A 202 ASN A 203 GLY A 204 VAL A 207 TYR A 252 TYR A 262 MET A 266 LYS A 270 PRO A 299 ALA A 304 ALA A 305 ILE A 308 PHE A 332 ILE A 333	TCL A 400
3NRC_A_TCLA262	3nrc	TCL	Triclosan (DB08604)	Francisella tularensis subsp. tularensis	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (NADH)	adh_short_C2	14	ALA A 92 PHE A 93 ALA A 94 LEU A 99 TYR A 146 TYR A 156 MET A 159 LYS A 163 PRO A 191 ALA A 196 ALA A 197 ILE A 200 PHE A 203 MET A 206	TCL A 262
3OID_A_TCLA601	3oid	TCL	Triclosan (DB08604)	Bacillus subtilis	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH]	adh_short_C2	14	ALA A 91 SER A 92 GLY A 93 LEU A 95 SER A 141 LEU A 148 TYR A 151 VAL A 154 LYS A 158 ALA A 186 ALA A 191 LEU A 192 HIS A 194 PHE A 195	TCL A 601
3OIF_A_TCLA502	3oif	TCL	Triclosan (DB08604)	Bacillus subtilis	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]	adh_short_C2	13	ALA A 96 PHE A 97 ALA A 98 LEU A 103 TYR A 148 TYR A 158 MET A 161 LYS A 165 PRO A 193 SER A 198 ALA A 199 ILE A 202 PHE A 205	TCL A 502
3P9T_A_TCLA221	3p9t	TCL	Triclosan (DB08604)	Stenotrophomonas maltophilia	REPRESSOR	TetR_C_2 TetR_N	16	HIS A 67 PHE A 70 MET A 71 MET A 93 MET A 110 MET A 113 LEU A 114 GLY A 132 PHE A 133 ALA A 136 MET A 140 LEU A 166 HIS A 167 VAL A 170 LEU A 171 LEU A 174	TCL A 221
3P9T_A_TCLA222	3p9t	TCL	Triclosan (DB08604)	Stenotrophomonas maltophilia	REPRESSOR	TetR_C_2 TetR_N	14	VAL A 63 VAL A 66 HIS A 67 PHE A 70 MET A 71 SER A 96 PHE A 97 LEU A 100 LEU A 106 MET A 110 MET A 113 MET A 128 GLN A 129 LEU A 174	TCL A 222
4ALI_A_TCLA1258	4ali	TCL	Triclosan (DB08604)	Staphylococcus aureus	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH]	adh_short_C2	13	ALA A 95 PHE A 96 ALA A 97 LEU A 102 TYR A 147 TYR A 157 MET A 160 LYS A 164 PRO A 192 SER A 197 ALA A 198 VAL A 201 PHE A 204	TCL A1258
4M89_A_TCLA302	4m89	TCL	Triclosan (DB08604)	Neisseria meningitidis	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]	adh_short_C2	16	ILE A 92 GLY A 93 PHE A 94 ALA A 95 LEU A 100 TYR A 147 TYR A 157 MET A 160 LYS A 164 PRO A 192 THR A 195 ALA A 197 ALA A 198 ILE A 201 PHE A 204 LEU A 207	TCL A 302
4NR0_A_TCLA302	4nr0	TCL	Triclosan (DB08604)	Pseudomonas aeruginosa	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] FABI	adh_short_C2	14	GLY A 95 PHE A 96 ALA A 97 LEU A 102 TYR A 149 TYR A 159 MET A 162 LYS A 166 PRO A 194 ALA A 199 ALA A 200 ILE A 203 PHE A 206 MET A 209	TCL A 302
4W9N_B_TCLB1905	4w9n	TCL	Triclosan (DB08604)	Homo sapiens	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE	ADH_zinc_N	16	LEU A1748 LEU B1748 LEU A1753 LEU B1753 VAL B1757 VAL A1757 PHE B1766 PHE A1766 LEU B1780 LEU A1780 ILE B1784 ILE A1784 VAL A1789 VAL B1789 PHE B1791 PHE A1791	TCL B1905
5IFL_B_TCLB301	5ifl	TCL	Triclosan (DB08604)	Burkholderia pseudomallei	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]	adh_short_C2	13	GLY B 93 PHE B 94 ALA B 95 ILE B 100 TYR B 146 TYR B 156 MET B 159 LYS B 163 PRO B 191 ALA B 196 ALA B 197 ILE B 200 PHE B 203	TCL B 301
5YCS_A_TCLA502	5ycs	TCL	Triclosan (DB08604)	Bacillus cereus (strain atcc 14579 / dsm 31 / jcm 2152 / nbrc 15305 / ncimb 9373 / nrrl b-3711)	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] FABI	adh_short_C2	13	ALA A 95 PHE A 96 ALA A 97 LEU A 102 TYR A 147 TYR A 157 MET A 160 LYS A 164 PRO A 192 SER A 197 ALA A 198 VAL A 201 PHE A 204	TCL A 502
6AH9_A_TCLA302	6ah9	TCL	Triclosan (DB08604)	Acinetobacter baumannii atcc 19606 = cip 70.34 = jcm 6841	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]	adh_short_C2	13	GLY A 95 PHE A 96 ALA A 97 LEU A 102 TYR A 149 TYR A 159 LYS A 166 PRO A 194 ALA A 199 ALA A 200 ILE A 203 PHE A 206 MET A 209	TCL A 302
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1D7O_A_TCLA502","1d7o","TCL","Triclosan (DB08604)","Brassica napus","ENOYL-[ACYL-CARRIER PROTEIN] REDUCTASE (NADH) PRECURSOR","adh_short_C2",11,"ALA A 138;ASN A 139;GLY A 140;VAL A 143;TYR A 188;TYR A 198;MET A 202;LYS A 206;PRO A 235;PHE A 246;ILE A 247","TCL A 502\r"],["1QSG_A_TCLA1302","1qsg","TCL","Triclosan (DB08604)","Escherichia coli","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE","adh_short_C2",14,"GLY A  93;PHE A  94;ALA A  95;LEU A 100;TYR A 146;TYR A 156;MET A 159;LYS A 163;PRO A 191;ALA A 196;ALA A 197;ILE A 200;PHE A 203;MET A 206","TCL A1302\r"],["2B35_A_TCLA300","2b35","TCL","Triclosan (DB08604)","Mycobacterium tuberculosis","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]","adh_short_C2",9,"GLY A  96;PHE A  97;MET A  98;MET A 103;PHE A 149;TYR A 158;MET A 161;LYS A 165;PRO A 193","TCL A 300\r"],["2O2S_A_TCLA705","2o2s","TCL","Triclosan (DB08604)","Toxoplasma gondii","ENOYL-ACYL CARRIER REDUCTASE","adh_short_C2",14,"ALA A 129;ASN A 130;GLY A 131;VAL A 134;TYR A 179;TYR A 189;MET A 193;LYS A 197;PRO A 226;ALA A 231;ALA A 232;ILE A 235;PHE A 243;ILE A 244","TCL A 705\r"],["2PD3_A_TCLA2414","2pd3","TCL","Triclosan (DB08604)","Helicobacter pylori","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]","adh_short_C2",12,"ALA A  93;PHE A  94;ALA A  95;TYR A 145;TYR A 155;MET A 158;LYS A 162;PRO A 190;ALA A 195;SER A 196;ILE A 199;PHE A 202","TCL A2414\r"],["2WYW_A_TCLA1261","2wyw","TCL","Triclosan (DB08604)","Thermus thermophilus","ENOYL-[ACYL CARRIER PROTEIN] REDUCTASE","adh_short_C2",15,"ALA A  95;PHE A  96;ALA A  97;MET A 102;TYR A 147;TYR A 157;MET A 160;LYS A 164;PRO A 192;ALA A 197;ALA A 198;SER A 200;ILE A 201;PHE A 204;MET A 207","TCL A1261\r"],["3AM5_A_TCLA802","3am5","TCL","Triclosan (DB08604)","Plasmodium falciparum","ENOYL-ACP REDUCTASE","adh_short_C2",14,"ALA A 217;ASN A 218;ALA A 219;VAL A 222;TYR A 267;TYR A 277;MET A 281;LYS A 285;PRO A 314;ALA A 319;ALA A 320;ILE A 323;PHE A 368;ILE A 369","TCL A 802\r"],["3F4B_A_TCLA400","3f4b","TCL","Triclosan (DB08604)","Plasmodium berghei","ENOYL-ACYL CARRIER PROTEIN REDUCTASE","adh_short_C2",14,"ALA A 202;ASN A 203;GLY A 204;VAL A 207;TYR A 252;TYR A 262;MET A 266;LYS A 270;PRO A 299;ALA A 304;ALA A 305;ILE A 308;PHE A 332;ILE A 333","TCL A 400\r"],["3NRC_A_TCLA262","3nrc","TCL","Triclosan (DB08604)","Francisella tularensis subsp. tularensis","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (NADH)","adh_short_C2",14,"ALA A  92;PHE A  93;ALA A  94;LEU A  99;TYR A 146;TYR A 156;MET A 159;LYS A 163;PRO A 191;ALA A 196;ALA A 197;ILE A 200;PHE A 203;MET A 206","TCL A 262\r"],["3OID_A_TCLA601","3oid","TCL","Triclosan (DB08604)","Bacillus subtilis","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH]","adh_short_C2",14,"ALA A  91;SER A  92;GLY A  93;LEU A  95;SER A 141;LEU A 148;TYR A 151;VAL A 154;LYS A 158;ALA A 186;ALA A 191;LEU A 192;HIS A 194;PHE A 195","TCL A 601\r"],["3OIF_A_TCLA502","3oif","TCL","Triclosan (DB08604)","Bacillus subtilis","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]","adh_short_C2",13,"ALA A  96;PHE A  97;ALA A  98;LEU A 103;TYR A 148;TYR A 158;MET A 161;LYS A 165;PRO A 193;SER A 198;ALA A 199;ILE A 202;PHE A 205","TCL A 502\r"],["3P9T_A_TCLA221","3p9t","TCL","Triclosan (DB08604)","Stenotrophomonas maltophilia","REPRESSOR","TetR_C_2;TetR_N",16,"HIS A  67;PHE A  70;MET A  71;MET A  93;MET A 110;MET A 113;LEU A 114;GLY A 132;PHE A 133;ALA A 136;MET A 140;LEU A 166;HIS A 167;VAL A 170;LEU A 171;LEU A 174","TCL A 221\r"],["3P9T_A_TCLA222","3p9t","TCL","Triclosan (DB08604)","Stenotrophomonas maltophilia","REPRESSOR","TetR_C_2;TetR_N",14,"VAL A  63;VAL A  66;HIS A  67;PHE A  70;MET A  71;SER A  96;PHE A  97;LEU A 100;LEU A 106;MET A 110;MET A 113;MET A 128;GLN A 129;LEU A 174","TCL A 222\r"],["4ALI_A_TCLA1258","4ali","TCL","Triclosan (DB08604)","Staphylococcus aureus","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH]","adh_short_C2",13,"ALA A  95;PHE A  96;ALA A  97;LEU A 102;TYR A 147;TYR A 157;MET A 160;LYS A 164;PRO A 192;SER A 197;ALA A 198;VAL A 201;PHE A 204","TCL A1258\r"],["4M89_A_TCLA302","4m89","TCL","Triclosan (DB08604)","Neisseria meningitidis","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]","adh_short_C2",16,"ILE A  92;GLY A  93;PHE A  94;ALA A  95;LEU A 100;TYR A 147;TYR A 157;MET A 160;LYS A 164;PRO A 192;THR A 195;ALA A 197;ALA A 198;ILE A 201;PHE A 204;LEU A 207","TCL A 302\r"],["4NR0_A_TCLA302","4nr0","TCL","Triclosan (DB08604)","Pseudomonas aeruginosa","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] FABI","adh_short_C2",14,"GLY A  95;PHE A  96;ALA A  97;LEU A 102;TYR A 149;TYR A 159;MET A 162;LYS A 166;PRO A 194;ALA A 199;ALA A 200;ILE A 203;PHE A 206;MET A 209","TCL A 302\r"],["4W9N_B_TCLB1905","4w9n","TCL","Triclosan (DB08604)","Homo sapiens","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE","ADH_zinc_N",16,"LEU A1748;LEU B1748;LEU A1753;LEU B1753;VAL B1757;VAL A1757;PHE B1766;PHE A1766;LEU B1780;LEU A1780;ILE B1784;ILE A1784;VAL A1789;VAL B1789;PHE B1791;PHE A1791","TCL B1905\r"],["5IFL_B_TCLB301","5ifl","TCL","Triclosan (DB08604)","Burkholderia pseudomallei","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]","adh_short_C2",13,"GLY B  93;PHE B  94;ALA B  95;ILE B 100;TYR B 146;TYR B 156;MET B 159;LYS B 163;PRO B 191;ALA B 196;ALA B 197;ILE B 200;PHE B 203","TCL B 301\r"],["5YCS_A_TCLA502","5ycs","TCL","Triclosan (DB08604)","Bacillus cereus (strain atcc 14579 \/ dsm 31 \/ jcm 2152 \/ nbrc 15305 \/ ncimb 9373 \/ nrrl b-3711)","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] FABI","adh_short_C2",13,"ALA A  95;PHE A  96;ALA A  97;LEU A 102;TYR A 147;TYR A 157;MET A 160;LYS A 164;PRO A 192;SER A 197;ALA A 198;VAL A 201;PHE A 204","TCL A 502\r"],["6AH9_A_TCLA302","6ah9","TCL","Triclosan (DB08604)","Acinetobacter baumannii atcc 19606 = cip 70.34 = jcm 6841","ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH]","adh_short_C2",13,"GLY A  95;PHE A  96;ALA A  97;LEU A 102;TYR A 149;TYR A 159;LYS A 166;PRO A 194;ALA A 199;ALA A 200;ILE A 203;PHE A 206;MET A 209","TCL A 302\r"]]