Results: Ligand

Ligand ID: COM

Drugbank ID:
Coenzyme m
(DB09110)

Indication:
Coenzyme M is a uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract.

LIST OF BINDING INTERFACES for query 'DB09110'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1E6V_A_COMA1555	1e6v	COM	Coenzyme m (DB09110)	Methanopyrus kandleri	METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT; METHYL-COENZYME M REDUCTASE I BETA SUBUNIT; METHYL-COENZYME M REDUCTASE I GAMMA SUBUNIT	MCR_alpha MCR_alpha_N MCR_beta MCR_beta_N MCR_gamma	8	LEU F 121 ARG F 124 TYR D 336 PHE E 362 SER E 366 TYR E 368 PHE D 446 TYR D 447	COM A1555
1E6Y_A_COMA2572	1e6y	COM	Coenzyme m (DB09110)	Methanosarcina barkeri	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT; METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA; METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA	MCR_alpha MCR_alpha_N MCR_beta MCR_beta_N MCR_gamma	8	TYR A1346 PHE A1463 PHE A1464 PHE B2359 SER B2363 TYR B2365 LEU C3118 ARG C3121	COM A2572
3Q6J_B_COMB525	3q6j	COM	Coenzyme m (DB09110)	Xanthobacter autotrophicus	2-OXOPROPYL-COM REDUCTASE, CARBOXYLATING	Pyr_redox Pyr_redox_dim	12	GLY B 52 ALA B 53 ARG B 56 PHE B 57 GLY B 79 CYS B 82 PRO B 83 VAL B 88 MET B 140 MET B 361 ARG B 365 PHE A 501	COM B 525
3SQG_A_COMA1003	3sqg	COM	Coenzyme m (DB09110)	Uncultured archaeon	METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT; METHYL-COENZYME M REDUCTASE, BETA SUBUNIT; METHYL-COENZYME M REDUCTASE, GAMMA SUBUNIT	MCR_alpha MCR_alpha_N MCR_beta MCR_beta_N MCR_gamma	8	LEU C 117 ARG C 120 TYR A 347 PHE B 357 SER B 361 TYR B 363 PHE A 462 PHE A 463	COM A1003
4AY8_A_COMA500	4ay8	COM	Coenzyme m (DB09110)	Methanosarcina mazei	METHYLCOBALAMIN: COENZYME M METHYLTRANSFERASE	URO-D	12	THR A 31 GLN A 32 ARG A 73 TYR A 76 LEU A 78 GLN A 97 ALA A 204 PRO A 206 HIS A 240 CYS A 242 CYS A 319 GLY A 320	COM A 500
4POM_A_COMA200	4pom	COM	Coenzyme m (DB09110)	Homo sapiens	THIOREDOXIN	Thioredoxin	7	LYS A 8 PHE A 11 GLN A 12 GLU A 68 CYS A 69 GLN A 78 PHE A 80	COM A 200
4RQR_A_COMA202	4rqr	COM	Coenzyme m (DB09110)	Homo sapiens	GLUTAREDOXIN-1	Glutaredoxin	5	TYR A 24 ARG A 27 CYS A 82 SER A 83 VAL A 86	COM A 202
4RQX_A_COMA301	4rqx	COM	Coenzyme m (DB09110)	Homo sapiens	PEROXIREDOXIN-4	1-cysPrx_C AhpC-TSA	3	CYS A 124 PRO A 125 ARG A 164	COM A 301
4TT7_A_COMA1501	4tt7	COM	Coenzyme m (DB09110)	Homo sapiens	ALK TYROSINE KINASE RECEPTOR	PK_Tyr_Ser-Thr	4	ARG A1231 CYS A1235 GLN A1238 LEU A1380	COM A1501
4TT7_A_COMA1502	4tt7	COM	Coenzyme m (DB09110)	Homo sapiens	ALK TYROSINE KINASE RECEPTOR	PK_Tyr_Ser-Thr	4	GLY A1128 VAL A1155 CYS A1156 ASP A1160	COM A1502
5A0Y_A_COMA555	5a0y	COM	Coenzyme m (DB09110)	Methanothermobacter marburgensis	METHYL-COENZYME M REDUCTASE I SUBUNIT ALPHA; METHYL-COENZYME M REDUCTASE I SUBUNIT BETA; METHYL-COENZYME M REDUCTASE I SUBUNIT GAMMA	MCR_alpha MCR_alpha_N MCR_beta MCR_beta_N MCR_gamma	8	LEU C 117 ARG C 120 TYR A 333 PHE B 361 SER B 365 TYR B 367 PHE A 443 TYR A 444	COM A 555
5A8W_A_COMA1553	5a8w	COM	Coenzyme m (DB09110)	Methanothermobacter wolfeii	METHYL-COENZYME M II REDUCTASE; METHYL-COENZYME M REDUCTASE II	MCR_alpha MCR_alpha_N MCR_beta MCR_beta_N MCR_gamma	8	LEU C 120 ARG C 123 TYR A 336 PHE B 361 SER B 365 TYR B 367 PHE A 446 TYR A 447	COM A1553
5AXR_A_COMA309	5axr	COM	Coenzyme m (DB09110)	Serratia marcescens	METALLO-BETA-LACTAMASE	Lactamase_B	11	TRP A 5 HIS A 72 HIS A 74 ASP A 76 HIS A 77 GLN A 113 LEU A 117 HIS A 150 SER A 175 VAL A 179 HIS A 215	COM A 309
5N1Q_A_COMA604	5n1q	COM	Coenzyme m (DB09110)	Methanothermococcus thermolithotrophicus dsm 2095	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT ALPHA; METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA; METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA	MCR_alpha MCR_alpha_N MCR_beta MCR_beta_N MCR_gamma	8	LEU F 120 ARG F 123 TYR D 336 PHE E 361 SER E 365 TYR E 367 PHE D 446 TYR D 447	COM A 604
5ODH_B_COMB303	5odh	COM	Coenzyme m (DB09110)	Methanothermococcus thermolithotrophicus dsm 2095	HETERODISULFIDE REDUCTASE, SUBUNIT B; HETERODISULFIDE REDUCTASE, SUBUNIT C	CCG Fer4_8	12	ALA B 44 PRO B 45 GLY B 46 VAL B 47 THR C 79 GLY B 80 HIS B 154 GLY B 197 GLY B 198 GLY B 199 CYS B 231 PHE B 233	COM B 303
7NKG_A_COMA603	7nkg	COM	Coenzyme m (DB09110)	Methermicoccus shengliensis dsm 18856	METHYL-COENZYME M REDUCTASE ALPHA SUBUNIT; METHYL-COENZYME M REDUCTASE BETA SUBUNIT; METHYL-COENZYME M REDUCTASE GAMMA SUBUNIT	NA	8	LEU C 118 ARG C 121 TYR A 350 PHE B 358 SER B 362 TYR B 364 PHE A 461 PHE A 462	COM A 603
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1E6V_A_COMA1555","1e6v","COM","Coenzyme m (DB09110)","Methanopyrus kandleri","METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE I BETA SUBUNIT;METHYL-COENZYME M REDUCTASE I GAMMA SUBUNIT","MCR_alpha;MCR_alpha_N;MCR_beta;MCR_beta_N;MCR_gamma",8,"LEU F 121;ARG F 124;TYR D 336;PHE E 362;SER E 366;TYR E 368;PHE D 446;TYR D 447","COM A1555\r"],["1E6Y_A_COMA2572","1e6y","COM","Coenzyme m (DB09110)","Methanosarcina barkeri","METHYL-COENZYME M REDUCTASE I BETA SUBUNIT;METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA;METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA","MCR_alpha;MCR_alpha_N;MCR_beta;MCR_beta_N;MCR_gamma",8,"TYR A1346;PHE A1463;PHE A1464;PHE B2359;SER B2363;TYR B2365;LEU C3118;ARG C3121","COM A2572\r"],["3Q6J_B_COMB525","3q6j","COM","Coenzyme m (DB09110)","Xanthobacter autotrophicus","2-OXOPROPYL-COM REDUCTASE, CARBOXYLATING","Pyr_redox;Pyr_redox_dim",12,"GLY B  52;ALA B  53;ARG B  56;PHE B  57;GLY B  79;CYS B  82;PRO B  83;VAL B  88;MET B 140;MET B 361;ARG B 365;PHE A 501","COM B 525\r"],["3SQG_A_COMA1003","3sqg","COM","Coenzyme m (DB09110)","Uncultured archaeon","METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE, BETA SUBUNIT;METHYL-COENZYME M REDUCTASE, GAMMA SUBUNIT","MCR_alpha;MCR_alpha_N;MCR_beta;MCR_beta_N;MCR_gamma",8,"LEU C 117;ARG C 120;TYR A 347;PHE B 357;SER B 361;TYR B 363;PHE A 462;PHE A 463","COM A1003\r"],["4AY8_A_COMA500","4ay8","COM","Coenzyme m (DB09110)","Methanosarcina mazei","METHYLCOBALAMIN: COENZYME M METHYLTRANSFERASE","URO-D",12,"THR A  31;GLN A  32;ARG A  73;TYR A  76;LEU A  78;GLN A  97;ALA A 204;PRO A 206;HIS A 240;CYS A 242;CYS A 319;GLY A 320","COM A 500\r"],["4POM_A_COMA200","4pom","COM","Coenzyme m (DB09110)","Homo sapiens","THIOREDOXIN","Thioredoxin",7,"LYS A   8;PHE A  11;GLN A  12;GLU A  68;CYS A  69;GLN A  78;PHE A  80","COM A 200\r"],["4RQR_A_COMA202","4rqr","COM","Coenzyme m (DB09110)","Homo sapiens","GLUTAREDOXIN-1","Glutaredoxin",5,"TYR A  24;ARG A  27;CYS A  82;SER A  83;VAL A  86","COM A 202\r"],["4RQX_A_COMA301","4rqx","COM","Coenzyme m (DB09110)","Homo sapiens","PEROXIREDOXIN-4","1-cysPrx_C;AhpC-TSA",3,"CYS A 124;PRO A 125;ARG A 164","COM A 301\r"],["4TT7_A_COMA1501","4tt7","COM","Coenzyme m (DB09110)","Homo sapiens","ALK TYROSINE KINASE RECEPTOR","PK_Tyr_Ser-Thr",4,"ARG A1231;CYS A1235;GLN A1238;LEU A1380","COM A1501\r"],["4TT7_A_COMA1502","4tt7","COM","Coenzyme m (DB09110)","Homo sapiens","ALK TYROSINE KINASE RECEPTOR","PK_Tyr_Ser-Thr",4,"GLY A1128;VAL A1155;CYS A1156;ASP A1160","COM A1502\r"],["5A0Y_A_COMA555","5a0y","COM","Coenzyme m (DB09110)","Methanothermobacter marburgensis","METHYL-COENZYME M REDUCTASE I SUBUNIT ALPHA;METHYL-COENZYME M REDUCTASE I SUBUNIT BETA;METHYL-COENZYME M REDUCTASE I SUBUNIT GAMMA","MCR_alpha;MCR_alpha_N;MCR_beta;MCR_beta_N;MCR_gamma",8,"LEU C 117;ARG C 120;TYR A 333;PHE B 361;SER B 365;TYR B 367;PHE A 443;TYR A 444","COM A 555\r"],["5A8W_A_COMA1553","5a8w","COM","Coenzyme m (DB09110)","Methanothermobacter wolfeii","METHYL-COENZYME M II REDUCTASE;METHYL-COENZYME M REDUCTASE II","MCR_alpha;MCR_alpha_N;MCR_beta;MCR_beta_N;MCR_gamma",8,"LEU C 120;ARG C 123;TYR A 336;PHE B 361;SER B 365;TYR B 367;PHE A 446;TYR A 447","COM A1553\r"],["5AXR_A_COMA309","5axr","COM","Coenzyme m (DB09110)","Serratia marcescens","METALLO-BETA-LACTAMASE","Lactamase_B",11,"TRP A   5;HIS A  72;HIS A  74;ASP A  76;HIS A  77;GLN A 113;LEU A 117;HIS A 150;SER A 175;VAL A 179;HIS A 215","COM A 309\r"],["5N1Q_A_COMA604","5n1q","COM","Coenzyme m (DB09110)","Methanothermococcus thermolithotrophicus dsm 2095","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT ALPHA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","MCR_alpha;MCR_alpha_N;MCR_beta;MCR_beta_N;MCR_gamma",8,"LEU F 120;ARG F 123;TYR D 336;PHE E 361;SER E 365;TYR E 367;PHE D 446;TYR D 447","COM A 604\r"],["5ODH_B_COMB303","5odh","COM","Coenzyme m (DB09110)","Methanothermococcus thermolithotrophicus dsm 2095","HETERODISULFIDE REDUCTASE, SUBUNIT B;HETERODISULFIDE REDUCTASE, SUBUNIT C","CCG;Fer4_8",12,"ALA B  44;PRO B  45;GLY B  46;VAL B  47;THR C  79;GLY B  80;HIS B 154;GLY B 197;GLY B 198;GLY B 199;CYS B 231;PHE B 233","COM B 303\r"],["7NKG_A_COMA603","7nkg","COM","Coenzyme m (DB09110)","Methermicoccus shengliensis dsm 18856","METHYL-COENZYME M REDUCTASE ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE BETA SUBUNIT;METHYL-COENZYME M REDUCTASE GAMMA SUBUNIT","NA",8,"LEU C 118;ARG C 121;TYR A 350;PHE B 358;SER B 362;TYR B 364;PHE A 461;PHE A 462","COM A 603\r"]]