Results: Ligand

Ligand ID: XIN

Drugbank ID:
Nintedanib
(DB09079)

Indication:
Nintedanib is a triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer.

LIST OF BINDING INTERFACES for query 'XIN'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3C7Q_A_XINA1172	3c7q	XIN	Nintedanib (DB09079)	Homo sapiens	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	PK_Tyr_Ser-Thr	19	LEU A 840 GLY A 841 VAL A 848 GLU A 850 ALA A 866 LYS A 868 GLU A 885 LEU A 889 VAL A 899 VAL A 916 GLU A 917 PHE A 918 CYS A 919 LYS A 920 PHE A 921 GLY A 922 LEU A1035 CYS A1045 ASP A1046	XIN A1172
5MAF_A_XINA403	5maf	XIN	Nintedanib (DB09079)	Homo sapiens	MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE	Pkinase	22	GLU A 15 ILE A 17 GLY A 18 THR A 19 VAL A 25 LEU A 27 ALA A 38 LYS A 40 GLU A 57 LEU A 61 CYS A 70 LEU A 86 GLU A 87 TYR A 88 CYS A 89 PRO A 90 GLY A 92 GLU A 93 LEU A 139 ILE A 149 ASP A 150 PHE A 151	XIN A 403
5TE0_A_XINA401	5te0	XIN	Nintedanib (DB09079)	Homo sapiens	AP2-ASSOCIATED PROTEIN KINASE 1	Pkinase	25	GLU A 50 LEU A 52 ALA A 53 VAL A 60 LEU A 62 ALA A 72 LYS A 74 GLU A 90 MET A 94 SER A 98 VAL A 104 ILE A 124 MET A 126 ASP A 127 PHE A 128 CYS A 129 ARG A 130 GLY A 131 GLY A 132 GLN A 133 ASN A 136 LEU A 183 CYS A 193 ASP A 194 PHE A 195	XIN A 401
6NEC_A_XINA1101	6nec	XIN	Nintedanib (DB09079)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET	PK_Tyr_Ser-Thr	21	THR A 729 LEU A 730 GLY A 731 GLU A 732 VAL A 738 ALA A 756 LYS A 758 GLU A 775 LEU A 779 ILE A 788 VAL A 804 GLU A 805 TYR A 806 ALA A 807 LYS A 808 TYR A 809 GLY A 810 SER A 811 LEU A 881 SER A 891 ASP A 892	XIN A1101
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3C7Q_A_XINA1172","3c7q","XIN","Nintedanib (DB09079)","Homo sapiens","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","PK_Tyr_Ser-Thr",19,"LEU A 840;GLY A 841;VAL A 848;GLU A 850;ALA A 866;LYS A 868;GLU A 885;LEU A 889;VAL A 899;VAL A 916;GLU A 917;PHE A 918;CYS A 919;LYS A 920;PHE A 921;GLY A 922;LEU A1035;CYS A1045;ASP A1046","XIN A1172\r"],["5MAF_A_XINA403","5maf","XIN","Nintedanib (DB09079)","Homo sapiens","MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE","Pkinase",22,"GLU A  15;ILE A  17;GLY A  18;THR A  19;VAL A  25;LEU A  27;ALA A  38;LYS A  40;GLU A  57;LEU A  61;CYS A  70;LEU A  86;GLU A  87;TYR A  88;CYS A  89;PRO A  90;GLY A  92;GLU A  93;LEU A 139;ILE A 149;ASP A 150;PHE A 151","XIN A 403\r"],["5TE0_A_XINA401","5te0","XIN","Nintedanib (DB09079)","Homo sapiens","AP2-ASSOCIATED PROTEIN KINASE 1","Pkinase",25,"GLU A  50;LEU A  52;ALA A  53;VAL A  60;LEU A  62;ALA A  72;LYS A  74;GLU A  90;MET A  94;SER A  98;VAL A 104;ILE A 124;MET A 126;ASP A 127;PHE A 128;CYS A 129;ARG A 130;GLY A 131;GLY A 132;GLN A 133;ASN A 136;LEU A 183;CYS A 193;ASP A 194;PHE A 195","XIN A 401\r"],["6NEC_A_XINA1101","6nec","XIN","Nintedanib (DB09079)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET","PK_Tyr_Ser-Thr",21,"THR A 729;LEU A 730;GLY A 731;GLU A 732;VAL A 738;ALA A 756;LYS A 758;GLU A 775;LEU A 779;ILE A 788;VAL A 804;GLU A 805;TYR A 806;ALA A 807;LYS A 808;TYR A 809;GLY A 810;SER A 811;LEU A 881;SER A 891;ASP A 892","XIN A1101\r"]]