Results: Ligand

Ligand ID: 9CR

Drugbank ID:
Alitretinoin
(DB00523)

Indication:
Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.

LIST OF BINDING INTERFACES for query 'DB00523'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1EPB_A_9CRA165	1epb	9CR	Alitretinoin (DB00523)	Rattus norvegicus	EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN	Lipocalin	19	PHE A 6 ILE A 8 PHE A 11 TRP A 15 MET A 39 VAL A 41 LEU A 48 LEU A 50 ALA A 67 PHE A 76 VAL A 78 LYS A 85 VAL A 87 VAL A 89 ALA A 98 ILE A 100 ILE A 102 LYS A 115 TYR A 117	9CR A 165
1TYR_A_9CRA131	1tyr	9CR	Alitretinoin (DB00523)	Homo sapiens	TRANSTHYRETIN	Transthyretin	8	LYS A 15 LEU A 17 ALA A 108 ALA A 109 LEU A 110 SER A 117 THR A 118 THR A 119	9CR A 131
1XDK_B_9CRB600	1xdk	9CR	Alitretinoin (DB00523)	Mus musculus; synthetic construct	RETINOIC ACID RECEPTOR, BETA	Hormone_recep	21	PHE B 192 TRP B 218 PHE B 221 LEU B 224 ALA B 225 CYS B 228 LEU B 259 LEU B 262 ILE B 263 ILE B 266 ARG B 269 PHE B 279 SER B 280 GLY B 294 PHE B 295 LEU B 298 GLY B 384 ARG B 387 VAL B 388 ILE B 403 LEU B 407	9CR B 600
1XIU_A_9CRA201	1xiu	9CR	Alitretinoin (DB00523)	Biomphalaria glabrata; synthetic construct	RXR-LIKE PROTEIN	Hormone_recep	20	ILE A 242 CYS A 243 ALA A 245 ALA A 246 GLN A 249 TRP A 279 ASN A 280 LEU A 283 ILE A 284 PHE A 287 ARG A 290 LEU A 300 ALA A 301 VAL A 316 ILE A 319 PHE A 320 CYS A 406 HIS A 409 LEU A 410 PHE A 413	9CR A 201
2NNH_A_9CRA501	2nnh	9CR	Alitretinoin (DB00523)	Homo sapiens	CYTOCHROME P450 2C8	p450	16	ARG A 97 GLY A 98 ASN A 99 SER A 100 SER A 103 ILE A 113 SER A 114 PHE A 205 VAL A 296 ALA A 297 THR A 301 VAL A 362 VAL A 366 PRO A 367 ILE A 476 VAL A 477	9CR A 501
2NNH_A_9CRA502	2nnh	9CR	Alitretinoin (DB00523)	Homo sapiens	CYTOCHROME P450 2C8	p450	17	SER A 100 ILE A 102 SER A 103 ILE A 106 PHE A 201 ASN A 204 PHE A 205 LEU A 208 ASN A 209 ILE A 213 GLN A 214 ASN A 217 VAL A 237 ARG A 241 VAL A 296 ILE A 476 VAL A 477	9CR A 502
5JI0_A_9CRA501	5ji0	9CR	Alitretinoin (DB00523)	Homo sapiens; synthetic construct	RETINOIC ACID RECEPTOR RXR-ALPHA	Hormone_recep	18	ILE A 268 ALA A 271 ALA A 272 GLN A 275 TRP A 305 ASN A 306 LEU A 309 PHE A 313 ARG A 316 ILE A 324 LEU A 325 LEU A 326 ALA A 327 VAL A 342 ILE A 345 PHE A 346 CYS A 432 LEU A 436	9CR A 501
5M24_A_9CRA501	5m24	9CR	Alitretinoin (DB00523)	Homo sapiens	RETINOIC ACID RECEPTOR GAMMA	Hormone_recep	21	TRP A 227 PHE A 230 LEU A 233 ALA A 234 CYS A 237 LEU A 268 LEU A 271 MET A 272 ILE A 275 ARG A 278 PHE A 288 SER A 289 GLY A 303 PHE A 304 LEU A 307 GLY A 393 ALA A 397 LEU A 400 MET A 408 ILE A 412 MET A 415	9CR A 501
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1EPB_A_9CRA165","1epb","9CR","Alitretinoin (DB00523)","Rattus norvegicus","EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN","Lipocalin",19,"PHE A   6;ILE A   8;PHE A  11;TRP A  15;MET A  39;VAL A  41;LEU A  48;LEU A  50;ALA A  67;PHE A  76;VAL A  78;LYS A  85;VAL A  87;VAL A  89;ALA A  98;ILE A 100;ILE A 102;LYS A 115;TYR A 117","9CR A 165\r"],["1TYR_A_9CRA131","1tyr","9CR","Alitretinoin (DB00523)","Homo sapiens","TRANSTHYRETIN","Transthyretin",8,"LYS A  15;LEU A  17;ALA A 108;ALA A 109;LEU A 110;SER A 117;THR A 118;THR A 119","9CR A 131\r"],["1XDK_B_9CRB600","1xdk","9CR","Alitretinoin (DB00523)","Mus musculus;synthetic construct","RETINOIC ACID RECEPTOR, BETA","Hormone_recep",21,"PHE B 192;TRP B 218;PHE B 221;LEU B 224;ALA B 225;CYS B 228;LEU B 259;LEU B 262;ILE B 263;ILE B 266;ARG B 269;PHE B 279;SER B 280;GLY B 294;PHE B 295;LEU B 298;GLY B 384;ARG B 387;VAL B 388;ILE B 403;LEU B 407","9CR B 600\r"],["1XIU_A_9CRA201","1xiu","9CR","Alitretinoin (DB00523)","Biomphalaria glabrata;synthetic construct","RXR-LIKE PROTEIN","Hormone_recep",20,"ILE A 242;CYS A 243;ALA A 245;ALA A 246;GLN A 249;TRP A 279;ASN A 280;LEU A 283;ILE A 284;PHE A 287;ARG A 290;LEU A 300;ALA A 301;VAL A 316;ILE A 319;PHE A 320;CYS A 406;HIS A 409;LEU A 410;PHE A 413","9CR A 201\r"],["2NNH_A_9CRA501","2nnh","9CR","Alitretinoin (DB00523)","Homo sapiens","CYTOCHROME P450 2C8","p450",16,"ARG A  97;GLY A  98;ASN A  99;SER A 100;SER A 103;ILE A 113;SER A 114;PHE A 205;VAL A 296;ALA A 297;THR A 301;VAL A 362;VAL A 366;PRO A 367;ILE A 476;VAL A 477","9CR A 501\r"],["2NNH_A_9CRA502","2nnh","9CR","Alitretinoin (DB00523)","Homo sapiens","CYTOCHROME P450 2C8","p450",17,"SER A 100;ILE A 102;SER A 103;ILE A 106;PHE A 201;ASN A 204;PHE A 205;LEU A 208;ASN A 209;ILE A 213;GLN A 214;ASN A 217;VAL A 237;ARG A 241;VAL A 296;ILE A 476;VAL A 477","9CR A 502\r"],["5JI0_A_9CRA501","5ji0","9CR","Alitretinoin (DB00523)","Homo sapiens;synthetic construct","RETINOIC ACID RECEPTOR RXR-ALPHA","Hormone_recep",18,"ILE A 268;ALA A 271;ALA A 272;GLN A 275;TRP A 305;ASN A 306;LEU A 309;PHE A 313;ARG A 316;ILE A 324;LEU A 325;LEU A 326;ALA A 327;VAL A 342;ILE A 345;PHE A 346;CYS A 432;LEU A 436","9CR A 501\r"],["5M24_A_9CRA501","5m24","9CR","Alitretinoin (DB00523)","Homo sapiens","RETINOIC ACID RECEPTOR GAMMA","Hormone_recep",21,"TRP A 227;PHE A 230;LEU A 233;ALA A 234;CYS A 237;LEU A 268;LEU A 271;MET A 272;ILE A 275;ARG A 278;PHE A 288;SER A 289;GLY A 303;PHE A 304;LEU A 307;GLY A 393;ALA A 397;LEU A 400;MET A 408;ILE A 412;MET A 415","9CR A 501\r"]]