Ligand ID: 1LT

Drugbank ID:
Alpelisib
(DB12015)

Indication:
Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid...

LIST OF BINDING INTERFACES for query '1LT'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4JPS_A_1LTA1102	4jps	1LT	Alpelisib (DB12015)	Homo sapiens	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM	PI3K_C2 PI3K_p85B PI3K_rbd PI3Ka PI3_PI4_kinase	19	MET A 772 PRO A 778 TRP A 780 ILE A 800 LYS A 802 TYR A 836 ILE A 848 GLU A 849 VAL A 850 VAL A 851 ARG A 852 ASN A 853 SER A 854 HIS A 855 GLN A 859 MET A 922 PHE A 930 ILE A 932 ASP A 933	1LT A1102		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4JPS_A_1LTA1102","4jps","1LT","Alpelisib (DB12015)","Homo sapiens","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","PI3K_C2;PI3K_p85B;PI3K_rbd;PI3Ka;PI3_PI4_kinase",19,"MET A 772;PRO A 778;TRP A 780;ILE A 800;LYS A 802;TYR A 836;ILE A 848;GLU A 849;VAL A 850;VAL A 851;ARG A 852;ASN A 853;SER A 854;HIS A 855;GLN A 859;MET A 922;PHE A 930;ILE A 932;ASP A 933","1LT A1102\r"]]