Ligand ID: 2YQ

Drugbank ID:
Talazoparib
(DB11760)

Indication:
Talazoparib is a poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer.


LIST OF BINDING INTERFACES for query 'DB11760'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
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DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details
4PJV_A_2YQA6014pjv 2YQTalazoparib
(DB11760) 		Homo sapiens POLY [ADP-RIBOSE] POLYMERASE 2 PARP 16SER A 328
GLN A 332
GLU A 335
TRP A 427
HIS A 428
GLY A 429
GLY A 454
TYR A 455
TYR A 462
PHE A 463
ALA A 464
LYS A 469
SER A 470
TYR A 473
ASN A 557
GLU A 558
2YQ A 601
7KK3_A_2YQA90017kk3 2YQTalazoparib
(DB11760) 		Homo sapiens POLY [ADP-RIBOSE] POLYMERASE 1 PARP
PARP_reg 		14GLU A 763
TRP A 861
HIS A 862
GLY A 863
GLY A 888
TYR A 889
TYR A 896
PHE A 897
ALA A 898
LYS A 903
SER A 904
TYR A 907
ASN A 987
GLU A 988
2YQ A9001
7KKN_A_2YQA90027kkn 2YQTalazoparib
(DB11760) 		Homo sapiens POLY [ADP-RIBOSE] POLYMERASE PARP 14PHE A1183
HIS A1184
GLY A1185
GLY A1205
GLY A1206
TYR A1213
PHE A1214
ALA A1215
LYS A1220
SER A1221
TYR A1224
ILE A1228
ALA A1290
GLU A1291
2YQ A9002
DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details