Results: Ligand

Ligand ID: 1YN

Drugbank ID:
Itraconazole
(DB01167)

Indication:
Itraconazole is an antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis.

LIST OF BINDING INTERFACES for query 'DB01167'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
5ESG_A_1YNA701	5esg	1YN	Itraconazole (DB01167)	Saccharomyces cerevisiae (strain yjm789)	LANOSTEROL 14-ALPHA DEMETHYLASE	p450	29	TYR A 72 GLU A 73 LEU A 96 TYR A 126 LEU A 129 THR A 130 PHE A 134 ILE A 139 TYR A 140 PHE A 236 PRO A 238 ILE A 239 PHE A 241 VAL A 242 GLY A 310 VAL A 311 GLY A 314 GLY A 315 THR A 318 LEU A 380 HIS A 381 SER A 382 LEU A 383 PHE A 384 CYS A 470 PHE A 506 THR A 507 SER A 508 MET A 509	1YN A 701
5JLC_A_1YNA602	5jlc	1YN	Itraconazole (DB01167)	Candida glabrata (strain atcc 2001 / cbs 138 / jcm 3761 / nbrc 0622 / nrrl y-65)	LANOSTEROL 14-ALPHA DEMETHYLASE	p450	29	ALA A 70 ILE A 71 TYR A 73 GLY A 74 THR A 75 LEU A 96 TYR A 127 THR A 131 PHE A 135 ILE A 140 TYR A 141 PHE A 237 PRO A 239 PHE A 242 GLY A 311 VAL A 312 MET A 314 GLY A 315 THR A 319 LEU A 381 HIS A 382 SER A 383 LEU A 384 PHE A 385 CYS A 472 PHE A 509 THR A 510 SER A 511 MET A 512	1YN A 602
5V5Z_A_1YNA602	5v5z	1YN	Itraconazole (DB01167)	Candida albicans (strain sc5314 / atcc mya-2876)	LANOSTEROL 14-ALPHA DEMETHYLASE	p450	25	ALA A 61 TYR A 64 GLY A 65 TYR A 118 THR A 122 PHE A 126 ILE A 131 TYR A 132 PHE A 228 PRO A 230 PHE A 233 LEU A 300 GLY A 303 ILE A 304 GLY A 307 GLY A 308 THR A 311 LEU A 376 HIS A 377 SER A 378 PHE A 380 TYR A 505 SER A 506 SER A 507 MET A 508	1YN A 602
6AYC_A_1YNA502	6ayc	1YN	Itraconazole (DB01167)	Naegleria fowleri	PROTEIN CYP51	p450	27	PHE A 50 PHE A 53 ALA A 54 PRO A 57 TYR A 107 PHE A 109 MET A 110 PHE A 114 VAL A 119 TYR A 120 PRO A 213 LEU A 214 PHE A 216 PHE A 217 ALA A 289 GLY A 290 PHE A 292 ALA A 293 THR A 297 LEU A 358 ILE A 359 MET A 360 MET A 362 CYS A 430 TYR A 464 THR A 465 LEU A 467	1YN A 502
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["5ESG_A_1YNA701","5esg","1YN","Itraconazole (DB01167)","Saccharomyces cerevisiae (strain yjm789)","LANOSTEROL 14-ALPHA DEMETHYLASE","p450",29,"TYR A  72;GLU A  73;LEU A  96;TYR A 126;LEU A 129;THR A 130;PHE A 134;ILE A 139;TYR A 140;PHE A 236;PRO A 238;ILE A 239;PHE A 241;VAL A 242;GLY A 310;VAL A 311;GLY A 314;GLY A 315;THR A 318;LEU A 380;HIS A 381;SER A 382;LEU A 383;PHE A 384;CYS A 470;PHE A 506;THR A 507;SER A 508;MET A 509","1YN A 701\r"],["5JLC_A_1YNA602","5jlc","1YN","Itraconazole (DB01167)","Candida glabrata (strain atcc 2001 \/ cbs 138 \/ jcm 3761 \/ nbrc 0622 \/ nrrl y-65)","LANOSTEROL 14-ALPHA DEMETHYLASE","p450",29,"ALA A  70;ILE A  71;TYR A  73;GLY A  74;THR A  75;LEU A  96;TYR A 127;THR A 131;PHE A 135;ILE A 140;TYR A 141;PHE A 237;PRO A 239;PHE A 242;GLY A 311;VAL A 312;MET A 314;GLY A 315;THR A 319;LEU A 381;HIS A 382;SER A 383;LEU A 384;PHE A 385;CYS A 472;PHE A 509;THR A 510;SER A 511;MET A 512","1YN A 602\r"],["5V5Z_A_1YNA602","5v5z","1YN","Itraconazole (DB01167)","Candida albicans (strain sc5314 \/ atcc mya-2876)","LANOSTEROL 14-ALPHA DEMETHYLASE","p450",25,"ALA A  61;TYR A  64;GLY A  65;TYR A 118;THR A 122;PHE A 126;ILE A 131;TYR A 132;PHE A 228;PRO A 230;PHE A 233;LEU A 300;GLY A 303;ILE A 304;GLY A 307;GLY A 308;THR A 311;LEU A 376;HIS A 377;SER A 378;PHE A 380;TYR A 505;SER A 506;SER A 507;MET A 508","1YN A 602\r"],["6AYC_A_1YNA502","6ayc","1YN","Itraconazole (DB01167)","Naegleria fowleri","PROTEIN CYP51","p450",27,"PHE A  50;PHE A  53;ALA A  54;PRO A  57;TYR A 107;PHE A 109;MET A 110;PHE A 114;VAL A 119;TYR A 120;PRO A 213;LEU A 214;PHE A 216;PHE A 217;ALA A 289;GLY A 290;PHE A 292;ALA A 293;THR A 297;LEU A 358;ILE A 359;MET A 360;MET A 362;CYS A 430;TYR A 464;THR A 465;LEU A 467","1YN A 502\r"]]