Results: Ligand

Ligand ID: DGX

Drugbank ID:
Digoxin
(DB00390)

Indication:
Digoxin is a cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation.

LIST OF BINDING INTERFACES for query 'DB00390'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1IGJ_B_DGXB228	1igj	DGX	Digoxin (DB00390)	Mus musculus	IGG2A-KAPPA 26-10 FAB (HEAVY CHAIN); IGG2A-KAPPA 26-10 FAB (LIGHT CHAIN)	NA	13	TYR B 33 ASN A 34 ASN B 35 TYR A 36 TYR B 47 TYR B 50 SER A 89 THR A 91 SER B 95 PRO A 96 ALA B 100 TRP B 100 MET B 100	DGX B 228
3B0W_A_DGXA1	3b0w	DGX	Digoxin (DB00390)	Homo sapiens	NUCLEAR RECEPTOR ROR-GAMMA	Hormone_recep	24	CYS A 285 GLN A 286 LEU A 287 LEU A 292 TRP A 317 CYS A 320 ALA A 321 LEU A 324 ALA A 327 VAL A 361 LEU A 362 ARG A 364 MET A 365 ARG A 367 ALA A 368 VAL A 376 PHE A 377 PHE A 378 PHE A 388 LEU A 391 CYS A 393 LEU A 396 GLN A 478 HIS A 479	DGX A 1
7DDH_A_DGXA1110	7ddh	DGX	Digoxin (DB00390)	Sus scrofa	SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1	Cation_ATPase Cation_ATPase_C Cation_ATPase_N E1-E2_ATPase Na_K-ATPase	20	GLN B 84 GLN A 111 GLU A 115 GLN A 119 ASP A 121 ASN A 122 LEU A 125 GLU A 312 ILE A 315 PHE A 316 GLY A 319 VAL A 322 ALA A 323 PHE A 783 PHE A 786 LEU A 793 THR A 797 ILE A 800 ARG A 880 ASP A 884	DGX A1110
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1IGJ_B_DGXB228","1igj","DGX","Digoxin (DB00390)","Mus musculus","IGG2A-KAPPA 26-10 FAB (HEAVY CHAIN);IGG2A-KAPPA 26-10 FAB (LIGHT CHAIN)","NA",13,"TYR B  33;ASN A  34;ASN B  35;TYR A  36;TYR B  47;TYR B  50;SER A  89;THR A  91;SER B  95;PRO A  96;ALA B 100;TRP B 100;MET B 100","DGX B 228\r"],["3B0W_A_DGXA1","3b0w","DGX","Digoxin (DB00390)","Homo sapiens","NUCLEAR RECEPTOR ROR-GAMMA","Hormone_recep",24,"CYS A 285;GLN A 286;LEU A 287;LEU A 292;TRP A 317;CYS A 320;ALA A 321;LEU A 324;ALA A 327;VAL A 361;LEU A 362;ARG A 364;MET A 365;ARG A 367;ALA A 368;VAL A 376;PHE A 377;PHE A 378;PHE A 388;LEU A 391;CYS A 393;LEU A 396;GLN A 478;HIS A 479","DGX A   1\r"],["7DDH_A_DGXA1110","7ddh","DGX","Digoxin (DB00390)","Sus scrofa","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1;SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1","Cation_ATPase;Cation_ATPase_C;Cation_ATPase_N;E1-E2_ATPase;Na_K-ATPase",20,"GLN B  84;GLN A 111;GLU A 115;GLN A 119;ASP A 121;ASN A 122;LEU A 125;GLU A 312;ILE A 315;PHE A 316;GLY A 319;VAL A 322;ALA A 323;PHE A 783;PHE A 786;LEU A 793;THR A 797;ILE A 800;ARG A 880;ASP A 884","DGX A1110\r"]]