Ligand ID: NIL

Drugbank ID:
Nilotinib
(DB04868)

Indication:
Nilotinib is a kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib.

LIST OF BINDING INTERFACES for query 'NIL'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3GP0_A_NILA1	3gp0	NIL	Nilotinib (DB04868)	Homo sapiens	MITOGEN-ACTIVATED PROTEIN KINASE 11	Pkinase	27	VAL A  30 VAL A  38 ALA A  51 VAL A  52 LYS A  53 ARG A  67 ARG A  70 GLU A  71 LEU A  74 LEU A  75 LEU A  78 VAL A  83 ILE A  84 LEU A 104 THR A 106 THR A 107 LEU A 108 MET A 109 ALA A 111 ASP A 112 ILE A 141 HIS A 148 ALA A 157 ILE A 166 LEU A 167 ASP A 168 PHE A 169	NIL A   1		Details
5MO4_A_NILA601	5mo4	NIL	Nilotinib (DB04868)	Homo sapiens	TYROSINE-PROTEIN KINASE ABL1	PK_Tyr_Ser-Thr SH2 SH3_1	26	LEU A 267 TYR A 272 VAL A 275 ALA A 288 VAL A 289 LYS A 290 LYS A 304 GLU A 305 VAL A 308 MET A 309 ILE A 312 LEU A 317 VAL A 318 ILE A 332 ILE A 334 PHE A 336 MET A 337 GLY A 340 LEU A 373 PHE A 378 HIS A 380 LEU A 389 VAL A 398 ALA A 399 ASP A 400 PHE A 401	NIL A 601		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3GP0_A_NILA1","3gp0","NIL","Nilotinib (DB04868)","Homo sapiens","MITOGEN-ACTIVATED PROTEIN KINASE 11","Pkinase",27,"VAL A 30;VAL A 38;ALA A 51;VAL A 52;LYS A 53;ARG A 67;ARG A 70;GLU A 71;LEU A 74;LEU A 75;LEU A 78;VAL A 83;ILE A 84;LEU A 104;THR A 106;THR A 107;LEU A 108;MET A 109;ALA A 111;ASP A 112;ILE A 141;HIS A 148;ALA A 157;ILE A 166;LEU A 167;ASP A 168;PHE A 169","NIL A 1\r"],["5MO4_A_NILA601","5mo4","NIL","Nilotinib (DB04868)","Homo sapiens","TYROSINE-PROTEIN KINASE ABL1","PK_Tyr_Ser-Thr;SH2;SH3_1",26,"LEU A 267;TYR A 272;VAL A 275;ALA A 288;VAL A 289;LYS A 290;LYS A 304;GLU A 305;VAL A 308;MET A 309;ILE A 312;LEU A 317;VAL A 318;ILE A 332;ILE A 334;PHE A 336;MET A 337;GLY A 340;LEU A 373;PHE A 378;HIS A 380;LEU A 389;VAL A 398;ALA A 399;ASP A 400;PHE A 401","NIL A 601\r"]]