Results: Ligand

Ligand ID: TPF

Drugbank ID:
Fluconazole
(DB00196)

Indication:
Fluconazole is a triazole antifungal used to treat various fungal infections including candidiasis.

LIST OF BINDING INTERFACES for query 'DB00196'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1EA1_A_TPFA470	1ea1	TPF	Fluconazole (DB00196)	Mycobacterium tuberculosis	CYTOCHROME P450 51-LIKE RV0764C	p450	13	TYR A 76 PHE A 78 MET A 79 PHE A 83 ARG A 96 MET A 99 LEU A 100 PHE A 255 ALA A 256 HIS A 259 THR A 260 LEU A 321 MET A 433	TPF A 470
2IJ7_A_TPFA2472	2ij7	TPF	Fluconazole (DB00196)	Mycobacterium tuberculosis	CYTOCHROME P450 121	p450	15	MET A 62 THR A 77 VAL A 78 VAL A 82 VAL A 83 ASN A 85 MET A 86 ALA A 167 PHE A 168 THR A 229 ALA A 233 SER A 237 PHE A 280 GLN A 385 ARG A 386	TPF A2472
2WV2_A_TPFA1	2wv2	TPF	Fluconazole (DB00196)	Trypanosoma brucei	LANOSTEROL 14-ALPHA-DEMETHYLASE	p450	13	TYR A 103 MET A 106 PHE A 110 TYR A 116 LEU A 127 ALA A 287 PHE A 290 ALA A 291 THR A 295 LEU A 356 CYS A 422 MET A 460 VAL A 461	TPF A 1
2WX2_A_TPFA1460	2wx2	TPF	Fluconazole (DB00196)	Trypanosoma cruzi	LANOSTEROL 14-ALPHA-DEMETHYLASE	p450	13	TYR A 103 MET A 106 PHE A 110 TYR A 116 LEU A 127 ALA A 287 PHE A 290 ALA A 291 THR A 295 LEU A 356 MET A 358 CYS A 422 MET A 460	TPF A1460
3L4D_A_TPFA490	3l4d	TPF	Fluconazole (DB00196)	Leishmania infantum	STEROL 14-ALPHA DEMETHYLASE	p450	12	TYR A 102 MET A 105 PHE A 109 TYR A 115 LEU A 126 ALA A 286 PHE A 289 ALA A 290 THR A 294 LEU A 355 CYS A 422 MET A 459	TPF A 490
5ESM_A_TPFA602	5esm	TPF	Fluconazole (DB00196)	Saccharomyces cerevisiae (strain yjm789)	LANOSTEROL 14-ALPHA DEMETHYLASE	p450	14	TYR A 126 PHE A 134 ILE A 139 TYR A 140 PHE A 236 GLY A 310 VAL A 311 GLY A 314 GLY A 315 THR A 318 LEU A 380 LEU A 383 CYS A 470 MET A 509	TPF A 602
6AY4_A_TPFA506	6ay4	TPF	Fluconazole (DB00196)	Naegleria fowleri	CYP51, STEROL 14ALPHA-DEMETHYLASE	p450	14	TYR A 107 MET A 110 PHE A 114 VAL A 119 TYR A 120 ALA A 289 GLY A 290 PHE A 292 ALA A 293 THR A 297 LEU A 358 MET A 360 CYS A 430 LEU A 467	TPF A 506
6H1S_A_TPFA501	6h1s	TPF	Fluconazole (DB00196)	Bacillus megaterium	BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE	p450	14	ALA A 74 LEU A 75 VAL A 78 PHE A 82 VAL A 87 LEU A 181 ILE A 263 ALA A 264 GLU A 267 THR A 268 ALA A 328 CYS A 400 LEU A 437 THR A 438	TPF A 501
6MA7_A_TPFA602	6ma7	TPF	Fluconazole (DB00196)	Homo sapiens	CYTOCHROME P450 3A4	p450	8	ARG A 105 SER A 119 ARG A 212 PHE A 304 ALA A 305 THR A 309 ILE A 369 ALA A 370	TPF A 602
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1EA1_A_TPFA470","1ea1","TPF","Fluconazole (DB00196)","Mycobacterium tuberculosis","CYTOCHROME P450 51-LIKE RV0764C","p450",13,"TYR A  76;PHE A  78;MET A  79;PHE A  83;ARG A  96;MET A  99;LEU A 100;PHE A 255;ALA A 256;HIS A 259;THR A 260;LEU A 321;MET A 433","TPF A 470\r"],["2IJ7_A_TPFA2472","2ij7","TPF","Fluconazole (DB00196)","Mycobacterium tuberculosis","CYTOCHROME P450 121","p450",15,"MET A  62;THR A  77;VAL A  78;VAL A  82;VAL A  83;ASN A  85;MET A  86;ALA A 167;PHE A 168;THR A 229;ALA A 233;SER A 237;PHE A 280;GLN A 385;ARG A 386","TPF A2472\r"],["2WV2_A_TPFA1","2wv2","TPF","Fluconazole (DB00196)","Trypanosoma brucei","LANOSTEROL 14-ALPHA-DEMETHYLASE","p450",13,"TYR A 103;MET A 106;PHE A 110;TYR A 116;LEU A 127;ALA A 287;PHE A 290;ALA A 291;THR A 295;LEU A 356;CYS A 422;MET A 460;VAL A 461","TPF A   1\r"],["2WX2_A_TPFA1460","2wx2","TPF","Fluconazole (DB00196)","Trypanosoma cruzi","LANOSTEROL 14-ALPHA-DEMETHYLASE","p450",13,"TYR A 103;MET A 106;PHE A 110;TYR A 116;LEU A 127;ALA A 287;PHE A 290;ALA A 291;THR A 295;LEU A 356;MET A 358;CYS A 422;MET A 460","TPF A1460\r"],["3L4D_A_TPFA490","3l4d","TPF","Fluconazole (DB00196)","Leishmania infantum","STEROL 14-ALPHA DEMETHYLASE","p450",12,"TYR A 102;MET A 105;PHE A 109;TYR A 115;LEU A 126;ALA A 286;PHE A 289;ALA A 290;THR A 294;LEU A 355;CYS A 422;MET A 459","TPF A 490\r"],["5ESM_A_TPFA602","5esm","TPF","Fluconazole (DB00196)","Saccharomyces cerevisiae (strain yjm789)","LANOSTEROL 14-ALPHA DEMETHYLASE","p450",14,"TYR A 126;PHE A 134;ILE A 139;TYR A 140;PHE A 236;GLY A 310;VAL A 311;GLY A 314;GLY A 315;THR A 318;LEU A 380;LEU A 383;CYS A 470;MET A 509","TPF A 602\r"],["6AY4_A_TPFA506","6ay4","TPF","Fluconazole (DB00196)","Naegleria fowleri","CYP51, STEROL 14ALPHA-DEMETHYLASE","p450",14,"TYR A 107;MET A 110;PHE A 114;VAL A 119;TYR A 120;ALA A 289;GLY A 290;PHE A 292;ALA A 293;THR A 297;LEU A 358;MET A 360;CYS A 430;LEU A 467","TPF A 506\r"],["6H1S_A_TPFA501","6h1s","TPF","Fluconazole (DB00196)","Bacillus megaterium","BIFUNCTIONAL CYTOCHROME P450\/NADPH--P450 REDUCTASE","p450",14,"ALA A  74;LEU A  75;VAL A  78;PHE A  82;VAL A  87;LEU A 181;ILE A 263;ALA A 264;GLU A 267;THR A 268;ALA A 328;CYS A 400;LEU A 437;THR A 438","TPF A 501\r"],["6MA7_A_TPFA602","6ma7","TPF","Fluconazole (DB00196)","Homo sapiens","CYTOCHROME P450 3A4","p450",8,"ARG A 105;SER A 119;ARG A 212;PHE A 304;ALA A 305;THR A 309;ILE A 369;ALA A 370","TPF A 602\r"]]