Ligand ID: 5P8

Drugbank ID:
Lorlatinib
(DB12130)

Indication:
Lorlatinib is an anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.


LIST OF BINDING INTERFACES for query 'DB12130'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
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DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details
4UXL_A_5P8A32304uxl 5P8Lorlatinib
(DB12130) 		Homo sapiens PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS PK_Tyr_Ser-Thr 20LEU A1951
GLY A1952
VAL A1959
GLU A1961
ALA A1978
LYS A1980
LEU A2010
LEU A2026
GLU A2027
LEU A2028
MET A2029
GLU A2030
GLY A2032
ASP A2033
ARG A2083
ASN A2084
CYS A2085
LEU A2086
GLY A2101
ASP A2102
5P8 A3230
5A9U_A_5P8A24025a9u 5P8Lorlatinib
(DB12130) 		Homo sapiens ALK TYROSINE KINASE RECEPTOR PK_Tyr_Ser-Thr 19LEU A1122
GLY A1123
VAL A1130
ALA A1148
LYS A1150
VAL A1180
LEU A1196
GLU A1197
LEU A1198
MET A1199
ALA A1200
GLY A1202
ASP A1203
ARG A1253
ASN A1254
CYS A1255
LEU A1256
GLY A1269
ASP A1270
5P8 A2402
DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details