Ligand ID: DX4

Drugbank ID:
Tioguanine
(DB00352)

Indication:
Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias.

LIST OF BINDING INTERFACES for query 'DB00352'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3JQA_A_DX4A270	3jqa	DX4	Tioguanine (DB00352)	Trypanosoma brucei	PTERIDINE REDUCTASE 1	adh_short_C2	7	ARG A  14 SER A  95 PHE A  97 ASP A 161 TYR A 174 LEU A 208 PRO A 210	DX4 A 270		Details
4M5M_A_DX4A401	4m5m	DX4	Tioguanine (DB00352)	Escherichia coli	2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE	HPPK	12	GLY A   8 THR A  42 PRO A  43 PRO A  44 LEU A  45 GLN A  50 TYR A  53 ASN A  55 TRP A  89 ARG A  92 ASP A  95 PHE A 123	DX4 A 401		Details
4XP3_A_DX4A401	4xp3	DX4	Tioguanine (DB00352)	Rattus norvegicus	MITOGEN-ACTIVATED PROTEIN KINASE 1	Pkinase	10	ILE A  29 VAL A  37 ALA A  50 LYS A  52 ILE A  82 GLN A 103 ASP A 104 LEU A 105 MET A 106 LEU A 154	DX4 A 401		Details
5XU8_A_DX4A701	5xu8	DX4	Tioguanine (DB00352)	Homo sapiens; bos taurus	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2	UCH	14	GLY A 268 LEU A 269 ASN A 271 CYS A 276 ASN A 279 SER A 280 GLN A 283 TYR A 558 THR A 559 ALA A 560 PHE A 573 ASN A 574 ASP A 575 SER A 576	DX4 A 701		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3JQA_A_DX4A270","3jqa","DX4","Tioguanine (DB00352)","Trypanosoma brucei","PTERIDINE REDUCTASE 1","adh_short_C2",7,"ARG A 14;SER A 95;PHE A 97;ASP A 161;TYR A 174;LEU A 208;PRO A 210","DX4 A 270\r"],["4M5M_A_DX4A401","4m5m","DX4","Tioguanine (DB00352)","Escherichia coli","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","HPPK",12,"GLY A 8;THR A 42;PRO A 43;PRO A 44;LEU A 45;GLN A 50;TYR A 53;ASN A 55;TRP A 89;ARG A 92;ASP A 95;PHE A 123","DX4 A 401\r"],["4XP3_A_DX4A401","4xp3","DX4","Tioguanine (DB00352)","Rattus norvegicus","MITOGEN-ACTIVATED PROTEIN KINASE 1","Pkinase",10,"ILE A 29;VAL A 37;ALA A 50;LYS A 52;ILE A 82;GLN A 103;ASP A 104;LEU A 105;MET A 106;LEU A 154","DX4 A 401\r"],["5XU8_A_DX4A701","5xu8","DX4","Tioguanine (DB00352)","Homo sapiens;bos taurus","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2","UCH",14,"GLY A 268;LEU A 269;ASN A 271;CYS A 276;ASN A 279;SER A 280;GLN A 283;TYR A 558;THR A 559;ALA A 560;PHE A 573;ASN A 574;ASP A 575;SER A 576","DX4 A 701\r"]]