Results: Ligand

Ligand ID: B49

Drugbank ID:
Sunitinib
(DB01268)

Indication:
Sunitinib is a receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).

LIST OF BINDING INTERFACES for query 'B49'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
2Y7J_A_B49A1294	2y7j	B49	Sunitinib (DB01268)	Homo sapiens	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM	Pkinase	16	VAL A 29 ILE A 30 GLY A 31 ARG A 32 VAL A 38 ALA A 51 ILE A 91 PHE A 107 ASP A 108 LEU A 109 MET A 110 ARG A 111 GLY A 113 GLU A 114 LEU A 160 ASP A 171	B49 A1294
3G0E_A_B49A9000	3g0e	B49	Sunitinib (DB01268)	Homo sapiens	MAST/STEM CELL GROWTH FACTOR RECEPTOR	PK_Tyr_Ser-Thr	18	LYS A 593 LEU A 595 VAL A 603 ALA A 621 LYS A 623 VAL A 654 THR A 670 GLU A 671 TYR A 672 CYS A 673 CYS A 674 TYR A 675 GLY A 676 LEU A 799 CYS A 809 ASP A 810 PHE A 811 ALA A 814	B49 A9000
3MIY_A_B49A1	3miy	B49	Sunitinib (DB01268)	Homo sapiens	TYROSINE-PROTEIN KINASE ITK/TSK	PK_Tyr_Ser-Thr	16	ILE A 369 VAL A 377 ALA A 389 LYS A 391 VAL A 419 PHE A 435 GLU A 436 PHE A 437 MET A 438 GLU A 439 HIS A 440 GLY A 441 CYS A 442 LEU A 489 SER A 499 ASP A 500	B49 A 1
3TI1_A_B49A299	3ti1	B49	Sunitinib (DB01268)	Homo sapiens	CYCLIN-DEPENDENT KINASE 2	Pkinase	19	ILE A 10 GLY A 11 VAL A 18 ALA A 31 LYS A 33 VAL A 64 PHE A 80 GLU A 81 PHE A 82 LEU A 83 HIS A 84 GLN A 85 ASP A 86 LYS A 88 LYS A 89 GLN A 131 LEU A 134 ALA A 144 ASP A 145	B49 A 299
4AGD_A_B49A2000	4agd	B49	Sunitinib (DB01268)	Homo sapiens	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	PK_Tyr_Ser-Thr	18	LYS A 838 LEU A 840 GLY A 841 VAL A 848 ALA A 866 LYS A 868 VAL A 899 VAL A 916 GLU A 917 PHE A 918 CYS A 919 LYS A 920 PHE A 921 GLY A 922 LEU A1035 CYS A1045 ASP A1046 PHE A1047	B49 A2000
4KS8_A_B49A701	4ks8	B49	Sunitinib (DB01268)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE PAK 6	Pkinase	15	ILE A 413 GLY A 414 VAL A 421 ALA A 434 VAL A 465 MET A 481 GLU A 482 PHE A 483 LEU A 484 GLN A 485 GLY A 487 ASP A 491 LEU A 533 SER A 543 ASP A 544	B49 A 701
4QMZ_A_B49A401	4qmz	B49	Sunitinib (DB01268)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE 24	Pkinase	16	ILE A 30 GLY A 31 VAL A 38 ALA A 51 THR A 83 MET A 99 GLU A 100 TYR A 101 LEU A 102 GLY A 103 GLY A 105 ASP A 109 LEU A 151 ALA A 161 TYR A 291 LYS A 295	B49 A 401
6JOK_A_B49A1001	6jok	B49	Sunitinib (DB01268)	Homo sapiens	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA	PK_Tyr_Ser-Thr	15	LEU A 599 VAL A 607 ALA A 625 LYS A 627 VAL A 658 THR A 674 GLU A 675 TYR A 676 CYS A 677 PHE A 678 TYR A 679 GLY A 680 ASN A 684 LEU A 825 PHE A 837	B49 A1001
6M11_A_B49A1001	6m11	B49	Sunitinib (DB01268)	Sus scrofa	RIBONUCLEASE L	Ank_2 Ank_3 Ank_4 Pkinase Ribonuc_2-5A	15	ARG a 340 ILE a 369 ALA a 370 ILE a 377 ALA a 388 LEU a 432 ALA a 433 LEU a 434 CYS a 435 THR a 438 GLN a 440 GLU a 441 GLN a 486 LEU a 489 ASP a 500	B49 a1001
6NG0_A_B49A9000	6ng0	B49	Sunitinib (DB01268)	Homo sapiens	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1	Pkinase	19	GLN A 21 ARG A 22 LEU A 23 GLY A 24 VAL A 31 ALA A 44 LYS A 46 VAL A 75 MET A 91 GLU A 92 PHE A 93 CYS A 94 GLY A 95 ALA A 96 GLY A 97 ASP A 101 LEU A 144 ALA A 154 ASP A 155	B49 A9000
6V0X_A_B49A301	6v0x	B49	Sunitinib (DB01268)	Homo sapiens	BROMODOMAIN-CONTAINING PROTEIN 9	Bromodomain	13	PHE A 160 PHE A 161 PHE A 163 VAL A 165 ILE A 169 ALA A 170 TYR A 173 ASN A 211 ALA A 212 TYR A 215 ASN A 216 ARG A 217 TYR A 222	B49 A 301
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["2Y7J_A_B49A1294","2y7j","B49","Sunitinib (DB01268)","Homo sapiens","PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS\/LIVER ISOFORM","Pkinase",16,"VAL A  29;ILE A  30;GLY A  31;ARG A  32;VAL A  38;ALA A  51;ILE A  91;PHE A 107;ASP A 108;LEU A 109;MET A 110;ARG A 111;GLY A 113;GLU A 114;LEU A 160;ASP A 171","B49 A1294\r"],["3G0E_A_B49A9000","3g0e","B49","Sunitinib (DB01268)","Homo sapiens","MAST\/STEM CELL GROWTH FACTOR RECEPTOR","PK_Tyr_Ser-Thr",18,"LYS A 593;LEU A 595;VAL A 603;ALA A 621;LYS A 623;VAL A 654;THR A 670;GLU A 671;TYR A 672;CYS A 673;CYS A 674;TYR A 675;GLY A 676;LEU A 799;CYS A 809;ASP A 810;PHE A 811;ALA A 814","B49 A9000\r"],["3MIY_A_B49A1","3miy","B49","Sunitinib (DB01268)","Homo sapiens","TYROSINE-PROTEIN KINASE ITK\/TSK","PK_Tyr_Ser-Thr",16,"ILE A 369;VAL A 377;ALA A 389;LYS A 391;VAL A 419;PHE A 435;GLU A 436;PHE A 437;MET A 438;GLU A 439;HIS A 440;GLY A 441;CYS A 442;LEU A 489;SER A 499;ASP A 500","B49 A   1\r"],["3TI1_A_B49A299","3ti1","B49","Sunitinib (DB01268)","Homo sapiens","CYCLIN-DEPENDENT KINASE 2","Pkinase",19,"ILE A  10;GLY A  11;VAL A  18;ALA A  31;LYS A  33;VAL A  64;PHE A  80;GLU A  81;PHE A  82;LEU A  83;HIS A  84;GLN A  85;ASP A  86;LYS A  88;LYS A  89;GLN A 131;LEU A 134;ALA A 144;ASP A 145","B49 A 299\r"],["4AGD_A_B49A2000","4agd","B49","Sunitinib (DB01268)","Homo sapiens","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","PK_Tyr_Ser-Thr",18,"LYS A 838;LEU A 840;GLY A 841;VAL A 848;ALA A 866;LYS A 868;VAL A 899;VAL A 916;GLU A 917;PHE A 918;CYS A 919;LYS A 920;PHE A 921;GLY A 922;LEU A1035;CYS A1045;ASP A1046;PHE A1047","B49 A2000\r"],["4KS8_A_B49A701","4ks8","B49","Sunitinib (DB01268)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE PAK 6","Pkinase",15,"ILE A 413;GLY A 414;VAL A 421;ALA A 434;VAL A 465;MET A 481;GLU A 482;PHE A 483;LEU A 484;GLN A 485;GLY A 487;ASP A 491;LEU A 533;SER A 543;ASP A 544","B49 A 701\r"],["4QMZ_A_B49A401","4qmz","B49","Sunitinib (DB01268)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE 24","Pkinase",16,"ILE A  30;GLY A  31;VAL A  38;ALA A  51;THR A  83;MET A  99;GLU A 100;TYR A 101;LEU A 102;GLY A 103;GLY A 105;ASP A 109;LEU A 151;ALA A 161;TYR A 291;LYS A 295","B49 A 401\r"],["6JOK_A_B49A1001","6jok","B49","Sunitinib (DB01268)","Homo sapiens","PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA","PK_Tyr_Ser-Thr",15,"LEU A 599;VAL A 607;ALA A 625;LYS A 627;VAL A 658;THR A 674;GLU A 675;TYR A 676;CYS A 677;PHE A 678;TYR A 679;GLY A 680;ASN A 684;LEU A 825;PHE A 837","B49 A1001\r"],["6M11_A_B49A1001","6m11","B49","Sunitinib (DB01268)","Sus scrofa","RIBONUCLEASE L","Ank_2;Ank_3;Ank_4;Pkinase;Ribonuc_2-5A",15,"ARG a 340;ILE a 369;ALA a 370;ILE a 377;ALA a 388;LEU a 432;ALA a 433;LEU a 434;CYS a 435;THR a 438;GLN a 440;GLU a 441;GLN a 486;LEU a 489;ASP a 500","B49 a1001\r"],["6NG0_A_B49A9000","6ng0","B49","Sunitinib (DB01268)","Homo sapiens","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1","Pkinase",19,"GLN A  21;ARG A  22;LEU A  23;GLY A  24;VAL A  31;ALA A  44;LYS A  46;VAL A  75;MET A  91;GLU A  92;PHE A  93;CYS A  94;GLY A  95;ALA A  96;GLY A  97;ASP A 101;LEU A 144;ALA A 154;ASP A 155","B49 A9000\r"],["6V0X_A_B49A301","6v0x","B49","Sunitinib (DB01268)","Homo sapiens","BROMODOMAIN-CONTAINING PROTEIN 9","Bromodomain",13,"PHE A 160;PHE A 161;PHE A 163;VAL A 165;ILE A 169;ALA A 170;TYR A 173;ASN A 211;ALA A 212;TYR A 215;ASN A 216;ARG A 217;TYR A 222","B49 A 301\r"]]