Results: Ligand

Ligand ID: CLM

Drugbank ID:
Chloramphenicol
(DB00446)

Indication:
Chloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity.

LIST OF BINDING INTERFACES for query 'CLM'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1QHY_A_CLMA888	1qhy	CLM	Chloramphenicol (DB00446)	Streptomyces venezuelae	CHLORAMPHENICOL PHOSPHOTRANSFERASE	CPT	7	PRO A 44 LYS A 46 MET A 47 SER A 49 ALA A 50 GLU A 51 GLU A 67	CLM A 888
1QHY_A_CLMA999	1qhy	CLM	Chloramphenicol (DB00446)	Streptomyces venezuelae	CHLORAMPHENICOL PHOSPHOTRANSFERASE	CPT	14	SER A 12 VAL A 36 ASP A 37 ILE A 40 ILE A 54 PHE A 56 VAL A 62 ILE A 64 ASP A 93 VAL A 94 LEU A 96 ARG A 136 MET A 140 GLN A 144	CLM A 999
1USQ_A_CLMA1143	1usq	CLM	Chloramphenicol (DB00446)	Escherichia coli	DR HEMAGGLUTININ STRUCTURAL SUBUNIT	Adhesin_Dr	9	PRO A 40 ILE A 41 GLY A 42 PRO A 43 THR A 88 ILE A 111 GLY A 113 ILE A 114 TYR A 115	CLM A1143
2UXP_A_CLMA1211	2uxp	CLM	Chloramphenicol (DB00446)	Pseudomonas putida	HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR	TetR_C_2 TetR_N	16	LEU A 66 HIS A 67 HIS A 70 ALA A 74 SER A 77 GLU A 78 LEU A 92 LEU A 93 VAL A 96 CYS A 137 GLY A 140 ILE A 141 MET A 167 PHE A 168 VAL A 171 ILE A 175	CLM A1211
2XAT_A_CLMA301	2xat	CLM	Chloramphenicol (DB00446)	Pseudomonas aeruginosa	XENOBIOTIC ACETYLTRANSFERASE	Hexapep	6	PRO A 8 PHE A 9 ARG A 10 GLY A 11 TYR A 30 SER A 32	CLM A 301
3U9F_A_CLMA221	3u9f	CLM	Chloramphenicol (DB00446)	Escherichia coli	CHLORAMPHENICOL ACETYLTRANSFERASE	CAT	16	PHE B 25 ALA B 29 CYS B 31 CYS A 91 THR A 93 PHE A 102 SER A 104 TYR A 133 PHE A 134 PHE A 144 SER A 146 LEU A 158 VAL A 160 PHE A 166 VAL A 170 HIS B 193	CLM A 221
4BN6_A_CLMA1203	4bn6	CLM	Chloramphenicol (DB00446)	Lactococcus lactis	COPPER INDUCED NITROREDUCTASE D	Nitroreductase	6	TYR A 14 LEU A 68 LYS A 88 GLN A 151 HIS A 152 TYR A 153	CLM A1203
4OAE_A_CLMA207	4oae	CLM	Chloramphenicol (DB00446)	Pseudomonas aeruginosa	GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794	Acetyltransf_1	15	PHE A 19 PRO A 20 GLU A 25 LEU A 26 TYR A 28 ALA A 29 MET A 81 MET A 82 VAL A 83 ARG A 88 ALA A 93 ASN A 121 ALA A 123 GLY A 124 LEU A 127	CLM A 207
4OAE_A_CLMA208	4oae	CLM	Chloramphenicol (DB00446)	Pseudomonas aeruginosa	GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794	Acetyltransf_1	4	ALA A 40 ALA A 43 ALA A 44 ALA A 47	CLM A 208
6IEY_A_CLMA401	6iey	CLM	Chloramphenicol (DB00446)	Uncultured bacterium	ESTERASE	Abhydrolase_3	18	PHE B 34 LEU B 37 ALA B 38 GLY A 81 GLY A 82 ILE A 85 THR A 90 HIS A 91 ASP A 152 ALA A 153 TYR A 181 TYR A 202 LEU A 203 PHE A 211 HIS A 279 GLY A 280 SER A 283 MET A 284	CLM A 401
6VRZ_A_CLMA501	6vrz	CLM	Chloramphenicol (DB00446)	Escherichia coli	MULTIDRUG TRANSPORTER MDFA	MFS_1	12	TYR A 30 ASN A 33 MET A 34 TYR A 61 LEU A 62 LEU A 119 GLU A 150 SER A 232 LEU A 236 ASN A 331 GLN A 357 PHE A 361	CLM A 501
6X7Q_A_CLMA304	6x7q	CLM	Chloramphenicol (DB00446)	NA	CHLORAMPHENICOL ACETYLTRANSFERASE 3	NA	16	PHE A 19 TYR A 20 LEU A 24 CYS A 26 GLN C 86 THR C 88 PHE C 97 ALA C 99 PHE C 129 ASN C 140 SER C 142 LEU C 154 VAL C 156 TYR C 162 ILE C 166 HIS A 189	CLM A 304
7C4G_A_CLMA303	7c4g	CLM	Chloramphenicol (DB00446)	Legionella pneumophila	N-ACETYLTRANSFERASE	Acetyltransf_1	10	ASN A 32 LEU A 33 TYR A 34 ILE A 35 HIS A 36 GLU A 129 PHE A 131 ASP A 251 GLU A 253 TYR A 276	CLM A 303
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1QHY_A_CLMA888","1qhy","CLM","Chloramphenicol (DB00446)","Streptomyces venezuelae","CHLORAMPHENICOL PHOSPHOTRANSFERASE","CPT",7,"PRO A  44;LYS A  46;MET A  47;SER A  49;ALA A  50;GLU A  51;GLU A  67","CLM A 888\r"],["1QHY_A_CLMA999","1qhy","CLM","Chloramphenicol (DB00446)","Streptomyces venezuelae","CHLORAMPHENICOL PHOSPHOTRANSFERASE","CPT",14,"SER A  12;VAL A  36;ASP A  37;ILE A  40;ILE A  54;PHE A  56;VAL A  62;ILE A  64;ASP A  93;VAL A  94;LEU A  96;ARG A 136;MET A 140;GLN A 144","CLM A 999\r"],["1USQ_A_CLMA1143","1usq","CLM","Chloramphenicol (DB00446)","Escherichia coli","DR HEMAGGLUTININ STRUCTURAL SUBUNIT","Adhesin_Dr",9,"PRO A  40;ILE A  41;GLY A  42;PRO A  43;THR A  88;ILE A 111;GLY A 113;ILE A 114;TYR A 115","CLM A1143\r"],["2UXP_A_CLMA1211","2uxp","CLM","Chloramphenicol (DB00446)","Pseudomonas putida","HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR","TetR_C_2;TetR_N",16,"LEU A  66;HIS A  67;HIS A  70;ALA A  74;SER A  77;GLU A  78;LEU A  92;LEU A  93;VAL A  96;CYS A 137;GLY A 140;ILE A 141;MET A 167;PHE A 168;VAL A 171;ILE A 175","CLM A1211\r"],["2XAT_A_CLMA301","2xat","CLM","Chloramphenicol (DB00446)","Pseudomonas aeruginosa","XENOBIOTIC ACETYLTRANSFERASE","Hexapep",6,"PRO A   8;PHE A   9;ARG A  10;GLY A  11;TYR A  30;SER A  32","CLM A 301\r"],["3U9F_A_CLMA221","3u9f","CLM","Chloramphenicol (DB00446)","Escherichia coli","CHLORAMPHENICOL ACETYLTRANSFERASE","CAT",16,"PHE B  25;ALA B  29;CYS B  31;CYS A  91;THR A  93;PHE A 102;SER A 104;TYR A 133;PHE A 134;PHE A 144;SER A 146;LEU A 158;VAL A 160;PHE A 166;VAL A 170;HIS B 193","CLM A 221\r"],["4BN6_A_CLMA1203","4bn6","CLM","Chloramphenicol (DB00446)","Lactococcus lactis","COPPER INDUCED NITROREDUCTASE D","Nitroreductase",6,"TYR A  14;LEU A  68;LYS A  88;GLN A 151;HIS A 152;TYR A 153","CLM A1203\r"],["4OAE_A_CLMA207","4oae","CLM","Chloramphenicol (DB00446)","Pseudomonas aeruginosa","GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794","Acetyltransf_1",15,"PHE A  19;PRO A  20;GLU A  25;LEU A  26;TYR A  28;ALA A  29;MET A  81;MET A  82;VAL A  83;ARG A  88;ALA A  93;ASN A 121;ALA A 123;GLY A 124;LEU A 127","CLM A 207\r"],["4OAE_A_CLMA208","4oae","CLM","Chloramphenicol (DB00446)","Pseudomonas aeruginosa","GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794","Acetyltransf_1",4,"ALA A  40;ALA A  43;ALA A  44;ALA A  47","CLM A 208\r"],["6IEY_A_CLMA401","6iey","CLM","Chloramphenicol (DB00446)","Uncultured bacterium","ESTERASE","Abhydrolase_3",18,"PHE B  34;LEU B  37;ALA B  38;GLY A  81;GLY A  82;ILE A  85;THR A  90;HIS A  91;ASP A 152;ALA A 153;TYR A 181;TYR A 202;LEU A 203;PHE A 211;HIS A 279;GLY A 280;SER A 283;MET A 284","CLM A 401\r"],["6VRZ_A_CLMA501","6vrz","CLM","Chloramphenicol (DB00446)","Escherichia coli","MULTIDRUG TRANSPORTER MDFA","MFS_1",12,"TYR A  30;ASN A  33;MET A  34;TYR A  61;LEU A  62;LEU A 119;GLU A 150;SER A 232;LEU A 236;ASN A 331;GLN A 357;PHE A 361","CLM A 501\r"],["6X7Q_A_CLMA304","6x7q","CLM","Chloramphenicol (DB00446)","NA","CHLORAMPHENICOL ACETYLTRANSFERASE 3","NA",16,"PHE A  19;TYR A  20;LEU A  24;CYS A  26;GLN C  86;THR C  88;PHE C  97;ALA C  99;PHE C 129;ASN C 140;SER C 142;LEU C 154;VAL C 156;TYR C 162;ILE C 166;HIS A 189","CLM A 304\r"],["7C4G_A_CLMA303","7c4g","CLM","Chloramphenicol (DB00446)","Legionella pneumophila","N-ACETYLTRANSFERASE","Acetyltransf_1",10,"ASN A  32;LEU A  33;TYR A  34;ILE A  35;HIS A  36;GLU A 129;PHE A 131;ASP A 251;GLU A 253;TYR A 276","CLM A 303\r"]]