Results: Ligand

Ligand ID: FK5

Drugbank ID:
Tacrolimus
(DB00864)

Indication:
Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.

LIST OF BINDING INTERFACES for query 'DB00864'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1BKF_A_FK5A108	1bkf	FK5	Tacrolimus (DB00864)	Homo sapiens	FK506 BINDING PROTEIN	FKBP_C	14	TYR A 26 PHE A 36 ASP A 37 LYS A 42 PHE A 46 GLU A 54 VAL A 55 ILE A 56 TRP A 59 ALA A 81 TYR A 82 VAL A 87 ILE A 91 PHE A 99	FK5 A 108
1Q6I_A_FK5A301	1q6i	FK5	Tacrolimus (DB00864)	Escherichia coli	FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA	FKBP_C FKBP_N	14	TYR A 146 PHE A 156 ASP A 157 LEU A 166 PHE A 168 GLY A 172 VAL A 173 ILE A 174 TRP A 177 ALA A 199 TYR A 200 VAL A 205 ILE A 208 PHE A 216	FK5 A 301
2VN1_A_FK5A501	2vn1	FK5	Tacrolimus (DB00864)	Plasmodium falciparum	70 KDA PEPTIDYLPROLYL ISOMERASE	FKBP_C	26	LEU B 23 HIS B 43 TYR B 44 TYR A 44 VAL B 45 PHE A 55 ASP A 56 SER B 57 PHE B 59 ASP B 60 ARG A 61 PHE A 65 GLY A 72 GLU A 73 VAL A 74 ILE A 75 TRP A 78 LYS B 90 GLY A 100 TYR A 101 CYS A 106 ILE A 110 PHE A 118 GLU B 119 ILE B 120 GLU B 121	FK5 A 501
3IHZ_A_FK5A501	3ihz	FK5	Tacrolimus (DB00864)	Plasmodium vivax	70 KDA PEPTIDYLPROLYL ISOMERASE, PUTATIVE	FKBP_C	26	TYR A 43 TYR B 43 PHE A 54 PHE B 54 ASP B 55 ASP A 55 ARG A 60 ARG B 60 PHE A 64 PHE B 64 GLU A 72 VAL A 73 ILE A 74 TRP A 77 TRP B 77 GLY A 99 TYR A 100 TYR B 100 CYS B 105 CYS A 105 GLY B 106 GLU B 107 SER B 108 ILE B 109 ILE A 109 PHE A 117	FK5 A 501
3O5R_A_FK5A1001	3o5r	FK5	Tacrolimus (DB00864)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5	FKBP_C	15	TYR A 57 PHE A 67 ASP A 68 ARG A 73 PHE A 77 GLN A 85 VAL A 86 ILE A 87 TRP A 90 ALA A 112 TYR A 113 SER A 118 LYS A 121 ILE A 122 PHE A 130	FK5 A1001
3UF8_A_FK5A114	3uf8	FK5	Tacrolimus (DB00864)	Saccharomyces cerevisiae; burkholderia pseudomallei	UBIQUITIN-LIKE PROTEIN SMT3, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE	FKBP_C ubiquitin	15	TYR A 33 PHE A 43 ASP A 44 ARG A 49 PHE A 53 MET A 61 VAL A 62 ILE A 63 TRP A 66 GLY A 88 TYR A 89 ALA A 94 VAL A 97 ILE A 98 PHE A 106	FK5 A 114
4LAX_A_FK5A301	4lax	FK5	Tacrolimus (DB00864)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4	FKBP_C	14	TYR A 57 PHE A 67 ASP A 68 PHE A 77 GLU A 85 VAL A 86 ILE A 87 TRP A 90 ALA A 112 TYR A 113 SER A 118 LYS A 121 ILE A 122 PHE A 130	FK5 A 301
4NNR_A_FK5A201	4nnr	FK5	Tacrolimus (DB00864)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2	FKBP_C	17	TYR A 56 PHE A 66 ASP A 67 PRO B 71 PHE A 76 GLN A 84 VAL A 85 ILE A 86 TRP A 89 GLY A 111 TYR A 112 ARG A 115 ALA A 117 LYS A 120 ILE A 121 LEU A 127 PHE A 129	FK5 A 201
4ODO_A_FK5A205	4odo	FK5	Tacrolimus (DB00864)	Thermus thermophilus	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD	FKBP_C	22	THR C 10 ILE A 11 ILE C 11 ARG C 12 TYR A 13 LEU A 15 ASP A 23 GLU C 26 LEU A 27 ARG A 34 ASN A 35 LEU A 36 ILE A 37 PRO A 38 LEU A 40 ALA A 62 TYR A 63 LEU A 121 PHE A 128 VAL C 133 LYS C 134 SER C 151	FK5 A 205
4ODR_A_FK5A201	4odr	FK5	Tacrolimus (DB00864)	Thermus thermophilus; homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA	FKBP_C	15	ILE A 11 TYR A 13 LEU A 15 ASP A 23 LEU A 27 ASN A 35 LEU A 36 ILE A 37 LEU A 40 ALA A 62 TYR A 63 ILE A 71 ILE A 72 PHE A 80 PRO B 102	FK5 A 201
5B8I_C_FK5C201	5b8i	FK5	Tacrolimus (DB00864)	Coccidioides immitis (strain rs)	CALCINEURIN SUBUNIT B, VARIANT; PEPTIDYLPROLYL ISOMERASE; SERINE/THREONINE-PROTEIN PHOSPHATASE	EF-hand_5 EF-hand_7 FKBP_C Metallophos	27	TYR C 36 PHE C 55 ASP C 56 ARG C 61 PHE C 64 VAL C 72 VAL C 73 ILE C 74 TRP C 77 ALA C 99 TYR C 100 PHE C 105 LEU C 108 ILE C 109 LEU B 116 PHE C 117 MET B 119 VAL B 120 ASN B 123 TYR A 359 LEU A 361 PRO A 362 TRP A 370 SER A 371 PRO A 373 PHE A 374 GLU A 377	FK5 C 201
5D75_A_FK5A301	5d75	FK5	Tacrolimus (DB00864)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3	FKBP_C	15	TYR A 135 PHE A 145 ASP A 146 LEU A 162 LYS A 170 VAL A 171 ILE A 172 TRP A 175 ALA A 197 TYR A 198 GLN A 203 ASP A 205 ALA A 206 ILE A 208 PHE A 216	FK5 A 301
5HUA_A_FK5A201	5hua	FK5	Tacrolimus (DB00864)	Candida glabrata (strain atcc 2001 / cbs 138 / jcm 3761 / nbrc 0622 / nrrl y-65)	FK506-BINDING PROTEIN 1	FKBP_C	17	TYR A 33 GLY A 35 PHE A 43 ASP A 44 ARG A 49 PHE A 53 GLN A 61 VAL A 62 ILE A 63 TRP A 66 ALA A 88 TYR A 89 PHE A 94 LEU A 97 ILE A 98 LEU A 104 PHE A 106	FK5 A 201
5HWC_A_FK5A201	5hwc	FK5	Tacrolimus (DB00864)	Neosartorya fumigata (strain atcc mya-4609 / af293 / cbs 101355 / fgsc a1100)	FK506-BINDING PROTEIN 1A	FKBP_C	15	TYR A 27 PHE A 37 ASP A 38 ARG A 43 PHE A 47 ARG A 55 VAL A 56 ILE A 57 TRP A 60 GLY A 82 TYR A 83 PHE A 88 VAL A 91 ILE A 92 PHE A 100	FK5 A 201
6J2M_A_FK5A501	6j2m	FK5	Tacrolimus (DB00864)	Arabidopsis thaliana	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP53	FKBP_C	14	TYR A 396 PHE A 407 ASP A 408 PHE A 416 SER A 424 VAL A 425 ILE A 426 TRP A 429 GLY A 451 TYR A 452 ALA A 457 GLY A 458 ILE A 461 PHE A 469	FK5 A 501
6MKE_A_FK5A201	6mke	FK5	Tacrolimus (DB00864)	Naegleria fowleri	PEPTIDYLPROLYL ISOMERASE	FKBP_C	17	TYR A 38 PHE A 48 ASP A 49 ARG A 54 PHE A 58 GLU A 66 VAL A 67 ILE A 68 TRP A 71 ALA A 93 TYR D 94 TYR A 94 ASN D 97 ILE A 99 ILE D 99 ILE A 103 PHE A 111	FK5 A 201
6TZ6_C_FK5C200	6tz6	FK5	Tacrolimus (DB00864)	Candida albicans (strain wo-1); candida albicans (strain sc5314 / atcc mya-2876)	CALCINEURIN SUBUNIT B; FK506-BINDING PROTEIN 1; SERINE/THREONINE-PROTEIN PHOSPHATASE	EF-hand_7 FKBP_C Metallophos	26	TYR C 30 PHE C 40 ASP C 41 ARG C 46 PHE C 50 GLN C 58 VAL C 59 ILE C 60 TRP C 63 ALA C 96 TYR C 97 ILE C 102 ILE C 105 ILE C 106 PHE C 114 MET B 118 MET B 121 VAL B 122 ASN B 125 LEU A 392 PRO A 393 TRP A 401 SER A 402 PRO A 404 PHE A 405 GLU A 408	FK5 C 200
6TZ8_C_FK5C200	6tz8	FK5	Tacrolimus (DB00864)	Cryptococcus neoformans var. grubii serotype a (strain h99 / atcc 208821 / cbs 10515 / fgsc 9487)	CALCINEURIN SUBUNIT B; FK506-BINDING PROTEIN 1; SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT A1	EF-hand_7 FKBP_C Metallophos	27	TYR C 27 PHE C 37 ASP C 38 ARG C 43 PHE C 47 GLN C 55 VAL C 56 ILE C 57 TRP C 60 ALA C 82 TYR C 83 PHE C 88 ILE C 92 PHE C 100 LEU B 119 MET B 122 VAL B 123 ASN B 126 LEU B 127 TYR A 371 LEU A 373 PRO A 374 TRP A 382 SER A 383 PRO A 385 PHE A 386 GLU A 389	FK5 C 200
6VRX_A_FK5A201	6vrx	FK5	Tacrolimus (DB00864)	Mucor circinelloides	PEPTIDYLPROLYL ISOMERASE	FKBP_C	15	TYR A 27 PHE A 37 ASP A 38 ARG A 43 PHE A 47 GLN A 55 VAL A 56 ILE A 57 TRP A 60 ALA A 82 TYR A 83 TYR A 88 LEU A 91 ILE A 92 PHE A 100	FK5 A 201
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1BKF_A_FK5A108","1bkf","FK5","Tacrolimus (DB00864)","Homo sapiens","FK506 BINDING PROTEIN","FKBP_C",14,"TYR A  26;PHE A  36;ASP A  37;LYS A  42;PHE A  46;GLU A  54;VAL A  55;ILE A  56;TRP A  59;ALA A  81;TYR A  82;VAL A  87;ILE A  91;PHE A  99","FK5 A 108\r"],["1Q6I_A_FK5A301","1q6i","FK5","Tacrolimus (DB00864)","Escherichia coli","FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA","FKBP_C;FKBP_N",14,"TYR A 146;PHE A 156;ASP A 157;LEU A 166;PHE A 168;GLY A 172;VAL A 173;ILE A 174;TRP A 177;ALA A 199;TYR A 200;VAL A 205;ILE A 208;PHE A 216","FK5 A 301\r"],["2VN1_A_FK5A501","2vn1","FK5","Tacrolimus (DB00864)","Plasmodium falciparum","70 KDA PEPTIDYLPROLYL ISOMERASE","FKBP_C",26,"LEU B  23;HIS B  43;TYR B  44;TYR A  44;VAL B  45;PHE A  55;ASP A  56;SER B  57;PHE B  59;ASP B  60;ARG A  61;PHE A  65;GLY A  72;GLU A  73;VAL A  74;ILE A  75;TRP A  78;LYS B  90;GLY A 100;TYR A 101;CYS A 106;ILE A 110;PHE A 118;GLU B 119;ILE B 120;GLU B 121","FK5 A 501\r"],["3IHZ_A_FK5A501","3ihz","FK5","Tacrolimus (DB00864)","Plasmodium vivax","70 KDA PEPTIDYLPROLYL ISOMERASE, PUTATIVE","FKBP_C",26,"TYR A  43;TYR B  43;PHE A  54;PHE B  54;ASP B  55;ASP A  55;ARG A  60;ARG B  60;PHE A  64;PHE B  64;GLU A  72;VAL A  73;ILE A  74;TRP A  77;TRP B  77;GLY A  99;TYR A 100;TYR B 100;CYS B 105;CYS A 105;GLY B 106;GLU B 107;SER B 108;ILE B 109;ILE A 109;PHE A 117","FK5 A 501\r"],["3O5R_A_FK5A1001","3o5r","FK5","Tacrolimus (DB00864)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5","FKBP_C",15,"TYR A  57;PHE A  67;ASP A  68;ARG A  73;PHE A  77;GLN A  85;VAL A  86;ILE A  87;TRP A  90;ALA A 112;TYR A 113;SER A 118;LYS A 121;ILE A 122;PHE A 130","FK5 A1001\r"],["3UF8_A_FK5A114","3uf8","FK5","Tacrolimus (DB00864)","Saccharomyces cerevisiae;burkholderia pseudomallei","UBIQUITIN-LIKE PROTEIN SMT3, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE","FKBP_C;ubiquitin",15,"TYR A  33;PHE A  43;ASP A  44;ARG A  49;PHE A  53;MET A  61;VAL A  62;ILE A  63;TRP A  66;GLY A  88;TYR A  89;ALA A  94;VAL A  97;ILE A  98;PHE A 106","FK5 A 114\r"],["4LAX_A_FK5A301","4lax","FK5","Tacrolimus (DB00864)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4","FKBP_C",14,"TYR A  57;PHE A  67;ASP A  68;PHE A  77;GLU A  85;VAL A  86;ILE A  87;TRP A  90;ALA A 112;TYR A 113;SER A 118;LYS A 121;ILE A 122;PHE A 130","FK5 A 301\r"],["4NNR_A_FK5A201","4nnr","FK5","Tacrolimus (DB00864)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2","FKBP_C",17,"TYR A  56;PHE A  66;ASP A  67;PRO B  71;PHE A  76;GLN A  84;VAL A  85;ILE A  86;TRP A  89;GLY A 111;TYR A 112;ARG A 115;ALA A 117;LYS A 120;ILE A 121;LEU A 127;PHE A 129","FK5 A 201\r"],["4ODO_A_FK5A205","4odo","FK5","Tacrolimus (DB00864)","Thermus thermophilus","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD","FKBP_C",22,"THR C  10;ILE A  11;ILE C  11;ARG C  12;TYR A  13;LEU A  15;ASP A  23;GLU C  26;LEU A  27;ARG A  34;ASN A  35;LEU A  36;ILE A  37;PRO A  38;LEU A  40;ALA A  62;TYR A  63;LEU A 121;PHE A 128;VAL C 133;LYS C 134;SER C 151","FK5 A 205\r"],["4ODR_A_FK5A201","4odr","FK5","Tacrolimus (DB00864)","Thermus thermophilus;homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA","FKBP_C",15,"ILE A  11;TYR A  13;LEU A  15;ASP A  23;LEU A  27;ASN A  35;LEU A  36;ILE A  37;LEU A  40;ALA A  62;TYR A  63;ILE A  71;ILE A  72;PHE A  80;PRO B 102","FK5 A 201\r"],["5B8I_C_FK5C201","5b8i","FK5","Tacrolimus (DB00864)","Coccidioides immitis (strain rs)","CALCINEURIN SUBUNIT B, VARIANT;PEPTIDYLPROLYL ISOMERASE;SERINE\/THREONINE-PROTEIN PHOSPHATASE","EF-hand_5;EF-hand_7;FKBP_C;Metallophos",27,"TYR C  36;PHE C  55;ASP C  56;ARG C  61;PHE C  64;VAL C  72;VAL C  73;ILE C  74;TRP C  77;ALA C  99;TYR C 100;PHE C 105;LEU C 108;ILE C 109;LEU B 116;PHE C 117;MET B 119;VAL B 120;ASN B 123;TYR A 359;LEU A 361;PRO A 362;TRP A 370;SER A 371;PRO A 373;PHE A 374;GLU A 377","FK5 C 201\r"],["5D75_A_FK5A301","5d75","FK5","Tacrolimus (DB00864)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3","FKBP_C",15,"TYR A 135;PHE A 145;ASP A 146;LEU A 162;LYS A 170;VAL A 171;ILE A 172;TRP A 175;ALA A 197;TYR A 198;GLN A 203;ASP A 205;ALA A 206;ILE A 208;PHE A 216","FK5 A 301\r"],["5HUA_A_FK5A201","5hua","FK5","Tacrolimus (DB00864)","Candida glabrata (strain atcc 2001 \/ cbs 138 \/ jcm 3761 \/ nbrc 0622 \/ nrrl y-65)","FK506-BINDING PROTEIN 1","FKBP_C",17,"TYR A  33;GLY A  35;PHE A  43;ASP A  44;ARG A  49;PHE A  53;GLN A  61;VAL A  62;ILE A  63;TRP A  66;ALA A  88;TYR A  89;PHE A  94;LEU A  97;ILE A  98;LEU A 104;PHE A 106","FK5 A 201\r"],["5HWC_A_FK5A201","5hwc","FK5","Tacrolimus (DB00864)","Neosartorya fumigata (strain atcc mya-4609 \/ af293 \/ cbs 101355 \/ fgsc a1100)","FK506-BINDING PROTEIN 1A","FKBP_C",15,"TYR A  27;PHE A  37;ASP A  38;ARG A  43;PHE A  47;ARG A  55;VAL A  56;ILE A  57;TRP A  60;GLY A  82;TYR A  83;PHE A  88;VAL A  91;ILE A  92;PHE A 100","FK5 A 201\r"],["6J2M_A_FK5A501","6j2m","FK5","Tacrolimus (DB00864)","Arabidopsis thaliana","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP53","FKBP_C",14,"TYR A 396;PHE A 407;ASP A 408;PHE A 416;SER A 424;VAL A 425;ILE A 426;TRP A 429;GLY A 451;TYR A 452;ALA A 457;GLY A 458;ILE A 461;PHE A 469","FK5 A 501\r"],["6MKE_A_FK5A201","6mke","FK5","Tacrolimus (DB00864)","Naegleria fowleri","PEPTIDYLPROLYL ISOMERASE","FKBP_C",17,"TYR A  38;PHE A  48;ASP A  49;ARG A  54;PHE A  58;GLU A  66;VAL A  67;ILE A  68;TRP A  71;ALA A  93;TYR D  94;TYR A  94;ASN D  97;ILE A  99;ILE D  99;ILE A 103;PHE A 111","FK5 A 201\r"],["6TZ6_C_FK5C200","6tz6","FK5","Tacrolimus (DB00864)","Candida albicans (strain wo-1);candida albicans (strain sc5314 \/ atcc mya-2876)","CALCINEURIN SUBUNIT B;FK506-BINDING PROTEIN 1;SERINE\/THREONINE-PROTEIN PHOSPHATASE","EF-hand_7;FKBP_C;Metallophos",26,"TYR C  30;PHE C  40;ASP C  41;ARG C  46;PHE C  50;GLN C  58;VAL C  59;ILE C  60;TRP C  63;ALA C  96;TYR C  97;ILE C 102;ILE C 105;ILE C 106;PHE C 114;MET B 118;MET B 121;VAL B 122;ASN B 125;LEU A 392;PRO A 393;TRP A 401;SER A 402;PRO A 404;PHE A 405;GLU A 408","FK5 C 200\r"],["6TZ8_C_FK5C200","6tz8","FK5","Tacrolimus (DB00864)","Cryptococcus neoformans var. grubii serotype a (strain h99 \/ atcc 208821 \/ cbs 10515 \/ fgsc 9487)","CALCINEURIN SUBUNIT B;FK506-BINDING PROTEIN 1;SERINE\/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT A1","EF-hand_7;FKBP_C;Metallophos",27,"TYR C  27;PHE C  37;ASP C  38;ARG C  43;PHE C  47;GLN C  55;VAL C  56;ILE C  57;TRP C  60;ALA C  82;TYR C  83;PHE C  88;ILE C  92;PHE C 100;LEU B 119;MET B 122;VAL B 123;ASN B 126;LEU B 127;TYR A 371;LEU A 373;PRO A 374;TRP A 382;SER A 383;PRO A 385;PHE A 386;GLU A 389","FK5 C 200\r"],["6VRX_A_FK5A201","6vrx","FK5","Tacrolimus (DB00864)","Mucor circinelloides","PEPTIDYLPROLYL ISOMERASE","FKBP_C",15,"TYR A  27;PHE A  37;ASP A  38;ARG A  43;PHE A  47;GLN A  55;VAL A  56;ILE A  57;TRP A  60;ALA A  82;TYR A  83;TYR A  88;LEU A  91;ILE A  92;PHE A 100","FK5 A 201\r"]]