Results: Ligand

Ligand ID: MIX

Drugbank ID:
Mitoxantrone
(DB01204)

Indication:
Mitoxantrone is a chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis.

LIST OF BINDING INTERFACES for query 'DB01204'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
2FUM_A_MIXA539	2fum	MIX	Mitoxantrone (DB01204)	Mycobacterium tuberculosis h37rv	PROBABLE SERINE/THREONINE-PROTEIN KINASE PKNB	Pkinase	21	LEU A 17 GLY A 18 PHE A 19 VAL A 25 ALA A 38 VAL A 72 MET A 92 GLU A 93 TYR A 94 VAL A 95 GLY A 97 VAL A 98 THR A 99 ASP A 102 ASP A 138 LYS A 140 ALA A 142 ASN A 143 MET A 145 MET A 155 ASP A 156	MIX A 539
4G0V_A_MIXA1301	4g0v	MIX	Mitoxantrone (DB01204)	Homo sapiens; synthetic construct	DNA TOPOISOMERASE 2-BETA	DNA_topoisoIV TOPRIM_C Toprim	9	ARG A 503 GLY A 504 LYS A 505 ILE A 506 LEU A 507 ASN A 520 GLU A 522 GLN A 778 MET A 782	MIX A1301
4I41_A_MIXA500	4i41	MIX	Mitoxantrone (DB01204)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE PIM-1	Pkinase	21	LEU A 44 GLY A 45 PHE A 49 VAL A 52 ALA A 65 LYS A 67 ILE A 104 LEU A 120 GLU A 121 ARG A 122 VAL A 126 GLN A 127 ASP A 128 ASP A 131 ASP A 167 LYS A 169 GLU A 171 ASN A 172 LEU A 174 ILE A 185 ASP A 186	MIX A 500
4I41_A_MIXA501	4i41	MIX	Mitoxantrone (DB01204)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE PIM-1	Pkinase	18	PHE A 130 ILE A 133 THR A 134 LYS A 169 ASP A 170 GLU A 171 THR A 204 VAL A 206 TYR A 207 ASP A 234 GLY A 238 ASP A 239 ILE A 240 PRO A 241 PHE A 242 GLU A 243 GLU A 247 ARG A 256	MIX A 501
6GH9_A_MIXA1003	6gh9	MIX	Mitoxantrone (DB01204)	Homo sapiens	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15	UCH	8	ASN A 264 GLY A 266 TYR A 855 GLY A 856 GLY A 860 GLY A 861 HIS A 862 ASP A 879	MIX A1003
7NFD_B_MIXB1201	7nfd	MIX	Mitoxantrone (DB01204)	Homo sapiens; mus musculus	ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2	ABC2_membrane ABC2_membrane_7 ABC_tran	16	PHE A 432 PHE B 432 THR B 435 THR A 435 ASN A 436 ASN B 436 PHE A 439 PHE B 439 LEU B 539 THR B 542 THR A 542 ILE B 543 VAL B 546 VAL A 546 MET B 549 MET A 549	MIX B1201
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["2FUM_A_MIXA539","2fum","MIX","Mitoxantrone (DB01204)","Mycobacterium tuberculosis h37rv","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","Pkinase",21,"LEU A  17;GLY A  18;PHE A  19;VAL A  25;ALA A  38;VAL A  72;MET A  92;GLU A  93;TYR A  94;VAL A  95;GLY A  97;VAL A  98;THR A  99;ASP A 102;ASP A 138;LYS A 140;ALA A 142;ASN A 143;MET A 145;MET A 155;ASP A 156","MIX A 539\r"],["4G0V_A_MIXA1301","4g0v","MIX","Mitoxantrone (DB01204)","Homo sapiens;synthetic construct","DNA TOPOISOMERASE 2-BETA","DNA_topoisoIV;TOPRIM_C;Toprim",9,"ARG A 503;GLY A 504;LYS A 505;ILE A 506;LEU A 507;ASN A 520;GLU A 522;GLN A 778;MET A 782","MIX A1301\r"],["4I41_A_MIXA500","4i41","MIX","Mitoxantrone (DB01204)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE PIM-1","Pkinase",21,"LEU A  44;GLY A  45;PHE A  49;VAL A  52;ALA A  65;LYS A  67;ILE A 104;LEU A 120;GLU A 121;ARG A 122;VAL A 126;GLN A 127;ASP A 128;ASP A 131;ASP A 167;LYS A 169;GLU A 171;ASN A 172;LEU A 174;ILE A 185;ASP A 186","MIX A 500\r"],["4I41_A_MIXA501","4i41","MIX","Mitoxantrone (DB01204)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE PIM-1","Pkinase",18,"PHE A 130;ILE A 133;THR A 134;LYS A 169;ASP A 170;GLU A 171;THR A 204;VAL A 206;TYR A 207;ASP A 234;GLY A 238;ASP A 239;ILE A 240;PRO A 241;PHE A 242;GLU A 243;GLU A 247;ARG A 256","MIX A 501\r"],["6GH9_A_MIXA1003","6gh9","MIX","Mitoxantrone (DB01204)","Homo sapiens","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15","UCH",8,"ASN A 264;GLY A 266;TYR A 855;GLY A 856;GLY A 860;GLY A 861;HIS A 862;ASP A 879","MIX A1003\r"],["7NFD_B_MIXB1201","7nfd","MIX","Mitoxantrone (DB01204)","Homo sapiens;mus musculus","ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2","ABC2_membrane;ABC2_membrane_7;ABC_tran",16,"PHE A 432;PHE B 432;THR B 435;THR A 435;ASN A 436;ASN B 436;PHE A 439;PHE B 439;LEU B 539;THR B 542;THR A 542;ILE B 543;VAL B 546;VAL A 546;MET B 549;MET A 549","MIX B1201\r"]]