Results: Ligand

Ligand ID: STI

Drugbank ID:
Imatinib
(DB00619)

Indication:
Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.

LIST OF BINDING INTERFACES for query 'STI'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1T46_A_STIA3	1t46	STI	Imatinib (DB00619)	Homo sapiens	HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG	PK_Tyr_Ser-Thr	26	LEU A 595 VAL A 603 ALA A 621 VAL A 622 LYS A 623 GLU A 640 VAL A 643 LEU A 644 LEU A 647 VAL A 654 VAL A 668 THR A 670 GLU A 671 TYR A 672 CYS A 673 GLY A 676 LEU A 783 CYS A 788 ILE A 789 HIS A 790 ARG A 791 LEU A 799 ILE A 808 CYS A 809 ASP A 810 PHE A 811	STI A 3
1XBB_A_STIA1	1xbb	STI	Imatinib (DB00619)	Homo sapiens	TYROSINE-PROTEIN KINASE SYK	PK_Tyr_Ser-Thr	16	LEU A 377 GLY A 378 SER A 379 VAL A 385 ALA A 400 VAL A 433 MET A 448 GLU A 449 MET A 450 ALA A 451 GLU A 452 LEU A 453 GLY A 454 PRO A 455 LEU A 501 SER A 511	STI A 1
2OIQ_A_STIA1001	2oiq	STI	Imatinib (DB00619)	Gallus gallus	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	PK_Tyr_Ser-Thr	24	LEU A 273 VAL A 281 ALA A 293 ILE A 294 LYS A 295 GLU A 310 VAL A 313 MET A 314 LEU A 317 LEU A 322 VAL A 323 ILE A 336 THR A 338 TYR A 340 MET A 341 GLY A 344 TYR A 382 VAL A 383 HIS A 384 ARG A 385 LEU A 393 ALA A 403 ASP A 404 PHE A 405	STI A1001
2PL0_A_STIA200	2pl0	STI	Imatinib (DB00619)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK	PK_Tyr_Ser-Thr	24	VAL A 259 ALA A 271 VAL A 272 LYS A 273 GLU A 288 LEU A 291 MET A 292 LEU A 295 LEU A 300 VAL A 301 ILE A 314 THR A 316 GLU A 317 TYR A 318 MET A 319 GLY A 322 TYR A 360 ILE A 361 HIS A 362 LEU A 371 ILE A 380 ALA A 381 ASP A 382 PHE A 383	STI A 200
3FW1_A_STIA233	3fw1	STI	Imatinib (DB00619)	Homo sapiens	RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]	Flavodoxin_2	10	TRP A 105 PHE A 106 GLY A 149 GLY A 150 THR A 151 MET A 154 TYR A 155 ASN A 161 GLU A 193 ILE A 194	STI A 233
3GVU_A_STIA1001	3gvu	STI	Imatinib (DB00619)	Homo sapiens	TYROSINE-PROTEIN KINASE ABL2	PK_Tyr_Ser-Thr	25	LEU A 294 TYR A 299 VAL A 302 ALA A 315 VAL A 316 LYS A 317 GLU A 332 VAL A 335 MET A 336 ILE A 339 VAL A 345 ILE A 359 THR A 361 GLU A 362 TYR A 363 MET A 364 GLY A 367 PHE A 405 ILE A 406 HIS A 407 ARG A 408 LEU A 416 ALA A 426 ASP A 427 PHE A 428	STI A1001
3GVU_A_STIA1002	3gvu	STI	Imatinib (DB00619)	Homo sapiens	TYROSINE-PROTEIN KINASE ABL2	PK_Tyr_Ser-Thr	14	ALA A 383 VAL A 384 LEU A 386 LEU A 387 ALA A 479 TYR A 481 GLU A 508 GLY A 509 CYS A 510 PRO A 511 VAL A 514 MET A 542 PHE A 543 SER A 546	STI A1002
3HEC_A_STIA1	3hec	STI	Imatinib (DB00619)	Homo sapiens	MITOGEN-ACTIVATED PROTEIN KINASE 14	Pkinase	22	VAL A 30 VAL A 38 ALA A 51 VAL A 52 LYS A 53 GLU A 71 LEU A 74 LEU A 75 ILE A 84 LEU A 104 THR A 106 HIS A 107 LEU A 108 MET A 109 ILE A 146 ILE A 147 HIS A 148 ARG A 149 ASP A 150 LEU A 167 ASP A 168 PHE A 169	STI A 1
3K5V_A_STIA2	3k5v	STI	Imatinib (DB00619)	Mus musculus	TYROSINE-PROTEIN KINASE ABL1	PK_Tyr_Ser-Thr	25	LEU A 267 TYR A 272 VAL A 275 ALA A 288 VAL A 289 LYS A 290 GLU A 305 VAL A 308 MET A 309 ILE A 312 VAL A 318 ILE A 332 THR A 334 GLU A 335 PHE A 336 MET A 337 GLY A 340 PHE A 378 ILE A 379 HIS A 380 ARG A 381 LEU A 389 ALA A 399 ASP A 400 PHE A 401	STI A 2
4BKJ_A_STIA1000	4bkj	STI	Imatinib (DB00619)	Homo sapiens	EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1	PK_Tyr_Ser-Thr	23	LEU A 616 VAL A 624 ALA A 653 VAL A 654 LYS A 655 GLU A 672 ILE A 675 MET A 676 LEU A 679 ILE A 685 MET A 699 THR A 701 ASP A 702 TYR A 703 MET A 704 PHE A 762 VAL A 763 HIS A 764 ARG A 765 LEU A 773 ALA A 783 ASP A 784 PHE A 785	STI A1000
4CSV_A_STIA1265	4csv	STI	Imatinib (DB00619)	Synthetic construct	SRC-ABL TYROSINE KINASE ANCESTOR	NA	24	LEU A 14 VAL A 22 ALA A 35 VAL A 36 LYS A 37 GLU A 52 ILE A 55 MET A 56 LEU A 59 VAL A 65 ILE A 79 THR A 81 GLU A 82 TYR A 83 MET A 84 GLY A 87 PHE A 125 ILE A 126 HIS A 127 ARG A 128 LEU A 136 ALA A 146 ASP A 147 PHE A 148	STI A1265
4R7I_A_STIA1001	4r7i	STI	Imatinib (DB00619)	Homo sapiens	MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR	PK_Tyr_Ser-Thr	24	LEU A 588 VAL A 596 ALA A 614 VAL A 615 LYS A 616 GLU A 633 ILE A 636 MET A 637 LEU A 640 VAL A 647 VAL A 661 THR A 663 GLU A 664 TYR A 665 CYS A 666 GLY A 669 CYS A 774 ILE A 775 HIS A 776 ARG A 777 LEU A 785 GLY A 795 ASP A 796 PHE A 797	STI A1001
5MQT_A_STIA302	5mqt	STI	Imatinib (DB00619)	Homo sapiens	DEOXYCYTIDINE KINASE	dNK	18	ILE A 30 GLU A 53 VAL A 55 LEU A 82 MET A 85 TYR A 86 PRO A 89 GLU A 90 PHE A 96 GLN A 97 ARG A 128 PHE A 137 LEU A 141 SER A 144 CYS A 146 ARG A 192 GLU A 197 TYR A 204	STI A 302
6JOL_A_STIA1001	6jol	STI	Imatinib (DB00619)	Homo sapiens	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA	PK_Tyr_Ser-Thr	23	LEU A 599 VAL A 607 ALA A 625 VAL A 626 LYS A 627 GLU A 644 ILE A 647 MET A 648 VAL A 658 ILE A 672 THR A 674 GLU A 675 TYR A 676 CYS A 677 GLY A 680 CYS A 814 VAL A 815 HIS A 816 ARG A 817 LEU A 825 CYS A 835 ASP A 836 PHE A 837	STI A1001
6KTN_A_STIA501	6ktn	STI	Imatinib (DB00619)	Homo sapiens; synthetic construct	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA	Hormone_recep	28	TYR A 222 PHE A 226 LEU A 228 THR A 229 LYS A 230 LEU A 255 GLU A 259 ILE A 262 LYS A 263 LYS A 265 ARG A 280 ILE A 281 GLY A 284 CYS A 285 ALA A 288 SER A 289 ALA A 292 GLU A 295 ILE A 326 MET A 329 LEU A 330 SER A 332 LEU A 333 ILE A 341 SER A 342 MET A 348 LEU A 353 MET A 364	STI A 501
6VXH_B_STIB701	6vxh	STI	Imatinib (DB00619)	Homo sapiens	BROAD SUBSTRATE SPECIFICITY ATP-BINDING CASSETTE TRANSPORTER ABCG2	ABC2_membrane ABC2_membrane_7 ABC_tran	14	VAL A 401 PHE A 432 PHE B 432 THR B 435 THR A 435 ASN A 436 ASN B 436 PHE A 439 PHE B 439 ILE B 543 VAL B 546 VAL A 546 MET B 549 MET A 549	STI B 701
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1T46_A_STIA3","1t46","STI","Imatinib (DB00619)","Homo sapiens","HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG","PK_Tyr_Ser-Thr",26,"LEU A 595;VAL A 603;ALA A 621;VAL A 622;LYS A 623;GLU A 640;VAL A 643;LEU A 644;LEU A 647;VAL A 654;VAL A 668;THR A 670;GLU A 671;TYR A 672;CYS A 673;GLY A 676;LEU A 783;CYS A 788;ILE A 789;HIS A 790;ARG A 791;LEU A 799;ILE A 808;CYS A 809;ASP A 810;PHE A 811","STI A   3\r"],["1XBB_A_STIA1","1xbb","STI","Imatinib (DB00619)","Homo sapiens","TYROSINE-PROTEIN KINASE SYK","PK_Tyr_Ser-Thr",16,"LEU A 377;GLY A 378;SER A 379;VAL A 385;ALA A 400;VAL A 433;MET A 448;GLU A 449;MET A 450;ALA A 451;GLU A 452;LEU A 453;GLY A 454;PRO A 455;LEU A 501;SER A 511","STI A   1\r"],["2OIQ_A_STIA1001","2oiq","STI","Imatinib (DB00619)","Gallus gallus","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","PK_Tyr_Ser-Thr",24,"LEU A 273;VAL A 281;ALA A 293;ILE A 294;LYS A 295;GLU A 310;VAL A 313;MET A 314;LEU A 317;LEU A 322;VAL A 323;ILE A 336;THR A 338;TYR A 340;MET A 341;GLY A 344;TYR A 382;VAL A 383;HIS A 384;ARG A 385;LEU A 393;ALA A 403;ASP A 404;PHE A 405","STI A1001\r"],["2PL0_A_STIA200","2pl0","STI","Imatinib (DB00619)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK","PK_Tyr_Ser-Thr",24,"VAL A 259;ALA A 271;VAL A 272;LYS A 273;GLU A 288;LEU A 291;MET A 292;LEU A 295;LEU A 300;VAL A 301;ILE A 314;THR A 316;GLU A 317;TYR A 318;MET A 319;GLY A 322;TYR A 360;ILE A 361;HIS A 362;LEU A 371;ILE A 380;ALA A 381;ASP A 382;PHE A 383","STI A 200\r"],["3FW1_A_STIA233","3fw1","STI","Imatinib (DB00619)","Homo sapiens","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","Flavodoxin_2",10,"TRP A 105;PHE A 106;GLY A 149;GLY A 150;THR A 151;MET A 154;TYR A 155;ASN A 161;GLU A 193;ILE A 194","STI A 233\r"],["3GVU_A_STIA1001","3gvu","STI","Imatinib (DB00619)","Homo sapiens","TYROSINE-PROTEIN KINASE ABL2","PK_Tyr_Ser-Thr",25,"LEU A 294;TYR A 299;VAL A 302;ALA A 315;VAL A 316;LYS A 317;GLU A 332;VAL A 335;MET A 336;ILE A 339;VAL A 345;ILE A 359;THR A 361;GLU A 362;TYR A 363;MET A 364;GLY A 367;PHE A 405;ILE A 406;HIS A 407;ARG A 408;LEU A 416;ALA A 426;ASP A 427;PHE A 428","STI A1001\r"],["3GVU_A_STIA1002","3gvu","STI","Imatinib (DB00619)","Homo sapiens","TYROSINE-PROTEIN KINASE ABL2","PK_Tyr_Ser-Thr",14,"ALA A 383;VAL A 384;LEU A 386;LEU A 387;ALA A 479;TYR A 481;GLU A 508;GLY A 509;CYS A 510;PRO A 511;VAL A 514;MET A 542;PHE A 543;SER A 546","STI A1002\r"],["3HEC_A_STIA1","3hec","STI","Imatinib (DB00619)","Homo sapiens","MITOGEN-ACTIVATED PROTEIN KINASE 14","Pkinase",22,"VAL A  30;VAL A  38;ALA A  51;VAL A  52;LYS A  53;GLU A  71;LEU A  74;LEU A  75;ILE A  84;LEU A 104;THR A 106;HIS A 107;LEU A 108;MET A 109;ILE A 146;ILE A 147;HIS A 148;ARG A 149;ASP A 150;LEU A 167;ASP A 168;PHE A 169","STI A   1\r"],["3K5V_A_STIA2","3k5v","STI","Imatinib (DB00619)","Mus musculus","TYROSINE-PROTEIN KINASE ABL1","PK_Tyr_Ser-Thr",25,"LEU A 267;TYR A 272;VAL A 275;ALA A 288;VAL A 289;LYS A 290;GLU A 305;VAL A 308;MET A 309;ILE A 312;VAL A 318;ILE A 332;THR A 334;GLU A 335;PHE A 336;MET A 337;GLY A 340;PHE A 378;ILE A 379;HIS A 380;ARG A 381;LEU A 389;ALA A 399;ASP A 400;PHE A 401","STI A   2\r"],["4BKJ_A_STIA1000","4bkj","STI","Imatinib (DB00619)","Homo sapiens","EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1","PK_Tyr_Ser-Thr",23,"LEU A 616;VAL A 624;ALA A 653;VAL A 654;LYS A 655;GLU A 672;ILE A 675;MET A 676;LEU A 679;ILE A 685;MET A 699;THR A 701;ASP A 702;TYR A 703;MET A 704;PHE A 762;VAL A 763;HIS A 764;ARG A 765;LEU A 773;ALA A 783;ASP A 784;PHE A 785","STI A1000\r"],["4CSV_A_STIA1265","4csv","STI","Imatinib (DB00619)","Synthetic construct","SRC-ABL TYROSINE KINASE ANCESTOR","NA",24,"LEU A  14;VAL A  22;ALA A  35;VAL A  36;LYS A  37;GLU A  52;ILE A  55;MET A  56;LEU A  59;VAL A  65;ILE A  79;THR A  81;GLU A  82;TYR A  83;MET A  84;GLY A  87;PHE A 125;ILE A 126;HIS A 127;ARG A 128;LEU A 136;ALA A 146;ASP A 147;PHE A 148","STI A1265\r"],["4R7I_A_STIA1001","4r7i","STI","Imatinib (DB00619)","Homo sapiens","MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR","PK_Tyr_Ser-Thr",24,"LEU A 588;VAL A 596;ALA A 614;VAL A 615;LYS A 616;GLU A 633;ILE A 636;MET A 637;LEU A 640;VAL A 647;VAL A 661;THR A 663;GLU A 664;TYR A 665;CYS A 666;GLY A 669;CYS A 774;ILE A 775;HIS A 776;ARG A 777;LEU A 785;GLY A 795;ASP A 796;PHE A 797","STI A1001\r"],["5MQT_A_STIA302","5mqt","STI","Imatinib (DB00619)","Homo sapiens","DEOXYCYTIDINE KINASE","dNK",18,"ILE A  30;GLU A  53;VAL A  55;LEU A  82;MET A  85;TYR A  86;PRO A  89;GLU A  90;PHE A  96;GLN A  97;ARG A 128;PHE A 137;LEU A 141;SER A 144;CYS A 146;ARG A 192;GLU A 197;TYR A 204","STI A 302\r"],["6JOL_A_STIA1001","6jol","STI","Imatinib (DB00619)","Homo sapiens","PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA","PK_Tyr_Ser-Thr",23,"LEU A 599;VAL A 607;ALA A 625;VAL A 626;LYS A 627;GLU A 644;ILE A 647;MET A 648;VAL A 658;ILE A 672;THR A 674;GLU A 675;TYR A 676;CYS A 677;GLY A 680;CYS A 814;VAL A 815;HIS A 816;ARG A 817;LEU A 825;CYS A 835;ASP A 836;PHE A 837","STI A1001\r"],["6KTN_A_STIA501","6ktn","STI","Imatinib (DB00619)","Homo sapiens;synthetic construct","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","Hormone_recep",28,"TYR A 222;PHE A 226;LEU A 228;THR A 229;LYS A 230;LEU A 255;GLU A 259;ILE A 262;LYS A 263;LYS A 265;ARG A 280;ILE A 281;GLY A 284;CYS A 285;ALA A 288;SER A 289;ALA A 292;GLU A 295;ILE A 326;MET A 329;LEU A 330;SER A 332;LEU A 333;ILE A 341;SER A 342;MET A 348;LEU A 353;MET A 364","STI A 501\r"],["6VXH_B_STIB701","6vxh","STI","Imatinib (DB00619)","Homo sapiens","BROAD SUBSTRATE SPECIFICITY ATP-BINDING CASSETTE TRANSPORTER ABCG2","ABC2_membrane;ABC2_membrane_7;ABC_tran",14,"VAL A 401;PHE A 432;PHE B 432;THR B 435;THR A 435;ASN A 436;ASN B 436;PHE A 439;PHE B 439;ILE B 543;VAL B 546;VAL A 546;MET B 549;MET A 549","STI B 701\r"]]