Results: Ligand

Ligand ID: BAX

Drugbank ID:
Sorafenib
(DB00398)

Indication:
Sorafenib is a kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma.

LIST OF BINDING INTERFACES for query 'DB00398'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3GCS_A_BAXA401	3gcs	BAX	Sorafenib (DB00398)	Homo sapiens	MITOGEN-ACTIVATED PROTEIN KINASE 14	Pkinase	24	VAL A 30 VAL A 38 ALA A 51 LYS A 53 ARG A 70 GLU A 71 LEU A 74 LEU A 75 MET A 78 VAL A 83 ILE A 84 LEU A 104 THR A 106 HIS A 107 LEU A 108 MET A 109 GLY A 110 ILE A 141 ILE A 146 HIS A 148 ILE A 166 LEU A 167 ASP A 168 PHE A 169	BAX A 401
3RGF_A_BAXA465	3rgf	BAX	Sorafenib (DB00398)	Homo sapiens	CYCLIN-DEPENDENT KINASE 8	Pkinase	25	VAL A 35 ALA A 50 LYS A 52 GLU A 66 LEU A 69 LEU A 70 LEU A 73 VAL A 78 ILE A 79 PHE A 97 ASP A 98 TYR A 99 ALA A 100 GLU A 101 ASP A 103 LEU A 142 VAL A 147 LEU A 148 HIS A 149 LEU A 158 ILE A 171 ALA A 172 ASP A 173 MET A 174 PHE A 176	BAX A 465
3WZE_A_BAXA1201	3wze	BAX	Sorafenib (DB00398)	Homo sapiens	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	PK_Tyr_Ser-Thr	23	LEU A 840 VAL A 848 ALA A 866 LYS A 868 GLU A 885 ILE A 888 LEU A 889 ILE A 892 VAL A 898 VAL A 899 VAL A 916 GLU A 917 PHE A 918 CYS A 919 LYS A 920 GLY A 922 LEU A1019 HIS A1026 LEU A1035 ILE A1044 CYS A1045 ASP A1046 PHE A1047	BAX A1201
5HI2_A_BAXA801	5hi2	BAX	Sorafenib (DB00398)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE B-RAF	PK_Tyr_Ser-Thr	23	ILE A 463 VAL A 471 ALA A 481 LYS A 483 GLU A 501 VAL A 504 LEU A 505 THR A 508 ILE A 513 LEU A 514 THR A 529 GLN A 530 TRP A 531 CYS A 532 GLY A 534 LEU A 567 ILE A 572 HIS A 574 PHE A 583 ILE A 592 GLY A 593 ASP A 594 PHE A 595	BAX A 801
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3GCS_A_BAXA401","3gcs","BAX","Sorafenib (DB00398)","Homo sapiens","MITOGEN-ACTIVATED PROTEIN KINASE 14","Pkinase",24,"VAL A  30;VAL A  38;ALA A  51;LYS A  53;ARG A  70;GLU A  71;LEU A  74;LEU A  75;MET A  78;VAL A  83;ILE A  84;LEU A 104;THR A 106;HIS A 107;LEU A 108;MET A 109;GLY A 110;ILE A 141;ILE A 146;HIS A 148;ILE A 166;LEU A 167;ASP A 168;PHE A 169","BAX A 401\r"],["3RGF_A_BAXA465","3rgf","BAX","Sorafenib (DB00398)","Homo sapiens","CYCLIN-DEPENDENT KINASE 8","Pkinase",25,"VAL A  35;ALA A  50;LYS A  52;GLU A  66;LEU A  69;LEU A  70;LEU A  73;VAL A  78;ILE A  79;PHE A  97;ASP A  98;TYR A  99;ALA A 100;GLU A 101;ASP A 103;LEU A 142;VAL A 147;LEU A 148;HIS A 149;LEU A 158;ILE A 171;ALA A 172;ASP A 173;MET A 174;PHE A 176","BAX A 465\r"],["3WZE_A_BAXA1201","3wze","BAX","Sorafenib (DB00398)","Homo sapiens","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","PK_Tyr_Ser-Thr",23,"LEU A 840;VAL A 848;ALA A 866;LYS A 868;GLU A 885;ILE A 888;LEU A 889;ILE A 892;VAL A 898;VAL A 899;VAL A 916;GLU A 917;PHE A 918;CYS A 919;LYS A 920;GLY A 922;LEU A1019;HIS A1026;LEU A1035;ILE A1044;CYS A1045;ASP A1046;PHE A1047","BAX A1201\r"],["5HI2_A_BAXA801","5hi2","BAX","Sorafenib (DB00398)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE B-RAF","PK_Tyr_Ser-Thr",23,"ILE A 463;VAL A 471;ALA A 481;LYS A 483;GLU A 501;VAL A 504;LEU A 505;THR A 508;ILE A 513;LEU A 514;THR A 529;GLN A 530;TRP A 531;CYS A 532;GLY A 534;LEU A 567;ILE A 572;HIS A 574;PHE A 583;ILE A 592;GLY A 593;ASP A 594;PHE A 595","BAX A 801\r"]]