Ligand ID: 1LT

Drugbank ID:
Alpelisib
(DB12015)

Indication:
Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid...

LIST OF BINDING INTERFACES for query 'DB12015'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
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DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4JPS_A_1LTA1102	4jps	1LT	Alpelisib (DB12015)	Homo sapiens	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM	PI3K_C2 PI3K_p85B PI3K_rbd PI3Ka PI3_PI4_kinase	19	MET A 772 PRO A 778 TRP A 780 ILE A 800 LYS A 802 TYR A 836 ILE A 848 GLU A 849 VAL A 850 VAL A 851 ARG A 852 ASN A 853 SER A 854 HIS A 855 GLN A 859 MET A 922 PHE A 930 ILE A 932 ASP A 933	1LT A1102		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4JPS_A_1LTA1102","4jps","1LT","Alpelisib (DB12015)","Homo sapiens","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","PI3K_C2;PI3K_p85B;PI3K_rbd;PI3Ka;PI3_PI4_kinase",19,"MET A 772;PRO A 778;TRP A 780;ILE A 800;LYS A 802;TYR A 836;ILE A 848;GLU A 849;VAL A 850;VAL A 851;ARG A 852;ASN A 853;SER A 854;HIS A 855;GLN A 859;MET A 922;PHE A 930;ILE A 932;ASP A 933","1LT A1102\r"]]