Results: Ligand

Ligand ID: NCT

Drugbank ID:
Nicotine
(DB00184)

Indication:
Nicotine is a stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

LIST OF BINDING INTERFACES for query 'DB00184'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
1P2Y_A_NCTA440	1p2y	NCT	Nicotine (DB00184)	Pseudomonas putida	CYTOCHROME P450-CAM	p450	11	PHE A 87 THR A 185 LEU A 244 VAL A 247 GLY A 248 THR A 252 VAL A 295 ASP A 297 CYS A 357 ILE A 395 VAL A 396	NCT A 440
1UW6_A_NCTA1208	1uw6	NCT	Nicotine (DB00184)	Lymnaea stagnalis	ACETYLCHOLINE-BINDING PROTEIN	Neur_chan_LBD	12	TRP B 53 TYR A 89 ARG B 104 LEU B 112 MET B 114 SER A 142 TRP A 143 THR A 144 TYR A 185 CYS A 187 CYS A 188 TYR A 192	NCT A1208
2YK1_H_NCTH300	2yk1	NCT	Nicotine (DB00184)	Homo sapiens	FAB FRAGMENT, HEAVY CHAIN; FAB FRAGMENT, LIGHT CHAIN	NA	14	ILE H 29 TRP H 30 GLY H 31 TYR L 34 TYR L 36 ILE H 37 SER H 50 ALA L 89 VAL H 93 ALA H 94 TRP H 95 TRP L 96 PHE L 98 GLU H 101	NCT H 300
4EJJ_A_NCTA501	4ejj	NCT	Nicotine (DB00184)	Homo sapiens	CYTOCHROME P450 2A6	p450	11	PHE A 107 PHE A 111 VAL A 117 PHE A 118 PHE A 209 ASN A 297 ILE A 300 GLY A 301 THR A 305 ILE A 366 PHE A 480	NCT A 501
5O87_A_NCTA601	5o87	NCT	Nicotine (DB00184)	Aplysia californica	SOLUBLE ACETYLCHOLINE RECEPTOR	Neur_chan_LBD	11	TYR B 72 TYR A 110 VAL B 125 MET B 133 ILE B 135 TRP A 164 VAL A 165 TYR A 205 CYS A 207 CYS A 208 TYR A 212	NCT A 601
6CNJ_A_NCTA402	6cnj	NCT	Nicotine (DB00184)	Homo sapiens; mus musculus	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4; NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2	Neur_chan_LBD Neur_chan_memb	11	TRP B 57 TYR A 100 VAL B 111 PHE B 119 LEU B 121 TRP A 156 THR A 157 TYR A 197 CYS A 199 CYS A 200 TYR A 204	NCT A 402
6PV7_A_NCTA701	6pv7	NCT	Nicotine (DB00184)	Homo sapiens; escherichia coli o11; mus musculus	FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 AND SOLUBLE CYTOCHROME B562; FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4 AND SOLUBLE CYTOCHROME B562	Neur_chan_LBD Neur_chan_memb	11	TRP B 59 TYR A 93 ILE B 113 LEU B 121 LEU B 123 TRP A 149 SER A 150 TYR A 190 CYS A 192 CYS A 193 TYR A 197	NCT A 701
7KHN_A_NCTA502	7khn	NCT	Nicotine (DB00184)	Pseudomonas putida (strain s16)	AMINE OXIDASE	Amino_oxidase	9	LEU A 217 TYR A 218 GLU A 249 THR A 250 TRP A 364 THR A 381 TYR A 427 ALA A 461 TYR A 462	NCT A 502
7KHN_A_NCTA503	7khn	NCT	Nicotine (DB00184)	Pseudomonas putida (strain s16)	AMINE OXIDASE	Amino_oxidase	9	LEU A 135 PHE A 155 GLY A 156 TYR A 214 MET A 246 GLU A 249 PHE A 353 PHE A 355 TRP A 364	NCT A 503
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["1P2Y_A_NCTA440","1p2y","NCT","Nicotine (DB00184)","Pseudomonas putida","CYTOCHROME P450-CAM","p450",11,"PHE A  87;THR A 185;LEU A 244;VAL A 247;GLY A 248;THR A 252;VAL A 295;ASP A 297;CYS A 357;ILE A 395;VAL A 396","NCT A 440\r"],["1UW6_A_NCTA1208","1uw6","NCT","Nicotine (DB00184)","Lymnaea stagnalis","ACETYLCHOLINE-BINDING PROTEIN","Neur_chan_LBD",12,"TRP B  53;TYR A  89;ARG B 104;LEU B 112;MET B 114;SER A 142;TRP A 143;THR A 144;TYR A 185;CYS A 187;CYS A 188;TYR A 192","NCT A1208\r"],["2YK1_H_NCTH300","2yk1","NCT","Nicotine (DB00184)","Homo sapiens","FAB FRAGMENT, HEAVY CHAIN;FAB FRAGMENT, LIGHT CHAIN","NA",14,"ILE H  29;TRP H  30;GLY H  31;TYR L  34;TYR L  36;ILE H  37;SER H  50;ALA L  89;VAL H  93;ALA H  94;TRP H  95;TRP L  96;PHE L  98;GLU H 101","NCT H 300\r"],["4EJJ_A_NCTA501","4ejj","NCT","Nicotine (DB00184)","Homo sapiens","CYTOCHROME P450 2A6","p450",11,"PHE A 107;PHE A 111;VAL A 117;PHE A 118;PHE A 209;ASN A 297;ILE A 300;GLY A 301;THR A 305;ILE A 366;PHE A 480","NCT A 501\r"],["5O87_A_NCTA601","5o87","NCT","Nicotine (DB00184)","Aplysia californica","SOLUBLE ACETYLCHOLINE RECEPTOR","Neur_chan_LBD",11,"TYR B  72;TYR A 110;VAL B 125;MET B 133;ILE B 135;TRP A 164;VAL A 165;TYR A 205;CYS A 207;CYS A 208;TYR A 212","NCT A 601\r"],["6CNJ_A_NCTA402","6cnj","NCT","Nicotine (DB00184)","Homo sapiens;mus musculus","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2","Neur_chan_LBD;Neur_chan_memb",11,"TRP B  57;TYR A 100;VAL B 111;PHE B 119;LEU B 121;TRP A 156;THR A 157;TYR A 197;CYS A 199;CYS A 200;TYR A 204","NCT A 402\r"],["6PV7_A_NCTA701","6pv7","NCT","Nicotine (DB00184)","Homo sapiens;escherichia coli o11;mus musculus","FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 AND SOLUBLE CYTOCHROME B562;FUSION PROTEIN OF NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4 AND SOLUBLE CYTOCHROME B562","Neur_chan_LBD;Neur_chan_memb",11,"TRP B  59;TYR A  93;ILE B 113;LEU B 121;LEU B 123;TRP A 149;SER A 150;TYR A 190;CYS A 192;CYS A 193;TYR A 197","NCT A 701\r"],["7KHN_A_NCTA502","7khn","NCT","Nicotine (DB00184)","Pseudomonas putida (strain s16)","AMINE OXIDASE","Amino_oxidase",9,"LEU A 217;TYR A 218;GLU A 249;THR A 250;TRP A 364;THR A 381;TYR A 427;ALA A 461;TYR A 462","NCT A 502\r"],["7KHN_A_NCTA503","7khn","NCT","Nicotine (DB00184)","Pseudomonas putida (strain s16)","AMINE OXIDASE","Amino_oxidase",9,"LEU A 135;PHE A 155;GLY A 156;TYR A 214;MET A 246;GLU A 249;PHE A 353;PHE A 355;TRP A 364","NCT A 503\r"]]