Ligand ID: ZOL

Drugbank ID:
Zoledronic acid
(DB00399)

Indication:
Zoledronic acid is a bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors.

LIST OF BINDING INTERFACES for query 'ZOL'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
(Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
2E91_A_ZOLA901	2e91	ZOL	Zoledronic acid (DB00399)	Saccharomyces cerevisiae	GERANYLGERANYL PYROPHOSPHATE SYNTHETASE	polyprenyl_synt	12	LEU A  77 ASP A  80 ASP A  84 ARG A  89 GLN A 147 LYS A 174 THR A 175 TYR A 210 GLN A 211 ASP A 214 ASP A 233 LYS A 238	ZOL A 901		Details
2Q58_A_ZOLA1	2q58	ZOL	Zoledronic acid (DB00399)	Cryptosporidium parvum	FARNESYL PYROPHOSPHATE SYNTHASE	polyprenyl_synt	12	LEU A1112 ASP A1115 ASP A1119 ARG A1124 GLN A1184 ASP A1187 LYS A1210 THR A1211 TYR A1214 GLN A1251 ASN A1254 ASP A1255	ZOL A   1		Details
3EZ3_A_ZOLA397	3ez3	ZOL	Zoledronic acid (DB00399)	Plasmodium vivax	FARNESYL PYROPHOSPHATE SYNTHASE, PUTATIVE	polyprenyl_synt	14	LEU A 123 ASP A 126 ASP A 127 ASP A 130 ARG A 135 GLN A 195 ASP A 198 LYS A 243 THR A 244 TYR A 247 GLN A 284 ASP A 287 LYS A 301 ASP A 305	ZOL A 397		Details
3IBA_A_ZOLA901	3iba	ZOL	Zoledronic acid (DB00399)	Trypanosoma cruzi	FARNESYL PYROPHOSPHATE SYNTHASE	polyprenyl_synt	12	ASP A  98 ASP A  99 ASP A 102 ARG A 107 GLN A 167 LYS A 207 THR A 208 TYR A 211 GLN A 247 ASP A 250 LYS A 264 ASP A 268	ZOL A 901		Details
3N45_F_ZOLF354	3n45	ZOL	Zoledronic acid (DB00399)	Homo sapiens	FARNESYL PYROPHOSPHATE SYNTHASE	polyprenyl_synt	13	LEU F 100 ASP F 103 ASP F 104 ASP F 107 ARG F 112 GLN F 171 LYS F 200 THR F 201 TYR F 204 GLN F 240 ASP F 243 LYS F 257 ASP F 261	ZOL F 354		Details
6G31_A_ZOLA401	6g31	ZOL	Zoledronic acid (DB00399)	Homo sapiens	GERANYLGERANYL PYROPHOSPHATE SYNTHASE	polyprenyl_synt	10	LEU A  61 ASP A  64 ASP A  65 ASP A  68 ARG A  73 GLN A 126 LYS A 151 GLN A 185 TYR A 188 LYS A 212	ZOL A 401		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["2E91_A_ZOLA901","2e91","ZOL","Zoledronic acid (DB00399)","Saccharomyces cerevisiae","GERANYLGERANYL PYROPHOSPHATE SYNTHETASE","polyprenyl_synt",12,"LEU A 77;ASP A 80;ASP A 84;ARG A 89;GLN A 147;LYS A 174;THR A 175;TYR A 210;GLN A 211;ASP A 214;ASP A 233;LYS A 238","ZOL A 901\r"],["2Q58_A_ZOLA1","2q58","ZOL","Zoledronic acid (DB00399)","Cryptosporidium parvum","FARNESYL PYROPHOSPHATE SYNTHASE","polyprenyl_synt",12,"LEU A1112;ASP A1115;ASP A1119;ARG A1124;GLN A1184;ASP A1187;LYS A1210;THR A1211;TYR A1214;GLN A1251;ASN A1254;ASP A1255","ZOL A 1\r"],["3EZ3_A_ZOLA397","3ez3","ZOL","Zoledronic acid (DB00399)","Plasmodium vivax","FARNESYL PYROPHOSPHATE SYNTHASE, PUTATIVE","polyprenyl_synt",14,"LEU A 123;ASP A 126;ASP A 127;ASP A 130;ARG A 135;GLN A 195;ASP A 198;LYS A 243;THR A 244;TYR A 247;GLN A 284;ASP A 287;LYS A 301;ASP A 305","ZOL A 397\r"],["3IBA_A_ZOLA901","3iba","ZOL","Zoledronic acid (DB00399)","Trypanosoma cruzi","FARNESYL PYROPHOSPHATE SYNTHASE","polyprenyl_synt",12,"ASP A 98;ASP A 99;ASP A 102;ARG A 107;GLN A 167;LYS A 207;THR A 208;TYR A 211;GLN A 247;ASP A 250;LYS A 264;ASP A 268","ZOL A 901\r"],["3N45_F_ZOLF354","3n45","ZOL","Zoledronic acid (DB00399)","Homo sapiens","FARNESYL PYROPHOSPHATE SYNTHASE","polyprenyl_synt",13,"LEU F 100;ASP F 103;ASP F 104;ASP F 107;ARG F 112;GLN F 171;LYS F 200;THR F 201;TYR F 204;GLN F 240;ASP F 243;LYS F 257;ASP F 261","ZOL F 354\r"],["6G31_A_ZOLA401","6g31","ZOL","Zoledronic acid (DB00399)","Homo sapiens","GERANYLGERANYL PYROPHOSPHATE SYNTHASE","polyprenyl_synt",10,"LEU A 61;ASP A 64;ASP A 65;ASP A 68;ARG A 73;GLN A 126;LYS A 151;GLN A 185;TYR A 188;LYS A 212","ZOL A 401\r"]]