Ligand ID: FMM

Drugbank ID:
Lapatinib
(DB01259)

Indication:
Lapatinib is an antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments.


LIST OF BINDING INTERFACES for query 'DB01259'
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DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details
1XKK_A_FMMA911xkk FMMLapatinib
(DB01259) 		Homo sapiens EPIDERMAL GROWTH FACTOR RECEPTOR PK_Tyr_Ser-Thr 28LEU A 718
GLY A 719
VAL A 726
ALA A 743
ILE A 744
LYS A 745
MET A 766
CYS A 775
ARG A 776
LEU A 777
LEU A 788
ILE A 789
THR A 790
GLN A 791
LEU A 792
MET A 793
GLY A 796
CYS A 797
LEU A 799
ASP A 800
ARG A 803
ARG A 841
LEU A 844
THR A 854
ASP A 855
PHE A 856
LEU A 858
MET A1002
FMM A  91
3BBT_B_FMMB913bbt FMMLapatinib
(DB01259) 		Homo sapiens RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 PK_Tyr_Ser-Thr 19LEU B 699
VAL B 707
ALA B 724
ILE B 725
LYS B 726
MET B 747
VAL B 756
LEU B 758
LEU B 769
THR B 771
LEU B 773
MET B 774
GLY B 777
CYS B 778
LEU B 825
THR B 835
ASP B 836
PHE B 837
LEU B 839
FMM B  91
DrReposER ID PDB Ligand Drug Organism Macromolecule Pfam Res. Interface HETATM View Details