Ligand ID: 1E8

Drugbank ID:
Ibrutinib
(DB09053)

Indication:
Ibrutinib is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia.

LIST OF BINDING INTERFACES for query 'DB09053'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
4IFG_A_1E8A601	4ifg	1E8	Ibrutinib (DB09053)	Toxoplasma gondii	CALMODULIN-DOMAIN PROTEIN KINASE 1	EF-hand_7 Pkinase	21	LEU A  57 GLY A  58 LYS A  59 VAL A  65 ALA A  78 VAL A  79 LYS A  80 MET A 112 LEU A 114 LEU A 126 GLU A 129 VAL A 130 TYR A 131 GLY A 134 GLU A 135 ASP A 138 LEU A 181 ILE A 194 ASP A 195 PHE A 196 LEU A 198	1E8 A 601		Details
4RZ7_A_1E8A901	4rz7	1E8	Ibrutinib (DB09053)	Plasmodium vivax sal-1	CGMP-DEPENDENT PROTEIN KINASE, PUTATIVE	Pkinase cNMP_binding	15	ILE A 540 VAL A 548 ALA A 561 LYS A 563 THR A 586 ILE A 595 PHE A 609 THR A 611 GLU A 612 LEU A 613 VAL A 614 GLU A 618 LEU A 664 ILE A 674 TYR A 815	1E8 A 901		Details
5P9I_A_1E8A701	5p9i	1E8	Ibrutinib (DB09053)	Homo sapiens	TYROSINE-PROTEIN KINASE BTK	PK_Tyr_Ser-Thr	22	LEU A 408 GLY A 409 THR A 410 GLY A 411 VAL A 416 ALA A 428 LYS A 430 MET A 449 VAL A 458 ILE A 472 THR A 474 GLU A 475 TYR A 476 MET A 477 GLY A 480 CYS A 481 ASN A 484 LEU A 528 SER A 538 ASP A 539 PHE A 540 LEU A 542	1E8 A 701		Details
5YU9_A_1E8A1101	5yu9	1E8	Ibrutinib (DB09053)	Homo sapiens	EPIDERMAL GROWTH FACTOR RECEPTOR	PK_Tyr_Ser-Thr	22	LEU A 718 GLY A 719 VAL A 726 ALA A 743 LYS A 745 MET A 766 CYS A 775 LEU A 777 LEU A 788 MET A 790 GLN A 791 LEU A 792 MET A 793 GLY A 796 CYS A 797 ASP A 800 ARG A 841 LEU A 844 THR A 854 ASP A 855 PHE A 856 LEU A 858	1E8 A1101		Details
6L8L_A_1E8A600	6l8l	1E8	Ibrutinib (DB09053)	Gallus gallus	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	PK_Tyr_Ser-Thr	18	LEU A 273 GLY A 274 VAL A 281 ALA A 293 LYS A 295 VAL A 323 ILE A 336 THR A 338 GLU A 339 TYR A 340 MET A 341 GLY A 344 SER A 345 ASP A 348 LEU A 393 ALA A 403 ASP A 404 PHE A 405	1E8 A 600		Details
6YZ4_A_1E8A514	6yz4	1E8	Ibrutinib (DB09053)	Homo sapiens	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7	Pkinase	16	GLY A 120 TYR A 121 LEU A 122 ALA A 131 ILE A 133 LEU A 136 ASN A 138 TRP A 151 MET A 153 VAL A 164 GLN A 166 GLY A 200 THR A 201 PHE A 202 PHE A 209 ALA A 211	1E8 A 514		Details
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["4IFG_A_1E8A601","4ifg","1E8","Ibrutinib (DB09053)","Toxoplasma gondii","CALMODULIN-DOMAIN PROTEIN KINASE 1","EF-hand_7;Pkinase",21,"LEU A 57;GLY A 58;LYS A 59;VAL A 65;ALA A 78;VAL A 79;LYS A 80;MET A 112;LEU A 114;LEU A 126;GLU A 129;VAL A 130;TYR A 131;GLY A 134;GLU A 135;ASP A 138;LEU A 181;ILE A 194;ASP A 195;PHE A 196;LEU A 198","1E8 A 601\r"],["4RZ7_A_1E8A901","4rz7","1E8","Ibrutinib (DB09053)","Plasmodium vivax sal-1","CGMP-DEPENDENT PROTEIN KINASE, PUTATIVE","Pkinase;cNMP_binding",15,"ILE A 540;VAL A 548;ALA A 561;LYS A 563;THR A 586;ILE A 595;PHE A 609;THR A 611;GLU A 612;LEU A 613;VAL A 614;GLU A 618;LEU A 664;ILE A 674;TYR A 815","1E8 A 901\r"],["5P9I_A_1E8A701","5p9i","1E8","Ibrutinib (DB09053)","Homo sapiens","TYROSINE-PROTEIN KINASE BTK","PK_Tyr_Ser-Thr",22,"LEU A 408;GLY A 409;THR A 410;GLY A 411;VAL A 416;ALA A 428;LYS A 430;MET A 449;VAL A 458;ILE A 472;THR A 474;GLU A 475;TYR A 476;MET A 477;GLY A 480;CYS A 481;ASN A 484;LEU A 528;SER A 538;ASP A 539;PHE A 540;LEU A 542","1E8 A 701\r"],["5YU9_A_1E8A1101","5yu9","1E8","Ibrutinib (DB09053)","Homo sapiens","EPIDERMAL GROWTH FACTOR RECEPTOR","PK_Tyr_Ser-Thr",22,"LEU A 718;GLY A 719;VAL A 726;ALA A 743;LYS A 745;MET A 766;CYS A 775;LEU A 777;LEU A 788;MET A 790;GLN A 791;LEU A 792;MET A 793;GLY A 796;CYS A 797;ASP A 800;ARG A 841;LEU A 844;THR A 854;ASP A 855;PHE A 856;LEU A 858","1E8 A1101\r"],["6L8L_A_1E8A600","6l8l","1E8","Ibrutinib (DB09053)","Gallus gallus","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","PK_Tyr_Ser-Thr",18,"LEU A 273;GLY A 274;VAL A 281;ALA A 293;LYS A 295;VAL A 323;ILE A 336;THR A 338;GLU A 339;TYR A 340;MET A 341;GLY A 344;SER A 345;ASP A 348;LEU A 393;ALA A 403;ASP A 404;PHE A 405","1E8 A 600\r"],["6YZ4_A_1E8A514","6yz4","1E8","Ibrutinib (DB09053)","Homo sapiens","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7","Pkinase",16,"GLY A 120;TYR A 121;LEU A 122;ALA A 131;ILE A 133;LEU A 136;ASN A 138;TRP A 151;MET A 153;VAL A 164;GLN A 166;GLY A 200;THR A 201;PHE A 202;PHE A 209;ALA A 211","1E8 A 514\r"]]