Results: Ligand

Ligand ID: 0LI

Drugbank ID:
Ponatinib
(DB08901)

Indication:
Ponatinib is a kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML).

LIST OF BINDING INTERFACES for query 'DB08901'
(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details
3IK3_A_0LIA1	3ik3	0LI	Ponatinib (DB08901)	Mus musculus	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1	PK_Tyr_Ser-Thr	27	LEU A 248 TYR A 253 VAL A 256 ALA A 269 VAL A 270 LYS A 271 GLU A 286 VAL A 289 MET A 290 ILE A 293 LEU A 298 VAL A 299 ILE A 313 ILE A 315 GLU A 316 PHE A 317 MET A 318 GLY A 321 LEU A 354 ILE A 360 HIS A 361 ARG A 362 LEU A 370 VAL A 379 ALA A 380 ASP A 381 PHE A 382	0LI A 1
3ZOS_A_0LIA1000	3zos	0LI	Ponatinib (DB08901)	Homo sapiens	EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1	PK_Tyr_Ser-Thr	28	LEU A 616 VAL A 624 ALA A 653 VAL A 654 LYS A 655 GLU A 672 ILE A 675 MET A 676 LEU A 679 ILE A 684 ILE A 685 MET A 699 THR A 701 ASP A 702 TYR A 703 MET A 704 GLY A 707 LEU A 757 PHE A 762 VAL A 763 HIS A 764 ARG A 765 LEU A 773 ILE A 782 ALA A 783 ASP A 784 PHE A 785 ARG A 789	0LI A1000
3ZOS_A_0LIA1004	3zos	0LI	Ponatinib (DB08901)	Homo sapiens	EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1	PK_Tyr_Ser-Thr	20	VAL A 799 VAL B 799 GLN A 800 ALA B 803 ALA A 803 LEU B 805 LEU A 805 CYS B 814 CYS A 814 ILE A 815 ILE B 815 LEU A 816 LEU B 816 MET B 817 GLY B 818 GLY A 818 PHE B 820 PHE A 820 ILE A 854 PHE A 861	0LI A1004
4C8B_A_0LIA1000	4c8b	0LI	Ponatinib (DB08901)	Homo sapiens	RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2	PK_Tyr_Ser-Thr	25	LEU A 24 VAL A 32 ALA A 45 VAL A 46 LYS A 47 GLU A 66 ILE A 69 LEU A 70 ILE A 78 LEU A 79 ILE A 93 THR A 95 GLU A 96 TYR A 97 MET A 98 LEU A 135 LEU A 142 LEU A 143 HIS A 144 HIS A 145 LEU A 153 ILE A 162 ALA A 163 ASP A 164 PHE A 165	0LI A1000
4U0I_A_0LIA1001	4u0i	0LI	Ponatinib (DB08901)	Homo sapiens	MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT	PK_Tyr_Ser-Thr	27	LEU A 595 VAL A 603 ALA A 621 VAL A 622 LYS A 623 GLU A 640 VAL A 643 LEU A 644 LEU A 647 ILE A 653 VAL A 654 VAL A 668 THR A 670 GLU A 671 TYR A 672 CYS A 673 GLY A 676 LEU A 783 CYS A 788 ILE A 789 HIS A 790 ARG A 791 LEU A 799 ILE A 808 CYS A 809 ASP A 810 PHE A 811	0LI A1001
4UXQ_A_0LIA1752	4uxq	0LI	Ponatinib (DB08901)	Homo sapiens	FIBROBLAST GROWTH FACTOR RECEPTOR 4	PK_Tyr_Ser-Thr	26	LEU A 473 VAL A 481 ALA A 501 VAL A 502 LYS A 503 GLU A 520 VAL A 523 MET A 524 ILE A 527 ILE A 534 VAL A 548 VAL A 550 GLU A 551 CYS A 552 ALA A 553 GLY A 556 LEU A 603 CYS A 608 ILE A 609 HIS A 610 ARG A 611 LEU A 619 ILE A 628 ALA A 629 ASP A 630 PHE A 631	0LI A1752
4V04_A_0LIA1772	4v04	0LI	Ponatinib (DB08901)	Homo sapiens	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B	PK_Tyr_Ser-Thr	27	LEU A 484 VAL A 492 ALA A 512 VAL A 513 LYS A 514 GLU A 531 MET A 534 MET A 535 ILE A 538 ILE A 544 ILE A 545 VAL A 561 GLU A 562 TYR A 563 ALA A 564 LEU A 614 CYS A 619 ILE A 620 HIS A 621 ARG A 622 LEU A 630 ILE A 639 ALA A 640 ASP A 641 PHE A 642 GLY A 643 LEU A 644	0LI A1772
6EG9_A_0LIA501	6eg9	0LI	Ponatinib (DB08901)	Homo sapiens	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4	PK_Tyr_Ser-Thr	24	MET A 192 VAL A 200 ALA A 211 LYS A 213 GLU A 233 VAL A 236 MET A 237 CYS A 240 LEU A 245 VAL A 246 TYR A 262 VAL A 263 TYR A 264 MET A 265 LEU A 302 HIS A 307 ILE A 308 HIS A 309 ARG A 310 LEU A 318 ILE A 327 SER A 328 ASP A 329 PHE A 330	0LI A 501
6P3D_A_0LIA1001	6p3d	0LI	Ponatinib (DB08901)	Homo sapiens	SERINE/THREONINE-PROTEIN KINASE B-RAF	PK_Tyr_Ser-Thr	28	ILE A 463 VAL A 471 ALA A 481 VAL A 482 LYS A 483 GLU A 501 VAL A 504 LEU A 505 THR A 508 ILE A 513 LEU A 514 ILE A 527 THR A 529 GLN A 530 TRP A 531 CYS A 532 LEU A 567 ILE A 572 ILE A 573 HIS A 574 ARG A 575 ASP A 576 PHE A 583 ILE A 592 GLY A 593 ASP A 594 PHE A 595 LEU A 597	0LI A1001
6TU9_A_0LIA801	6tu9	0LI	Ponatinib (DB08901)	Homo sapiens	INACTIVE TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR1	PK_Tyr_Ser-Thr	25	LEU A 479 ILE A 487 ALA A 504 ILE A 505 LYS A 506 GLU A 523 LEU A 526 MET A 527 LEU A 530 ILE A 535 VAL A 536 PHE A 552 GLU A 553 TYR A 554 ILE A 555 LEU A 606 PHE A 611 VAL A 612 HIS A 613 LYS A 614 LEU A 622 ILE A 631 SER A 632 ASP A 633 LEU A 634	0LI A 801
DrReposER ID	PDB	Ligand	Drug	Organism	Macromolecule	Pfam	Res.	Interface	HETATM	View	Details

[["3IK3_A_0LIA1","3ik3","0LI","Ponatinib (DB08901)","Mus musculus","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","PK_Tyr_Ser-Thr",27,"LEU A 248;TYR A 253;VAL A 256;ALA A 269;VAL A 270;LYS A 271;GLU A 286;VAL A 289;MET A 290;ILE A 293;LEU A 298;VAL A 299;ILE A 313;ILE A 315;GLU A 316;PHE A 317;MET A 318;GLY A 321;LEU A 354;ILE A 360;HIS A 361;ARG A 362;LEU A 370;VAL A 379;ALA A 380;ASP A 381;PHE A 382","0LI A   1\r"],["3ZOS_A_0LIA1000","3zos","0LI","Ponatinib (DB08901)","Homo sapiens","EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1","PK_Tyr_Ser-Thr",28,"LEU A 616;VAL A 624;ALA A 653;VAL A 654;LYS A 655;GLU A 672;ILE A 675;MET A 676;LEU A 679;ILE A 684;ILE A 685;MET A 699;THR A 701;ASP A 702;TYR A 703;MET A 704;GLY A 707;LEU A 757;PHE A 762;VAL A 763;HIS A 764;ARG A 765;LEU A 773;ILE A 782;ALA A 783;ASP A 784;PHE A 785;ARG A 789","0LI A1000\r"],["3ZOS_A_0LIA1004","3zos","0LI","Ponatinib (DB08901)","Homo sapiens","EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1","PK_Tyr_Ser-Thr",20,"VAL A 799;VAL B 799;GLN A 800;ALA B 803;ALA A 803;LEU B 805;LEU A 805;CYS B 814;CYS A 814;ILE A 815;ILE B 815;LEU A 816;LEU B 816;MET B 817;GLY B 818;GLY A 818;PHE B 820;PHE A 820;ILE A 854;PHE A 861","0LI A1004\r"],["4C8B_A_0LIA1000","4c8b","0LI","Ponatinib (DB08901)","Homo sapiens","RECEPTOR-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 2","PK_Tyr_Ser-Thr",25,"LEU A  24;VAL A  32;ALA A  45;VAL A  46;LYS A  47;GLU A  66;ILE A  69;LEU A  70;ILE A  78;LEU A  79;ILE A  93;THR A  95;GLU A  96;TYR A  97;MET A  98;LEU A 135;LEU A 142;LEU A 143;HIS A 144;HIS A 145;LEU A 153;ILE A 162;ALA A 163;ASP A 164;PHE A 165","0LI A1000\r"],["4U0I_A_0LIA1001","4u0i","0LI","Ponatinib (DB08901)","Homo sapiens","MAST\/STEM CELL GROWTH FACTOR RECEPTOR KIT","PK_Tyr_Ser-Thr",27,"LEU A 595;VAL A 603;ALA A 621;VAL A 622;LYS A 623;GLU A 640;VAL A 643;LEU A 644;LEU A 647;ILE A 653;VAL A 654;VAL A 668;THR A 670;GLU A 671;TYR A 672;CYS A 673;GLY A 676;LEU A 783;CYS A 788;ILE A 789;HIS A 790;ARG A 791;LEU A 799;ILE A 808;CYS A 809;ASP A 810;PHE A 811","0LI A1001\r"],["4UXQ_A_0LIA1752","4uxq","0LI","Ponatinib (DB08901)","Homo sapiens","FIBROBLAST GROWTH FACTOR RECEPTOR 4","PK_Tyr_Ser-Thr",26,"LEU A 473;VAL A 481;ALA A 501;VAL A 502;LYS A 503;GLU A 520;VAL A 523;MET A 524;ILE A 527;ILE A 534;VAL A 548;VAL A 550;GLU A 551;CYS A 552;ALA A 553;GLY A 556;LEU A 603;CYS A 608;ILE A 609;HIS A 610;ARG A 611;LEU A 619;ILE A 628;ALA A 629;ASP A 630;PHE A 631","0LI A1752\r"],["4V04_A_0LIA1772","4v04","0LI","Ponatinib (DB08901)","Homo sapiens","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","PK_Tyr_Ser-Thr",27,"LEU A 484;VAL A 492;ALA A 512;VAL A 513;LYS A 514;GLU A 531;MET A 534;MET A 535;ILE A 538;ILE A 544;ILE A 545;VAL A 561;GLU A 562;TYR A 563;ALA A 564;LEU A 614;CYS A 619;ILE A 620;HIS A 621;ARG A 622;LEU A 630;ILE A 639;ALA A 640;ASP A 641;PHE A 642;GLY A 643;LEU A 644","0LI A1772\r"],["6EG9_A_0LIA501","6eg9","0LI","Ponatinib (DB08901)","Homo sapiens","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4","PK_Tyr_Ser-Thr",24,"MET A 192;VAL A 200;ALA A 211;LYS A 213;GLU A 233;VAL A 236;MET A 237;CYS A 240;LEU A 245;VAL A 246;TYR A 262;VAL A 263;TYR A 264;MET A 265;LEU A 302;HIS A 307;ILE A 308;HIS A 309;ARG A 310;LEU A 318;ILE A 327;SER A 328;ASP A 329;PHE A 330","0LI A 501\r"],["6P3D_A_0LIA1001","6p3d","0LI","Ponatinib (DB08901)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE B-RAF","PK_Tyr_Ser-Thr",28,"ILE A 463;VAL A 471;ALA A 481;VAL A 482;LYS A 483;GLU A 501;VAL A 504;LEU A 505;THR A 508;ILE A 513;LEU A 514;ILE A 527;THR A 529;GLN A 530;TRP A 531;CYS A 532;LEU A 567;ILE A 572;ILE A 573;HIS A 574;ARG A 575;ASP A 576;PHE A 583;ILE A 592;GLY A 593;ASP A 594;PHE A 595;LEU A 597","0LI A1001\r"],["6TU9_A_0LIA801","6tu9","0LI","Ponatinib (DB08901)","Homo sapiens","INACTIVE TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR1","PK_Tyr_Ser-Thr",25,"LEU A 479;ILE A 487;ALA A 504;ILE A 505;LYS A 506;GLU A 523;LEU A 526;MET A 527;LEU A 530;ILE A 535;VAL A 536;PHE A 552;GLU A 553;TYR A 554;ILE A 555;LEU A 606;PHE A 611;VAL A 612;HIS A 613;LYS A 614;LEU A 622;ILE A 631;SER A 632;ASP A 633;LEU A 634","0LI A 801\r"]]